the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; EC 188.8.131.52; Hydrolase
Cellular Component: Golgi apparatus; membrane; basolateral plasma membrane; endoplasmic reticulum; integral to membrane; plasma membrane; melanosome; sodium:potassium-exchanging ATPase complex; sarcolemma
Molecular Function: 4-nitrophenylphosphatase activity; protein binding; metal ion binding; chaperone binding; sodium:potassium-exchanging ATPase activity; ATP binding
Biological Process: response to drug; negative regulation of heart contraction; regulation of blood pressure; ATP biosynthetic process; positive regulation of striated muscle contraction; regulation of sodium ion transport; positive regulation of heart contraction; transmembrane transport; regulation of the force of heart contraction; negative regulation of glucocorticoid biosynthetic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.