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BDP1 (human)

Overview BDP1 a member of the non-receptor protein tyrosine phosphatase (PTP) family. Contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor) Cellular Component: cytoplasm; nucleus Molecular Function: non-membrane spanning protein tyrosine phosphatase activity Biological Process: protein amino acid dephosphorylation Reference #:  Q99952 (UniProtKB) Alt. Names/Synonyms: BDP1; Brain-derived phosphatase; protein tyrosine phosphatase, non-receptor type 18 (brain-derived); PTN18; PTP-HSCF; PTPN18; Tyrosine-protein phosphatase non-receptor type 18 Gene Symbols: PTPN18 Molecular weight: 50,482 Da Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BDP1 2OC3 - A=6-299 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Sites Implicated In
molecular association, regulation: Y281‑p, Y303‑p, Y354‑p, Y389‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S10-p	RSLDSARsFLERLEA
0	1		S76-p	DQTRVILsLLQEEGH
1	0		Y281-p	AVQTEEQyRFLYHTV
1	0		Y303-p	LQNASPHyQNIKENC
0	11		Y314-p	KENCAPLyDDALFLR
0	1		T322-p	DDALFLRtPQALLAI
0	1		S345-p	RSISVPGsPGHAMAD
1	0		Y354-p	GHAMADTyAVVQKRG
0	1		T370-p	PAGAGSGtQTGtGtG
0	1		T374-p	GSGtQTGtGtGTGAR
0	1		T376-p	GtQTGtGtGTGARSA
1	676		Y389-p	SAEEAPLysKVtPRA
0	2		S390-p	AEEAPLysKVtPRAQ
0	5		T393-p	APLysKVtPRAQRPG
0	2		S419-p	GRVPADQsPAGsGAy
0	1		S423-p	ADQsPAGsGAyEDVA
0	13		Y426-p	sPAGsGAyEDVAGGA
0	1		T435-p	DVAGGAQtGGLGFNL
0	1		T458-p	RDPPAEWtRV_____

	mouse
S10	RHTDLVRSFLEQLEA
S76	DETRVILSLLQEEGH
Y281	AVQTEEQYRFLYHTV
Y303	LQDTSPHYQNLKENC
C314	KENCAPICKEAFSLR
T322	KEAFSLRTSSALPAT
P345	RSISVPAPPTLPMAD
Y354	TLPMADTYAVVQKRG
P370	SAGTGPGPRAPTSTD
T374	GPGPRAPTSTDTPIy
T376	GPRAPTSTDTPIysQ
Y381-p	TSTDTPIysQVAPRA
S382-p	STDTPIysQVAPRAQ
A385	TPIysQVAPRAQRPV
N412	RRVPADQNSSGPDAY
P416	ADQNSSGPDAYEEVT
Y419	NSSGPDAYEEVTDGA
T428	EVTDGAQTGGLGFNL
T451	RDPPAEWTRV_____

	rat
S10	RQSDLVRSFLEQQEA
S76	DETRVILSLLQEEGH
Y281-p	AVQTEEQyRFLYHTV
Y303	LQNNSPLYQNLKENR
C314	KENRAPICKDSSSLR
T322	KDSSSLRTSSALPAT
P345	RSISVPGPPTLPMAD
Y354	TLPMADTYAVVQKRG
T370	SGSTGPGTRAPNSTD
N374	GPGTRAPNSTDTPIY
T376	GTRAPNSTDTPIYSQ
Y381	NSTDTPIYSQVAPRI
S382	STDTPIYSQVAPRIQ
A385	TPIYSQVAPRIQRPV
N412	GRVPADENPSGPDAY
P416	ADENPSGPDAYEEVT
Y419	NPSGPDAYEEVTDGA
T428	EVTDGAQTGGLGFNL
T451	RDPPAEWTRV_____

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