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Protein Page:
TUBB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TUBB Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. May interact with RNABP10. Interacts with PIFO/C1orf88. Ubiquitously expressed with highest levels in spleen, thymus and immature brain. Belongs to the tubulin family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Cellular Component: microtubule; cytoskeleton; nuclear envelope lumen; nucleus; cytosol
Molecular Function: GTPase activity; protein domain specific binding; protein binding; GTP binding; structural constituent of cytoskeleton; MHC class I protein binding; protein complex binding; GTPase activating protein binding; structural molecule activity
Biological Process: protein polymerization; cell division; natural killer cell mediated cytotoxicity; GTP catabolic process; mitotic cell cycle; spindle assembly; cytoskeleton-dependent intracellular transport; G2/M transition of mitotic cell cycle; cell motility; cellular process; microtubule-based process
Reference #:  P07437 (UniProtKB)
Alt. Names/Synonyms: beta 5-tubulin; beta Ib tubulin; beta-4 tubulin; M40; MGC117247; MGC16435; OK/SW-cl.56; TBB5; TUBB; TUBB1; TUBB5; Tubulin beta chain; tubulin beta polypeptide; tubulin beta-1 chain; Tubulin beta-5 chain; tubulin, beta; tubulin, beta polypeptide
Gene Symbols: TUBB
Molecular weight: 49,671 Da
Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TUBB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K19-ac CGNQIGAkFWEVIsD
0 1 K19-m2 CGNQIGAkFWEVIsD
0 1 S25-p AkFWEVIsDEHGIDP
0 3 T33-p DEHGIDPtGtyHGDs
0 24 T35-p HGIDPtGtyHGDsDL
0 94 Y36-p GIDPtGtyHGDsDLQ
0 6 S40-p tGtyHGDsDLQLDrI
0 4 R46-m1 DsDLQLDrIsVyyNE
0 6 S48-p DLQLDrIsVyyNEAt
0 249 Y50-p QLDrIsVyyNEAtGG
0 254 Y51-p LDrIsVyyNEAtGGk
0 13 T55-p sVyyNEAtGGkyVPR
0 12 K58-ac yNEAtGGkyVPRAIL
0 117 K58-ub yNEAtGGkyVPRAIL
0 37 Y59-p NEAtGGkyVPRAILV
0 3 T72-p LVDLEPGtMDsVRsG
0 11 S75-p LEPGtMDsVRsGPFG
0 10 S78-p GtMDsVRsGPFGQIF
0 10 S95-p DNFVFGQsGAGNNWA
0 1 K103-ac GAGNNWAkGHytEGA
0 3 K103-ub GAGNNWAkGHytEGA
0 132 Y106-p NNWAkGHytEGAELV
1 8 T107-p NWAkGHytEGAELVD
0 13 S115-p EGAELVDsVLDVVRk
0 16 K122-ub sVLDVVRkEAEsCDC
0 3 S126-p VVRkEAEsCDCLQGF
0 1 S138-p QGFQLTHsLGGGtGs
0 2 T143-p THsLGGGtGsGMGTL
0 1 S145-p sLGGGtGsGMGTLLI
0 21 K154-ub MGTLLISkIREEyPD
0 9 Y159-p ISkIREEyPDRIMNT
0 4 S168-p DRIMNTFsVVPsPkV
1 14 S172-p NTFsVVPsPkVSDTV
0 2 K174-ub FsVVPsPkVSDTVVE
0 220 Y208-p CIDNEALyDICFRTL
0 116 K216-ub DICFRTLkLttPtyG
0 7 T218-p CFRTLkLttPtyGDL
0 10 T219-p FRTLkLttPtyGDLN
0 98 T221-p TLkLttPtyGDLNHL
