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Protein Page:
TLR3 (human)

Overview
TLR3 a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 4q35
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; cell surface; membrane; integral to plasma membrane; lysosomal membrane; cytoplasm; endosome membrane
Molecular Function: protein binding; transmembrane receptor activity; double-stranded RNA binding; receptor activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; negative regulation of osteoclast differentiation; positive regulation of apoptosis; positive regulation of interleukin-12 production; positive regulation of JNK cascade; pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity; positive regulation of interferon-alpha biosynthetic process; positive regulation of NF-kappaB import into nucleus; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to exogenous dsRNA; positive regulation of interferon-beta production; inflammatory response; toll-like receptor 4 signaling pathway; defense response to virus; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; male gonad development; activation of NF-kappaB-inducing kinase; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine production; hyperosmotic response; positive regulation of chemokine biosynthetic process; detection of virus; positive regulation of interferon-beta biosynthetic process; defense response to bacterium; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; I-kappaB phosphorylation; positive regulation of interferon-gamma biosynthetic process; microglial cell activation during immune response; positive regulation of inflammatory response
Reference #:  O15455 (UniProtKB)
Alt. Names/Synonyms: CD283; TLR3; Toll-like receptor 3
Gene Symbols: TLR3
Molecular weight: 103,829 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TLR3

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: Y759‑p
phosphorylation: Y759‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 - gap
0 1 - gap
0 1 - gap
0 1 Y9 RQTLPCIYFWGGLLP
0 1 - gap
0 1 T29 ASSTTKCTVSHEVAD
0 1 T72-p RLPAANFtRYSQLTS
0 1 T86 SLDVGFNTISKLEPE
0 2 S205-p SLKKLELssNQIKEF
0 2 S206-p LKKLELssNQIKEFS
0 4 S350-p LPKIDDFsFQWLKCL
0 1 Y383-p TGLINLKyLSLSNSF
0 1 T391-p LSLSNSFtsLRTLTN
0 1 S392-p SLSNSFtsLRTLTNE
4 0 Y759-p EQFEYAAyIIHAYKD
0 1 T818-p RKIIFVItHHLLKDP
1 0 Y858-p FLEEIPDyKLNHALC
  mouse

 
S5 ___MKGCSSYLMYSF
S6 __MKGCSSYLMYSFG
Y7 _MKGCSSYLMYSFGG
Y10 GCSSYLMYSFGGLLS
S17 YSFGGLLSLWILLVS
T30 VSSTNQCTVRYNVAD
T73 RLPPTNFTRYSQLAI
S87-p ILDAGFNsISKLEPE
S206 SLRKLDLSSNPLKEF
S207 LRKLDLSSNPLKEFS
S351 HPNIDDFSFQWLKYL
Y384 TGLVSLKYLSLSKTF
T392 LSLSKTFTSLQTLTN
S393 SLSKTFTSLQTLTNE
Y760-p EQFEYTAyIIHAHKD
T819 RKIIFVITHHLLKDP
Y859 FLQNIPDYKLNHALC
  rat

 
S5-p ___MKGRssyLIySF
S6-p __MKGRssyLIySFG
Y7-p _MKGRssyLIySFGG
Y10-p GRssyLIySFGGLLs
S17-p ySFGGLLsLWILVVS
T30-p VSSTNQCtVRYNVAD
T73 GLPPANFTRYSQLAL
S87 LLDAGFNSISKLEPE
S206 SLQKLDLSSNPLKEF
S207 LQKLDLSSNPLKEFS
S351 HPNIDDFSFQWLKCL
Y384 TGLVSLKYLSLSKTF
T392 LSLSKTFTGLQTLTN
G393 SLSKTFTGLQTLTNE
Y760-p EQFEYTAyIIHAQKD
T819 RKIIFVITHHLLKDP
Y859 FLQNIPDYKLNHALC
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