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SRC-1 (human)

Overview SRC-1 a transcriptional coactivator for steroid and nuclear hormone receptors. A member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, and bHLH and PAS domains. Phosphorylated and activated via the mitogen-activated protein kinase pathway. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: EC 2.3.1.48; Acetyltransferase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; DNA binding protein Cellular Component: nucleoplasm; nuclear chromatin Molecular Function: protein dimerization activity; ligand-dependent nuclear receptor binding; transcription coactivator activity; protein N-terminus binding; signal transducer activity; protein binding; enzyme binding; histone acetyltransferase activity; androgen receptor binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; chromatin binding; nuclear hormone receptor binding Biological Process: positive regulation of transcription from RNA polymerase II promoter by galactose; response to retinoic acid; transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; cellular lipid metabolic process; response to estradiol stimulus; cellular response to hormone stimulus; estrous cycle phase; androgen receptor signaling pathway; cerebellum development; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; positive regulation of neuron differentiation Reference #:  Q15788 (UniProtKB) Alt. Names/Synonyms: bHLHe42; BHLHE74; Class E basic helix-loop-helix protein 74; F-SRC-1; Hin-2 protein; KAT13A; MGC129719; MGC129720; NCoA-1; NCOA1; Nuclear receptor coactivator 1; PAX3/NCOA1 fusion protein; Protein Hin-2; Renal carcinoma antigen NY-REN-52; RIP160; SRC-1; SRC1; Steroid receptor coactivator 1; steroid receptor coactivator-1 Gene Symbols: NCOA1 Molecular weight: 156,757 Da Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SRC-1 1FM6 - B/E/V/Y=676-700 (human) 1FM9 - B/E=676-700 (human) 1K4W - B=686-700 (human) 1K74 - B/E=676-700 (human) 1K7L - B/D/F/H=680-700 (human) 1KV6 - C/D=686-700 (human) 1N4H - B=686-700 (human) 1NQ7 - B=687-696 (human) 1NRL - C/D=676-700 (human) 1P8D - C/D=676-700 (human) 1PZL - B=687-700 (human) 1RDT - B=687-700 (human) 1TFC - C/D=686-700 (human) 1U3R - C/D=630-640 (human) 