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Protein Page:
SRC-1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SRC-1 a transcriptional coactivator for steroid and nuclear hormone receptors. A member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, and bHLH and PAS domains. Phosphorylated and activated via the mitogen-activated protein kinase pathway. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; EC 2.3.1.48; Transcription, coactivator/corepressor; Acetyltransferase; Nuclear receptor co-regulator
Cellular Component: nucleoplasm; neuron projection; cytoplasm; nuclear chromatin
Molecular Function: protein dimerization activity; ligand-dependent nuclear receptor binding; transcription coactivator activity; protein N-terminus binding; retinoid X receptor binding; signal transducer activity; protein binding; histone acetyltransferase activity; enzyme binding; androgen receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; protein complex binding; estrogen receptor binding; chromatin binding; progesterone receptor binding; nuclear hormone receptor binding
Biological Process: lactation; hypothalamus development; male mating behavior; response to retinoic acid; positive regulation of transcription from RNA polymerase II promoter by galactose; transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; male gonad development; hippocampus development; positive regulation of female receptivity; cellular lipid metabolic process; response to estradiol stimulus; cellular response to hormone stimulus; estrous cycle phase; androgen receptor signaling pathway; cerebellum development; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; response to progesterone stimulus; positive regulation of neuron differentiation
Reference #:  Q15788 (UniProtKB)
Alt. Names/Synonyms: bHLHe42; BHLHE74; Class E basic helix-loop-helix protein 74; F-SRC-1; Hin-2 protein; KAT13A; MGC129719; MGC129720; NCoA-1; NCOA1; Nuclear receptor coactivator 1; PAX3/NCOA1 fusion protein; Protein Hin-2; Renal carcinoma antigen NY-REN-52; RIP160; SRC-1; SRC1; Steroid receptor coactivator 1; steroid receptor coactivator-1
Gene Symbols: NCOA1
Molecular weight: 156,757 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SRC-1

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: T1179‑p, S1185‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 6 S22-p DSHKRKGsPCDtLAS
0 1 T26-p RKGsPCDtLASSTEK
0 2 S103-p KSDISSSsQGVIEKE
0 1 T209-p HPPDEPGtENQEACQ
1 0 S325-p MTRGTASsPSYRFIL
1 4 S372-p DREHSGLsPQDDTNS
0 2 S393-p VNPSVNPsIsPAHGV
2 25 S395-p PSVNPsIsPAHGVAR
0 1 A401 IsPAHGVARSSTLPP
1 1 S488-p ISLAQFMsPRRQVTS
1 0 S517-p PNISTLSsPVGMTSS
0 3 S558-p SVGFSASsPVLRQMs
0 5 S565-p sPVLRQMssQNsPSR
0 2 S566-p PVLRQMssQNsPSRL
2 3 S569-p RQMssQNsPSRLNIQ
0 1 S659-p TSCKDVLsCTGTSNS
0 5 S698-p HRLLQEGsPSDITTL
1 0 K732-s VQGNSSIkLELDASK
1 0 K774-s SLDDVKVkVEKKEQM
1 0 T789-p DPCNTNPtPMTKPTP
1 0 T979-p RFPPQQAtPPLIMEE
1 0 S997-p LYSQPYSsPSPTANL
1 0 S1006-p SPTANLPsPFQGMVR
1 0 T1026-p GTMPVQVtPPrGAFs
0 3 R1029-m2 PVQVtPPrGAFsPGM
2 0 S1033-p tPPrGAFsPGMGMQP
0 3 R1041-m2 PGMGMQPrQTLNRPP
0 1 R1046 QPrQTLNRPPAAPNQ
0 2 R1055 PAAPNQLRLQLQQRL
0 1 R1061 LRLQLQQRLQGQQQL
0 1 R1073 QQLIHQNRQAILNQF
0 1 R1091 APVGINMRSGMQQQI
0 1 R1124 YSQQHRQRQLIQQQr
0 3 R1131-m2 RQLIQQQrAMLMRQQ
4 0 T1179-p NYGTNPGtPPASTsP
4 0 S1185-p GtPPASTsPFSQLAA
1 0 S1250-p ANFAPSLsPGSSMVP
1 0 T1271-p QSSLLQQtPPASGYQ
1 0 S1279-p PPASGYQsPDMKAWQ
0 1 S1372-p GLYCNQLsSTDLLKT
1 0 T1426-p KPTSGPQtPQAQQKS
  SRC-1 iso2  
S22 DSHKRKGSPCDTLAS
T26 RKGSPCDTLASSTEK
S103 KSDISSSSQGVIEKE
T209 HPPDEPGTENQEACQ
S325 MTRGTASSPSYRFIL
S372 DREHSGLSPQDDTNS
S393 VNPSVNPSISPAHGV
S395 PSVNPSISPAHGVAR
A401 ISPAHGVARSSTLPP
S488 ISLAQFMSPRRQVTS
S517 PNISTLSSPVGMTSS
S558 SVGFSASSPVLRQMS
S565 SPVLRQMSSQNSPSR
S566 PVLRQMSSQNSPSRL
S569 RQMSSQNSPSRLNIQ
S659 TSCKDVLSCTGTSNS
S698 HRLLQEGSPSDITTL
K732 VQGNSSIKLELDASK
K774 SLDDVKVKVEKKEQM
T789 DPCNTNPTPMTKPTP
T979 RFPPQQATPPLIMEE
S997 LYSQPYSSPSPTANL
S1006 SPTANLPSPFQGMVR
T1026 GTMPVQVTPPRGAFS
R1029 PVQVTPPRGAFSPGM
S1033 TPPRGAFSPGMGMQP
R1041 PGMGMQPRQTLNRPP
R1046 QPRQTLNRPPAAPNQ
R1055 PAAPNQLRLQLQQRL
R1061 LRLQLQQRLQGQQQL
R1073 QQLIHQNRQAILNQF
R1091 APVGINMRSGMQQQI
R1124 YSQQHRQRQLIQQQR
R1131 RQLIQQQRAMLMRQQ
T1179 NYGTNPGTPPASTSP
S1185 GTPPASTSPFSQLAA
S1250 ANFAPSLSPGSSMVP
T1271 QSSLLQQTPPASGYQ
S1279 PPASGYQSPDMKAWQ
S1372 GLYCNQLSSTDLLKT
- gap
  mouse

