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Protein Page:
GJB6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GJB6 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily. A connexon is composed of a hexamer of connexins. Interacts with CNST.
Protein type: Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: connexon complex; apical plasma membrane; integral to membrane; cytosol
Biological Process: negative regulation of cell proliferation; sensory perception of sound; apoptosis; cell communication; ear morphogenesis; inner ear development
Reference #:  O95452 (UniProtKB)
Alt. Names/Synonyms: connexin 30; connexin-30; CX30; DFNA3; DFNA3B; DFNB1B; ectodermal dysplasia 2, hidrotic (Clouston syndrome); ED2; EDH; gap junction beta-6 protein; gap junction protein, beta 6; gap junction protein, beta 6, 30kDa; GJB6; HED
Gene Symbols: GJB6
Molecular weight: 30,387 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
Select Structure to View Below

GJB6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K116 GEKRNDFKDIEDIKK
  mouse

 
K116-ub GEKRNEFkDLEDIKR
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