a small GTPase protein of the Ras family. Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Mutations are implicated in a variety of human tumors. Note: This description may include information from UniProtKB.
Protein type: G protein; Motility/polarity/chemotaxis; G protein, monomeric, Ras; G protein, monomeric
Molecular Function: protein C-terminus binding; protein binding; GTP binding; nucleotide binding
Biological Process: regulation of long-term neuronal synaptic plasticity; apoptosis; protein heterooligomerization; mitotic cell cycle checkpoint; cell aging; positive regulation of JNK cascade; endocytosis; signal transduction; cell proliferation; negative regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; GTP catabolic process; small GTPase mediated signal transduction; positive regulation of cell proliferation; Ras protein signal transduction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Rac GTPase activity; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; negative regulation of neuron apoptosis; cell cycle arrest; positive regulation of epithelial cell proliferation; positive regulation of DNA replication; positive regulation of cell migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.