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Protein Page:
BIM (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BIM a pro-apoptotic member of the BCL-2 protein family. Interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. Eight alternatively spliced transcript variants of this gene have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Cellular Component: microtubule; extrinsic to membrane; mitochondrion; intracellular membrane-bound organelle; membrane; cytoplasm; intracellular; cytosol
Molecular Function: protein binding; microtubule binding
Biological Process: apoptosis; positive regulation of apoptosis; cell-matrix adhesion; myeloid cell homeostasis; pigmentation during development; positive regulation of caspase activity; ear development; B cell apoptosis; cellular process regulating host cell cycle in response to virus; positive regulation of apoptosis by virus; post-embryonic development; regulation of apoptosis; B cell homeostasis; mammary gland development; positive regulation of neuron apoptosis; T cell homeostasis; kidney development; post-embryonic organ morphogenesis; leukocyte homeostasis; caspase activation; spleen development; thymus development; in utero embryonic development; positive regulation of protein homooligomerization; male gonad development; positive regulation of cell cycle; regulation of organ growth; lumen formation; odontogenesis of dentine-containing teeth; DNA damage response, signal transduction resulting in induction of apoptosis; regulation of pigmentation during development; spermatogenesis; lymphocyte homeostasis
Reference #:  O54918 (UniProtKB)
Alt. Names/Synonyms: 1500006F24Rik; B2L11; Bcl-2-like protein 11; Bcl2 interacting mediator of cell death; Bcl2-interacting mediator of cell death; Bcl2-L-11; BCL2-like 11 (apoptosis facilitator); Bcl2l11; Bim; Bod; OTTMUSP00000016362; OTTMUSP00000016364; OTTMUSP00000016365; RP23-134I15.1
Gene Symbols: Bcl2l11
Molecular weight: 22,067 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BIM

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S55‑p, S65‑p, S100‑p, T112‑p
apoptosis, induced: S65‑p, T112‑p
apoptosis, inhibited: S55‑p, S65‑p, S73‑p, S105‑p
molecular association, regulation: S55‑p, S65‑p, S100‑p, T112‑p
protein degradation: S55‑p, S65‑p, S73‑p, S105‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 K3 _____MAKQPSDVSS
0 1 T34 QLRPGAPTSLQTEPQ
0 1 S35 LRPGAPTSLQTEPQG
0 1 T38 GAPTSLQTEPQGNPD
5 0 S55-p GDRCPHGsPQGPLAP
18 1 S65-p GPLAPPAsPGPFATR
2 12 S73-p PGPFATRsPLFIFVR
1 4 S83-p FIFVRRSsLLsRSSs
0 1 S86-p VRRSsLLsRSSsGYF
1 0 S89 SsLLsRSSsGYFSFD
1 3 S90-p sLLsRSSsGYFSFDT
1 0 S94 RSSsGYFSFDTDRsP
8 0 S100-p FSFDTDRsPAPMsCD
1 0 S105-p DRsPAPMsCDKStQt
1 0 K108 PAPMsCDKStQtPsP
1 1 S109 APMsCDKStQtPsPP
1 1 T110-p PMsCDKStQtPsPPC
8 1 T112-p sCDKStQtPsPPCQA
5 2 S114-p DKStQtPsPPCQAFN
0 1 S129 HYLSAMASIRQSQEE
4550 : Phospho-Bim (Ser55) Antibody
4581 : Phospho-Bim (Ser69) Antibody
4585 : Phospho-Bim (Ser69) (D7E11) Rabbit mAb
12433 : Phospho-Bim (Ser77) (D4H12) Rabbit mAb
  human

► Hide Isoforms
 
K3 _____MAKQPSDVSS
T34 QLRPGAPTSLQTEPQ
S35 LRPGAPTSLQTEPQG
T38 GAPTSLQTEPQGNPE
S59-p GDSCPHGsPQGPLAP
S69-p GPLAPPAsPGPFATR
S77-p PGPFATRsPLFIFMR
S87-p FIFMRRSsLLSRSss
S90 MRRSsLLSRSssGYF
S93-p SsLLSRSssGYFsFD
S94-p sLLSRSssGYFsFDT
S98-p RSssGYFsFDTDRsP
S104-p FsFDTDRsPAPMSCD
S109 DRsPAPMSCDKsTQt
K112 PAPMSCDKsTQtPsP
S113-p APMSCDKsTQtPsPP
T114 PMSCDKsTQtPsPPC
T116-p SCDKsTQtPsPPCQA
S118-p DKsTQtPsPPCQAFN
S133 HYLSAMASMRQAEPA
4550 : Phospho-Bim (Ser55) Antibody
4581 : Phospho-Bim (Ser69) Antibody
4585 : Phospho-Bim (Ser69) (D7E11) Rabbit mAb
12433 : Phospho-Bim (Ser77) (D4H12) Rabbit mAb
  BIM iso2  
K3 _____MAKQPSDVSS
T34 QLRPGAPTSLQTEPQ
S35 LRPGAPTSLQTEPQD
T38 GAPTSLQTEPQDRsP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S44-p QTEPQDRsPAPMSCD
S49 DRsPAPMSCDKSTQt
K52 PAPMSCDKSTQtPsP
S53 APMSCDKSTQtPsPP
T54 PMSCDKSTQtPsPPC
T56-p SCDKSTQtPsPPCQA
S58-p DKSTQtPsPPCQAFN
S73 HYLSAMASMRQAEPA
  BIM iso3  
K3 _____MAKQPSDVSS
T34-p QLRPGAPtsLQtEPQ
S35-p LRPGAPtsLQtEPQA
T38-p GAPtsLQtEPQAsMR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S43-p LQtEPQAsMRQAEPA
  rat

 
K3-ub _____MAkQPSDVNS
T34 QLRPGAPTSLQTESQ
S35 LRPGAPTSLQTESQG
T38 GAPTSLQTESQGNPD
S55-p GDRCPHGsPQGPLAP
S65-p GPLAPPAsPGPFATR
S73-p PGPFATRsPLFIFVR
S83-p FIFVRRSsLLSRSSS
S86 VRRSsLLSRSSSGYF
S89 SsLLSRSSSGYFSFD
S90 sLLSRSSSGYFSFDT
S94 RSSSGYFSFDTDRsP
S100-p FSFDTDRsPAPMSCD
S105 DRsPAPMSCDkstQt
K108-ub PAPMSCDkstQtPSP
S109-p APMSCDkstQtPSPP
T110-p PMSCDkstQtPSPPC
T112-p SCDkstQtPSPPCQA
S114 DkstQtPSPPCQAFN
S129 HYLSAMASIRQSQEE
4550 : Phospho-Bim (Ser55) Antibody
4581 : Phospho-Bim (Ser69) Antibody
4585 : Phospho-Bim (Ser69) (D7E11) Rabbit mAb
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