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ATP1A1 (rat)

Overview ATP1A1 the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Hydrolase; Membrane protein, integral; EC 3.6.3.9 Cellular Component: Golgi apparatus; endoplasmic reticulum; basolateral plasma membrane; T-tubule; integral to membrane; caveola; lipid raft; membrane; plasma membrane; melanosome; sodium:potassium-exchanging ATPase complex; endosome; sarcolemma Molecular Function: potassium ion binding; 4-nitrophenylphosphatase activity; protein domain specific binding; sodium ion binding; protein binding; chaperone binding; sodium:potassium-exchanging ATPase activity; phosphoinositide 3-kinase binding; ankyrin binding; ADP binding; protein kinase binding; ATP binding Biological Process: response to drug; ATP catabolic process; negative regulation of heart contraction; membrane hyperpolarization; sodium ion transport; positive regulation of striated muscle contraction; regulation of sodium ion transport; negative regulation of glucocorticoid biosynthetic process; dephosphorylation; energy coupled proton transport, against electrochemical gradient; potassium ion import; regulation of blood pressure; ATP biosynthetic process; positive regulation of heart contraction; regulation of the force of heart contraction; potassium ion transport Reference #:  P06685 (UniProtKB) Alt. Names/Synonyms: AT1A1; Atp1a1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; Na(+)/K(+) ATPase alpha-1 subunit; Nkaa1b; Sodium pump subunit alpha-1; Sodium/potassium-transporting ATPase subunit alpha-1 Gene Symbols: Atp1a1 Molecular weight: 113,054 Da Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ATP1A1 1MO7 - A=383-595 (rat) 1MO8 - A=383-595 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1MO7 1MO8  |  ENZYME  |  Phospho3D  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene

	Sites Implicated In
exocytosis, altered: Y542‑p activation: Y10‑p enzymatic activity, induced: S16‑p, S23‑p, Y542‑p enzymatic activity, inhibited: S16‑p inhibition: S943‑p intracellular localization: S16‑p, S23‑p molecular association, regulation: S16‑p, S23‑p protein conformation: S16‑p, S23‑p protein degradation: S16‑p receptor internalization, induced: S23‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			rat
0	14		K9	GKGVGRDKyEPAAVs
1	185		Y10-p	KGVGRDKyEPAAVsE
12	6		S16-p	KyEPAAVsEHGDkks
1	5		K21-u	AVsEHGDkkskkAKK
1	1		K22-u	VsEHGDkkskkAKKE
19	1		S23-p	sEHGDkkskkAKKER
