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Protein Page:
DBN1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DBN1 a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. Expressed in brain neurons, heart, placenta, skeletal muscle, kidney and pancreas. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein; Actin binding protein
Cellular Component: cytoplasm; dendrite; actomyosin; actin cytoskeleton
Molecular Function: actin binding; profilin binding
Biological Process: regulation of dendrite development; actin filament organization; regulation of neuronal synaptic plasticity
Reference #:  Q16643 (UniProtKB)
Alt. Names/Synonyms: D0S117E; DBN1; Developmentally-regulated brain protein; DKFZp434D064; DREB; Drebrin; drebrin 1; drebrin E; drebrin E2; drebrin-1
Gene Symbols: DBN1
Molecular weight: 71,429 Da
Basal Isoelectric point: 4.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DBN1
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 S5-p ___MAGVsFsGHRLE
0 3 S7-p _MAGVsFsGHRLELL
0 1 Y32-p SAADWALyTYEDGSD
0 1 Y65-p FENQKVMyGFCSVkD
0 3 K71-u MyGFCSVkDsQAALP
0 3 S73-p GFCSVkDsQAALPKY
0 2 S134-p GAIGQRLsNGLARLs
0 9 S141-p sNGLARLssPVLHRL
0 61 S142-p NGLARLssPVLHRLR
0 5 T162-p NAEPVGTtyQKTdAA
0 79 Y163-p AEPVGTtyQKTdAAV
0 1 K165 PVGTtyQKTdAAVEM
0 1 D167-ca GTtyQKTdAAVEMKR
0 1 K173 TdAAVEMKRINREQF
0 4 T241-p EHRRKQQtLEAEEAK
0 3 S274 THMKKSESEVEEAAA
0 1 S307-p VASASAGsCDVPsPF
0 5 S312-p AGsCDVPsPFNHRPG
0 1 - gap
0 1 - gap
0 5 - gap
0 4 S320-p PFNHRPGsHLDSHRR
0 20 T331-p SHRRMAPtPIPtRsP
0 18 T335-p MAPtPIPtRsPsDss
0 29 S337-p PtPIPtRsPsDsstA
0 43 S339-p PIPtRsPsDsstAst
0 7 S341-p PtRsPsDsstAstPV
0 14 S342-p tRsPsDsstAstPVA
0 8 T343-p RsPsDsstAstPVAE
0 20 S345-p PsDsstAstPVAEQI
0 49 T346-p sDsstAstPVAEQIE
0 2 T377-p PPPPAQEtQEPsPIL
0 1 S381-p AQEtQEPsPILDSEE
0 2 T497-p QGEPRAPtPPSGTEV
0 1 T559-p ESLAAPQtPTLPSAL
0 2 S594-p QKEGTQAsEGyFsQs
0 78 Y597-p GTQAsEGyFsQsQEE
0 4 S599-p QAsEGyFsQsQEEEF
0 16 S601-p sEGyFsQsQEEEFAQ
0 48 Y622-p KAPPPVFyNKPPEID
  mouse

► Hide Isoforms 		 
S5 ___MAGVSFsGHRLE
S7-p _MAGVSFsGHRLELL
Y32 SAADWALYTYEDGSD
Y65 FENQKVMYGFCSVKD
K71 MYGFCSVKDsQAALP
S73-p GFCSVKDsQAALPKY
S134-p GAIGQRLsNGLARLs
S141-p sNGLARLssPVLHRL
S142-p NGLARLssPVLHRLR
T162-p NAEPVGTtyQkTDAA
Y163-p AEPVGTtyQkTDAAV
K165-a PVGTtyQkTDAAVEM
D167 GTtyQkTDAAVEMkR
K173-a TDAAVEMkRINREQF
S241-p EHRRKQQsLEAEEAK
S274-p SQMKKSEsEVEEAAA
S307 VASASGGSCDAPAPA
- gap
S336-p KASDSGPsSSSSSsS
S342-p PsSSSSSsSsPPRTP
S344-p SSSSSsSsPPRTPFP
S368 LSSSLPCSHLDSHRR
T379-p SHRRMAPtPIPtRsP
T383-p MAPtPIPtRsPsDss
S385-p PtPIPtRsPsDsstA
S387-p PIPtRsPsDsstAst
S389-p PtRsPsDsstAstPI
S390-p tRsPsDsstAstPIA
T391-p RsPsDsstAstPIAE
S393-p PsDsstAstPIAEQI
