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uPAR (human)

Overview uPAR Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Membrane protein, anchored; Receptor, misc. Cellular Component: endoplasmic reticulum membrane; cell surface; extrinsic to membrane; endoplasmic reticulum lumen; integral to plasma membrane; integral to membrane; plasma membrane; extracellular region Molecular Function: protein binding; U-plasminogen activator receptor activity; enzyme binding; receptor activity Biological Process: skeletal muscle regeneration; C-terminal protein lipidation; signal transduction; post-translational protein modification; chemotaxis; fibrinolysis; cellular protein metabolic process; mesenchymal cell differentiation; attachment of GPI anchor to protein; regulation of proteolysis; blood coagulation; cell motility; negative regulation of apoptosis Reference #:  Q03405 (UniProtKB) Alt. Names/Synonyms: CD87; MO3; Monocyte activation antigen Mo3; plasminogen activator, urokinase receptor; PLAUR; U-PAR; u-plasminogen activator receptor form 2; UPAR; URKR; Urokinase plasminogen activator surface receptor Gene Symbols: PLAUR Molecular weight: 36,978 Da Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below uPAR 1YWH - A/O/M/C/K/I/G/E=23-335 (human) 3BT1 - U=23-303 (human) 3BT2 - U=23-303 (human) 3U73 - U=23-305 (human) 3U74 - U=23-305 (human) 3LAQ - V/U=24-300 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y217-p	PQNGRQCySCKGNST
0	1		T30-p	LRCMQCKtNGDCRVE

	mouse
Y216	PPNGFQCYSCEGNNT
S31	LQCMQCESNQSCLVE

	rat
Y217	PPNGFQCYSCEGNST
S32	LRCIQCESNQDCLVE

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