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Protein Page:
SLC5A3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC5A3 a sodium/myo-inositol cotransporter. An integral membrane protein. Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function. Belongs to the sodium:solute symporter (SSF) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family
Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane
Molecular Function: myo-inositol:sodium symporter activity
Biological Process: transport; myo-inositol transport; sodium ion transport; transmembrane transport
Reference #:  P53794 (UniProtKB)
Alt. Names/Synonyms: human solute carrier family 5, member 3, Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; SC5A3; SLC5A3; SMIT; SMIT2; Sodium/myo-inositol cotransporter; sodium/myo-inositol cotransporter 1; solute carrier family 5 (inositol transporter), member 3; solute carrier family 5 (inositol transporters), member 3; solute carrier family 5 (sodium/myo-inositol cotransporter), member 3; Solute carrier family 5 member 3
Gene Symbols: SLC5A3
Molecular weight: 79,694 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
Select Structure to View Below

SLC5A3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y16-p DIAIVALyFILVMCI
0 1 K115-ub TMPEYLSkRFGGHRI
0 1 S226 LASPDVTSILLTYNL
0 1 S298-p NIAHAKGstLMAGFL
0 1 T299-p IAHAKGstLMAGFLK
0 3 S320-p IVVPGMIsRILFTDD
0 1 K555 SKKNLVVKENCSPKE
0 1 K570 EPYQMQEKSILRCSE
0 2 S591-p HIIPNGKsEDsIkGL
0 3 S594-p PNGKsEDsIkGLQPE
0 3 K596-ub GKsEDsIkGLQPEDV
0 2 Y631-p AETPVDAysNGQAAL
0 2 S632-p ETPVDAysNGQAALM
0 1 K642-ub QAALMGEkERKKETD
  mouse

 
Y16 DIAVVALYFILVMCI
K115 TMPEYLSKRFGGHRI
S226-p LASPDVAsILLKYNL
S298 NIAHAKGSTLMAGFL
T299 IAHAKGSTLMAGFLK
S320-p IVVPGMIsRIVFADE
K555-ub SKKTLVTkESCSQKD
K570-ub EPYKMQEkSILQCSE
S591-p HTIPNGKsEDsIkGL
S594-p PNGKsEDsIkGLQPE
K596-ub GKsEDsIkGLQPEDV
Y631 AETPVDAYsNGQAAL
S632-p ETPVDAYsNGQAALM
R642 QAALMGEREREKETE
  rat

 
Y16 DIAIVALYFVLVMCI
K115 TMPEYLSKRFGGHRI
S226 LASPNVASILLTHNL
S298 NIAHAKGSTLMAGFL
T299 IAHAKGSTLMAGFLK
S320 IVVPGMISRILFVDD
K555 SKKTVVTKESCSQKD
K570 EPYKMQEKSILRCSE
S591 HTIPNGKSEDSIKGL
S594 PNGKSEDSIKGLQPE
K596 GKSEDSIKGLQPEDV
Y631 AETPVDAYSNGQAAL
S632 ETPVDAYSNGQAALM
R642 QAALMGERAREKETE
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