the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; Membrane protein, integral; EC 188.8.131.52
Molecular Function: potassium ion binding; 4-nitrophenylphosphatase activity; protein domain specific binding; sodium ion binding; protein binding; chaperone binding; sodium:potassium-exchanging ATPase activity; phosphoinositide 3-kinase binding; ankyrin binding; ADP binding; protein kinase binding; ATP binding
Biological Process: response to drug; ATP catabolic process; negative regulation of heart contraction; membrane hyperpolarization; sodium ion transport; positive regulation of striated muscle contraction; regulation of sodium ion transport; negative regulation of glucocorticoid biosynthetic process; dephosphorylation; energy coupled proton transport, against electrochemical gradient; potassium ion import; regulation of blood pressure; ATP biosynthetic process; positive regulation of heart contraction; regulation of the force of heart contraction; potassium ion transport
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.