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Protein Page:
ChAT (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ChAT an enzyme that catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Four alternative splice variants have been described. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; Lipid Metabolism - glycerophospholipid; EC 2.3.1.6
Cellular Component: mitochondrion; cell soma; axon; cytoplasm; cytosol; nucleus
Molecular Function: choline O-acetyltransferase activity
Biological Process: muscle development; rhythmic excitation; neurotransmitter secretion; glycerophospholipid biosynthetic process; adult walking behavior; synaptic transmission; rhythmic behavior; phospholipid metabolic process; dendrite development; phosphatidylcholine biosynthetic process; neuromuscular synaptic transmission; establishment of synaptic specificity at neuromuscular junction; neurotransmitter biosynthetic process
Reference #:  P28329 (UniProtKB)
Alt. Names/Synonyms: acetyl CoA:choline O-acetyltransferase; CHAT; CHOACTase; Choline acetylase; choline acetyltransferase; Choline O-acetyltransferase; CLAT; CMS1A; CMS1A2
Gene Symbols: CHAT
Molecular weight: 82,536 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
Select Structure to View Below

ChAT

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 15 K16-a RGLGGGGkWkREEGG
0 15 K18-a LGGGGkWkREEGGGt
0 2 T25-p kREEGGGtRGRREVR
0 2 S125-p KMAAKTPsSEESGLP
1 0 T373 TVLVKDSTNRDSLDM
1 0 S464 LLKHVTQSSRKLIRA
1 0 S465 LKHVTQSSRKLIRAD
0 4 S473-p RKLIRADsVsELPAP
0 2 S475-p LIRADsVsELPAPRR
2 1 S558 VPTYESASIRRFQEG
1 1 T574 VDNIRSATPEALAFV
1 0 S594 HKAAVPASEKLLLLK
  ChAT iso3  
- gap
- gap
- gap
S7 _MAAKTPSSEESGLP
T255-p TVLVKDStNRDSLDM
S346-p LLKHVTQssRKLIRA
S347-p LKHVTQssRKLIRAD
S355 RKLIRADSVSELPAP
S357 LIRADSVSELPAPRR
S440-p VPTYESAsIRRFQEG
T456-p VDNIRSAtPEALAFV
S476-p HKAAVPAsEKLLLLK
  mouse

 
- gap
- gap
- gap
S17 KMPVQASSCEEVLDL
T266 TVLLKDSTNRDSLDM
G357 LLKHMMTGNKKLVRV
N358 LKHMMTGNKKLVRVD
S366-p KKLVRVDsVSELPAP
S368 LVRVDsVSELPAPRR
S451 VPTYESASIRRFQEG
T467 VDNIRSATPEALAFV
S487 HKAAVLASEKLQLLQ
  rat

 
- under review  
- under review  
- under review  
- under review  
T265 TVLLKDSTNRDSLDM
S356 LLKHMMTSNKKLVRA
N357 LKHMMTSNKKLVRAD
S365 KKLVRADSVSELPAP
S367 LVRADSVSELPAPRR
S450 VPTYESASIRRFQEG
T466 VDNIRSATPEALAFV
S486 HKAAMPASEKLQLLQ
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