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Protein Page:
GLI2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GLI2 Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Implicated in the transduction of SHH signal. Interaction with ZIC. Belongs to the GLI C2H2-type zinc-finger protein family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 2q14
Cellular Component: membrane; cytoplasm; motile primary cilium; nuclear speck; nucleus
Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
Biological Process: axon guidance; developmental growth; ventral midline development; spinal cord ventral commissure morphogenesis; heart development; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; spinal cord dorsal/ventral patterning; negative regulation of transcription from RNA polymerase II promoter; positive regulation of T cell differentiation in the thymus; mammary gland development; regulation of transcription, DNA-dependent; chondrocyte differentiation; kidney development; smoothened signaling pathway involved in ventral spinal cord interneuron specification; skeletal development; embryonic gut development; proximal/distal pattern formation; hindbrain development; smoothened signaling pathway; floor plate formation; transcription, DNA-dependent; in utero embryonic development; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; ventral spinal cord development; notochord regression; pattern specification process; odontogenesis of dentine-containing teeth; osteoblast development; osteoblast differentiation; cell proliferation; cerebellar cortex morphogenesis; branching morphogenesis of a tube; pituitary gland development; response to mechanical stimulus; epidermal cell differentiation; neuron development; positive regulation of transcription from RNA polymerase II promoter; hindgut morphogenesis; embryonic digit morphogenesis; positive regulation of neuron differentiation; tube development; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; positive regulation of DNA replication; lung development; regulation of smoothened signaling pathway
Reference #:  P10070 (UniProtKB)
Alt. Names/Synonyms: GLI family zinc finger 2; GLI-Kruppel family member GLI2; GLI2; glioma-associated oncogene family zinc finger 2; HPE9; oncogene GLI2; Tax helper protein; tax helper protein 1; tax helper protein 2; tax-responsive element-2 holding protein; tax-responsive element-25-bp sequence binding protein; THP; THP1; THP2; Zinc finger protein GLI2
Gene Symbols: GLI2
Molecular weight: 167,783 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Select Structure to View Below

GLI2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T8-p METSASAtAsEKQEA
0 1 S10-p TSASAtAsEKQEAKS
0 3 S132-p HMEHYLRsVHssPTL
0 1 S135-p HYLRsVHssPTLSMI
0 1 S136-p YLRsVHssPTLSMIs
0 1 S143-p sPTLSMIsAARGLsP
1 2 S149-p IsAARGLsPADVAQE
0 4 T224-p RFSSPRVtPRLSRKR
0 3 S234-p LSRKRALsIsPLsDA
0 3 S236-p RKRALsIsPLsDAsL
0 1 S239-p ALsIsPLsDAsLDLQ
0 1 S242-p IsPLsDAsLDLQRMI
0 1 S255-p MIRTSPNsLVAYINN
0 1 K376 VAIHKRSKVKTEPEG
1 2 S388-p PEGLRPAsPLALTQG
0 1 S559 KHQNRTHSNEKPYIC
0 1 Y564 THSNEKPYICKIPGC
0 1 T620 NGDSEAGTEPGGPES
0 1 S627 TEPGGPESTEASSTS
0 1 S631 GPESTEASSTSQAVE
1 0 K647 CLHVRAIKTESSGLC
1 0 K733 MHRFEQLKKEKLKSL
1 0 K757-ac TPHTRNTkLPPLPGS
1 3 S808-p QLQERRDsSTSTVSS
