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Protein Page:
HRas (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HRas a small GTPase protein of the Ras family. Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Mutations are implicated in a variety of human tumors. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; G protein, monomeric, Ras; G protein, monomeric; G protein
Cellular Component: Golgi apparatus; membrane; intracellular membrane-bound organelle; plasma membrane; intracellular
Molecular Function: protein C-terminus binding; protein binding; GTP binding; nucleotide binding
Biological Process: regulation of long-term neuronal synaptic plasticity; apoptosis; protein heterooligomerization; positive regulation of JNK cascade; signal transduction; positive regulation of MAP kinase activity; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; GTP catabolic process; small GTPase mediated signal transduction; positive regulation of cell proliferation; negative regulation of neuron apoptosis; cell cycle arrest; mitotic cell cycle checkpoint; cell aging; endocytosis; cell proliferation; Ras protein signal transduction; positive regulation of Rac GTPase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Ras protein signal transduction; positive regulation of protein amino acid phosphorylation; positive regulation of epithelial cell proliferation; positive regulation of DNA replication; positive regulation of cell migration
Reference #:  Q61411 (UniProtKB)
Alt. Names/Synonyms: c-H-ras; c-Ha-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-rasHa; GTPase HRas; GTPase HRas, N-terminally processed; H-Ras; H-ras; H-ras 1 protein; H-Ras-1; Ha-ras; Harvey rat sarcoma virus oncogene 1; Harvey-ras; Hras; Hras-1; Hras1; Kras2; OTTMUSP00000017718; OTTMUSP00000017719; p21ras; ras; RASH; Transforming protein p21
Gene Symbols: Hras1
Molecular weight: 21,298 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-├č Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HRas

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 6 Y32 QNHFVDEYDPTIEDs
1 0 T35 FVDEYDPTIEDsYRK
0 5 S39-p YDPTIEDsYRKQVVI
1 3 Y64 DTAGQEEYSAMRDQY
1 0 - under review  
0 1 K101-ub HQYREQIkRVKDSDD
1 0 K117 PMVLVGNKCDLAART
1 0 T144 YGIPYIETSAkTRQG
0 1 S145 GIPYIETSAkTRQGV
1 1 K147-ub PYIETSAkTRQGVED
1 1 T148 YIETSAkTRQGVEDA
0 13 Y157 QGVEDAFYTLVREIR
0 1 K170-ub IRQHKLRkLNPPDEs
1 1 S177-p kLNPPDEsGPGCMSC
1 0 S183 EsGPGCMSCKCVLS_
  human

 
Y32-p QNHFVDEyDPtIEDs
T35-p FVDEyDPtIEDsYRK
S39-p yDPtIEDsYRKQVVI
Y64-p DTAGQEEySAMRDQY
Y96-p SFEDIHQyREQIKRV
K101 HQyREQIKRVKDSDD
K117-ub PMVLVGNkCDLAART
T144-p YGIPYIEtsAktRQG
S145-p GIPYIEtsAktRQGV
K147-ub PYIEtsAktRQGVED
T148-p YIEtsAktRQGVEDA
Y157-p QGVEDAFyTLVREIR
K170 IRQHKLRKLNPPDES
S177 KLNPPDESGPGCMsC
S183-p ESGPGCMsCKCVLS_
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