1U3S - C/D=630-640 (human) 1X76 - C/D=630-640 (human) 1X78 - C/D=630-640 (human) 1X7B - C/D=630-640 (human) 1X7J - C/D=630-640 (human) 1XIU - E/F=686-700 (human) 1XV9 - E/F/G/H=685-697 (human) 1XVP - E/F/G/H=685-697 (human) 1YY4 - C/D=630-640 (human) 1YYE - C/D=630-640 (human) 1ZAF - C/D=630-640 (human) 2A3I - B=1430-1441 (human) 2C52 - B=920-970 (human) 2FVJ - B=628-640 (human) 2GTK - B=631-640 (human) 2HBH - B=686-700 (human) 2HC4 - B=686-700 (human) 2HCD - B=686-700 (human) 2HFP - B=680-700 (human) 2P54 - B=685-696 (human) 2PRG - C=623-710 (human) 3BEJ - F/E=676-700 (human) 3BQD - B=1429-1441 (human) 3CTB - A/B=678-700 (human) 3CWD - D/C=685-700 (human) 3DCT - B=741-761 (human) 3DCU - B=741-761 (human) 3DR1 - B=686-700 (human) 3ET1 - Q/P=681-696 (human) 3ET3 - P=680-695 (human) 3FEI - Z=744-756 (human) 3FEJ - B=628-640 (human) 3FUR - H=629-640 (human) 3FXV - B=744-756 (human) 3G8I - Z=744-756 (human) 3G9E - B=628-640 (human) 3H0A - E/B=629-640 (human) 3HC5 - B=741-761 (human) 3HC6 - B=741-761 (human) 3HVL - A/B=678-700 (human) 3IPQ - B=676-700 (human) 3IPS - D/C=676-700 (human) 3IPU - D/C=676-700 (human) 3KMR - C=686-698 (human) 3LMP - C=686-700 (human) 3OKH - B=744-757 (human) 3OKI - D/B=744-757 (human) 3OLF - D/B=744-757 (human) 3OLL - D/C=683-701 (human) 3OLS - D/C=683-701 (human) 3OMK - D/B=744-757 (human) 3OMM - D/B=744-757 (human) 3OMO - D/C=683-701 (human) 3OMP - D/C=683-701 (human) 3OMQ - D/C=683-701 (human) 3OOF - D/B=744-757 (human) 3OOK - D/B=744-757 (human) 3QT0 - C=685-700 (human) 3RUT - B=745-755 (human) 3RUU - B=745-755 (human) 3RVF - B=741-761 (human) 3S9S - B=685-697 (human) 3T03 - D/C=683-700 (human) 3UU7 - F/G=686-698 (human) 3UUA - F/G=686-698 (human) 3UUD - D/C=686-698 (human) 3V9Y - B=686-700 (human) 3VN2 - C=685-700 (human) 4DK7 - D/B=745-756 (human) 4DK8 - D/B=745-756 (human) 4DM6 - F/E=676-700 (human) 4DM8 - D/C=676-700 (human) 4DQM - A/C=182-415 (human) 4F9M - C=686-700 (human) 4FGY - B=686-696 (human) 4G1D - B=686-700 (human) 4G1Y - B=686-700 (human) 4G1Z - B=686-700 (human) 4G20 - B=686-700 (human) 4G21 - B=686-700 (human) 4G2H - B=686-700 (human) 1OJ5 - A=257-385 (mouse) 4DMA - F/E=690-704 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1FM6 1FM9 1K4W 1K74 1K7L 1KV6 1N4H 1NQ7 1NRL 