0 1 S815 sSTSTVSSAYtVsRR
0 1 T818-p STVSSAYtVsRRSsG
0 2 S820-p VSSAYtVsRRSsGIS
1 4 S824-p YtVsRRSsGISPYFS
1 2 S836-p YFSSRRSsEAsPLGA
0 1 S839-p SRRSsEAsPLGAGRP
0 1 S850 AGRPHNASSADSYDP
0 1 S859-p ADSYDPIstDASRRS
0 1 T860-p DSYDPIstDASRRSs
1 0 S867-p tDASRRSsEAsQCSG
0 1 S870-p SRRSsEAsQCSGGSG
1 1 T903 ATGGPPPTPLPGLER
0 1 R933 TLPAGCPRPLGPRRG
1 3 S941-p PLGPRRGsDGPTYGH
1 6 S970-p GGGARRAsDPVRRPD
0 3 S989-p PRVQRFHstHNVNPG
0 1 T990-p RVQRFHstHNVNPGP
0 1 S1011-p RRGLRLQsHPSTDGG
0 1 A1020 PSTDGGLARGAYSPR
1 0 S1025 GLARGAYSPRPPsIS
0 5 S1030-p AYSPRPPsISENVAM
0 1 S1101-p SDNPRLPsPGLHGQR
0 1 S1194 SPQGLQASPGGLDST
  GLI2 iso1  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K48-ac VAIHKRSkVKTEPEG
S60 PEGLRPASPLALTQG
S231-p KHQNRTHsNEKPyIC
Y236-p THsNEKPyICKIPGC
T292-p NGDSEAGtEPGGPEs
S299-p tEPGGPEsTEAsSTS
S303-p GPEsTEAsSTSQAVE
K319 CLHVRAIKTESSGLC
K405 MHRFEQLKKEKLKSL
K429 TPHTRNTKLPPLPGS
S480 QLQERRDSSTSTVSS
S487 SSTSTVSSAYTVSRR
T490 STVSSAYTVSRRSSG
S492 VSSAYTVSRRSSGIS
S496 YTVSRRSSGISPYFS
S508 YFSSRRSSEASPLGA
S511 SRRSSEASPLGAGRP
S522 AGRPHNASSADSYDP
S531 ADSYDPISTDASRRS
T532 DSYDPISTDASRRSS
S539 TDASRRSSEASQCSG
S542 SRRSSEASQCSGGSG
T575 ATGGPPPTPLPGLER
R605-m2 TLPAGCPrPLGPRRG
S613 PLGPRRGSDGPTYGH
S642 GGGARRASDPVRRPD
S661 PRVQRFHSTHNVNPG
T662 RVQRFHSTHNVNPGP
S683-p RRGLRLQsHPSTDGG
A692 PSTDGGLARGAYSPR
S697 GLARGAYSPRPPsIS
S702-p AYSPRPPsISENVAM
S773 SDNPRLPSPGLHGQR
S866-p SPQGLQAsPGGLDST
  GLI2 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K48 VAIHKRSKVKTEPEG
S60-p PEGLRPAsPLALTQE
S214 KHQNRTHSNEKPYIC
Y219 THSNEKPYICKIPGC
T275 NGDSEAGTEPGGPES
S282 TEPGGPESTEASSTS
S286 GPESTEASSTSQAVE
K302 CLHVRAIKTESSGLC
K388 MHRFEQLKKEKLKSL
K412 TPHTRNTKLPPLPGS
S463 QLQERRDSSTSTVSS
S470 SSTSTVSSAYTVSRR
T473 STVSSAYTVSRRSSG
S475 VSSAYTVSRRSSGIS
S479 YTVSRRSSGISPYFS
S491 YFSSRRSSEASPLGA
S494 SRRSSEASPLGAGRP
S505 AGRPHNASSADSYDP
S514 ADSYDPISTDASRRS
T515 DSYDPISTDASRRSS
S522 TDASRRSSEASQCSG
S525 SRRSSEASQCSGGSG
T558 ATGGPPPTPLPGLER
R588 TLPAGCPRPLGPRRG
S596 PLGPRRGSDGPTYGH
S625 GGGARRASDPVRRPD
S644 PRVQRFHSTHNVNPG
T645 RVQRFHSTHNVNPGP
S666 RRGLRLQSHPSTDGG
A675 PSTDGGLARGAYSPR
S680 GLARGAYSPRPPSIS
S685 AYSPRPPSISENVAM
S756 SDNPRLPSPGLHGQR
S849 SPQGLQASPGGLDST
  mouse

 
P8 METSAPAPALEKKEA
L10 TSAPAPALEKKEAKS
S128 HMEHYLRSVHSSPTL
S131 HYLRSVHSSPTLSMI
S132 YLRSVHSSPTLSMIS
S139 SPTLSMISAARGLSP
S145 ISAARGLSPADVAHE
T220 RFSSPRVTPRLSRKR
S230 LSRKRALSISPLSDA
S232 RKRALSISPLSDASL
S235 ALSISPLSDASLDLQ
S238 ISPLSDASLDLQRMI
S251 MIRTSPNSLVAYINN
K373 ITIHKRSKVKTEAEG
S385-p AEGLRPAsPLGLTQE
S539 KHQNRTHSNEKPYIC
Y544 THSNEKPYICKIPGC
A600 NGDNEASAEPGGRGP
S610 GGRGPEESVEASSTS
S614 PEESVEASSTSHTVE
K630-sm CLHIKAIkTESSGLC
K716-sm VHRFEQLkREKLKSL
K740-ac APHTRNTkLPPLPVN
S789-p QLQERRDsSTSTMSs
S796-p sSTSTMSsAYTVSRR
T799 STMSsAYTVSRRSsG
S801 MSsAYTVSRRSsGIS
S805-p YTVSRRSsGISPYFS
S817-p YFSSRRSsEASPLGG
S820 SRRSsEASPLGGLRP
S831-p GLRPHNAsSADSYDP
S840 ADSYDPISTDASRRS
T841 DSYDPISTDASRRSs
S848-p TDASRRSsEASQCSG
S851 SRRSsEASQCSGGGP
T885-p ATGGPPPtPLPGLDR
H915 ALPGACPHPLGPRRG
S923-p PLGPRRGsDGPTYSH
S956-p NSSTRRAsDPVRRPD
S975 PRVQRFHSTHNMNPG
T976 RVQRFHSTHNMNPGS
S997 RRGLHVQSHPSVDSN
T1006-p PSVDSNLtRNAYsPR
S1011-p NLtRNAYsPRPPSIN
S1016 AYsPRPPSINENVVM
S1087 PENSKLPSPGLQGHR
S1180 NPQSVQSSSGGLDST
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