0 96 Y222-p LkLttPtyGDLNHLV
0 1 K252 QLNADLRKLAVNMVP
0 83 K252-ub QLNADLRkLAVNMVP
0 17 T274-p MPGFAPLtsRGsQQy
0 11 S275-p PGFAPLtsRGsQQyR
0 19 S278-p APLtsRGsQQyRALt
0 19 Y281-p tsRGsQQyRALtVPE
0 22 T285-p sQQyRALtVPELtQQ
0 1 T290-p ALtVPELtQQVFDAk
0 105 K297-ub tQQVFDAkNMMAACD
0 9 Y310-p CDPRHGRyLtVAAVF
0 7 T312-p PRHGRyLtVAAVFRG
0 83 K324-ub FRGRMSMkEVDEQML
0 54 K336-ub QMLNVQNkNsSyFVE
0 4 S338-p LNVQNkNsSyFVEWI
0 372 Y340-p VQNkNsSyFVEWIPN
0 84 K350-ub EWIPNNVkTAVCDIP
0 48 K362-ub DIPPRGLkMAVtFIG
0 6 T366-p RGLkMAVtFIGNSTA
0 66 K379-ac TAIQELFkRIsEQFT
0 52 K379-ub TAIQELFkRIsEQFT
0 3 S382-p QELFkRIsEQFTAMF
0 3 K392-ub FTAMFRRkAFLHWYT
1 0 T409 GMDEMEFTEAESNMN
1 0 S420 SNMNDLVSEyQQyQD
0 3 Y422-p MNDLVSEyQQyQDAt
0 7 Y425-p LVSEyQQyQDAtAEE
0 1 T429-p yQQyQDAtAEEEEDF
  mouse

 
K19 CGNQIGAKFWEVISD
K19 CGNQIGAKFWEVISD
S25 AKFWEVISDEHGIDP
T33-p DEHGIDPtGTyHGDs
T35 HGIDPtGTyHGDsDL
Y36-p GIDPtGTyHGDsDLQ
S40-p tGTyHGDsDLQLDrI
R46-m1 DsDLQLDrISVyYNE
S48 DLQLDrISVyYNEAt
Y50-p QLDrISVyYNEAtGG
Y51 LDrISVyYNEAtGGk
T55-p SVyYNEAtGGkYVPR
K58 YNEAtGGKYVPRAIL
K58-ub YNEAtGGkYVPRAIL
Y59 NEAtGGkYVPRAILV
T72-p LVDLEPGtMDsVRsG
S75-p LEPGtMDsVRsGPFG
S78-p GtMDsVRsGPFGQIF
S95 DNFVFGQSGAGNNWA
K103 GAGNNWAKGHytEGA
K103 GAGNNWAKGHytEGA
Y106-p NNWAKGHytEGAELV
T107-p NWAKGHytEGAELVD
S115-p EGAELVDsVLDVVRk
K122-ub sVLDVVRkEAEsCDC
S126-p VVRkEAEsCDCLQGF
S138 QGFQLTHSLGGGTGS
T143 THSLGGGTGSGMGTL
S145 SLGGGTGSGMGTLLI
K154-ub MGTLLISkIREEYPD
Y159 ISkIREEYPDRIMNT
S168-p DRIMNTFsVVPsPKV
S172-p NTFsVVPsPKVSDTV
K174 FsVVPsPKVSDTVVE
Y208-p CIDNEALyDICFRTL
K216-ub DICFRTLkLttPtyG
T218-p CFRTLkLttPtyGDL
T219-p FRTLkLttPtyGDLN
T221-p TLkLttPtyGDLNHL
Y222-p LkLttPtyGDLNHLV
K252-ac QLNADLRkLAVNMVP
K252-ub QLNADLRkLAVNMVP
T274-p MPGFAPLtsRGsQQY
S275-p PGFAPLtsRGsQQYR
S278-p APLtsRGsQQYRALT
Y281 tsRGsQQYRALTVPE
T285 sQQYRALTVPELTQQ
T290 ALTVPELTQQVFDAk
K297-ub TQQVFDAkNMMAACD
Y310 CDPRHGRYLtVAAVF
T312-p PRHGRYLtVAAVFRG
K324-ub FRGRMSMkEVDEQML
K336-ub QMLNVQNkNsSyFVE
S338-p LNVQNkNsSyFVEWI
Y340-p VQNkNsSyFVEWIPN
K350-ub EWIPNNVkTAVCDIP
K362 DIPPRGLKMAVtFIG
T366-p RGLKMAVtFIGNSTA
K379-ac TAIQELFkRIsEQFT
K379 TAIQELFKRIsEQFT
S382-p QELFkRIsEQFTAMF
K392 FTAMFRRKAFLHWYT
T409 GMDEMEFTEAESNMN
S420 SNMNDLVSEYQQYQD
Y422 MNDLVSEYQQYQDAT
Y425 LVSEYQQYQDATAEE
T429 YQQYQDATAEEEEDF
  rat

 
K19 CGNQIGAKFWEVISD
K19 CGNQIGAKFWEVISD
S25 AKFWEVISDEHGIDP
T33 DEHGIDPTGTyHGDS
T35 HGIDPTGTyHGDSDL
Y36-p GIDPTGTyHGDSDLQ
S40 TGTyHGDSDLQLDRI
R46 DSDLQLDRISVyyNE
S48 DLQLDRISVyyNEAT
Y50-p QLDRISVyyNEATGG
Y51-p LDRISVyyNEATGGk
T55 SVyyNEATGGkyVPR
K58 yNEATGGKyVPRAIL
K58-ub yNEATGGkyVPRAIL
Y59-p NEATGGkyVPRAILV
