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PhosphoSitePlus
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Protein Page:
WWOX (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
WWOX an enzyme which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). Expressed at high levels in hormonally regulated tissues such as testis, ovary, and prostate. Its SRD domain suggest a role for this gene in steroid metabolism. Shown to be an essential mediator of tumor necrosis factor-alpha-induced apoptosis in the mouse. May play a similar role in the human. May function as a suppressor of tumor growth. Alternative splicing of this gene generates 7 isoforms. Note: This description may include information from UniProtKB.
Protein type: EC 1.1.1.-; Apoptosis; Oxidoreductase
Cellular Component: Golgi apparatus; microvillus; mitochondrion; cytoplasm; plasma membrane; nucleus; cytosol
Molecular Function: protein dimerization activity; protein binding; enzyme binding; oxidoreductase activity; coenzyme binding; cofactor binding
Biological Process: steroid metabolic process; osteoblast differentiation; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; skeletal morphogenesis; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q9NZC7 (UniProtKB)
Alt. Names/Synonyms: D16S432E; FOR; FRA16D; Fragile site FRA16D oxidoreductase; HHCMA56; PRO0128; SDR41C1; short chain dehydrogenase/reductase family 41C, member 1; WOX1; WW domain containing oxidoreductase; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; WWOX
Gene Symbols: WWOX
Molecular weight: 46,677 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

WWOX

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y33‑p
apoptosis, induced: Y33‑p
enzymatic activity, induced: Y33‑p
intracellular localization: Y33‑p
molecular association, regulation: Y33‑p
protein degradation: Y287‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 Y6-p __MAALRyAGLDDtD
0 19 T12-p RyAGLDDtDsEDELP
0 21 S14-p AGLDDtDsEDELPPG
13 0 Y33-p TTKDGWVyYANHTEE
0 1 K100-ub TVDDNPTkPTTRQRY
0 1 T111-p RQRYDGStTAMEILQ
0 1 S134-p VVVTGANsGIGFETA
0 1 K274-ub DINDSLGkLDFSRLS
2 1 Y287-p LSPTKNDyWAMLAyN
0 1 Y293-p DyWAMLAyNRSKLCN
0 1 S411 LIQERLGSQSG____
  mouse

 
Y6-p __MAALRyAGLDDtD
T12-p RyAGLDDtDsEDELP
S14-p AGLDDtDsEDELPPG
Y33-p TTKDGWVyYANHTEE
K100 TVDDNPTKPTTRQRY
T111 RQRYDGSTTAMEILQ
S134 VLVTGANSGIGFETA
K274 DINDSSGKLDLSRLS
Y287 LSPPRSDYWAMLAYN
Y293 DYWAMLAYNRSKLCN
S411-p LIQDRLGsPSS____
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