1	0		K24-u	EHGDkkskkAKKERD
1	0		K25-u	HGDkkskkAKKERDM
0	1		K36	ERDMDELKKEVSMDD
0	2		K37	RDMDELKKEVSMDDH
0	1		S40	DELKKEVSMDDHKLs
0	2		K45	EVSMDDHKLsLDELH
0	7		S47-p	SMDDHKLsLDELHRK
0	2		K54	sLDELHRKyGTDLSR
1	67		Y55-p	LDELHRKyGTDLSRG
0	1		T57	ELHRKyGTDLSRGLT
0	1		S60	RKyGTDLSRGLTPAR
0	2		K156	YQEAKSSKIMESFkN
0	22		K162-u	SKIMESFkNMVPQQA
0	14		K177-u	LVIRNGEkMSINAED
0	2		K194	VGDLVEVKGGDRIPA
0	1		S207	PADLRIISANGCkVD
0	11		K212-u	IISANGCkVDNSsLT
0	2		S216	NGCkVDNSsLTGEsE
0	20		S217-p	GCkVDNSsLTGEsEP
0	1		T219	kVDNSsLTGEsEPQT
0	6		S222-p	NSsLTGEsEPQTRSP
0	3		T226	TGEsEPQTRSPDFTN
0	9		S228	EsEPQTRSPDFTNEN
0	1		S246	TRNIAFFSTNCVEGT
1	1358		Y260-p	TARGIVVyTGDRTVM
0	16		T261	ARGIVVyTGDRTVMG
0	2		T265	VVyTGDRTVMGRIAT
0	1		S275	GRIATLASGLEGGQT
0	2		K359	ARKNCLVKNLEAVET
0	1		K377	TSTICSDKTGTLTQN
0	6		K377	TSTICSDKTGTLTQN
0	1		T382	SDKTGTLTQNRMTVA
0	1		S407-p	ADTTENQsGVSFDKT
0	1		K413	QsGVSFDKTSATWFA
0	17		K444-u	QENLPILkRAVAGDA
0	3		S452	RAVAGDASESALLKC
0	1		S454	VAGDASESALLKCIE
0	11		M468	EVCCGSVMEMREKyT
1	0		Y474-p	VMEMREKyTKIVEIP
0	2		K476	EMREKyTKIVEIPFN
0	2		S484	IVEIPFNSTNKYQLS
0	1		T485	VEIPFNSTNKYQLSI
0	3		K487	IPFNSTNKYQLSIHK
0	2		K494	KYQLSIHKNPNASEP
0	1		K494	KYQLSIHKNPNASEP
0	1		S499	IHKNPNASEPKHLLV
0	1		K502	NPNASEPKHLLVMKG
0	3		K508	PKHLLVMKGAPERIL
0	3		K526-u	SSILLHGkEQPLDEE
0	5		K535	QPLDEELKDAFQNAy
0	1		K535	QPLDEELKDAFQNAy
1	134		Y542-p	KDAFQNAyLELGGLG
0	64		K605-u	AVPDAVGkCRSAGIK
0	3		K625	GDHPITAKAIAKGVG
0	4		K629	ITAKAIAKGVGIISE
0	3		S635	AKGVGIISEGNETVE
0	1		-	gap
0	1		-	gap
0	4		T640	IISEGNETVEDIAAR
0	4		N653	ARLNIPVNQVNPRDA
0	10		K661-u	QVNPRDAkACVVHGS
0	2		S668	kACVVHGSDLkDMTS
0	6		K671-u	VVHGSDLkDMTSEEL
0	2		S675	SDLkDMTSEELDDIL
0	12		R683	EELDDILRyHTEIVF
1	27		Y684-p	ELDDILRyHTEIVFA
0	3		T686	DDILRyHTEIVFART
0	2		K698	ARTSPQQKLIIVEGC
0	3		S722	TGDGVNDSPALkkAD
0	3		K726-a	VNDSPALkkADIGVA
0	5		K726-u	VNDSPALkkADIGVA
0	1		K727-a	NDSPALkkADIGVAM
0	7		K727-u	NDSPALkkADIGVAM
0	2		K773	RLIFDNLKKSIAYTL
0	28		K833	QAESDIMKRQPRNPK
0	24		K840	KRQPRNPKTDkLVNE
0	8		K843-u	PRNPKTDkLVNERLI
6	1		S943-p	ICKTRRNsVFQQGMK
0	5		K950	sVFQQGMKNKILIFG
0	4		K1019	RPGGWVEKETYY___

	human ► Hide Isoforms
K9-u	GKGVGRDkyEPAAVs
Y10-p	KGVGRDkyEPAAVsE
S16-p	kyEPAAVsEQGDkKG
K21-u	AVsEQGDkKGKKGKK
K22	VsEQGDkKGKKGKKD
G23	sEQGDkKGKKGKKDR
K24	EQGDkKGKKGKKDRD
K25	QGDkKGKKGKKDRDM
K36-u	DRDMDELkkEVSMDD
K37-u	RDMDELkkEVSMDDH
S40	DELkkEVSMDDHkLs
K45-u	EVSMDDHkLsLDELH
S47-p	SMDDHkLsLDELHRk
K54-u	sLDELHRkyGTDLsR
Y55-p	LDELHRkyGTDLsRG