1P8D 1PZL 1RDT 1TFC 1U3R 1U3S 1X76 1X78 1X7B 1X7J 1XIU 1XV9 1XVP 1YY4 1YYE 1ZAF 2A3I 2C52 2FVJ 2GTK 2HBH 2HC4 2HCD 2HFP 2P54 2PRG 3BEJ 3BQD 3CTB 3CWD 3DCT 3DCU 3DR1 3ET1 3ET3 3FEI 3FEJ 3FUR 3FXV 3G8I 3G9E 3H0A 3HC5 3HC6 3HVL 3IPQ 3IPS 3IPU 3KMR 3LMP 3OKH 3OKI 3OLF 3OLL 3OLS 3OMK 3OMM 3OMO 3OMP 3OMQ 3OOF 3OOK 3QT0 3RUT 3RUU 3RVF 3S9S 3T03 3UU7 3UUA 3UUD 3V9Y 3VN2 4DK7 4DK8 4DM6 4DM8 4DQM 4F9M 4FGY 4G1D 4G1Y 4G1Z 4G20 4G21 4G2H  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
transcription, altered: T1179‑p, S1185‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
1	4		S22-p	DSHKRKGsPCDtLAS
0	1		T26-p	RKGsPCDtLASSTEK
0	2		S103-p	KSDISSSsQGVIEKE
0	1		T209-p	HPPDEPGtENQEACQ
0	1		S274-p	DTTGKIIsIDtSSLR
0	1		T277-p	GKIIsIDtSSLRAAG
1	0		S325-p	MTRGTASsPSYRFIL
0	1		S369-p	HIIDREHsGLsPQDD
1	3		S372-p	DREHsGLsPQDDTNS
0	1		S389-p	SIPRVNPsVNPsIsP
0	2		S393-p	VNPsVNPsIsPAHGV
2	24		S395-p	PsVNPsIsPAHGVAR
0	1		A401	IsPAHGVARSSTLPP
0	1		S474	PSLNLNNSPMEGTGI
1	1		S488-p	ISLAQFMsPRRQVTS
1	0		S517-p	PNISTLSsPVGMTSS
0	3		S558-p	SVGFSASsPVLRQMs
0	5		S565-p	sPVLRQMssQNsPSR
0	2		S566-p	PVLRQMssQNsPSRL
2	3		S569-p	RQMssQNsPSRLNIQ
0	1		S582-p	IQPAKAEsKDNKEIA
0	1		S659-p	TSCKDVLsCTGTSNS
0	4		S698-p	HRLLQEGsPSDITTL
1	0		K732-s	VQGNSSIkLELDASK
1	0		K774-s	SLDDVKVkVEKKEQM
1	0		T789-p	DPCNTNPtPMTKPTP
1	0		T979-p	RFPPQQAtPPLIMEE
1	0		S997-p	LYSQPYSsPSPTANL
1	0		S1006-p	SPTANLPsPFQGMVR
1	0		T1026-p	GTMPVQVtPPrGAFs
0	3		R1029-m2	PVQVtPPrGAFsPGM
2	0		S1033-p	tPPrGAFsPGMGMQP
0	3		R1041-m2	PGMGMQPrQTLNRPP
0	1		R1055	PAAPNQLRLQLQQRL
0	2		R1131-m2	RQLIQQQrAMLMRQQ
4	0		T1179-p	NYGTNPGtPPASTsP
4	0		S1185-p	GtPPASTsPFSQLAA
1	0		S1250-p	ANFAPSLsPGSSMVP
1	0		T1271-p	QSSLLQQtPPASGYQ
0	1		A1274	LLQQtPPASGYQsPD
1	0		S1279-p	PPASGYQsPDMKAWQ
1	0		T1426-p	KPTSGPQtPQAQQKS

	SRC-1 iso2
S22	DSHKRKGSPCDTLAS
T26	RKGSPCDTLASSTEK
S103	KSDISSSSQGVIEKE
T209	HPPDEPGTENQEACQ
S274	DTTGKIISIDTSSLR
T277	GKIISIDTSSLRAAG
S325	MTRGTASSPSYRFIL
S369	HIIDREHSGLSPQDD
S372	DREHSGLSPQDDTNS
S389	SIPRVNPSVNPSISP
S393	VNPSVNPSISPAHGV
S395	PSVNPSISPAHGVAR
A401	ISPAHGVARSSTLPP
S474	PSLNLNNSPMEGTGI
S488	ISLAQFMSPRRQVTS
S517	PNISTLSSPVGMTSS
S558	SVGFSASSPVLRQMS
S565	SPVLRQMSSQNSPSR
S566	PVLRQMSSQNSPSRL
S569	RQMSSQNSPSRLNIQ
S582	IQPAKAESKDNKEIA
S659	TSCKDVLSCTGTSNS
S698	HRLLQEGSPSDITTL
