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WWOX (human)

Overview WWOX an enzyme which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). Expressed at high levels in hormonally regulated tissues such as testis, ovary, and prostate. Its SRD domain suggest a role for this gene in steroid metabolism. Shown to be an essential mediator of tumor necrosis factor-alpha-induced apoptosis in the mouse. May play a similar role in the human. May function as a suppressor of tumor growth. Alternative splicing of this gene generates 7 isoforms. Note: This description may include information from UniProtKB. Protein type: Apoptosis; EC 1.1.1.-; Oxidoreductase Cellular Component: Golgi apparatus; microvillus; mitochondrion; cytoplasm; plasma membrane; nucleus; cytosol Molecular Function: protein dimerization activity; protein binding; enzyme binding; nucleotide binding; oxidoreductase activity; coenzyme binding; cofactor binding Biological Process: steroid metabolic process; osteoblast differentiation; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; apoptosis; positive regulation of apoptosis; skeletal morphogenesis; induction of apoptosis; positive regulation of transcription from RNA polymerase II promoter Reference #:  Q9NZC7 (UniProtKB) Alt. Names/Synonyms: D16S432E; FOR; FRA16D; Fragile site FRA16D oxidoreductase; HHCMA56; PRO0128; SDR41C1; short chain dehydrogenase/reductase family 41C, member 1; WOX1; WW domain containing oxidoreductase; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; WWOX Gene Symbols: WWOX Molecular weight: 46,677 Da Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below WWOX 1WMV - A=51-101 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE 133239 605131  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Sites Implicated In
apoptosis, altered: Y33‑p apoptosis, induced: Y33‑p enzymatic activity, induced: Y33‑p intracellular localization: Y33‑p molecular association, regulation: Y33‑p protein degradation: Y287‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y6	__MAALRYAGLDDtD
0	17		T12-p	RYAGLDDtDsEDELP
0	18		S14-p	AGLDDtDsEDELPPG
12	0		Y33-p	TTKDGWVyYANHTEE
0	1		K100-u	TVDDNPTkPTTRQRY
0	1		T111-p	RQRYDGStTAMEILQ
0	1		S134-p	VVVTGANsGIGFETA
0	1		K274-u	DINDSLGkLDFSRLS
1	1		Y287-p	LSPTKNDyWAMLAyN
0	1		Y293-p	DyWAMLAyNRSKLCN

	mouse
Y6-p	__MAALRyAGLDDtD
T12-p	RyAGLDDtDsEDELP
S14-p	AGLDDtDsEDELPPG
Y33-p	TTKDGWVyYANHTEE
K100	TVDDNPTKPTTRQRY
T111	RQRYDGSTTAMEILQ
S134	VLVTGANSGIGFETA
K274	DINDSSGKLDLSRLS
Y287	LSPPRSDYWAMLAYN
Y293	DYWAMLAYNRSKLCN

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