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TLR3 (human)

Overview TLR3 a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Receptor, cytokine Cellular Component: Golgi membrane; endoplasmic reticulum membrane; cell surface; membrane; integral to plasma membrane; cytoplasm; endosome membrane Molecular Function: transmembrane receptor activity; double-stranded RNA binding; receptor activity Biological Process: I-kappaB kinase/NF-kappaB cascade; negative regulation of osteoclast differentiation; positive regulation of apoptosis; positive regulation of interleukin-12 production; pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; positive regulation of interferon-beta production; inflammatory response; toll-like receptor 4 signaling pathway; defense response to virus; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; male gonad development; activation of NF-kappaB-inducing kinase; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of chemokine production; Toll signaling pathway; positive regulation of toll-like receptor signaling pathway; hyperosmotic response; positive regulation of chemokine biosynthetic process; detection of virus; defense response to bacterium; positive regulation of interferon-beta biosynthetic process; innate immune response; positive regulation of transcription from RNA polymerase II promoter; I-kappaB phosphorylation; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process; microglial cell activation during immune response Reference #:  O15455 (UniProtKB) Alt. Names/Synonyms: CD283; TLR3; Toll-like receptor 3 Gene Symbols: TLR3 Molecular weight: 103,829 Da Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states CST Pathways:  NF-kB Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TLR3 1ZIW - A=27-700 (human) 2A0Z - A=22-703 (human) 3ULU - A=22-702 (human) 3ULV - A=22-702 (human) 3CIG - A=28-704 (mouse) 3CIY - A/B=28-704 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1ZIW 2A0Z 3ULU 3ULV  |  Phospho3D  |  DISEASE 603029 612479 613002  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
transcription, altered: Y759‑p phosphorylation: Y759‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		-	gap
0	1		-	gap
0	1		-	gap
0	1		Y9	RQTLPCIYFWGGLLP
0	1		-	gap
0	1		T29	ASSTTKCTVSHEVAD
0	1		T72-p	RLPAANFtRYSQLTS
0	1		T86	SLDVGFNTISKLEPE
0	2		S205-p	SLKKLELssNQIKEF
0	2		S206-p	LKKLELssNQIKEFS
0	4		S350-p	LPKIDDFsFQWLKCL
0	1		Y383-p	TGLINLKyLSLSNSF
0	1		T391-p	LSLSNSFtsLRTLTN
0	1		S392-p	SLSNSFtsLRTLTNE
3	0		Y759-p	EQFEYAAyIIHAYKD
0	1		T818-p	RKIIFVItHHLLKDP
1	0		Y858-p	FLEEIPDyKLNHALC

	mouse
S5	___MKGCSSYLMYSF
S6	__MKGCSSYLMYSFG
Y7	_MKGCSSYLMYSFGG
Y10	GCSSYLMYSFGGLLS
S17	YSFGGLLSLWILLVS
T30	VSSTNQCTVRYNVAD
T73	RLPPTNFTRYSQLAI
S87-p	ILDAGFNsISKLEPE
S206	SLRKLDLSSNPLKEF
S207	LRKLDLSSNPLKEFS
S351	HPNIDDFSFQWLKYL
Y384	TGLVSLKYLSLSKTF
T392	LSLSKTFTSLQTLTN
S393	SLSKTFTSLQTLTNE
Y760	EQFEYTAYIIHAHKD
T819	RKIIFVITHHLLKDP
Y859	FLQNIPDYKLNHALC

	rat
S5-p	___MKGRssyLIySF
S6-p	__MKGRssyLIySFG
Y7-p	_MKGRssyLIySFGG
Y10-p	GRssyLIySFGGLLs
S17-p	ySFGGLLsLWILVVS
T30-p	VSSTNQCtVRYNVAD
T73	GLPPANFTRYSQLAL
S87	LLDAGFNSISKLEPE
S206	SLQKLDLSSNPLKEF
S207	LQKLDLSSNPLKEFS
S351	HPNIDDFSFQWLKCL
Y384	TGLVSLKYLSLSKTF
T392	LSLSKTFTGLQTLTN
G393	SLSKTFTGLQTLTNE
Y760	EQFEYTAYIIHAQKD
T819	RKIIFVITHHLLKDP
Y859	FLQNIPDYKLNHALC

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