T57	ELHRkyGTDLsRGLT
S60-p	RkyGTDLsRGLTSAR
K156-u	YQEAKSSkIMESFkN
K162-u	SkIMESFkNMVPQQA
K177-u	LVIRNGEkMSINAEE
K194	VGDLVEVKGGDRIPA
S207-p	PADLRIIsANGCkVD
K212-u	IIsANGCkVDNssLT
S216-p	NGCkVDNssLTGEsE
S217-p	GCkVDNssLTGEsEP
T219	kVDNssLTGEsEPQt
S222-p	NssLTGEsEPQtRsP
T226-p	TGEsEPQtRsPDFTN
S228-p	EsEPQtRsPDFTNEN
S246-p	TRNIAFFsTNCVEGT
Y260-p	TARGIVVytGDRtVM
T261-p	ARGIVVytGDRtVMG
T265-p	VVytGDRtVMGRIAT
S275	GRIATLASGLEGGQT
K359-u	ARKNCLVkNLEAVET
K377-a	TSTICSDkTGTLtQN
K377-u	TSTICSDkTGTLtQN
T382-p	SDkTGTLtQNRMTVA
S407	ADTTENQSGVSFDKT
K413	QSGVSFDKTSATWLA
K444-u	QENLPILkRAVAGDA
S452	RAVAGDASESALLKC
S454	VAGDASESALLKCIE
K468-u	ELCCGSVkEMRERYA
Y474	VkEMRERYAkIVEIP
K476-u	EMRERYAkIVEIPFN
S484-p	IVEIPFNsTNkYQLS
T485	VEIPFNsTNkYQLSI
K487-u	IPFNsTNkYQLSIHk
K494-u	kYQLSIHkNPNTSEP
K494	kYQLSIHKNPNTSEP
S499	IHkNPNTSEPQHLLV
Q502	NPNTSEPQHLLVMkG
K508-u	PQHLLVMkGAPERIL
K526	SSILLHGKEQPLDEE
K535-u	QPLDEELkDAFQNAy
K535	QPLDEELKDAFQNAy
Y542-p	kDAFQNAyLELGGLG
K605-u	AVPDAVGkCRSAGIK
K625-u	GDHPITAkAIAkGVG
K629-u	ITAkAIAkGVGIISE
S635	AkGVGIISEGNETVE
-	gap
-	gap
T640	IISEGNETVEDIAAR
S653-p	ARLNIPVsQVNPRDA
K661-u	QVNPRDAkACVVHGS
S668	kACVVHGSDLkDMTS
K671-u	VVHGSDLkDMTSEQL
S675	SDLkDMTSEQLDDIL
K683-u	EQLDDILkyHtEIVF
Y684-p	QLDDILkyHtEIVFA
T686-p	DDILkyHtEIVFART
K698-u	ARTSPQQkLIIVEGC
S722-p	TGDGVNDsPALkkAD
K726-a	VNDsPALkkADIGVA
K726-u	VNDsPALkkADIGVA
K727-a	NDsPALkkADIGVAM
K727-u	NDsPALkkADIGVAM
K773-u	RLIFDNLkKSIAYTL
K833-u	QAESDIMkRQPRNPk
K840-u	kRQPRNPkTDkLVNE
K843-u	PRNPkTDkLVNERLI
S943-p	ICKTRRNsVFQQGMk
K950-u	sVFQQGMkNKILIFG
K1019-u	RPGGWVEkETYY___

	ATP1A1 iso2
K9	GKGVGRDKYEPAAVS
Y10	KGVGRDKYEPAAVSE
S16	KYEPAAVSEQGDKKG
K21	AVSEQGDKKGKKGKK
K22	VSEQGDKKGKKGKKD
G23	SEQGDKKGKKGKKDR
K24	EQGDKKGKKGKKDRD
K25	QGDKKGKKGKKDRDM
K36	DRDMDELKKEVSMDD
K37	RDMDELKKEVSMDDH
S40	DELKKEVSMDDHKLS
K45	EVSMDDHKLSLDELH
S47	SMDDHKLSLDELHRK
K54	SLDELHRKYGTDLSR
Y55	LDELHRKYGTDLSRG
T57	ELHRKYGTDLSRGLT
S60	RKYGTDLSRGLTSAR
K156	YQEAKSSKIMESFKN
K162	SKIMESFKNMVPQQA
K177	LVIRNGEKMSINAEE
K194	VGDLVEVKGGDRIPA
S207	PADLRIISANGCKVD
K212	IISANGCKVDNSSLT
S216	NGCKVDNSSLTGESE
S217	GCKVDNSSLTGESEP
T219	KVDNSSLTGESEPQT
S222	NSSLTGESEPQTRSP
T226	TGESEPQTRSPDFTN
S228	ESEPQTRSPDFTNEN
S246	TRNIAFFSTNCVEGT
Y260	TARGIVVYTGDRTVM
T261	ARGIVVYTGDRTVMG
T265	VVYTGDRTVMGRIAT
S275	GRIATLASGLEGGQT
K359	ARKNCLVKNLEAVET
K377	TSTICSDKTGTLTQN
K377	TSTICSDKTGTLTQN
T382	SDKTGTLTQNRMTVA
S407	ADTTENQSGVSFDKT
K413	QSGVSFDKTSATWLA
K444	QENLPILKRAVAGDA
S452	RAVAGDASESALLKC
S454	VAGDASESALLKCIE
