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IRAP (rat)

Overview IRAP a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin.. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; EC 3.4.11.3; Protease Cellular Component: cell surface; membrane; intracellular membrane-bound organelle; cell soma; perinuclear region of cytoplasm; cytoplasm; integral to membrane; plasma membrane; endomembrane system; intracellular organelle; intracellular; vesicle Molecular Function: zinc ion binding; metallopeptidase activity; peptide hormone binding; aminopeptidase activity; angiotensin receptor activity Biological Process: regulation of long-term neuronal synaptic plasticity; peptide catabolic process; response to hormone stimulus; protein catabolic process; proteolysis Reference #:  P97629 (UniProtKB) Alt. Names/Synonyms: aminopeptidase Vp165; Cystinyl aminopeptidase; GP160; Insulin-regulated membrane aminopeptidase; insulin-regulated membrane aminopeptidase IRAP; Insulin-responsive aminopeptidase; IRAP; LCAP; Leucyl-cystinyl aminopeptidase; leucyl/cystinyl aminopeptidase; Lnpep; OTase; Oxytocinase; P-LAP; Placental leucine aminopeptidase; Vesicle protein of 165 kDa; Vp165 Gene Symbols: Lnpep Molecular weight: 117,201 Da Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IRAP

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			rat
0	60		Y46	LEPDEVEYEPRGSRL
0	1		S51	VEYEPRGSRLLVRGL
0	662		Y70-p	MDEDEEDyESSAKLL
1	14		S80-p	SAKLLGMsFMNRSSG
1	10		S91-p	RSSGLRNsATGYRQS
0	1		T93	SGLRNsATGYRQSPD
0	1		Y95	LRNsATGYRQSPDGT
0	1		Y177	TAIIPQRYELSLHPN
0	1		S329	DEHHTALSNMPKKSS
0	2		Y508	IFKELNSYEDFLDAR
0	1		Y665	YVTDGRNYSEYRSVS
0	1		S666	VTDGRNYSEYRSVSL
0	2		Y668	DGRNYSEYRSVSLLD
0	1		S670	RNYSEYRSVSLLDKK
0	1		S672	YSEYRSVSLLDKKSD
0	1		S678	VSLLDKKSDVINLTE
0	1		K691	TEQVQWVKVNTNMTG
0	2		H784	NLLEKLGHMDLSSRL
0	2		S789	LGHMDLSSRLVTRVH

	human
Y46-p	LEPDEVEyEPRGsRL
S51-p	VEyEPRGsRLLVRGL
Y70-p	MEEDEEDyESSAKLL
S80-p	SAKLLGMsFMNRSSG
S91-p	RSSGLRNsAtGyRQS
T93-p	SGLRNsAtGyRQSPD
Y95-p	LRNsAtGyRQSPDGA
Y177-p	TAVVPLRyELSLHPN
S329-p	DEQYTALsNMPKKSS
Y508-p	IFKELSSyEDFLDAR
Y665-p	YVTEGRNysKyQsVs
S666-p	VTEGRNysKyQsVsL
Y668-p	EGRNysKyQsVsLLD
S670-p	RNysKyQsVsLLDKK
S672-p	ysKyQsVsLLDKKsG
S678-p	VsLLDKKsGVINLTE
K691-a	TEEVLWVkVNINMNG
Y784-p	NLLEKLGyMDLAsRL
S789-p	LGyMDLAsRLVTRVF

	mouse
Y46	LEPDEVEYEPRGSRL
S51	VEYEPRGSRLLVRGL
Y70-p	MDEDEEDyESSAKLL
S80-p	SAKLLGMsFMNRSSG
S91-p	RSSGLRNsAAGYRQS
A93	SGLRNsAAGYRQSPD
Y95	LRNsAAGYRQSPDGT
Y177	TAIIPLCYELSLHPN
S329	NEHHTALSNMPKKSS
Y508	IFKELNSYEDFLDAR
Y665	YVTDGRNYSEYRSVS
S666	VTDGRNYSEYRSVSL
Y668	DGRNYSEYRSVSLLD
S670	RNYSEYRSVSLLDKK
S672	YSEYRSVSLLDKKSD
S678	VSLLDKKSDVINLTE
K691	TEQVQWVKVNSNMTG
H784	NLLEKLGHMDLSSRL
S789	LGHMDLSSRLVARVH

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