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Protein Page:
TNNT2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TNNT2 Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor protein
Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament
Molecular Function: protein binding, bridging; troponin C binding; troponin I binding; ATPase activity; actin binding; tropomyosin binding
Biological Process: ATP catabolic process; actin crosslink formation; positive regulation of ATPase activity; regulation of muscle contraction; ventricular cardiac muscle morphogenesis; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding
Reference #:  P45379 (UniProtKB)
Alt. Names/Synonyms: Cardiac muscle troponin T; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; CMH2; CMPD2; cTnT; MGC3889; RCM3; TNNT2; TnTc; troponin T type 2 (cardiac); troponin T type 2, cardiac; Troponin T, cardiac muscle; troponin T2, cardiac
Gene Symbols: TNNT2
Molecular weight: 35,924 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TNNT2
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
1 0 S2-p ______MsDIEEVVE
0 1 K76-u PMEESKPkPRSFMPN
0 1 K88 MPNLVPPKIPDGERV
0 1 K186 EDEARKKKALSNMMH
0 1 S189 ARKKKALSNMMHFGG
0 2 Y197-p NMMHFGGyIQkQAQT
0 2 K200-u HFGGyIQkQAQTERK
3 0 T204 yIQkQAQTERKsGKR
4 0 S208-p QAQTERKsGKRQTER
5 0 T213 RKsGKRQTEREKKKK
0 1 K227 KILAERRKVLAIDHL
0 1 K242 NEDQLREKAKELWQS
0 12 Y251-p KELWQSIyNLEAEKF
0 1 K257 IyNLEAEKFDLQEKF
0 1 K263 EKFDLQEKFKQQKYE
0 1 K265 FDLQEKFKQQKYEIN
0 1 K265 FDLQEKFKQQKYEIN
0 1 K268 QEKFKQQKYEINVLR
0 1 K268 QEKFKQQKYEINVLR
0 1 K283 NRINDNQKVSKTRGk
3 0 S285 INDNQKVSKTRGkAk
0 1 K290-a KVSKTRGkAkVTGRW
0 1 K292-a SKTRGkAkVTGRWK_
4 0 T294 TRGkAkVTGRWK___
  mouse

► Hide Isoforms 		 
S2-p ______MsDAEEVVE
K78-u PVEDTKPkPSRLFMP
K91-u MPNLVPPkIPDGERV
K189-u EDEARKKkALsNMMH
S192-p ARKKkALsNMMHFGG
Y200 NMMHFGGYIQkQAQt
K203-u HFGGYIQkQAQtERK
T207-p YIQkQAQtERKsGKR
S211-p QAQtERKsGKRQtER
T216-p RKsGKRQtEREKKKK
K230-u KILAERRkALAIDHL
K245-u NEDQLREkAKELWQS
H254 KELWQSIHNLEAEkF
K260-a IHNLEAEkFDLQEkF
K266-u EkFDLQEkFkQQkYE
K268-u FDLQEkFkQQkYEIN
K268-a FDLQEkFkQQkYEIN
K271-u QEkFkQQkYEINVLR
K271-a QEkFkQQkYEINVLR
K286-u NRINDNQkVsKTRGK
S288-p INDNQkVsKTRGKAK
K293 kVsKTRGKAKVtGRW
K295 sKTRGKAKVtGRWK_
T297-p TRGKAKVtGRWK___
  TNNT2 iso2  
S2 ______MSDAEEVVE
K68 PVEDTKPKPSRLFMP
K81 MPNLVPPKIPDGERV
K179 EDEARKKKALSNMMH
S182 ARKKKALSNMMHFGG
Y190 NMMHFGGYIQkTERK
K193-u HFGGYIQkTERKSGK
T194 FGGYIQkTERKSGKR
S198 IQkTERKSGKRQTER
T203 RKSGKRQTEREKKKK
K217 KILAERRKALAIDHL
K232 NEDQLREKAKELWQS
H241 KELWQSIHNLEAEKF
K247 IHNLEAEKFDLQEKF
K253 EKFDLQEKFKQQKYE
K255 FDLQEKFKQQKYEIN
K255 FDLQEKFKQQKYEIN
K258 QEKFKQQKYEINVLR
K258 QEKFKQQKYEINVLR
K273 NRINDNQKVSKTRGK
S275 INDNQKVSKTRGKAK
K280 KVSKTRGKAKVTGRW
K282 SKTRGKAKVTGRWK_
T284 TRGKAKVTGRWK___
  rat