K468	ELCCGSVKEMRERYA
Y474	VKEMRERYAKIVEIP
K476	EMRERYAKIVEIPFN
S484	IVEIPFNSTNKYQLS
T485	VEIPFNSTNKYQLSI
K487	IPFNSTNKYQLSIHK
K494	KYQLSIHKNPNTSEP
K494	KYQLSIHKNPNTSEP
S499	IHKNPNTSEPQHLLV
Q502	NPNTSEPQHLLVMKG
K508	PQHLLVMKGAPERIL
K526	SSILLHGKEQPLDEE
K535	QPLDEELKDAFQNAY
K535	QPLDEELKDAFQNAY
Y542	KDAFQNAYLELGGLG
K605	AVPDAVGKCRSAGIK
K625	GDHPITAKAIAKGVG
K629	ITAKAIAKGVGIIsE
S635-p	AKGVGIIsEGsGPMs
S638-p	VGIIsEGsGPMsRGK
S642-p	sEGsGPMsRGKSWSS
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse
K9-u	GKGVGRDkyEPAAVs
Y10-p	KGVGRDkyEPAAVsE
S16-p	kyEPAAVsEHGDkkG
K21-u	AVsEHGDkkGKKAKK
K22-u	VsEHGDkkGKKAKKE
G23	sEHGDkkGKKAKKER
K24	EHGDkkGKKAKKERD
K25	HGDkkGKKAKKERDM
K36	ERDMDELKkEVsMDD
K37-u	RDMDELKkEVsMDDH
S40-p	DELKkEVsMDDHkLs
K45-u	EVsMDDHkLsLDELH
S47-p	sMDDHkLsLDELHRk
K54-u	sLDELHRkyGtDLSR
Y55-p	LDELHRkyGtDLSRG
T57-p	ELHRkyGtDLSRGLT
S60	RkyGtDLSRGLTPAR
K156-u	YQEAKSSkIMESFkN
K162-u	SkIMESFkNMVPQQA
K177-u	LVIRNGEkMSINAED
K194-u	VGDLVEVkGGDRIPA
S207-p	PADLRIIsANGCkVD
K212-u	IIsANGCkVDNSsLt
S216	NGCkVDNSsLtGEsE
S217-p	GCkVDNSsLtGEsEP
T219-p	kVDNSsLtGEsEPQt
S222-p	NSsLtGEsEPQtRsP
T226-p	tGEsEPQtRsPDFTN
S228-p	EsEPQtRsPDFTNEN
S246	TRNIAFFSTNCVEGT
Y260-p	TARGIVVytGDRtVM
T261-p	ARGIVVytGDRtVMG
T265-p	VVytGDRtVMGRIAT
S275-p	GRIATLAsGLEGGQT
K359-u	ARKNCLVkNLEAVET
K377-a	TSTICSDkTGTLtQN
K377-u	TSTICSDkTGTLtQN
T382-p	SDkTGTLtQNRMTVA
S407-p	ADTTENQsGVSFDkT
K413-u	QsGVSFDkTSATWFA
K444-u	QENLPILkRAVAGDA
S452-p	RAVAGDAsEsALLKC
S454-p	VAGDAsEsALLKCIE
M468	EVCCGSVMEMREKYS
Y474	VMEMREKYSkIVEIP
K476-u	EMREKYSkIVEIPFN
S484-p	IVEIPFNstNkYQLS
T485-p	VEIPFNstNkYQLSI
K487-u	IPFNstNkYQLSIHk
K494-u	kYQLSIHkNPNAsEP
K494-a	kYQLSIHkNPNAsEP
S499-p	IHkNPNAsEPkHLLV
K502-u	NPNAsEPkHLLVMkG
K508-u	PkHLLVMkGAPERIL
K526-u	SSILLHGkEQPLDEE
K535	QPLDEELKDAFQNAy
K535-a	QPLDEELkDAFQNAy
Y542-p	kDAFQNAyLELGGLG
K605-u	AVPDAVGkCRSAGIK
K625-u	GDHPITAkAIAkGVG
K629-u	ITAkAIAkGVGIIsE
S635-p	AkGVGIIsEGNEtVE
-	gap
-	gap
T640-p	IIsEGNEtVEDIAAR
N653	ARLNIPVNQVNPRDA
K661-u	QVNPRDAkACVVHGs
S668-p	kACVVHGsDLkDMTs
K671-u	VVHGsDLkDMTsEEL
S675-p	sDLkDMTsEELDDIL
R683	EELDDILRyHTEIVF
Y684-p	ELDDILRyHTEIVFA
T686	DDILRyHTEIVFART
K698-u	ARTSPQQkLIIVEGC
S722-p	TGDGVNDsPALkkAD
K726-a	VNDsPALkkADIGVA
K726-u	VNDsPALkkADIGVA
K727	NDsPALkKADIGVAM
K727-u	NDsPALkkADIGVAM
K773-u	RLIFDNLkKSIAYTL
K833-u	QAESDIMkRQPRNPk
K840-u	kRQPRNPkTDkLVNE
K843-u	PRNPkTDkLVNERLI
S943-p	ICKTRRNsVFQQGMk
K950-u	sVFQQGMkNKILIFG
K1019-u	RPGGWVEkETYY___

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