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Protein Page:
IRAP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRAP a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin.. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.11.3; Protease; Membrane protein, integral
Cellular Component: cytoplasmic vesicle membrane; membrane; perinuclear region of cytoplasm; lysosomal membrane; integral to plasma membrane; extracellular region; plasma membrane; intracellular; cytosol
Molecular Function: metallopeptidase activity; zinc ion binding; aminopeptidase activity
Biological Process: antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; cell-cell signaling; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein catabolic process; female pregnancy; proteolysis
Reference #:  Q9UIQ6 (UniProtKB)
Alt. Names/Synonyms: angiotensin IV receptor; AT (4) receptor; CAP; Cystinyl aminopeptidase; insulin-regulated aminopeptidase; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP; LCAP; Leucyl-cystinyl aminopeptidase; Leucyl-cystinyl aminopeptidase, pregnancy serum form; leucyl/cystinyl aminopeptidase; LNPEP; OTASE; Oxytocinase; P-LAP; Placental leucine aminopeptidase; PLAP; vasopressinase
Gene Symbols: LNPEP
Molecular weight: 117,349 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRAP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S19-p PRNMIENsMFEEEPD
0 62 Y46-p LEPDEVEyEPRGsRL
0 3 S51-p VEyEPRGsRLLVRGL
0 632 Y70-p MEEDEEDyESSAKLL
1 18 S80-p SAKLLGMsFMNRSSG
1 15 S91-p RSSGLRNsAtGyRQS
0 1 T93-p SGLRNsAtGyRQSPD
0 1 Y95-p LRNsAtGyRQSPDGA
0 1 Y177-p TAVVPLRyELSLHPN
0 1 S329-p DEQYTALsNMPKKSS
0 2 Y508-p IFKELSSyEDFLDAR
0 1 Y665-p YVTEGRNysKyQsVs
0 1 S666-p VTEGRNysKyQsVsL
0 2 Y668-p EGRNysKyQsVsLLD
0 1 S670-p RNysKyQsVsLLDKK
0 1 S672-p ysKyQsVsLLDKKsG
0 1 S678-p VsLLDKKsGVINLTE
0 1 K691-ac TEEVLWVkVNINMNG
0 2 Y784-p NLLEKLGyMDLAsRL
0 2 S789-p LGyMDLAsRLVTRVF
  mouse

 
S19 PRNMIENSMFEEEPD
Y46 LEPDEVEYEPRGSRL
S51 VEYEPRGSRLLVRGL
Y70-p MDEDEEDyESSAKLL
S80-p SAKLLGMsFMNRSSG
S91-p RSSGLRNsAAGYRQS
A93 SGLRNsAAGYRQSPD
Y95 LRNsAAGYRQSPDGT
Y177 TAIIPLCYELSLHPN
S329 NEHHTALSNMPKKSS
Y508 IFKELNSYEDFLDAR
Y665 YVTDGRNYSEYRSVS
S666 VTDGRNYSEYRSVSL
Y668 DGRNYSEYRSVSLLD
S670 RNYSEYRSVSLLDKK
S672 YSEYRSVSLLDKKSD
S678 VSLLDKKSDVINLTE
K691 TEQVQWVKVNSNMTG
H784 NLLEKLGHMDLSSRL
S789 LGHMDLSSRLVARVH
  rat

 
S19 PRNMIENSMFEEEPD
Y46 LEPDEVEYEPRGSRL
S51 VEYEPRGSRLLVRGL
Y70-p MDEDEEDyESSAKLL
S80-p SAKLLGMsFMNRSSG
S91-p RSSGLRNsATGYRQS
T93 SGLRNsATGYRQSPD
Y95 LRNsATGYRQSPDGT
Y177 TAIIPQRYELSLHPN
S329 DEHHTALSNMPKKSS
Y508 IFKELNSYEDFLDAR
Y665 YVTDGRNYSEYRSVS
S666 VTDGRNYSEYRSVSL
Y668 DGRNYSEYRSVSLLD
S670 RNYSEYRSVSLLDKK
S672 YSEYRSVSLLDKKSD
S678 VSLLDKKSDVINLTE
K691 TEQVQWVKVNTNMTG
H784 NLLEKLGHMDLSSRL
S789 LGHMDLSSRLVTRVH
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