T72 LVDLEPGTMDSVRSG
S75 LEPGTMDSVRSGPFG
S78 GTMDSVRSGPFGQIF
S95 DNFVFGQSGAGNNWA
K103 GAGNNWAKGHyTEGA
K103 GAGNNWAKGHyTEGA
Y106-p NNWAKGHyTEGAELV
T107 NWAKGHyTEGAELVD
S115 EGAELVDSVLDVVRK
K122 SVLDVVRKEAESCDC
S126 VVRKEAESCDCLQGF
S138 QGFQLTHSLGGGTGS
T143 THSLGGGTGSGMGTL
S145 SLGGGTGSGMGTLLI
K154 MGTLLISKIREEYPD
Y159 ISKIREEYPDRIMNT
S168 DRIMNTFSVVPSPKV
S172 NTFSVVPSPKVSDTV
K174 FSVVPSPKVSDTVVE
Y208 CIDNEALYDICFRTL
K216-ub DICFRTLkLTTPTyG
T218 CFRTLkLTTPTyGDL
T219 FRTLkLTTPTyGDLN
T221 TLkLTTPTyGDLNHL
Y222-p LkLTTPTyGDLNHLV
K252 QLNADLRKLAVNMVP
K252 QLNADLRKLAVNMVP
T274-p MPGFAPLtSRGSQQY
S275 PGFAPLtSRGSQQYR
S278 APLtSRGSQQYRALT
Y281 tSRGSQQYRALTVPE
T285 SQQYRALTVPELTQQ
T290 ALTVPELTQQVFDAK
K297 TQQVFDAKNMMAACD
Y310 CDPRHGRYLtVAAVF
T312-p PRHGRYLtVAAVFRG
K324-ub FRGRMSMkEVDEQML
K336-ub QMLNVQNkNSSyFVE
S338 LNVQNkNSSyFVEWI
Y340-p VQNkNSSyFVEWIPN
K350-ub EWIPNNVkTAVCDIP
K362 DIPPRGLKMAVTFIG
T366 RGLKMAVTFIGNSTA
K379 TAIQELFKRISEQFT
K379 TAIQELFKRISEQFT
S382 QELFKRISEQFTAMF
K392 FTAMFRRKAFLHWYT
T409-p GMDEMEFtEAESNMN
S420-p SNMNDLVsEYQQYQD
Y422 MNDLVsEYQQYQDAT
Y425 LVsEYQQYQDATAEE
T429 YQQYQDATAEEEEDF
  cow

 
K19 CGNQIGAKFWEVISD
K19 CGNQIGAKFWEVISD
S25 AKFWEVISDEHGIDP
T33 DEHGIDPTGTYHGDS
T35 HGIDPTGTYHGDSDL
Y36 GIDPTGTYHGDSDLQ
S40 TGTYHGDSDLQLDRI
R46 DSDLQLDRISVYYNE
S48 DLQLDRISVYYNEAT
Y50 QLDRISVYYNEATGG
Y51 LDRISVYYNEATGGK
T55 SVYYNEATGGKYVPR
K58 YNEATGGKYVPRAIL
K58 YNEATGGKYVPRAIL
Y59 NEATGGKYVPRAILV
T72 LVDLEPGTMDSVRSG
S75 LEPGTMDSVRSGPFG
S78 GTMDSVRSGPFGQIF
S95 DNFVFGQSGAGNNWA
K103 GAGNNWAKGHYtEGA
K103 GAGNNWAKGHYtEGA
Y106 NNWAKGHYtEGAELV
T107-p NWAKGHYtEGAELVD
S115 EGAELVDSVLDVVRK
K122 SVLDVVRKEAESCDC
S126 VVRKEAESCDCLQGF
S138 QGFQLTHSLGGGTGS
T143 THSLGGGTGSGMGTL
S145 SLGGGTGSGMGTLLI
K154 MGTLLISKIREEYPD
Y159 ISKIREEYPDRIMNT
S168 DRIMNTFSVVPSPKV
S172 NTFSVVPSPKVSDTV
K174 FSVVPSPKVSDTVVE
Y208 CIDNEALYDICFRTL
K216 DICFRTLKLTTPTYG
T218 CFRTLKLTTPTYGDL
T219 FRTLKLTTPTYGDLN
T221 TLKLTTPTYGDLNHL
Y222 LKLTTPTYGDLNHLV
K252 QLNADLRKLAVNMVP
K252 QLNADLRKLAVNMVP
T274 MPGFAPLTSRGSQQy
S275 PGFAPLTSRGSQQyR
S278 APLTSRGSQQyRALT
Y281-p TSRGSQQyRALTVPE
T285 SQQyRALTVPELTQQ
T290 ALTVPELTQQVFDAK
K297 TQQVFDAKNMMAACD
Y310 CDPRHGRYLTVAAVF
T312 PRHGRYLTVAAVFRG
K324 FRGRMSMKEVDEQML
K336 QMLNVQNKNSSYFVE
S338 LNVQNKNSSYFVEWI
Y340 VQNKNSSYFVEWIPN
K350 EWIPNNVKTAVCDIP
K362 DIPPRGLKMAVTFIG
T366 RGLKMAVTFIGNSTA
K379 TAIQELFKRISEQFT
K379 TAIQELFKRISEQFT
S382 QELFKRISEQFTAMF
K392 FTAMFRRKAFLHWYT
T409 GMDEMEFTEAESNMN
S420 SNMNDLVSEYQQYQD
Y422 MNDLVSEYQQYQDAT
Y425 LVSEYQQYQDATAEE
T429 YQQYQDATAEEEEDF
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