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Protein Page:
PIK3C2A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIK3C2A a protein of the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. Its PI3-kinase is not sensitive to nanomolar levels of the inhibitor wortmannin. Activated by insulin and may be involved in integrin-dependent signaling. Note: This description may include information from UniProtKB.
Protein type: Autophagy; EC 2.7.1.154; Motility/polarity/chemotaxis; Kinase, lipid; Carbohydrate Metabolism - inositol phosphate
Cellular Component: Golgi apparatus; clathrin-coated vesicle; membrane; cytoplasm; plasma membrane; nucleus; phosphoinositide 3-kinase complex; cytosol; vesicle
Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase activity; ATP binding; phosphoinositide binding; phosphatidylinositol-4-phosphate 3-kinase activity
Biological Process: epidermal growth factor receptor signaling pathway; clathrin cage assembly; phosphoinositide-mediated signaling; exocytosis; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; vascular smooth muscle contraction; insulin receptor signaling pathway; endocytosis; platelet-derived growth factor receptor signaling pathway
Reference #:  O00443 (UniProtKB)
Alt. Names/Synonyms: C2-containing phosphatidylinositol kinase; CPK; DKFZp686L193; MGC142218; P3C2A; Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; Phosphoinositide 3-kinase-C2-alpha; phosphoinositide-3-kinase, class 2, alpha polypeptide; PI3-K-C2(ALPHA); PI3-K-C2A; PI3K-C2-alpha; PI3K-C2alpha; PIK3C2A; PtdIns-3-kinase C2 subunit alpha
Gene Symbols: PIK3C2A
Molecular weight: 190,680 Da
Basal Isoelectric point: 8.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIK3C2A

Protein Structure Not Found.


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Sites Implicated In
protein conformation: S259‑p
protein degradation: S259‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S5-p ___MAQIssNsGFKE
0 1 S6-p __MAQIssNsGFKEC
0 1 S8-p MAQIssNsGFKECPS
0 1 K11 IssNsGFKECPSSHP
0 2 T49-p LQKDRQVtDNQRGFE
0 1 N51 KDRQVtDNQRGFELS
0 3 S60-p RGFELSSsTRKKAQV
0 1 Y68-p TRKKAQVyNKQDyDL
0 42 Y73-p QVyNKQDyDLMVFPE
0 1 K94-ac ALDIDVEkLTQAELE
0 1 K94-ub ALDIDVEkLTQAELE
0 8 S108-p EKLLLDDsFETkKTP
0 1 K112-ub LDDsFETkKTPVLPV
0 2 T120-p KTPVLPVtPILsPsF
0 5 S124-p LPVtPILsPsFSAQL
0 1 S126-p VtPILsPsFSAQLYF
0 2 R134 FSAQLYFRPTIQrGQ
0 1 R139-m2 YFRPTIQrGQWPPGL
0 1 R216 QGSLPIYRPVVSTDM
0 3 K229-ub DMAKLFDkIASTsEF
0 1 S234-p FDkIASTsEFLKNGK
0 1 K238 ASTsEFLKNGKARTD
0 1 K252-ub DLEITDSkVSNLQVs
1 26 S259-p kVSNLQVsPkSEDIS
