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Protein Page:
IRAP (human)

Overview
IRAP a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin.. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.4.11.3; Membrane protein, integral
Cellular Component: cytoplasmic vesicle membrane; lysosomal membrane; integral to plasma membrane; perinuclear region of cytoplasm; extracellular region; plasma membrane; intracellular; cytosol
Molecular Function: metallopeptidase activity; zinc ion binding; aminopeptidase activity
Biological Process: antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; cell-cell signaling; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein catabolic process; female pregnancy; proteolysis
Reference #:  Q9UIQ6 (UniProtKB)
Alt. Names/Synonyms: angiotensin IV receptor; AT (4) receptor; CAP; Cystinyl aminopeptidase; insulin-regulated aminopeptidase; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP; LCAP; Leucyl-cystinyl aminopeptidase; Leucyl-cystinyl aminopeptidase, pregnancy serum form; leucyl/cystinyl aminopeptidase; LNPEP; OTASE; Oxytocinase; P-LAP; Placental leucine aminopeptidase; PLAP; vasopressinase
Gene Symbols: LNPEP
Molecular weight: 117,349 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRAP

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 60 Y46-p LEPDEVEyEPRGsRL
0 3 S51-p VEyEPRGsRLLVRGL
0 662 Y70-p MEEDEEDyESSAKLL
1 15 S80-p SAKLLGMsFMNRSSG
1 13 S91-p RSSGLRNsATGYRQS
0 2 Y508-p IFKELSSyEDFLDAR
0 1 Y665-p YVTEGRNysKyQsVs
0 1 S666-p VTEGRNysKyQsVsL
0 2 Y668-p EGRNysKyQsVsLLD
0 1 S670-p RNysKyQsVsLLDKK
0 1 S672-p ysKyQsVsLLDKKSG
0 2 Y784-p NLLEKLGyMDLAsRL
0 2 S789-p LGyMDLAsRLVTRVF
  mouse

 
Y46 LEPDEVEYEPRGSRL
S51 VEYEPRGSRLLVRGL
Y70-p MDEDEEDyESSAKLL
S80-p SAKLLGMsFMNRSSG
S91-p RSSGLRNsAAGYRQS
Y508 IFKELNSYEDFLDAR
Y665 YVTDGRNYSEYRSVS
S666 VTDGRNYSEYRSVSL
Y668 DGRNYSEYRSVSLLD
S670 RNYSEYRSVSLLDKK
S672 YSEYRSVSLLDKKSD
H784 NLLEKLGHMDLSSRL
S789 LGHMDLSSRLVARVH
  rat

 
Y46 LEPDEVEYEPRGSRL
S51 VEYEPRGSRLLVRGL
Y70-p MDEDEEDyESSAKLL
S80-p SAKLLGMsFMNRSSG
S91-p RSSGLRNsATGYRQS
Y508 IFKELNSYEDFLDAR
Y665 YVTDGRNYSEYRSVS
S666 VTDGRNYSEYRSVSL
Y668 DGRNYSEYRSVSLLD
S670 RNYSEYRSVSLLDKK
S672 YSEYRSVSLLDKKSD
H784 NLLEKLGHMDLSSRL
S789 LGHMDLSSRLVTRVH
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