Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
TNNT2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TNNT2 Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor protein
Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament
Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding
Biological Process: ATP catabolic process; regulation of muscle contraction; atrial cardiac muscle morphogenesis; positive regulation of ATPase activity; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding
Reference #:  P45379 (UniProtKB)
Alt. Names/Synonyms: Cardiac muscle troponin T; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; CMH2; CMPD2; cTnT; MGC3889; RCM3; TNNT2; TnTc; troponin T type 2 (cardiac); troponin T type 2, cardiac; Troponin T, cardiac muscle; troponin T2, cardiac
Gene Symbols: TNNT2
Molecular weight: 35,924 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TNNT2

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S2-p ______MsDIEEVVE
0 1 K76 PMEESKPKPRSFMPN
0 1 K88 MPNLVPPKIPDGERV
0 1 K186 EDEARKKKALsNMMH
0 2 S189-p ARKKKALsNMMHFGG
0 2 Y197-p NMMHFGGyIQKQAQt
0 2 K200 HFGGyIQKQAQtERK
5 0 T204-p yIQKQAQtERKsGKR
7 0 S208-p QAQtERKsGKRQtER
7 0 T213-p RKsGKRQtEREKKKK
0 1 K227 KILAERRKVLAIDHL
0 1 K242 NEDQLREKAKELWQs
0 1 S249-p KAKELWQsIyNLEAE
0 15 Y251-p KELWQsIyNLEAEKF
0 1 K257 IyNLEAEKFDLQEKF
0 1 K263 EKFDLQEKFKQQKYE
0 1 K265 FDLQEKFKQQKYEIN
0 1 K265 FDLQEKFKQQKYEIN
0 1 K268 QEKFKQQKYEINVLR
0 1 K268 QEKFKQQKYEINVLR
0 1 K283 NRINDNQKVSKTRGk
3 0 S285 INDNQKVSKTRGkAk
0 1 K290-ac KVSKTRGkAkVtGRW
0 1 K292-ac SKTRGkAkVtGRWK_
6 0 T294-p TRGkAkVtGRWK___
  mouse

► Hide Isoforms
 
S2-p ______MsDAEEVVE
K78-ub PVEDTKPkPSRLFMP
K91-ub MPNLVPPkIPDGERV
K189-ub EDEARKKkALsNMMH
S192-p ARKKkALsNMMHFGG
Y200 NMMHFGGYIQkQAQt
K203-ub HFGGYIQkQAQtERK
T207-p YIQkQAQtERKsGKR
S211-p QAQtERKsGKRQtER
T216-p RKsGKRQtEREKKKK
K230-ub KILAERRkALAIDHL
K245-ub NEDQLREkAKELWQS
S252 kAKELWQSIHNLEAE
H254 KELWQSIHNLEAEkF
K260-ac IHNLEAEkFDLQEkF
K266-ub EkFDLQEkFkQQkYE
K268-ub FDLQEkFkQQkYEIN
K268-ac FDLQEkFkQQkYEIN
K271-ub QEkFkQQkYEINVLR
K271-ac QEkFkQQkYEINVLR
K286-ub NRINDNQkVsKTRGK
S288-p INDNQkVsKTRGKAK
K293 kVsKTRGKAKVtGRW
K295 sKTRGKAKVtGRWK_
T297-p TRGKAKVtGRWK___
  TNNT2 iso2  
S2 ______MSDAEEVVE
K68 PVEDTKPKPSRLFMP
K81 MPNLVPPKIPDGERV
K179 EDEARKKKALSNMMH
S182 ARKKKALSNMMHFGG
Y190 NMMHFGGYIQkTERK
K193-ub HFGGYIQkTERKSGK
T194 FGGYIQkTERKSGKR
S198 IQkTERKSGKRQTER
T203 RKSGKRQTEREKKKK
K217 KILAERRKALAIDHL
K232 NEDQLREKAKELWQS
S239 KAKELWQSIHNLEAE
H241 KELWQSIHNLEAEKF
K247 IHNLEAEKFDLQEKF
K253 EKFDLQEKFKQQKYE
K255 FDLQEKFKQQKYEIN
K255 FDLQEKFKQQKYEIN
K258 QEKFKQQKYEINVLR
K258 QEKFKQQKYEINVLR
K273 NRINDNQKVSKTRGK
S275 INDNQKVSKTRGKAK
K280 KVSKTRGKAKVTGRW
K282 SKTRGKAKVTGRWK_
T284 TRGKAKVTGRWK___
  rat