0 1 K261-ub SNLQVsPkSEDISkF
0 2 K267-ub PkSEDISkFDWLDLD
0 1 K278-ub LDLDPLSkPkVDNVE
0 1 K280-m2 LDPLSkPkVDNVEVL
0 1 K301-ub NVSSLLAkDPWDAVL
0 1 K326 LERKVNGKsLsVATV
0 4 S327-p ERKVNGKsLsVATVT
0 3 S329-p KVNGKsLsVATVTRs
0 1 S336-p sVATVTRsQsLNIRT
0 12 S338-p ATVTRsQsLNIRTTQ
0 1 K348 IRTTQLAKAQGHISQ
0 1 Y406-p NHRTNPGyLLsPVtA
0 2 S409-p TNPGyLLsPVtAQRN
0 1 T412-p GyLLsPVtAQRNICG
0 1 K532-ac ETPVDLNkHLYQIEK
0 1 C541 LYQIEKPCKEAMTRH
0 1 K579-ub RAVDQVIkAVRKICS
0 2 S612-p RAVNLPRsktADVTS
0 2 K613-ub AVNLPRsktADVTSL
0 1 T614-p VNLPRsktADVTSLF
0 1 S630-p GEDTSRSsTRGSLNP
0 1 S665-p LHANSGRsPtDCAQs
0 1 T667-p ANSGRsPtDCAQssK
0 1 S672-p sPtDCAQssKSVKEA
0 1 S673-p PtDCAQssKSVKEAW
0 1 Y737-p GTYKNFFyLIKWDEL
0 1 S771-p LFGILNQssGSSPDs
0 1 S772-p FGILNQssGSSPDsN
0 1 S778-p ssGSSPDsNKQRKGP
0 1 N863 RSIIQQHNLETLEND
0 1 K872-ac ETLENDIkGKLLDIL
0 2 K872-ub ETLENDIkGKLLDIL
0 1 K881-ac KLLDILHkDSSLGLS
0 1 K881-ub KLLDILHkDSSLGLS
0 1 K889-ac DSSLGLSkEDKAFLW
0 1 K889-ub DSSLGLSkEDKAFLW
0 1 Y900-p AFLWEKRyyCFKHPN
0 2 Y901-p FLWEKRyyCFKHPNC
0 1 K920 LASAPNWKWVNLAKT
0 1 S1069 KVRQASGSARQVVLQ
0 1 A1070 VRQASGSARQVVLQR
0 1 K1107 VAKELNIKSCSFFSS
0 1 K1162-ub IMDKIWLkEGLDLRM
0 1 S1190 MVELVPASDTLRKIQ
0 1 T1192 ELVPASDTLRKIQVE
0 1 K1217-ub PLAEWLRkYNPSEEE
0 2 S1281-p GHAQMFGsFKRDRAP
0 1 K1414 PILSFSPKTYSFRQD
0 1 R1419 SPKTYSFRQDGRIKE
0 1 R1423 YSFRQDGRIKEVSVF
0 1 S1551-p ARSADAGsFsPTPGQ
0 6 S1553-p SADAGsFsPTPGQIG
0 1 T1555 DAGsFsPTPGQIGGA
0 8 Y1595-p DGADPNPyVKTYLLP
0 1 K1611-ac NHKTSKRkTKISRKT
0 1 Y1632-p EMLVYSGysKETLRQ
0 1 S1633-p MLVYSGysKETLRQR
  mouse

 
S5 ___MAQISNNSEFkQ
N6 __MAQISNNSEFkQC
S8 MAQISNNSEFkQCSS
K11-ub ISNNSEFkQCSSSHP
T49-p LQKDRQMtDsPRGFE
S51-p KDRQMtDsPRGFELS
S60 RGFELSSSTRQRTQG
F68 TRQRTQGFNKQDYDL
Y73 QGFNKQDYDLMVFPE
K94 AVDIDVEKLTQAELE
K94 AVDIDVEKLTQAELE
N108 EKILLDDNFETRKPP
R112 LDDNFETRKPPALPV
T120 KPPALPVTPVLSPSF
S124 LPVTPVLSPSFSTQL
S126 VTPVLSPSFSTQLYL
R134-m2 FSTQLYLrPSGQRGQ
R139 YLrPSGQRGQWPPGL
R216-m2 QGSLPVYrPLVSPDM
K229-ub DMAKLFEkIASTSEF
S234 FEkIASTSEFLkNGK
K238-ub ASTSEFLkNGKARTD
K252 DLEIANSKASVCNLQ
S261-p SVCNLQIsPKSEDIN
K263 CNLQIsPKSEDINKF
K269 PKSEDINKFDWLDLD
K280 LDLDPLSKPKVDYVE
K282 LDPLSKPKVDYVEVL
E303 KDPVLLAEDPWDAVL
K327-ub LERKVNGkSLsGATV
S328 ERKVNGkSLsGATVT
S330-p KVNGkSLsGATVTRS
S337 sGATVTRSQsLIIRT
S339-p ATVTRSQsLIIRTAQ
K349-ub IRTAQFTkAQGQVSQ
Y407 DHCTNPGYLLSPVTV
S410 TNPGYLLSPVTVQRN
T413 GYLLSPVTVQRNMCG
K533 EAPVDLNKYLYQIEK
Y542-p LYQIEKPyKEVMTRH
K580 RAVDQVIKAVRKICS
N613 RAVNLPRNkSADVTS
K614-ub AVNLPRNkSADVTSL
S615 VNLPRNkSADVTSLS
S630 GSDTRKNSTKGSLNP
C665 LHANSSRCSTACPRG
