Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CD3E (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD3E a T cell surface glycoprotein that is a component of the T cell antigen receptor. The recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Contains 1 immunoglobulin-like domain and 1 ITAM domain. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral
Cellular Component: T cell receptor complex; membrane; plasma membrane; integral to membrane; immunological synapse; alpha-beta T cell receptor complex; intercellular junction; external side of plasma membrane
Molecular Function: protein binding; signal transducer activity; transmembrane receptor activity; protein heterodimerization activity; SH3 domain binding
Biological Process: positive regulation of interleukin-2 biosynthetic process; lymphocyte activation; positive regulation of calcium-mediated signaling; negative thymic T cell selection; T cell receptor signaling pathway; positive regulation of interleukin-4 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; negative regulation of smoothened signaling pathway; T cell costimulation; positive regulation of T cell proliferation; positive regulation of alpha-beta T cell proliferation; positive regulation of T cell activation; positive regulation of T cell anergy; response to nutrient
Reference #:  P22646 (UniProtKB)
Alt. Names/Synonyms: AI504783; CD3; CD3 antigen, epsilon polypeptide; Cd3e; CD3epsilon; OTTMUSP00000018104; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3e
Gene Symbols: Cd3e
Molecular weight: 21,393 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD3E

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
molecular association, regulation: Y170‑p, Y181‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 - gap
0 1 V68 QKHDKHLVLQDFSEV
0 3 K159-ub SRPRGQNkERPPPVP
4 383 Y170-p PPVPNPDyEPIRKGQ
4 398 Y181-p RKGQRDLySGLNQRA
0 18 S182 KGQRDLySGLNQRAV
  human

 
S77-p EDDKNIGsDEDHLsL
S83-p GsDEDHLsLKEFSEL
K177-ub GRQRGQNkERPPPVP
Y188-p PPVPNPDyEPIRKGQ
Y199-p RKGQRDLysGLNQRR
S200-p KGQRDLysGLNQRRI
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.