Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
BDP1 (human)

Overview
BDP1 a member of the non-receptor protein tyrosine phosphatase (PTP) family. Contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; non-membrane spanning protein tyrosine phosphatase activity
Biological Process: protein amino acid dephosphorylation
Reference #:  Q99952 (UniProtKB)
Alt. Names/Synonyms: BDP1; Brain-derived phosphatase; protein tyrosine phosphatase, non-receptor type 18 (brain-derived); PTN18; PTP-HSCF; PTPN18; Tyrosine-protein phosphatase non-receptor type 18
Gene Symbols: PTPN18
Molecular weight: 50,482 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BDP1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Sites Implicated In
molecular association, regulation: Y281‑p, Y303‑p, Y354‑p, Y389‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10-p RSLDSARsFLERLEA
0 1 S76-p DQTRVILsLLQEEGH
1 0 Y281-p AVQTEEQyRFLYHTV
1 0 Y303-p LQNASPHyQNIKENC
0 11 Y314-p KENCAPLyDDALFLR
0 1 T322-p DDALFLRtPQALLAI
0 1 S345-p RSISVPGsPGHAMAD
1 0 Y354-p GHAMADTyAVVQKRG
0 1 T370-p PAGAGSGtQTGtGtG
0 1 T374-p GSGtQTGtGtGTGAR
0 1 T376-p GtQTGtGtGTGARSA
1 678 Y389-p SAEEAPLysKVtPRA
0 2 S390-p AEEAPLysKVtPRAQ
0 6 T393-p APLysKVtPRAQRPG
0 2 S419-p GRVPADQsPAGSGAy
0 13 Y426-p sPAGSGAyEDVAGGA
  mouse

 
S10 RHTDLVRSFLEQLEA
S76 DETRVILSLLQEEGH
Y281 AVQTEEQYRFLYHTV
Y303 LQDTSPHYQNLKENC
C314 KENCAPICKEAFSLR
T322 KEAFSLRTSSALPAT
P345 RSISVPAPPTLPMAD
Y354 TLPMADTYAVVQKRG
P370 SAGTGPGPRAPTSTD
T374 GPGPRAPTSTDTPIy
T376 GPRAPTSTDTPIysQ
Y381-p TSTDTPIysQVAPRA
S382-p STDTPIysQVAPRAQ
A385 TPIysQVAPRAQRPV
N412 RRVPADQNSSGPDAY
Y419 NSSGPDAYEEVTDGA
  rat

 
S10 RQSDLVRSFLEQQEA
S76 DETRVILSLLQEEGH
Y281-p AVQTEEQyRFLYHTV
Y303 LQNNSPLYQNLKENR
C314 KENRAPICKDSSSLR
T322 KDSSSLRTSSALPAT
P345 RSISVPGPPTLPMAD
Y354 TLPMADTYAVVQKRG
T370 SGSTGPGTRAPNSTD
N374 GPGTRAPNSTDTPIY
T376 GTRAPNSTDTPIYSQ
Y381 NSTDTPIYSQVAPRI
S382 STDTPIYSQVAPRIQ
A385 TPIYSQVAPRIQRPV
N412 GRVPADENPSGPDAY
Y419 NPSGPDAYEEVTDGA
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.