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Protein Page:
TACE (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TACE a type I membrane protein with disintegrin and metalloprotease activity. An ubiquitously expressed ectoenzyme of peptidase family M12B. Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Possesses a narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha) to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, and the amyloid precursor protein. Also involved in the activation of Notch pathway. Binds 1 zinc ion per subunit. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Protease; EC 3.4.24.86
Cellular Component: focal adhesion; cell surface; integral to plasma membrane; apical plasma membrane; plasma membrane; intercellular junction; actin cytoskeleton; lipid raft
Molecular Function: integrin binding; protein binding; interleukin-6 receptor binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; Notch binding; SH3 domain binding; PDZ domain binding
Biological Process: extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; apoptosis; neutrophil mediated immunity; T cell differentiation in the thymus; cell motility involved in cell locomotion; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; proteolysis; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; extracellular matrix disassembly; positive regulation of epidermal growth factor receptor activity; positive regulation of cell proliferation; germinal center formation; negative regulation of interleukin-8 production; cell adhesion; response to drug; spleen development; epidermal growth factor receptor signaling pathway; Notch signaling pathway; membrane protein intracellular domain proteolysis; response to high density lipoprotein stimulus; membrane protein ectodomain proteolysis; positive regulation of transforming growth factor beta receptor signaling pathway; Notch receptor processing; positive regulation of cell motility; positive regulation of cell growth; positive regulation of chemokine production; regulation of mast cell apoptosis; collagen catabolic process; PMA-inducible membrane protein ectodomain proteolysis; B cell differentiation; response to hypoxia; cell adhesion mediated by integrin; positive regulation of protein amino acid phosphorylation; positive regulation of cell migration; wound healing, spreading of epidermal cells
Reference #:  P78536 (UniProtKB)
Alt. Names/Synonyms: ADA17; ADAM 17; ADAM metallopeptidase domain 17; ADAM metallopeptidase domain 18; ADAM17; ADAM18; CD156B; CSVP; Disintegrin and metalloproteinase domain-containing protein 17; MGC71942; Snake venom-like protease; TACE; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; tumor necrosis factor, alpha, converting enzyme
Gene Symbols: ADAM17
Molecular weight: 93,021 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  ErbB/HER Signaling  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TACE

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: T735‑p
enzymatic activity, induced: T735‑p, S819‑p
intracellular localization: T735‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K168-u DKRMLVYkSEDIKNV
0 1 K302-u EKHYNMAkSYPNEEK
0 1 Y379-p PVGKKNIyLNSGLTS
1 0 Y702 DKKLDKQYESLSLFH
0 3 K728-u SASVRIIkPFPAPQt
11 4 T735-p kPFPAPQtPGRLQPA
0 10 T761-p LDHQRMDtIQEDPST
0 1 S767 DtIQEDPSTDsHMDE
0 1 T768 tIQEDPSTDsHMDED
0 2 S770-p QEDPSTDsHMDEDGF
0 1 K779-u MDEDGFEkDPFPNSS
0 1 K790-u PNSSTAAksFEDLtD
3 20 S791-p NSSTAAksFEDLtDH
0 1 T796-p AksFEDLtDHPVTRS
2 1 S819-p QRQNRVDsKETEC__
  mouse

 
K168 DKRMLVYKSEDIKDF
K302 ERHFNMAKSFPNEEK
Y379 PTVKKNIYLNSGLTS
Y702 DKKLDKQYESLSLFH
K728-u SASVRIIkPFPAPQt
T735-p kPFPAPQtPGRLQAL
T764-p LDHQRMDtIQEDPst
S770-p DtIQEDPstDsHADD
T771-p tIQEDPstDsHADDD
S773-p QEDPstDsHADDDGF
K782 ADDDGFEKDPFPNSS
K793 PNSSTAAKsFEDLTD
S794-p NSSTAAKsFEDLTDH
T799 AKsFEDLTDHPVTRS
S822-p QRQSRVDsKETEC__
  rat

 
K168 DKRMLVYKSEDIKDF
K302 ERHFNMAKSFPNEEK
Y379 PGVKKNIYLNSGLTS
Y702-p DKKLDKQyESLSLFH
K728 SASVRIIKPFPAPQt
T735-p KPFPAPQtPGRLQAL
T764 LDHQRMDTIQEDPST
S770 DTIQEDPSTDSHVDD
T771 TIQEDPSTDSHVDDD
S773 QEDPSTDSHVDDDGF
K782 VDDDGFEKDPFPNSS
K793 PNSSAAAKSFEDLTD
S794 NSSAAAKSFEDLTDH
T799 AKSFEDLTDHPVTRS
S822 QRQSRVDSKETEC__
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