 
S22-p DSHKRKGsPCDTLAS
T26 RKGsPCDTLASSTEK
S103 KSDISSSSQGVIEKE
T209 HPPEDPGTENQEACQ
S325 MTRGTASSPSYRFIL
S372-p DREHSGLsPQDDSNS
G393 INPSVNPGISPAHGV
S395 PSVNPGISPAHGVtR
T401-gl ISPAHGVtRSSTLPP
S489 IALSQFMSPRRQANS
S518 PNIPTLSSPVGITSG
S559-p SVGFSAGsPVLRQMS
S566 sPVLRQMSSQNsPSR
S567 PVLRQMSSQNsPSRL
S570-p RQMSSQNsPSRLSMQ
S663 TSCKDVLSCTGTSSS
S702-p HRLLQEGsPSDITTL
K738 SQGSASIKLELDAAK
K780 CLDDVKVKVEKKEQM
T795 DPCNTNPTPMTKPAP
T985 RFPPQQATPPLMMED
S1003 LYSQPYSSPSPTAGL
G1012 SPTAGLSGPFQGMVR
T1032 GAMPVQVTPPRGTFS
R1035 PVQVTPPRGTFSPNM
S1039 TPPRGTFSPNMGMQP
R1047 PNMGMQPRQTLNrPP
R1052-m2 QPRQTLNrPPAAPNQ
R1061-m2 PAAPNQLrLQLQQrL
R1067-m2 LrLQLQQrLQGQQQL
R1079-m2 QQLMHQNrQAILNQF
R1097-m2 APVGMNMrSGMQQQI
R1130-m2 YSQQHRQrQIIQQQr
R1137-m2 rQIIQQQrAMLMRHQ
T1185 NYGTNPGTPPASTSP
S1191 GTPPASTSPFSQLAA
S1256 ATFAPSLSPGSSMVP
T1277 QSSLLQQTPPTSGYQ
S1285 PPTSGYQSPDMKAWQ
S1378 GLYCNQLSSTDLLKT
T1432 KPTSGPQTPQAQQKS
  rat

 
S22-p DSHKRKGsPCDTLAS
T26 RKGsPCDTLASSTEK
S103 KSDISSSSQGVIEKE
T179 LLPKSLGTENQEACQ
S263 MTRGTASSPSYRFIL
S310 DREHSGLSPQDDTNS
G331 INPSVNPGISPAHGV
S333 PSVNPGISPAHGVTR
T339 ISPAHGVTRSSTLPP
S427 ISLAQFMSPRRQANS
S456 PNIPTLSSPVGITSG
S497 SVGFSAGSPVLRQMS
S504 SPVLRQMSSQNSPSR
S505 PVLRQMSSQNSPSRL
S508 RQMSSQNSPSRLSMQ
S598 TSCKDVLSCTGTSSS
S637 HRLLQEGSPSDITTL
K673 AQGSASIKLELDASK
K715 SLDDVKVKVEKKEQM
A730 DPCNTNPAPVTKPAP
T920 RFPPQQATPPLMMED
S938 LYPQPYSSPSPTAGL
G947 SPTAGLSGPFQGMVR
T967 GTMPVQVTPPRGTFS
R970 PVQVTPPRGTFSPNM
S974 TPPRGTFSPNMGMQP
R982 PNMGMQPRQTLNRPP
R987 QPRQTLNRPPAAPNQ
R996 PAAPNQLRLQLQQRL
R1002 LRLQLQQRLQGQQQL
R1014 QQLMHQNRQAILNQF
R1032 APVGMNMRSGMQQQI
R1065 YSQQHRQRQIIQQQR
R1072 RQIIQQQRAMLMRHQ
T1120 NYGTNPGTPPASTSP
S1126 GTPPASTSPFSQLAA
S1191 ANFAPSLSPGSSMVP
T1211 QSSLLQQTPPTSGYQ
S1219 PPTSGYQSPDMKAWQ
S1312 GLYCNQLSSTDLLKT
- gap
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