T394-p sDsstAstPIAEQIE
A425 PPPPTQEAQETTPSL
T429 TQEAQETTPSLDEEL
T550-p QAEPRVPtPPSGAEA
V612 ETLAASQVLTMPSAL
S651 QKEGTQASEGyFsQs
Y654-p GTQASEGyFsQsQEE
S656-p QASEGyFsQsQEEEF
S658-p SEGyFsQsQEEEFAQ
Y679 KVPPPVFYNKPPEID
  DBN1 iso3  
S5 ___MAGVSFSGHRLE
S7 _MAGVSFSGHRLELL
Y32 SAADWALYTYEDGSD
Y65 FENQKVMYGFCSVKD
K71 MYGFCSVKDSQAALP
S73 GFCSVKDSQAALPKY
S134 GAIGQRLSNGLARLS
S141 SNGLARLSSPVLHRL
S142 NGLARLSSPVLHRLR
T162 NAEPVGTTYQKTDAA
Y163 AEPVGTTYQKTDAAV
K165 PVGTTYQKTDAAVEM
D167 GTTYQKTDAAVEMKR
K173 TDAAVEMKRINREQF
S241 EHRRKQQSLEAEEAK
S274 SQMKKSESEVEEAAA
S307 VASASGGSCDAPAPA
- gap
- gap
- gap
- gap
S322 PFNHRPGSHLDsHRR
T333 sHRRMAPTPIPTRSP
T337 MAPTPIPTRSPSDSS
S339 PTPIPTRSPSDSSTA
S341 PIPTRSPSDSSTAST
S343 PTRSPSDSSTASTPI
S344 TRSPSDSSTASTPIA
T345 RSPSDSSTASTPIAE
S347 PSDSSTASTPIAEQI
T348 SDSSTASTPIAEQIE
A379 PPPPTQEAQETTPSL
T383 TQEAQETTPSLDEEL
T504 QAEPRVPTPPSGAEA
V566 ETLAASQVLTMPSAL
S605 QKEGTQASEGYFSQS
Y608 GTQASEGYFSQSQEE
S610 QASEGYFSQSQEEEF
S612 SEGYFSQSQEEEFAQ
Y633 KVPPPVFYNKPPEID
  DBN1 iso4  
S5 ___MAGVSFSGHRLE
S7 _MAGVSFSGHRLELL
Y32 SAADWALYTYEDGSD
Y65 FENQKVMYGFCSVKD
K71 MYGFCSVKDSQAALP
S73 GFCSVKDSQAALPKY
S134 GAIGQRLSNGLARLS
S141 SNGLARLSSPVLHRL
S142 NGLARLSSPVLHRLR
T162 NAEPVGTTYQKTDAA
Y163 AEPVGTTYQKTDAAV
K165 PVGTTYQKTDAAVEM
D167 GTTYQKTDAAVEMKR
K173 TDAAVEMKRINREQF
S241 EHRRKQQSLEAEEAK
S274 SQMKKSESEVEEAAA
S307 VASASGGSCDAPAPA
- gap
- gap
- gap
- gap
S322 PFNHRPGSHLDsHRR
T333 sHRRMAPTPIPTRSP
T337 MAPTPIPTRSPSDSS
S339 PTPIPTRSPSDSSTA
S341 PIPTRSPSDSSTAST
S343 PTRSPSDSSTASTPI
S344 TRSPSDSSTASTPIA
T345 RSPSDSSTASTPIAE
S347 PSDSSTASTPIAEQI
T348 SDSSTASTPIAEQIE
A379 PPPPTQEAQETTPSL
T383 TQEAQETTPSLDEEL
T504 QAEPRVPTPPSGAEA
V566 ETLAASQVLTMPSAL
S606 KEGTQQASEGYFSQS
Y609 TQQASEGYFSQSQEE
S611 QASEGYFSQSQEEEF
S613 SEGYFSQSQEEEFAQ
Y634 KVPPPVFYNKPPEID
  rat

 
S5 ___MAGVSFSGHRLE
S7 _MAGVSFSGHRLELL
Y32 SAADWALYTYEDGSD
Y65 FENQKVMYGFCSVKD
K71 MYGFCSVKDSQAALP
S73 GFCSVKDSQAALPKY
S134 GAIGQRLSNGLARLS
S141 SNGLARLSSPVLHRL
S142 NGLARLSSPVLHRLR
T162 NAEPVGTTYQKTDAA
Y163 AEPVGTTYQKTDAAV
K165 PVGTTYQKTDAAVEM
D167 GTTYQKTDAAVEMKR
K173 TDAAVEMKRINREQF
S241 EHRRKQQSLEAEEAK
S274 SQMKKSESEVEEAAA
S307 VASASGGSCDAPSPF
S312 GGSCDAPSPFNHRPG
S334 KASDSGPSSSSSSSS
S340 PSSSSSSSSSPPRTP
S342 SSSSSSSSPPRTPFP
S366 LSSSLPCSHLDSHRR
T377 SHRRMAPTPIPTRSP
T381 MAPTPIPTRSPSDSS
S383 PTPIPTRSPSDSSTA
S385 PIPTRSPSDSSTAST
S387 PTRSPSDSSTASTPI
S388 TRSPSDSSTASTPIT
T389 RSPSDSSTASTPITE
S391 PSDSSTASTPITEQI
T392 SDSSTASTPITEQIE
A423 PPPPAQEAQESAPRL
A427 AQEAQESAPRLDGEE
T549 QAEPRVPTPPSGAEA
V612 EPLAASQVLTMPSAL
S652 KEGTQQASEGYFSQs
Y655 TQQASEGYFSQsQEE
S657 QASEGYFSQsQEEEF
S659-p SEGYFSQsQEEEFAQ
Y680 KAPPPVFYNKPPEID
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