K732	VQGNSSIKLELDASK
K774	SLDDVKVKVEKKEQM
T789	DPCNTNPTPMTKPTP
T979	RFPPQQATPPLIMEE
S997	LYSQPYSSPSPTANL
S1006	SPTANLPSPFQGMVR
T1026	GTMPVQVTPPRGAFS
R1029	PVQVTPPRGAFSPGM
S1033	TPPRGAFSPGMGMQP
R1041	PGMGMQPRQTLNRPP
R1055	PAAPNQLRLQLQQRL
R1131	RQLIQQQRAMLMRQQ
T1179	NYGTNPGTPPASTSP
S1185	GTPPASTSPFSQLAA
S1250	ANFAPSLSPGSSMVP
T1271	QSSLLQQTPPASGYQ
A1274	LLQQTPPASGYQSPD
S1279	PPASGYQSPDMKAWQ
-	gap

	mouse
S22-p	DSHKRKGsPCDTLAS
T26	RKGsPCDTLASSTEK
S103	KSDISSSSQGVIEKE
T209	HPPEDPGTENQEACQ
S274	DTTGKIISIDTSSLR
T277	GKIISIDTSSLRAAG
S325	MTRGTASSPSYRFIL
S369	HIIDREHSGLsPQDD
S372-p	DREHSGLsPQDDSNS
S389	SIPRINPSVNPGISP
G393	INPSVNPGISPAHGV
S395	PSVNPGISPAHGVtR
T401-g	ISPAHGVtRSSTLPP
S475-p	PSLNLNNsPMEGTGI
S489	IALSQFMSPRRQANS
S518	PNIPTLSSPVGITSG
S559-p	SVGFSAGsPVLRQMS
S566	sPVLRQMSSQNSPSR
S567	PVLRQMSSQNSPSRL
S570	RQMSSQNSPSRLSMQ
S583	MQPAKAESKDSKEIA
S663	TSCKDVLSCTGTSSS
S702-p	HRLLQEGsPSDITTL
K738	SQGSASIKLELDAAK
K780	CLDDVKVKVEKKEQM
T795	DPCNTNPTPMTKPAP
T985	RFPPQQATPPLMMED
S1003	LYSQPYSSPSPTAGL
G1012	SPTAGLSGPFQGMVR
T1032	GAMPVQVTPPRGTFS
R1035	PVQVTPPRGTFSPNM
S1039	TPPRGTFSPNMGMQP
R1047	PNMGMQPRQTLNRPP
R1061-m2	PAAPNQLrLQLQQRL
R1137	RQIIQQQRAMLMRHQ
T1185	NYGTNPGTPPASTSP
S1191	GTPPASTSPFSQLAA
S1256	ATFAPSLSPGSSMVP
T1277	QSSLLQQTPPtSGYQ
T1280-p	LLQQTPPtSGYQSPD
S1285	PPtSGYQSPDMKAWQ
T1432	KPTSGPQTPQAQQKS

	rat
S22-p	DSHKRKGsPCDTLAS
T26	RKGsPCDTLASSTEK
S103	KSDISSSSQGVIEKE
T179	LLPKSLGTENQEACQ
S212	DGEGKIISIDTSSLR
T215	GKIISIDTSSLRAAG
S263	MTRGTASSPSYRFIL
S307	HIIDREHSGLSPQDD
S310	DREHSGLSPQDDTNS
S327	SIPRINPSVNPGISP
G331	INPSVNPGISPAHGV
S333	PSVNPGISPAHGVTR
T339	ISPAHGVTRSSTLPP
S413	PSLNLNNSPMEGTGI
S427	ISLAQFMSPRRQANS
S456	PNIPTLSSPVGITSG
S497	SVGFSAGSPVLRQMS
S504	SPVLRQMSSQNSPSR
S505	PVLRQMSSQNSPSRL
S508	RQMSSQNSPSRLSMQ
S521	MQPAKAESKDNKEIA
S598	TSCKDVLSCTGTSSS
S637	HRLLQEGSPSDITTL
K673	AQGSASIKLELDASK
K715	SLDDVKVKVEKKEQM
A730	DPCNTNPAPVTKPAP
T920	RFPPQQATPPLMMED
S938	LYPQPYSSPSPTAGL
G947	SPTAGLSGPFQGMVR
T967	GTMPVQVTPPRGTFS
R970	PVQVTPPRGTFSPNM
S974	TPPRGTFSPNMGMQP
R982	PNMGMQPRQTLNRPP
R996	PAAPNQLRLQLQQRL
R1072	RQIIQQQRAMLMRHQ
T1120	NYGTNPGTPPASTSP
S1126	GTPPASTSPFSQLAA
S1191	ANFAPSLSPGSSMVP
T1211	QSSLLQQTPPTSGYQ
T1214	LLQQTPPTSGYQSPD
S1219	PPTSGYQSPDMKAWQ
-	gap

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