Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SRC-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SRC-1 a transcriptional coactivator for steroid and nuclear hormone receptors. A member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, and bHLH and PAS domains. Phosphorylated and activated via the mitogen-activated protein kinase pathway. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; EC 2.3.1.48; Nuclear receptor co-regulator; DNA binding protein; Acetyltransferase
Cellular Component: nucleoplasm; neuron projection; nuclear chromatin; cytoplasm
Molecular Function: protein dimerization activity; ligand-dependent nuclear receptor binding; transcription coactivator activity; protein N-terminus binding; retinoid X receptor binding; signal transducer activity; protein binding; histone acetyltransferase activity; enzyme binding; ligand-dependent nuclear receptor transcription coactivator activity; androgen receptor binding; protein complex binding; estrogen receptor binding; chromatin binding; progesterone receptor binding; nuclear hormone receptor binding
Biological Process: lactation; hypothalamus development; response to retinoic acid; positive regulation of transcription from RNA polymerase II promoter by galactose; male mating behavior; transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; hippocampus development; male gonad development; positive regulation of female receptivity; cellular lipid metabolic process; response to estradiol stimulus; cellular response to hormone stimulus; estrous cycle phase; androgen receptor signaling pathway; cerebellum development; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of neuron differentiation; response to progesterone stimulus
Reference #:  Q15788 (UniProtKB)
Alt. Names/Synonyms: bHLHe42; BHLHE74; Class E basic helix-loop-helix protein 74; F-SRC-1; Hin-2 protein; KAT13A; MGC129719; MGC129720; NCoA-1; NCOA1; Nuclear receptor coactivator 1; PAX3/NCOA1 fusion protein; Protein Hin-2; Renal carcinoma antigen NY-REN-52; RIP160; SRC-1; SRC1; Steroid receptor coactivator 1; steroid receptor coactivator-1
Gene Symbols: NCOA1
Molecular weight: 156,757 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SRC-1

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA


Sites Implicated In
transcription, altered: T1179‑p, S1185‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 8 S22-p DSHKRKGsPCDtLAS
