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HRas (mouse)

Overview HRas a small GTPase protein of the Ras family. Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Mutations are implicated in a variety of human tumors. Note: This description may include information from UniProtKB. Protein type: G protein; Motility/polarity/chemotaxis; G protein, monomeric (Ras) Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; membrane; plasma membrane Molecular Function: GTPase activity; protein C-terminus binding; protein binding; GTP binding; nucleotide binding Biological Process: regulation of long-term neuronal synaptic plasticity; protein heterooligomerization; apoptosis; G1/S transition checkpoint; cell aging; positive regulation of JNK cascade; endocytosis; signal transduction; negative regulation of cell proliferation; cell proliferation; positive regulation of MAPKKK cascade; GTP catabolic process; small GTPase mediated signal transduction; Ras protein signal transduction; positive regulation of cell proliferation; induction of apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; negative regulation of neuron apoptosis; cell cycle arrest; positive regulation of DNA replication; positive regulation of epithelial cell proliferation Reference #:  Q61411 (UniProtKB) Alt. Names/Synonyms: c-H-ras; c-Ha-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-rasHa; GTPase HRas; GTPase HRas, N-terminally processed; H-Ras; H-ras; H-ras 1 protein; H-Ras-1; Ha-ras; Harvey rat sarcoma virus oncogene 1; Harvey-ras; Hras; Hras-1; Hras1; Kras2; OTTMUSP00000017718; OTTMUSP00000017719; p21ras; ras; RASH; Transforming protein p21 Gene Symbols: Hras1 Molecular weight: 21,298 Da Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Jak/Stat/IL-6 Signaling  |  MAPK/Erk in Growth and Differentiation  |  NF-kB Signaling  |  Regulation of Actin Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HRas 121P - A=1-166 (human) 1AA9 - A=1-171 (human) 1AGP - A=1-166 (human) 1BKD - R=1-166 (human) 1CLU - A=1-166 (human) 1CRP - A=1-166 (human) 1CRQ - A=1-166 (human) 1CRR - A=1-166 (human) 1CTQ - A=1-166 (human) 1GNP - A=1-166 (human) 1GNQ - A=1-166 (human) 1GNR - A=1-166 (human) 1HE8 - B=1-166 (human) 1IAQ - A/B/C=1-166 (human) 1IOZ - A=1-171 (human) 1JAH - A=1-166 (human) 1JAI - A=1-166 (human) 1K8R - A=1-166 (human) 1LF0 - A=1-166 (human) 1LF5 - A=1-166 (human) 1LFD - B/D=1-167 (human) 1NVU - Q/R=1-166 (human) 1NVV - Q/R=1-166 (human) 1NVW - Q/R=1-166 (human) 1NVX - Q/R=1-166 (human) 1P2S - A=1-166 (human) 1P2T - A=1-166 (human) 1P2U - A=1-166 (human) 1P2V - A=1-166 (human) 1PLJ - A=1-166 (human) 1PLK - A=1-166 (human) 1PLL - A=1-166 (human) 1Q21 - A=1-171 (human) 1QRA - A=1-166 (human) 1RVD - A=1-166 (human) 1WQ1 - R=1-166 (human) 1XCM - A=1-167 (human) 1XD2 - A/B=1-166 (human) 1XJ0 - A=1-166 (human) 1ZVQ - A=1-166 (human) 1ZW6 - A=1-166 (human) 221P - A=1-166 (human) 2C5L - A/B=1-166 (human) 2CE2 - X=1-166 (human) 2CL0 - X=1-166 (human) 2CL6 - X=1-166 (human) 2CL7 - X=1-166 (human) 2CLC - X=1-166 (human) 2CLD - X=1-166 (human) 2EVW - X=1-166 (human) 2GDP - A=1-171 (human) 2LCF - A=1-166 (human) 2Q21 - A=1-171 (human) 2QUZ - A=1-166 (human) 2RGA - A=1-166 (human) 2RGB - A=1-166 (human) 2RGC - A=1-166 (human) 2RGD - A=1-166 (human) 2RGE - A=1-166 (human) 2RGG - A=1-166 (human) 2UZI - R=1-166 (human) 2VH5 - R=1-166 (human) 2X1V - A=1-166 (human) 3DDC - A=1-166 (human) 3I3S - R=1-166 (human) 3K8Y - A=1-166 (human) 3K9L - A/C/B=1-166 (human) 3K9N - A=1-166 (human) 3KKM - A=1-166 (human) 3KKN - A=1-166 (human) 3KUD - A=1-166 (human) 3L8Y - A=1-166 (human) 3L8Z - A=1-166 (human) 3LBH - A=1-166 (human) 3LBI - A=1-166 (human) 3LBN - A=1-166 (human) 3LO5 - A/C/E=1-166 (human) 3OIU - A=1-166 (human) 3OIV - A=1-166 (human) 3OIW - A=1-166 (human) 3RRY - A=1-166 (human) 3RRZ - A=1-166 (human) 3RS0 - A=1-166 (human) 3RS2 - A=1-166 (human) 3RS3 - A=1-166 (human) 3RS4 - A=1-166 (human) 3RS5 - A=1-166 (human) 3RS7 - A=1-166 (human) 3RSL - A=1-166 (human) 3RSO - A=1-166 (human) 3TGP - A=1-166 (human) 421P - A=1-166 (human) 4DLR - A=1-166 (human) 4DLS - A=1-166 (human) 4DLT - A=1-166 (human) 4DLU - A=1-166 (human) 4DLV - A=1-166 (human) 4DLW - A=1-166 (human) 4DLX - A=1-166 (human) 4DLY - A=1-166 (human) 4DLZ - A=1-166 (human) 4EFL - A=1-166 (human) 4EFM - A=1-166 (human) 4EFN - A=1-166 (human) 4Q21 - A=1-189 (human) 521P - A=1-166 (human) 5P21 - A=1-166 (human) 621P - A=1-166 (human) 6Q21 - A/B/C/D=1-171 (human) 721P - A=1-166 (human) 821P - A=1-166 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
1	0		T35	FVDEYDPTIEDsYRK
0	2		S39-p	YDPTIEDsYRKQVVI
0	4		Y64	DTAGQEEYSAMRDQY
0	1		K101-u	HQYREQIkRVKDSDD
1	0		T144	YGIPYIETSAkTRQG
0	1		S145	GIPYIETSAkTRQGV
0	1		K147-u	PYIETSAkTRQGVED
1	1		T148	YIETSAkTRQGVEDA
0	10		Y157	QGVEDAFYTLVREIR
0	1		K170-u	IRQHKLRkLNPPDEs
1	1		S177-p	kLNPPDEsGPGCMSC
1	0		S183	EsGPGCMSCKCVLS_

	human
T35-p	FVDEYDPtIEDsYRK
S39-p	YDPtIEDsYRKQVVI
Y64-p	DTAGQEEySAMRDQY
K101	HQYREQIKRVKDSDD
T144-p	YGIPYIEtsAKtRQG
S145-p	GIPYIEtsAKtRQGV
K147	PYIEtsAKtRQGVED
T148-p	YIEtsAKtRQGVEDA
Y157-p	QGVEDAFyTLVREIR
K170	IRQHKLRKLNPPDES
S177	KLNPPDESGPGCMsC
S183-p	ESGPGCMsCKCVLS_

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