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Protein Page:
BDP1 (human)

Overview
BDP1 a member of the non-receptor protein tyrosine phosphatase (PTP) family. Contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; non-membrane spanning protein tyrosine phosphatase activity
Biological Process: protein amino acid dephosphorylation
Reference #:  Q99952 (UniProtKB)
Alt. Names/Synonyms: BDP1; Brain-derived phosphatase; protein tyrosine phosphatase, non-receptor type 18 (brain-derived); PTN18; PTP-HSCF; PTPN18; Tyrosine-protein phosphatase non-receptor type 18
Gene Symbols: PTPN18
Molecular weight: 50,482 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BDP1

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y281‑p, Y303‑p, Y354‑p, Y389‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10-p RSLDSARsFLERLEA
0 1 S76-p DQTRVILsLLQEEGH
1 0 Y281-p AVQTEEQyRFLYHTV
1 0 Y303-p LQNASPHyQNIKENC
0 11 Y314-p KENCAPLyDDALFLR
0 1 T322-p DDALFLRtPQALLAI
0 2 S341-p GGVLRSIsVPGsPGH
0 3 S345-p RSIsVPGsPGHAMAD
1 0 Y354-p GHAMADTyAVVQKRG
0 1 T370-p PAGAGSGtQTGtGtG
0 1 T374-p GSGtQTGtGtGTGAR
0 1 T376-p GtQTGtGtGTGARSA
1 661 Y389-p SAEEAPLysKVtPRA
0 2 S390-p AEEAPLysKVtPRAQ
0 7 T393-p APLysKVtPRAQRPG
0 3 S419-p GRVPADQsPAGsGAy
0 1 S423-p ADQsPAGsGAyEDVA
0 10 Y426-p sPAGsGAyEDVAGGA
0 1 T435-p DVAGGAQtGGLGFNL
0 1 T458-p RDPPAEWtRV_____
  mouse

 
S10 RHTDLVRSFLEQLEA
S76 DETRVILSLLQEEGH
Y281 AVQTEEQYRFLYHTV
Y303 LQDTSPHYQNLKENC
C314 KENCAPICKEAFSLR
T322 KEAFSLRTSSALPAT
S341 GGVLRSISVPAPPTL
P345 RSISVPAPPTLPMAD
Y354 TLPMADTYAVVQKRG
P370 SAGTGPGPRAPTSTD
T374 GPGPRAPTSTDTPIy
T376 GPRAPTSTDTPIysQ
Y381-p TSTDTPIysQVAPRA
S382-p STDTPIysQVAPRAQ
A385 TPIysQVAPRAQRPV
N412 RRVPADQNSSGPDAY
P416 ADQNSSGPDAYEEVT
Y419 NSSGPDAYEEVTDGA
T428 EVTDGAQTGGLGFNL
T451 RDPPAEWTRV_____
  rat

 
S10 RQSDLVRSFLEQQEA
S76 DETRVILSLLQEEGH
Y281-p AVQTEEQyRFLYHTV
Y303 LQNNSPLYQNLKENR
C314 KENRAPICKDSSSLR
T322 KDSSSLRTSSALPAT
S341 GGVLRSISVPGPPTL
P345 RSISVPGPPTLPMAD
Y354 TLPMADTYAVVQKRG
T370 SGSTGPGTRAPNSTD
N374 GPGTRAPNSTDTPIY
T376 GTRAPNSTDTPIYSQ
Y381 NSTDTPIYSQVAPRI
S382 STDTPIYSQVAPRIQ
A385 TPIYSQVAPRIQRPV
N412 GRVPADENPSGPDAY
P416 ADENPSGPDAYEEVT
Y419 NPSGPDAYEEVTDGA
T428 EVTDGAQTGGLGFNL
T451 RDPPAEWTRV_____
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