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Protein Page:
ARHGAP5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ARHGAP5 a GTPase activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of p120GAP. Negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; GAPs; GAPs, Rac/Rho
Cellular Component: membrane; cytoplasm; cytosol
Molecular Function: GTPase activity; protein binding; GTP binding; Rho GTPase activator activity; SH2 domain binding
Biological Process: regulation of small GTPase mediated signal transduction; mammary gland development; GTP catabolic process; small GTPase mediated signal transduction; positive regulation of mesenchymal cell proliferation; cell adhesion; regulation of cell size; Rho protein signal transduction; positive regulation of Rho GTPase activity; positive regulation of cell migration
Reference #:  Q13017 (UniProtKB)
Alt. Names/Synonyms: ARHGAP5; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 RhoGAP; p190-B; p190BRhoGAP; RHG05; Rho GTPase activating protein 5; Rho GTPase-activating protein 5; Rho-type GTPase-activating protein 5; RHOGAP5
Gene Symbols: ARHGAP5
Molecular weight: 172,460 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ARHGAP5

Protein Structure Not Found.


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Sites Implicated In
cell differentiation, altered: Y306‑p
cell growth, altered: Y1109‑p
cell motility, altered: Y1109‑p
activity, induced: Y1109‑p
intracellular localization: Y306‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S12-p NKEPRPPsYTIsIVG
0 1 S16-p RPPsYTIsIVGLSGT
0 1 T199-p KPVIIAAtKCDECVD
0 1 K278 TATDKFEKLVQTVRD
0 1 T289 TVRDYHATWKTVSNK
1 0 Y306-p NHPDYEEyINLEGTR
0 1 K314-ac INLEGTRkARNTFSk
0 1 K321-ac kARNTFSkHIEQLKQ
0 1 K333 LKQEHIRKRREEYIN
0 1 T407 IPFDLLSTLEAEKVY
0 1 K436 EMKEKFKKTLEKIQF
0 4 S590-p RLRLYHDstNIDKVN
0 1 T591-p LRLYHDstNIDKVNL
0 1 Y630-p YALDGKIyELDLRPV
0 8 S765-p KHNLDVVsPIPANKD
0 1 Y836-p IQITILSyHSSIGVR
0 1 K858 YILVYSAKRKASMGM
0 1 S948-p KKNMIENsYLsDNTR
0 1 S951-p MIENsYLsDNTREST
0 1 T954 NsYLsDNTRESTHQS
0 1 S957 LsDNTRESTHQSEDV
0 1 T958 sDNTRESTHQSEDVF
0 7 S968-p SEDVFLPsPRDCFPY
0 2 S981-p PYNNYPDsDDDTEAP
0 1 T985 YPDsDDDTEAPPPYS
0 13 Y1019-p LDLEGNEyPIHStPN
0 1 T1024-p NEyPIHStPNCHDHE
0 1 K1060 KLDPNLLKTIEAGIG
0 2 S1088-p HPEDMDPsDNyAEPI
1 114 Y1091-p DMDPsDNyAEPIDTI
0 1 K1100 EPIDTIFKQKGysDE
0 1 K1102 IDTIFKQKGysDEIy
0 5 Y1104-p TIFKQKGysDEIyVV
0 3 S1105-p IFKQKGysDEIyVVP
2 173 Y1109-p KGysDEIyVVPDDsQ
0 5 S1115-p IyVVPDDsQNRIKIR
0 32 S1124-p NRIKIRNsFVNNtQG
0 7 T1129-p RNsFVNNtQGDEENG
0 3 S1138-p GDEENGFsDRTSKSH
0 4 T1171-p AKSYYRRtHsDAsDD
0 25 S1173-p SYYRRtHsDAsDDEA
0 28 S1176-p RRtHsDAsDDEAFTT
0 1 S1184-p DDEAFTTsKTKRKGR
0 21 S1195-p RKGRHRGsEEDPLLs
0 22 S1202-p sEEDPLLsPVEtWKG
0 1 T1206-p PLLsPVEtWKGGIDN
0 1 K1208 LsPVEtWKGGIDNPA
0 27 S1218-p IDNPAITsDQELDDK
0 1 K1243 EDKKQKKKTKNFNPP
0 1 Y1259 RRNWESNYFGMPLQD
0 1 K1272 QDLVTAEKPIPLFVE
0 1 S1396-p ITHLNRVsQQHKINL
  mouse