0 2 T26-p RKGsPCDtLASsTEK
0 1 S30-p PCDtLASsTEKRRRE
0 2 S103-p KSDISSSsQGVIEKE
0 1 T209-p HPPDEPGtENQEACQ
0 1 S274-p DTTGKIIsIDtSSLR
0 1 T277-p GKIIsIDtSSLRAAG
1 0 S325-p MTRGTASsPSYRFIL
0 1 S369-p HIIDREHsGLsPQDD
1 4 S372-p DREHsGLsPQDDTNS
0 1 S389-p SIPRVNPsVNPsIsP
0 3 S393-p VNPsVNPsIsPAHGV
2 30 S395-p PsVNPsIsPAHGVAR
0 1 A401 IsPAHGVARSSTLPP
0 2 S423-p TRINRQQsSDLHSSS
0 1 S474 PSLNLNNSPMEGTGI
1 1 S488-p ISLAQFMsPRRQVTS
1 0 S517-p PNISTLSsPVGMTSS
0 3 S558-p SVGFSASsPVLRQMs
0 9 S565-p sPVLRQMssQNsPSR
0 2 S566-p PVLRQMssQNsPSRL
2 3 S569-p RQMssQNsPSRLNIQ
0 1 S582-p IQPAKAEsKDNKEIA
0 1 K632-ac KYSQTSHkLVQLLTT
0 1 S659-p TSCKDVLsCTGTSNS
0 5 S698-p HRLLQEGsPSDITTL
1 0 K732-sm VQGNSSIkLELDASK
1 0 K774-sm SLDDVKVkVEKKEQM
1 0 T789-p DPCNTNPtPMTKPTP
1 0 T979-p RFPPQQAtPPLIMEE
1 0 S997-p LYSQPYSsPSPTANL
1 0 S1006-p SPTANLPsPFQGMVR
1 0 T1026-p GTMPVQVtPPrGAFs
0 3 R1029-m2 PVQVtPPrGAFsPGM
2 0 S1033-p tPPrGAFsPGMGMQP
0 3 R1041-m2 PGMGMQPrQTLNRPP
0 1 R1046 QPrQTLNRPPAAPNQ
0 2 R1055 PAAPNQLRLQLQQRL
0 1 R1061 LRLQLQQRLQGQQQL
0 1 R1073 QQLIHQNRQAILNQF
0 1 R1091 APVGINMRSGMQQQI
0 1 R1124 YSQQHRQRQLIQQQr
0 3 R1131-m2 RQLIQQQrAMLMRQQ
4 0 T1179-p NYGTNPGtPPASTsP
4 0 S1185-p GtPPASTsPFSQLAA
1 0 S1250-p ANFAPSLsPGSSMVP
1 0 T1271-p QSSLLQQtPPASGYQ
0 1 A1274 LLQQtPPASGYQsPD
1 0 S1279-p PPASGYQsPDMKAWQ
0 1 S1372-p GLYCNQLsSTDLLKT
1 0 T1426-p KPTSGPQtPQAQQKS
  SRC-1 iso2  
S22 DSHKRKGSPCDTLAS
T26 RKGSPCDTLASSTEK
S30 PCDTLASSTEKRRRE
S103 KSDISSSSQGVIEKE
T209 HPPDEPGTENQEACQ
S274 DTTGKIISIDTSSLR
T277 GKIISIDTSSLRAAG
S325 MTRGTASSPSYRFIL
S369 HIIDREHSGLSPQDD
S372 DREHSGLSPQDDTNS
S389 SIPRVNPSVNPSISP
S393 VNPSVNPSISPAHGV
S395 PSVNPSISPAHGVAR
A401 ISPAHGVARSSTLPP
S423 TRINRQQSSDLHSSS
S474 PSLNLNNSPMEGTGI
S488 ISLAQFMSPRRQVTS
S517 PNISTLSSPVGMTSS
S558 SVGFSASSPVLRQMS
S565 SPVLRQMSSQNSPSR
S566 PVLRQMSSQNSPSRL
S569 RQMSSQNSPSRLNIQ
S582 IQPAKAESKDNKEIA
K632 KYSQTSHKLVQLLTT
S659 TSCKDVLSCTGTSNS
S698 HRLLQEGSPSDITTL
K732 VQGNSSIKLELDASK
K774 SLDDVKVKVEKKEQM
T789 DPCNTNPTPMTKPTP
T979 RFPPQQATPPLIMEE
S997 LYSQPYSSPSPTANL
S1006 SPTANLPSPFQGMVR
T1026 GTMPVQVTPPRGAFS
R1029 PVQVTPPRGAFSPGM
S1033 TPPRGAFSPGMGMQP
R1041 PGMGMQPRQTLNRPP
R1046 QPRQTLNRPPAAPNQ
R1055 PAAPNQLRLQLQQRL
R1061 LRLQLQQRLQGQQQL
R1073 QQLIHQNRQAILNQF
R1091 APVGINMRSGMQQQI
R1124 YSQQHRQRQLIQQQR
R1131 RQLIQQQRAMLMRQQ
T1179 NYGTNPGTPPASTSP
S1185 GTPPASTSPFSQLAA
