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SLC5A3 (human)

Overview SLC5A3 a sodium/myo-inositol cotransporter. An integral membrane protein. Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function. Belongs to the sodium:solute symporter (SSF) family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Transporter Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane Molecular Function: myo-inositol:sodium symporter activity Biological Process: regulation of respiratory gaseous exchange; transport; inositol metabolic process; transmembrane transport; peripheral nervous system development Reference #:  P53794 (UniProtKB) Alt. Names/Synonyms: human solute carrier family 5, member 3, Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; SC5A3; SLC5A3; SMIT; SMIT2; Sodium/myo-inositol cotransporter; sodium/myo-inositol cotransporter 1; solute carrier family 5 (inositol transporter), member 3; solute carrier family 5 (inositol transporters), member 3; solute carrier family 5 (sodium/myo-inositol cotransporter), member 3; Solute carrier family 5 member 3 Gene Symbols: SLC5A3 Molecular weight: 79,694 Da Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states

Select Structure to View Below SLC5A3

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K115-u	TMPEYLSkRFGGHRI
0	1		Y16-p	DIAIVALyFILVMCI
0	1		S226	LASPDVTSILLTYNL
0	1		S298-p	NIAHAKGstLMAGFL
0	1		T299-p	IAHAKGstLMAGFLK
0	3		S320-p	IVVPGMIsRILFTDD
0	1		K555	SKKNLVVKENCSPKE
0	1		K570	EPYQMQEKSILRCSE
0	1		S591	HIIPNGKSEDSIkGL
0	1		S594	PNGKSEDSIkGLQPE
0	3		K596-u	GKSEDSIkGLQPEDV
0	2		Y631-p	AETPVDAySNGQAAL
0	1		S632	ETPVDAySNGQAALM
0	1		K642-u	QAALMGEkERKKETD

	mouse
K115	TMPEYLSKRFGGHRI
Y16	DIAVVALYFILVMCI
S226-p	LASPDVAsILLKYNL
S298	NIAHAKGSTLMAGFL
T299	IAHAKGSTLMAGFLK
S320-p	IVVPGMIsRIVFADE
K555-u	SKKTLVTkESCSQKD
K570-u	EPYKMQEkSILQCSE
S591-p	HTIPNGKsEDsIkGL
S594-p	PNGKsEDsIkGLQPE
K596-u	GKsEDsIkGLQPEDV
Y631	AETPVDAYsNGQAAL
S632-p	ETPVDAYsNGQAALM
R642	QAALMGEREREKETE

	rat
K115	TMPEYLSKRFGGHRI
Y16	DIAIVALYFVLVMCI
S226	LASPNVASILLTHNL
S298	NIAHAKGSTLMAGFL
T299	IAHAKGSTLMAGFLK
S320	IVVPGMISRILFVDD
K555	SKKTVVTKESCSQKD
K570	EPYKMQEKSILRCSE
S591	HTIPNGKSEDSIKGL
S594	PNGKSEDSIKGLQPE
K596	GKSEDSIKGLQPEDV
Y631	AETPVDAYSNGQAAL
S632	ETPVDAYSNGQAALM
R642	QAALMGERAREKETE

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