T667 ANSSRCSTACPRGSR
G672 CSTACPRGSRNIKEA
S673 STACPRGSRNIKEAW
Y737 GTYKNFFYLIKWDEL
S771 LFGVLNQSSGSSPDS
S772 FGVLNQSSGSSPDSN
S778 SSGSSPDSNKQRKGP
K863-ub RNIIQQDkLETLESD
K872 ETLESDIKGKLLDII
K872-ub ETLESDIkGKLLDII
R881 KLLDIIHRDSSFGLS
R881 KLLDIIHRDSSFGLS
K889 DSSFGLSKEDKVFLW
K889 DSSFGLSKEDKVFLW
Y900 VFLWENRYYCLKHPN
Y901 FLWENRYYCLKHPNC
K920-ub LASAPNWkWANLAKT
S1069-p KVRQASGstRQVVLQ
T1070-p VRQASGstRQVVLQK
K1107-ub VAKELNIkSCSFFSS
K1162 IMDKIWLKEGLDLRM
S1190 MVELVPASDTLRKIQ
T1192 ELVPASDTLRKIQVE
K1217 PLAEWLRKYNPSEEE
S1281 GHAQMFGSFKRDRAP
K1414-ub PILSFSPkTYSFRQD
R1419 SPkTYSFRQDGRIKE
R1423 YSFRQDGRIKEVSVF
P1551 ARSAGAVPFsPtLGQ
S1553-p SAGAVPFsPtLGQIG
T1555-p GAVPFsPtLGQIGGA
Y1595 DGADPNPYVKTYLLP
K1611 THKTSKRKTKISRKT
Y1632 EMLVYSGYSKETLRQ
S1633 MLVYSGYSKETLRQR
  rat

 
S5 ___MAQISNNSEFKQ
N6 __MAQISNNSEFKQC
S8 MAQISNNSEFKQCSS
K11 ISNNSEFKQCSSSHP
T49 LQKDRHMTDSPRGFE
S51 KDRHMTDSPRGFELS
S60 RGFELSNSTRQRTQG
F68 TRQRTQGFNKQDYDL
Y73 QGFNKQDYDLMVFPE
K94 ALDIDVEKLTQAELE
K94 ALDIDVEKLTQAELE
N108 EKILLDDNFETRKTP
R112 LDDNFETRKTPASPV
T120 KTPASPVTPVLSPSF
S124 SPVTPVLSPSFSAQL
S126 VTPVLSPSFSAQLYL
R134 FSAQLYLRPAVQRSQ
R139 YLRPAVQRSQWPPGL
R216 QGSLPVYRPLVSPDM
K229 DMAKLFDKIASTSEF
S234 FDKIASTSEFLKNGK
K238 ASTSEFLKNGKARTD
K252 DLEIANSKASVCNLQ
S261-p SVCNLQIsPKSEDIN
K263 CNLQIsPKSEDINKF
K269 PKSEDINKFDWLDLD
K280 LDLDPLSKPKIDCVE
K282 LDPLSKPKIDCVEVL
E303 KNPVLLAEDPWDAVL
K328 LERKVNGKSLsGATV
S329 ERKVNGKSLsGATVT
S331-p KVNGKSLsGATVTRS
S338 sGATVTRSQsLIVRT
S340-p ATVTRSQsLIVRTTQ
K350 VRTTQVTKAQSQVSQ
Y408 DHCTNPGYLLSPVTV
S411 TNPGYLLSPVTVQRN
T414 GYLLSPVTVQRNMCG
K534 EAPVDLNKYLYQIEK
Y543 LYQIEKPYKEVMTRH
K581 RAIDQVIKAVRKICS
N614 RAVNLPRNKSADVTS
K615 AVNLPRNKSADVTSL
S616 VNLPRNKSADVTSLS
S631 GGDTSKNSTRGSLNL
S666 LHTNSCKSSTVCPQG
T668 TNSCKSSTVCPQGSR
G673 SSTVCPQGSRNIKEA
S674 STVCPQGSRNIKEAW
Y738 GTYKNFFYLIKWDEL
S772 LFGVLNQSSGSSPDS
S773 FGVLNQSSGSSPDSN
S779 SSGSSPDSNKQRKGP
K864 RNIIQQYKLEALENE
K873 EALENEIKGKLLDIV
K873 EALENEIKGKLLDIV
R882 KLLDIVHRDSSFGLS
R882 KLLDIVHRDSSFGLS
K890 DSSFGLSKEDKAFLW
K890 DSSFGLSKEDKAFLW
Y901 AFLWEKRYYCLKHPN
Y902 FLWEKRYYCLKHPNC
K921 LASAPNWKWANLAKT
S1070 KVRQASGSARQVVLQ
A1071 VRQASGSARQVVLQK
K1108 VAKELNIKSCSFFSS
K1163 IMDKIWLKEGLDLRM
S1191-p MVELVPAsDtLRKIQ
T1193-p ELVPAsDtLRKIQVE
K1218 PLAEWLRKYNPSEEE
S1282 GHAQMFGSFKRDRAP
K1415 PILSFSPKTYSFrQD
R1420-m1 SPKTYSFrQDGrIKE
R1424-m1 YSFrQDGrIKEVSVF
P1552 ARSTGTSPFSPTLGQ
S1554 STGTSPFSPTLGQIG
T1556 GTSPFSPTLGQIGGA
Y1596 DGADPNPYVKTYLLP
K1612 THKTSKRKTKISRKT
Y1633 EMLVYSGYSRETLRQ
S1634 MLVYSGYSRETLRQR
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