► Hide Isoforms
 
S12 NKEPRPPSYTVSVVG
S16 RPPSYTVSVVGLSGT
T199 KPVIIAATKCDECVD
K278-ub TATDKFEkLVQTVRD
T289-p TVRDYHAtWKTVSNK
Y306 NHPDYEEYINLEGTR
K314 INLEGTRKARNTFSK
K321 KARNTFSKHIEQLKQ
K333-ub LKQEHIRkRREEYIS
T407-p IPFDLLStLEAEKVY
K436-ub EMKEKFKkTLEKIQF
S590 RVRLYHDSTNIDKVN
T591 VRLYHDSTNIDKVNL
Y630 YALDGKIYELDLRPV
S765-p KHNLDVVsPVPINKD
Y836 IQITILSYHSSIGVR
K858 YILVYSAKRKASMGM
S948 KKNMIENSYLSDNtR
S951 MIENSYLSDNtREst
T954-p NSYLSDNtREstHQS
S957-p LSDNtREstHQSEDV
T958-p SDNtREstHQSEDVF
S968-p SEDVFLPsPRDCFPY
S981-p PYNNYPDsDDDtEAP
T985-p YPDsDDDtEAPPPYS
Y1019 LDLEGNEYPVHSTPN
T1024 NEYPVHSTPNCHDHE
K1060-ub KLDPNLLkTIEAGIG
S1088 HPEDMDSSDNYVEPL
Y1091 DMDSSDNYVEPLDTI
K1100-ub EPLDTIFkQkGYsDE
K1102-ub LDTIFkQkGYsDEIy
Y1104 TIFkQkGYsDEIyVV
S1105-p IFkQkGYsDEIyVVP
Y1109-p kGYsDEIyVVPDDSQ
S1115 IyVVPDDSQNRIIKI
S1125 RIIKIRNSFVNNTQG
T1130 RNSFVNNTQGDEENG
S1139 GDEENGFSDPQKVME
- gap
- gap
- gap
- gap
S1194-p RKGRHRGsEEDPLLs
S1201-p sEEDPLLsPVETWkG
T1205 PLLsPVETWkGGIDN
K1207-ub LsPVETWkGGIDNPA
S1217-p IDNPAITsDQEVDDK
K1242-ac EDKKQKKkTKTFNPP
Y1258-p RRNWESNyFGMPLQD
K1271-ac QDLVTAEkPIPLFVE
S1395 ITHLNRVSQQNKINL
  ARHGAP5 iso3  
S12 NKEPRPPSYTVSVVG
S16 RPPSYTVSVVGLSGT
T199 KPVIIAATKCDECVD
K278 TATDKFEKLVQTVRD
T289 TVRDYHATWKTVSNK
Y306 NHPDYEEYINLEGTR
K314 INLEGTRKARNTFSK
K321 KARNTFSKHIEQLKQ
K333 LKQEHIRKRREEYIS
T407 IPFDLLSTLEAEKVY
K436 EMKEKFKKTLEKIQF
S590 RVRLYHDSTNIDKVN
T591 VRLYHDSTNIDKVNL
Y630 YALDGKIYELDLRPV
S765 KHNLDVVSPVPINKD
Y836 IQITILSYHSSIGVR
K858-ac YILVYSAkRKASMGM
S948 KKNMIENSYLSDNTR
S951 MIENSYLSDNTREST
T954 NSYLSDNTRESTHQS
S957 LSDNTRESTHQSEDV
T958 SDNTRESTHQSEDVF
S968 SEDVFLPSPRDCFPY
S981 PYNNYPDSDDDTEAP
T985 YPDSDDDTEAPPPYS
Y1019 LDLEGNEYPVHSTPN
T1024 NEYPVHSTPNCHDHE
K1060 KLDPNLLKTIEAGIG
S1088 HPEDMDSSDNYVEPL
Y1091 DMDSSDNYVEPLDTI
K1100 EPLDTIFKQKGYSDE
K1102 LDTIFKQKGYSDEIY
Y1104 TIFKQKGYSDEIYVV
S1105 IFKQKGYSDEIYVVP
Y1109 KGYSDEIYVVPDDSQ
S1115 IYVVPDDSQNRIIKI
S1125 RIIKIRNSFVNNTQG
T1130 RNSFVNNTQGDEENG
S1139 GDEENGFSDRTSKGH
T1172 AKSYYRRTHsDAsDD
S1174-p SYYRRTHsDAsDDEA
S1177-p RRTHsDAsDDEAFTT
S1185 DDEAFTTSKTKRKGR
S1196 RKGRHRGSEEDPLLS
S1203 SEEDPLLSPVETWKG
T1207 PLLSPVETWKGGIDN
K1209 LSPVETWKGGIDNPA
S1219 IDNPAITSDQEVDDK
K1244 EDKKQKKKTKTFNPP
Y1260 RRNWESNYFGMPLQD
K1273 QDLVTAEKPIPLFVE
S1397 ITHLNRVSQQNKINL
  rat

