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Protein Page:
GLI2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GLI2 Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Implicated in the transduction of SHH signal. Interaction with ZIC. Belongs to the GLI C2H2-type zinc-finger protein family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor
Cellular Component: membrane; cytoplasm; motile primary cilium; nuclear speck; nucleus
Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
Biological Process: developmental growth; axon guidance; ventral midline development; spinal cord ventral commissure morphogenesis; positive regulation of transcription, DNA-dependent; heart development; negative regulation of chondrocyte differentiation; spinal cord dorsal/ventral patterning; negative regulation of transcription from RNA polymerase II promoter; positive regulation of T cell differentiation in the thymus; mammary gland development; regulation of transcription, DNA-dependent; chondrocyte differentiation; kidney development; smoothened signaling pathway involved in ventral spinal cord interneuron specification; skeletal development; embryonic gut development; proximal/distal pattern formation; hindbrain development; smoothened signaling pathway; floor plate formation; transcription, DNA-dependent; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; in utero embryonic development; ventral spinal cord development; notochord regression; pattern specification process; odontogenesis of dentine-containing teeth; osteoblast development; osteoblast differentiation; cell proliferation; branching morphogenesis of a tube; cerebellar cortex morphogenesis; response to mechanical stimulus; pituitary gland development; epidermal cell differentiation; neuron development; positive regulation of transcription from RNA polymerase II promoter; hindgut morphogenesis; embryonic digit morphogenesis; positive regulation of neuron differentiation; tube development; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; positive regulation of DNA replication; regulation of smoothened signaling pathway; lung development
Reference #:  P10070 (UniProtKB)
Alt. Names/Synonyms: GLI family zinc finger 2; GLI-Kruppel family member GLI2; GLI2; glioma-associated oncogene family zinc finger 2; HPE9; oncogene GLI2; Tax helper protein; tax helper protein 1; tax helper protein 2; tax-responsive element-2 holding protein; tax-responsive element-25-bp sequence binding protein; THP; THP1; THP2; Zinc finger protein GLI2
Gene Symbols: GLI2
Molecular weight: 167,783 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Select Structure to View Below

GLI2

Protein Structure Not Found.


Scansite  |  Pfam  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S132-p HMEHYLRsVHSSPTL
0 1 S149-p ISAARGLsPADVAQE
0 3 T224-p RFSSPRVtPRLSRKR
0 2 S234-p LSRKRALsIsPLSDA
0 2 S236-p RKRALsIsPLSDAsL
0 1 S242-p IsPLSDAsLDLQRMI
1 2 S388-p PEGLRPAsPLALTQG
1 0 K647 CLHVRAIKTESSGLC
1 0 K733 MHRFEQLKKEKLKSL
1 0 K757-a TPHTRNTkLPPLPGS
1 3 S808-p QLQERRDsSTSTVSS
1 4 S824-p YTVSRRSsGISPYFS
1 0 S836 YFSSRRSSEASPLGA
1 0 S867-p TDASRRSsEAsQCSG
0 1 S870-p SRRSsEAsQCSGGSG
1 1 T903 ATGGPPPTPLPGLER
1 1 S941-p PLGPRRGsDGPTYGH
1 4 S970-p GGGARRAsDPVRRPD
0 1 S1011-p RRGLRLQsHPSTDGG
0 1 A1020 PSTDGGLARGAYSPR
1 0 S1025 GLARGAYSPRPPSIS
0 2 S1030 AYSPRPPSISENVAM
0 1 S1194 SPQGLQASPGGLDST
  GLI2 iso1  
- gap
- gap
- gap
- gap
- gap
- gap
S60 PEGLRPASPLALTQG
K319 CLHVRAIKTESSGLC
K405 MHRFEQLKKEKLKSL
K429 TPHTRNTKLPPLPGS
S480 QLQERRDSSTSTVSS
S496 YTVSRRSSGISPYFS
S508 YFSSRRSSEASPLGA
S539 TDASRRSSEASQCSG
S542 SRRSSEASQCSGGSG
T575 ATGGPPPTPLPGLER
S613 PLGPRRGSDGPTYGH
S642 GGGARRASDPVRRPD
S683-p RRGLRLQsHPSTDGG
A692 PSTDGGLARGAYSPR
S697 GLARGAYSPRPPsIS
S702-p AYSPRPPsISENVAM
S866-p SPQGLQAsPGGLDST
  GLI2 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
S60-p PEGLRPAsPLALTQE
K302 CLHVRAIKTESSGLC
K388 MHRFEQLKKEKLKSL
K412 TPHTRNTKLPPLPGS
S463 QLQERRDSSTSTVSS
S479 YTVSRRSSGISPYFS
S491 YFSSRRSSEASPLGA
S522 TDASRRSSEASQCSG
S525 SRRSSEASQCSGGSG
T558 ATGGPPPTPLPGLER
S596 PLGPRRGSDGPTYGH
S625 GGGARRASDPVRRPD
S666 RRGLRLQSHPSTDGG
A675 PSTDGGLARGAYSPR
S680 GLARGAYSPRPPSIS
S685 AYSPRPPSISENVAM
S849 SPQGLQASPGGLDST
  mouse

 
S128 HMEHYLRSVHSSPTL
S145 ISAARGLSPADVAHE
T220 RFSSPRVTPRLSRKR
S230 LSRKRALSISPLSDA
S232 RKRALSISPLSDASL
S238 ISPLSDASLDLQRMI
S385-p AEGLRPAsPLGLTQE
K630-s CLHIKAIkTESSGLC
K716-s VHRFEQLkREKLKSL
K740-a APHTRNTkLPPLPVN
S789-p QLQERRDsSTSTMSS
S805-p YTVSRRSsGISPYFS
S817-p YFSSRRSsEASPLGG
S848-p TDASRRSsEASQCSG
S851 SRRSsEASQCSGGGP
T885-p ATGGPPPtPLPGLDR
S923-p PLGPRRGsDGPTYSH
S956-p NSSTRRAsDPVRRPD
S997 RRGLHVQSHPSVDSN
T1006-p PSVDSNLtRNAYsPR
S1011-p NLtRNAYsPRPPSIN
S1016 AYsPRPPSINENVVM
S1180 NPQSVQSSSGGLDST
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