► Hide Isoforms
 
S2-p ______MsDAEEEVV
K77 PVEDSKPKPSRLFMP
K90 MPNLVPPKIPDGERV
K188 EDEARKKKALSNMMH
S191 ARKKKALSNMMHFGG
Y199 NMMHFGGYIQKAQtE
K202 HFGGYIQKAQtERKs
T205-p GYIQKAQtERKsGKR
S209-p KAQtERKsGKRQtER
T214-p RKsGKRQtEREKKKK
K228 KILAERRKVLAIDHL
K243 NEDQLREKAKELWQS
S250 KAKELWQSIHNLEAE
H252 KELWQSIHNLEAEKF
K258 IHNLEAEKFDLQEKF
K264 EKFDLQEKFKQQkYE
K266 FDLQEKFKQQkYEIN
K266 FDLQEKFKQQkYEIN
K269 QEKFKQQKYEINVLR
K269-ac QEKFKQQkYEINVLR
K284 NRINDNQKVSKTRGK
S286 INDNQKVSKTRGKAK
K291 KVSKTRGKAKVtGRW
K293 SKTRGKAKVtGRWK_
T295-p TRGKAKVtGRWK___
  TNNT2 iso2  
S2-p ______MsDAEEEVV
K67 PVEDSKPKPSRLFMP
K80 MPNLVPPKIPDGERV
K178 EDEARKKKALSNMMH
S181 ARKKKALSNMMHFGG
Y189 NMMHFGGYIQKAQtE
K192 HFGGYIQKAQtERKs
T195-p GYIQKAQtERKsGKR
S199-p KAQtERKsGKRQtER
T204-p RKsGKRQtEREKKKK
K218 KILAERRKVLAIDHL
K233 NEDQLREKAKELWQS
S240 KAKELWQSIHNLEAE
H242 KELWQSIHNLEAEKF
K248 IHNLEAEKFDLQEKF
K254 EKFDLQEKFKQQKYE
K256 FDLQEKFKQQKYEIN
K256 FDLQEKFKQQKYEIN
K259 QEKFKQQKYEINVLR
K259 QEKFKQQKYEINVLR
K274 NRINDNQKVSKTRGK
S276 INDNQKVSKTRGKAK
K281 KVSKTRGKAKVtGRW
K283 SKTRGKAKVtGRWK_
T285-p TRGKAKVtGRWK___
  rabbit

 
S2 ______MSDLEEVVE
K80 PVEESKPKPRPFMPN
K92 MPNLVPPKIPDGERV
K189 EDEARKKKALSNMMH
S192 ARKKKALSNMMHFGG
Y200 NMMHFGGYIQKQAQT
K203 HFGGYIQKQAQTERK
T207 YIQKQAQTERKSGKR
S211 QAQTERKSGKRQTER
T216 RKSGKRQTEREKKKK
K230 KILAERRKVLAIDHL
K245 NEDQLREKAKELWQS
S252 KAKELWQSIYNLEAE
Y254 KELWQSIYNLEAEKF
K260 IYNLEAEKFDLQEKF
K266 EKFDLQEKFKQQKYE
K268 FDLQEKFKQQKYEIN
K268 FDLQEKFKQQKYEIN
K271 QEKFKQQKYEINVLR
K271 QEKFKQQKYEINVLR
K286 NRINDNQKVSKTRGK
S288 INDNQKVSKTRGKAK
K293 KVSKTRGKAKVTGRW
K295 SKTRGKAKVTGRWK_
T297 TRGKAKVTGRWK___
  cow

 
S2 ______MSDVEEAVE
K64 PVEEFKPKPRPFMPN
K76 MPNLVPPKIPDGERV
K174 EDEARKKKALSNMMH
S177 ARKKKALSNMMHFGG
Y185 NMMHFGGYIQKAQtE
K188 HFGGYIQKAQtERKs
T191-p GYIQKAQtERKsGKR
S195-p KAQtERKsGKRQtER
T200-p RKsGKRQtEREKKKK
K214 KILAERRKVLAIDHL
K229 NEDQLREKAKELWQM
M236 KAKELWQMIYDLEAE
Y238 KELWQMIYDLEAEKF
K244 IYDLEAEKFDLQEKF
K250 EKFDLQEKFKQQKYE
K252 FDLQEKFKQQKYEIN
K252 FDLQEKFKQQKYEIN
K255 QEKFKQQKYEINVLR
K255 QEKFKQQKYEINVLR
K270 NRINDNQKVSKTRGK
S272 INDNQKVSKTRGKAK
K277 KVSKTRGKAKVtGRW
K279 SKTRGKAKVtGRWK_
T281-p TRGKAKVtGRWK___
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.