a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin.. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Protease; Membrane protein, integral
Cellular Component: cell surface; cell soma; intracellular membrane-bound organelle; membrane; perinuclear region of cytoplasm; lysosomal membrane; cytoplasm; integral to membrane; plasma membrane; intracellular organelle; intracellular; vesicle
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.