S1250 ANFAPSLSPGSSMVP
T1271 QSSLLQQTPPASGYQ
A1274 LLQQTPPASGYQSPD
S1279 PPASGYQSPDMKAWQ
S1372 GLYCNQLSSTDLLKT
- gap
  mouse

 
S22-p DSHKRKGsPCDTLAS
T26 RKGsPCDTLASSTEK
S30 PCDTLASSTEKRRRE
S103 KSDISSSSQGVIEKE
T209 HPPEDPGTENQEACQ
S274 DTTGKIISIDTSSLR
T277 GKIISIDTSSLRAAG
S325 MTRGTASSPSYRFIL
S369 HIIDREHSGLsPQDD
S372-p DREHSGLsPQDDSNS
S389 SIPRINPSVNPGISP
G393 INPSVNPGISPAHGV
S395 PSVNPGISPAHGVtR
T401-gl ISPAHGVtRSSTLPP
S423 ARVNRQQSSDLNSSS
S475-p PSLNLNNsPMEGTGI
S489 IALSQFMSPRRQANS
S518 PNIPTLSSPVGITSG
S559-p SVGFSAGsPVLRQMS
S566 sPVLRQMSSQNsPSR
S567 PVLRQMSSQNsPSRL
S570-p RQMSSQNsPSRLSMQ
S583 MQPAKAESKDSKEIA
K636 KYSQTSHKLVQLLTT
S663 TSCKDVLSCTGTSSS
S702-p HRLLQEGsPSDITTL
K738 SQGSASIKLELDAAK
K780 CLDDVKVKVEKKEQM
T795 DPCNTNPTPMTKPAP
T985 RFPPQQATPPLMMED
S1003 LYSQPYSSPSPTAGL
G1012 SPTAGLSGPFQGMVR
T1032 GAMPVQVTPPRGTFS
R1035 PVQVTPPRGTFSPNM
S1039 TPPRGTFSPNMGMQP
R1047 PNMGMQPRQTLNrPP
R1052-m2 QPRQTLNrPPAAPNQ
R1061-m2 PAAPNQLrLQLQQrL
R1067-m2 LrLQLQQrLQGQQQL
R1079-m2 QQLMHQNrQAILNQF
R1097-m2 APVGMNMrSGMQQQI
R1130-m2 YSQQHRQrQIIQQQr
R1137-m2 rQIIQQQrAMLMRHQ
T1185 NYGTNPGTPPASTSP
S1191 GTPPASTSPFSQLAA
S1256 ATFAPSLSPGSSMVP
T1277 QSSLLQQTPPtSGYQ
T1280-p LLQQTPPtSGYQSPD
S1285 PPtSGYQSPDMKAWQ
S1378 GLYCNQLSSTDLLKT
T1432 KPTSGPQTPQAQQKS
  rat

 
S22-p DSHKRKGsPCDTLAS
T26 RKGsPCDTLASSTEK
S30 PCDTLASSTEKRRRE
S103 KSDISSSSQGVIEKE
T179 LLPKSLGTENQEACQ
S212 DGEGKIISIDTSSLR
T215 GKIISIDTSSLRAAG
S263 MTRGTASSPSYRFIL
S307 HIIDREHSGLSPQDD
S310 DREHSGLSPQDDTNS
S327 SIPRINPSVNPGISP
G331 INPSVNPGISPAHGV
S333 PSVNPGISPAHGVTR
T339 ISPAHGVTRSSTLPP
S361 ARANRQQSTDLNSGS
S413 PSLNLNNSPMEGTGI
S427 ISLAQFMSPRRQANS
S456 PNIPTLSSPVGITSG
S497 SVGFSAGSPVLRQMS
S504 SPVLRQMSSQNSPSR
S505 PVLRQMSSQNSPSRL
S508 RQMSSQNSPSRLSMQ
S521 MQPAKAESKDNKEIA
K571 KYSQTSHKLVQLLTT
S598 TSCKDVLSCTGTSSS
S637 HRLLQEGSPSDITTL
K673 AQGSASIKLELDASK
K715 SLDDVKVKVEKKEQM
A730 DPCNTNPAPVTKPAP
T920 RFPPQQATPPLMMED
S938 LYPQPYSSPSPTAGL
G947 SPTAGLSGPFQGMVR
T967 GTMPVQVTPPRGTFS
R970 PVQVTPPRGTFSPNM
S974 TPPRGTFSPNMGMQP
R982 PNMGMQPRQTLNRPP
R987 QPRQTLNRPPAAPNQ
R996 PAAPNQLRLQLQQRL
R1002 LRLQLQQRLQGQQQL
R1014 QQLMHQNRQAILNQF
R1032 APVGMNMRSGMQQQI
R1065 YSQQHRQRQIIQQQR
R1072 RQIIQQQRAMLMRHQ
T1120 NYGTNPGTPPASTSP
S1126 GTPPASTSPFSQLAA
S1191 ANFAPSLSPGSSMVP
T1211 QSSLLQQTPPTSGYQ
T1214 LLQQTPPTSGYQSPD
S1219 PPTSGYQSPDMKAWQ
S1312 GLYCNQLSSTDLLKT
- gap
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.