 
S11 NKEPRPPSYTVSVVG
S15 RPPSYTVSVVGLSGT
T198 KPVIIAATKCDECVD
K277 TATDKFEKLVQTVRD
T288 TVRDYHATWKTVSNK
Y305 NHPDYEEYINLEGTR
K313 INLEGTRKARNTFSK
K320 KARNTFSKHIEQLKQ
K332 LKQEHIRKRREEYIS
T406 IPFDLLSTLEAEKVY
K435 EMKEKFKKTLEKIQF
S589 RSRLYHDSTNIDKVN
T590 SRLYHDSTNIDKVNL
Y629 YALDGKIYELDLRPV
S764 KHNLDVVSPVPINKD
Y835 IQITILSYHSSIGVR
K857 YILVYSAKRKASMGM
S947 KKNMIENSYLSDNTR
S950 MIENSYLSDNTREST
T953 NSYLSDNTRESTHQS
S956 LSDNTRESTHQSEDV
T957 SDNTRESTHQSEDVF
S967 SEDVFLPSPRDCFPY
S980 PYNNYPDSDDDTEAP
T984 YPDSDDDTEAPPPYS
Y1018 LDLEGNEYPVHSTPN
T1023 NEYPVHSTPNCHDHE
K1059 KLDPNLLKTIEAGIG
S1087 HPEDMDSSDNYAEPL
Y1090 DMDSSDNYAEPLDTI
K1099 EPLDTIFKQKGYPDE
K1101 LDTIFKQKGYPDEIy
Y1103 TIFKQKGYPDEIyVV
P1104 IFKQKGYPDEIyVVP
Y1108-p KGYPDEIyVVPDDSQ
S1114 IyVVPDDSQNRIIKI
S1124 RIIKIRNSFVNNTQG
T1129 RNSFVNNTQGDEENG
S1138 GDEENGFSDRTSKGH
T1171 AKSYYRRTHsDAsDD
S1173-p SYYRRTHsDAsDDEA
S1176-p RRTHsDAsDDEAFPT
S1184 DDEAFPTSKTKRKGR
S1195-p RKGRHRGsEEDPLLs
S1202-p sEEDPLLsPVETWKG
T1206 PLLsPVETWKGGIDN
K1208 LsPVETWKGGIDNPA
S1218-p IDNPAITsDQEVDDK
- gap
- gap
- gap
- gap
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