|
GLI2
Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Implicated in the transduction of SHH signal. Interaction with ZIC. Belongs to the GLI C2H2-type zinc-finger protein family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
|
| Protein type: C2H2-type zinc finger protein; Transcription factor |
|
Cellular Component: cytoplasm; motile primary cilium; nucleus
|
|
Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
|
|
Biological Process: developmental growth; axon guidance; ventral midline development; apoptosis; spinal cord ventral commissure morphogenesis; positive regulation of transcription, DNA-dependent; heart development; negative regulation of chondrocyte differentiation; spinal cord dorsal/ventral patterning; negative regulation of transcription from RNA polymerase II promoter; positive regulation of T cell differentiation in the thymus; regulation of transcription, DNA-dependent; mammary gland development; kidney development; skeletal development; smoothened signaling pathway involved in ventral spinal cord interneuron specification; embryonic gut development; proximal/distal pattern formation; hindbrain development; smoothened signaling pathway; floor plate formation; transcription, DNA-dependent; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; in utero embryonic development; ventral spinal cord development; notochord regression; pattern specification process; osteoblast development; odontogenesis of dentine-containing teeth; osteoblast differentiation; cell proliferation; branching morphogenesis of a tube; cerebellar cortex morphogenesis; pituitary gland development; epidermal cell differentiation; neuron development; positive regulation of transcription from RNA polymerase II promoter; hindgut morphogenesis; embryonic digit morphogenesis; positive regulation of neuron differentiation; tube development; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; positive regulation of DNA replication; lung development; regulation of smoothened signaling pathway
|
|
Reference #:
P10070 (UniProtKB)
|
| Alt. Names/Synonyms: GLI family zinc finger 2; GLI-Kruppel family member GLI2; GLI2; glioma-associated oncogene family zinc finger 2; HPE9; oncogene GLI2; Tax helper protein; tax helper protein 1; tax helper protein 2; tax-responsive element-2 holding protein; tax-responsive element-25-bp sequence binding protein; THP; THP1; THP2; Zinc finger protein GLI2 |
| Gene Symbols: GLI2 |
|
Molecular weight: 167,783 Da
|
|
Basal Isoelectric point: 6.9
Predict pI for various phosphorylation states
|
|
CST Pathways:
Hedgehog Signaling
|
