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MAX
a transcription factor. Forms a DNA- binding protein complex with MYC or MAD. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. CPG methylation of the recognition site greatly inhibits DNA binding, suggesting that DNA methylation may regulate the MYC/MAX complex in vivo. May repress transcription via the recruitment of a chromatin remodeling complex containing H3-K9 histone methyltransferase activity. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein; Transcription factor |
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Cellular Component: PML body; cytoplasm; dendrite; nucleolus; nucleus
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Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription cofactor activity; protein complex binding; transcription factor activity
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Biological Process: transcription from RNA polymerase II promoter; neuron apoptosis; retina development in camera-type eye; protein complex assembly; response to axon injury; cellular response to starvation; response to insulin stimulus
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Reference #:
P61244 (UniProtKB)
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| Alt. Names/Synonyms: BHLHD4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; Class D basic helix-loop-helix protein 4; helix-loop-helix zipper protein; MAX; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; MYC associated factor X; Myc-associated factor X; orf1; Protein max |
| Gene Symbols: MAX |
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Molecular weight: 18,275 Da
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Basal Isoelectric point: 5.88
Predict pI for various phosphorylation states
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CST Pathways:
Signaling Pathways Activating p38 MAPK
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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