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IRAP (human)

Overview IRAP a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin.. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Protease; EC 3.4.11.3 Cellular Component: integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; extracellular region; intracellular; cytosol Molecular Function: zinc ion binding; metallopeptidase activity; aminopeptidase activity Biological Process: antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; cell-cell signaling; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein catabolic process; female pregnancy; proteolysis Reference #:  Q9UIQ6 (UniProtKB) Alt. Names/Synonyms: angiotensin IV receptor; AT (4) receptor; CAP; Cystinyl aminopeptidase; insulin-regulated aminopeptidase; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP; LCAP; Leucyl-cystinyl aminopeptidase; Leucyl-cystinyl aminopeptidase, pregnancy serum form; leucyl/cystinyl aminopeptidase; LNPEP; OTASE; Oxytocinase; P-LAP; Placental leucine aminopeptidase; PLAP; vasopressinase Gene Symbols: LNPEP Molecular weight: 117,349 Da Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IRAP

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	60		Y46-p	LEPDEVEyEPRGsRL
0	1		S51-p	VEyEPRGsRLLVRGL
0	662		Y70-p	MEEDEEDyESSAKLL
1	14		S80-p	SAKLLGMsFMNRSSG
1	10		S91-p	RSSGLRNsAtGyRQS
0	1		T93-p	SGLRNsAtGyRQSPD
0	1		Y95-p	LRNsAtGyRQSPDGA
0	1		Y177-p	TAVVPLRyELSLHPN
0	1		S329-p	DEQYTALsNMPKKSS
0	2		Y508-p	IFKELSSyEDFLDAR
0	1		Y665-p	YVTEGRNysKyQsVs
0	1		S666-p	VTEGRNysKyQsVsL
0	2		Y668-p	EGRNysKyQsVsLLD
0	1		S670-p	RNysKyQsVsLLDKK
0	1		S672-p	ysKyQsVsLLDKKsG
0	1		S678-p	VsLLDKKsGVINLTE
0	1		K691-a	TEEVLWVkVNINMNG
0	2		Y784-p	NLLEKLGyMDLAsRL
0	2		S789-p	LGyMDLAsRLVTRVF

	mouse
Y46	LEPDEVEYEPRGSRL
S51	VEYEPRGSRLLVRGL
Y70-p	MDEDEEDyESSAKLL
S80-p	SAKLLGMsFMNRSSG
S91-p	RSSGLRNsAAGYRQS
A93	SGLRNsAAGYRQSPD
Y95	LRNsAAGYRQSPDGT
Y177	TAIIPLCYELSLHPN
S329	NEHHTALSNMPKKSS
Y508	IFKELNSYEDFLDAR
Y665	YVTDGRNYSEYRSVS
S666	VTDGRNYSEYRSVSL
Y668	DGRNYSEYRSVSLLD
S670	RNYSEYRSVSLLDKK
S672	YSEYRSVSLLDKKSD
S678	VSLLDKKSDVINLTE
K691	TEQVQWVKVNSNMTG
H784	NLLEKLGHMDLSSRL
S789	LGHMDLSSRLVARVH

	rat
Y46	LEPDEVEYEPRGSRL
S51	VEYEPRGSRLLVRGL
Y70-p	MDEDEEDyESSAKLL
S80-p	SAKLLGMsFMNRSSG
S91-p	RSSGLRNsATGYRQS
T93	SGLRNsATGYRQSPD
Y95	LRNsATGYRQSPDGT
Y177	TAIIPQRYELSLHPN
S329	DEHHTALSNMPKKSS
Y508	IFKELNSYEDFLDAR
Y665	YVTDGRNYSEYRSVS
S666	VTDGRNYSEYRSVSL
Y668	DGRNYSEYRSVSLLD
S670	RNYSEYRSVSLLDKK
S672	YSEYRSVSLLDKKSD
S678	VSLLDKKSDVINLTE
K691	TEQVQWVKVNTNMTG
H784	NLLEKLGHMDLSSRL
S789	LGHMDLSSRLVTRVH

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