a pro-apoptotic member of the BCL-2 protein family. Interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. Eight alternatively spliced transcript variants of this gene have been reported. Note: This description may include information from UniProtKB.
Molecular Function: protein binding; microtubule binding
Biological Process: nerve growth factor receptor signaling pathway; apoptosis; positive regulation of apoptosis; cell-matrix adhesion; pigmentation during development; myeloid cell homeostasis; positive regulation of caspase activity; ear development; B cell apoptosis; cellular process regulating host cell cycle in response to virus; positive regulation of apoptosis by virus; B cell homeostasis; mammary gland development; positive regulation of neuron apoptosis; T cell homeostasis; kidney development; post-embryonic organ morphogenesis; caspase activation; spleen development; thymus development; in utero embryonic development; positive regulation of protein homooligomerization; male gonad development; positive regulation of cell cycle; lumen formation; regulation of organ growth; odontogenesis of dentine-containing teeth; DNA damage response, signal transduction resulting in induction of apoptosis; spermatogenesis; regulation of pigmentation during development; brain development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.