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Protein Page:
IRAP (rat)

Overview
IRAP a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin.. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.11.3; Protease; Membrane protein, integral
Cellular Component: cell surface; membrane; intracellular membrane-bound organelle; cell soma; lysosomal membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; integral to membrane; intracellular organelle; intracellular; vesicle
Molecular Function: zinc ion binding; metallopeptidase activity; peptide hormone binding; aminopeptidase activity; angiotensin receptor activity
Biological Process: regulation of long-term neuronal synaptic plasticity; peptide catabolic process; response to hormone stimulus; protein catabolic process; proteolysis; positive regulation of blood pressure
Reference #:  P97629 (UniProtKB)
Alt. Names/Synonyms: aminopeptidase Vp165; Cystinyl aminopeptidase; GP160; Insulin-regulated membrane aminopeptidase; insulin-regulated membrane aminopeptidase IRAP; Insulin-responsive aminopeptidase; IRAP; LCAP; Leucyl-cystinyl aminopeptidase; leucyl/cystinyl aminopeptidase; Lnpep; OTase; Oxytocinase; P-LAP; Placental leucine aminopeptidase; Vesicle protein of 165 kDa; Vp165
Gene Symbols: Lnpep
Molecular weight: 117,201 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRAP

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
0 60 Y46 LEPDEVEYEPRGSRL
0 3 S51 VEYEPRGSRLLVRGL
0 662 Y70-p MDEDEEDyESSAKLL
1 15 S80-p SAKLLGMsFMNRSSG
1 13 S91-p RSSGLRNsATGYRQS
0 2 Y508 IFKELNSYEDFLDAR
0 1 Y665 YVTDGRNYSEYRSVS
0 1 S666 VTDGRNYSEYRSVSL
0 2 Y668 DGRNYSEYRSVSLLD
0 1 S670 RNYSEYRSVSLLDKK
0 1 S672 YSEYRSVSLLDKKSD
0 2 H784 NLLEKLGHMDLSSRL
0 2 S789 LGHMDLSSRLVTRVH
  human

 
Y46-p LEPDEVEyEPRGsRL
S51-p VEyEPRGsRLLVRGL
Y70-p MEEDEEDyESSAKLL
S80-p SAKLLGMsFMNRSSG
S91-p RSSGLRNsATGYRQS
Y508-p IFKELSSyEDFLDAR
Y665-p YVTEGRNysKyQsVs
S666-p VTEGRNysKyQsVsL
Y668-p EGRNysKyQsVsLLD
S670-p RNysKyQsVsLLDKK
S672-p ysKyQsVsLLDKKSG
Y784-p NLLEKLGyMDLAsRL
S789-p LGyMDLAsRLVTRVF
  mouse

 
Y46 LEPDEVEYEPRGSRL
S51 VEYEPRGSRLLVRGL
Y70-p MDEDEEDyESSAKLL
S80-p SAKLLGMsFMNRSSG
S91-p RSSGLRNsAAGYRQS
Y508 IFKELNSYEDFLDAR
Y665 YVTDGRNYSEYRSVS
S666 VTDGRNYSEYRSVSL
Y668 DGRNYSEYRSVSLLD
S670 RNYSEYRSVSLLDKK
S672 YSEYRSVSLLDKKSD
H784 NLLEKLGHMDLSSRL
S789 LGHMDLSSRLVARVH
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