 
S2 ______MSDAEEEVV
K77 PVEDSKPKPSRLFMP
K90 MPNLVPPKIPDGERV
K188 EDEARKKKALSNMMH
S191 ARKKKALSNMMHFGG
Y199 NMMHFGGYIQKAQtE
K202 HFGGYIQKAQtERKs
T205-p GYIQKAQtERKsGKR
S209-p KAQtERKsGKRQtER
T214-p RKsGKRQtEREKKKK
K228 KILAERRKVLAIDHL
K243 NEDQLREKAKELWQS
H252 KELWQSIHNLEAEKF
K258 IHNLEAEKFDLQEKF
K264 EKFDLQEKFKQQKYE
K266 FDLQEKFKQQKYEIN
K266 FDLQEKFKQQKYEIN
K269 QEKFKQQKYEINVLR
K269 QEKFKQQKYEINVLR
K284 NRINDNQKVSKTRGK
S286 INDNQKVSKTRGKAK
K291 KVSKTRGKAKVtGRW
K293 SKTRGKAKVtGRWK_
T295-p TRGKAKVtGRWK___
  rabbit

 
S2 ______MSDLEEVVE
K80 PVEESKPKPRPFMPN
K92 MPNLVPPKIPDGERV
K189 EDEARKKKALSNMMH
S192 ARKKKALSNMMHFGG
Y200 NMMHFGGYIQKQAQT
K203 HFGGYIQKQAQTERK
T207 YIQKQAQTERKSGKR
S211 QAQTERKSGKRQTER
T216 RKSGKRQTEREKKKK
K230 KILAERRKVLAIDHL
K245 NEDQLREKAKELWQS
Y254 KELWQSIYNLEAEKF
K260 IYNLEAEKFDLQEKF
K266 EKFDLQEKFKQQKYE
K268 FDLQEKFKQQKYEIN
K268 FDLQEKFKQQKYEIN
K271 QEKFKQQKYEINVLR
K271 QEKFKQQKYEINVLR
K286 NRINDNQKVSKTRGK
S288 INDNQKVSKTRGKAK
K293 KVSKTRGKAKVTGRW
K295 SKTRGKAKVTGRWK_
T297 TRGKAKVTGRWK___
  cow

 
S2 ______MSDVEEAVE
K64 PVEEFKPKPRPFMPN
K76 MPNLVPPKIPDGERV
K174 EDEARKKKALSNMMH
S177 ARKKKALSNMMHFGG
Y185 NMMHFGGYIQKAQtE
K188 HFGGYIQKAQtERKs
T191-p GYIQKAQtERKsGKR
S195-p KAQtERKsGKRQtER
T200-p RKsGKRQtEREKKKK
K214 KILAERRKVLAIDHL
K229 NEDQLREKAKELWQM
Y238 KELWQMIYDLEAEKF
K244 IYDLEAEKFDLQEKF
K250 EKFDLQEKFKQQKYE
K252 FDLQEKFKQQKYEIN
K252 FDLQEKFKQQKYEIN
K255 QEKFKQQKYEINVLR
K255 QEKFKQQKYEINVLR
K270 NRINDNQKVSKTRGK
S272 INDNQKVSKTRGKAK
K277 KVSKTRGKAKVtGRW
K279 SKTRGKAKVtGRWK_
T281-p TRGKAKVtGRWK___
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