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Protein Page:
IRAP (rat)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRAP a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin.. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.11.3; Membrane protein, integral; Protease
Cellular Component: cell surface; cell soma; membrane; intracellular membrane-bound organelle; lysosomal membrane; perinuclear region of cytoplasm; cytoplasm; integral to membrane; plasma membrane; intracellular organelle; intracellular; vesicle
Molecular Function: metallopeptidase activity; zinc ion binding; peptide hormone binding; aminopeptidase activity; angiotensin receptor activity
Biological Process: regulation of long-term neuronal synaptic plasticity; peptide catabolic process; response to hormone stimulus; protein catabolic process; proteolysis; positive regulation of blood pressure
Reference #:  P97629 (UniProtKB)
Alt. Names/Synonyms: aminopeptidase Vp165; Cystinyl aminopeptidase; GP160; Insulin-regulated membrane aminopeptidase; insulin-regulated membrane aminopeptidase IRAP; Insulin-responsive aminopeptidase; IRAP; LCAP; Leucyl-cystinyl aminopeptidase; leucyl/cystinyl aminopeptidase; Lnpep; OTase; Oxytocinase; P-LAP; Placental leucine aminopeptidase; Vesicle protein of 165 kDa; Vp165
Gene Symbols: Lnpep
Molecular weight: 117,201 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRAP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
0 1 S19 PRNMIENSMFEEEPD
0 60 Y46 LEPDEVEYEPRGSRL
0 3 S51 VEYEPRGSRLLVRGL
0 619 Y70-p MDEDEEDyESSAKLL
1 17 S80-p SAKLLGMsFMNRSSG
1 15 S91-p RSSGLRNsATGYRQS
0 1 T93 SGLRNsATGYRQSPD
0 1 Y95 LRNsATGYRQSPDGT
0 1 Y177 TAIIPQRYELSLHPN
0 1 S329 DEHHTALSNMPKKSS
0 2 Y508 IFKELNSYEDFLDAR
0 1 Y665 YVTDGRNYSEYRSVS
0 1 S666 VTDGRNYSEYRSVSL
0 2 Y668 DGRNYSEYRSVSLLD
0 1 S670 RNYSEYRSVSLLDKK
0 1 S672 YSEYRSVSLLDKKSD
0 1 S678 VSLLDKKSDVINLTE
0 1 K691 TEQVQWVKVNTNMTG
0 2 H784 NLLEKLGHMDLSSRL
0 2 S789 LGHMDLSSRLVTRVH
  human

 
S19-p PRNMIENsMFEEEPD
Y46-p LEPDEVEyEPRGsRL
S51-p VEyEPRGsRLLVRGL
Y70-p MEEDEEDyESSAKLL
S80-p SAKLLGMsFMNRSSG
S91-p RSSGLRNsAtGyRQS
T93-p SGLRNsAtGyRQSPD
Y95-p LRNsAtGyRQSPDGA
Y177-p TAVVPLRyELSLHPN
S329-p DEQYTALsNMPKKSS
Y508-p IFKELSSyEDFLDAR
Y665-p YVTEGRNysKyQsVs
S666-p VTEGRNysKyQsVsL
Y668-p EGRNysKyQsVsLLD
S670-p RNysKyQsVsLLDKK
S672-p ysKyQsVsLLDKKsG
S678-p VsLLDKKsGVINLTE
K691-ac TEEVLWVkVNINMNG
Y784-p NLLEKLGyMDLAsRL
S789-p LGyMDLAsRLVTRVF
  mouse

 
S19 PRNMIENSMFEEEPD
Y46 LEPDEVEYEPRGSRL
S51 VEYEPRGSRLLVRGL
Y70-p MDEDEEDyESSAKLL
S80-p SAKLLGMsFMNRSSG
S91-p RSSGLRNsAAGYRQS
A93 SGLRNsAAGYRQSPD
Y95 LRNsAAGYRQSPDGT
Y177 TAIIPLCYELSLHPN
S329 NEHHTALSNMPKKSS
Y508 IFKELNSYEDFLDAR
Y665 YVTDGRNYSEYRSVS
S666 VTDGRNYSEYRSVSL
Y668 DGRNYSEYRSVSLLD
S670 RNYSEYRSVSLLDKK
S672 YSEYRSVSLLDKKSD
S678 VSLLDKKSDVINLTE
K691 TEQVQWVKVNSNMTG
H784 NLLEKLGHMDLSSRL
S789 LGHMDLSSRLVARVH
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