Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
LAMTOR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LAMTOR1 Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2 and LAMTOR3. Interacts with LAMTOR2 and LAMTOR3; the interaction is direct. The Ragulator complex interacts with both the mTORC1 complex and heterodimers of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD. Interacts with RRAGB and RRAGD; the interaction is direct indicating that it probably constitutes the main RAG-interacting subunit of the Ragulator complex. Interacts with MMP14. Interacts with CDKN1B; prevents the interaction of CDKN1B with RHOA leaving RHOA in a form accessible to activation by ARHGEF2. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; late endosome membrane; lysosomal membrane; lysosome; plasma membrane; lipid raft
Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; protein complex scaffold
Biological Process: cholesterol homeostasis; endosome organization and biogenesis; lysosome localization; positive regulation of MAPKKK cascade; lysosome organization and biogenesis; regulation of receptor recycling; cell growth; endosome localization; positive regulation of TOR signaling pathway; positive regulation of GTPase activity
Reference #:  Q6IAA8 (UniProtKB)
Alt. Names/Synonyms: C11orf59; chromosome 11 open reading frame 59; CK059; FLJ20625; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; p18; p27Kip1-releasing factor from RhoA; p27RF-Rho; PDRO; Ragulator1; RhoA activator C11orf59
Gene Symbols: LAMTOR1
Molecular weight: 17,745 Da
Basal Isoelectric point: 5.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LAMTOR1

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y5-p ___MGCCyssENEDS
0 1 S6-p __MGCCyssENEDSD
0 1 S7-p _MGCCyssENEDSDQ
0 69 K20-ub DQDREERkLLLDPss
0 6 S26-p RkLLLDPssPPtkAL
0 11 S27-p kLLLDPssPPtkALN
0 16 P28 LLLDPssPPtkALNG
0 5 T30-p LDPssPPtkALNGAE
0 12 K31-ub DPssPPtkALNGAEP
0 605 Y40-p LNGAEPNyHsLPsAR
0 81 S42-p GAEPNyHsLPsARtD
0 5 S45-p PNyHsLPsARtDEQA
0 6 T48-p HsLPsARtDEQALLS
0 1 S55 tDEQALLSsILAkTA
0 12 S56-p DEQALLSsILAkTAs
0 2 K60-ub LLSsILAkTAsNIID
0 4 S63-p sILAkTAsNIIDVsA
0 3 S69-p AsNIIDVsAADsQGM
0 2 S73-p IDVsAADsQGMEQHE
0 7 S98-p RLAVLSSsLtHWKkL
0 2 T100-p AVLSSsLtHWKkLPP
0 1 K104-ub SsLtHWKkLPPLPSL
0 19 Y138-p QVSRIAAyAysALsQ
0 74 Y140-p SRIAAyAysALsQIR
0 3 S141-p RIAAyAysALsQIRV
0 1 S144-p AyAysALsQIRVDAK
  mouse

 
Y5 ___MGCCYSSENEDS
S6 __MGCCYSSENEDSD
S7 _MGCCYSSENEDSDQ
K20-ub DQDREERkLLLDPss
S26-p RkLLLDPsstPtkAL
S27-p kLLLDPsstPtkALN
T28-p LLLDPsstPtkALNG
T30-p LDPsstPtkALNGAE
K31-ub DPsstPtkALNGAEP
Y40-p LNGAEPNyHsLPSAR
S42-p GAEPNyHsLPSARTD
S45 PNyHsLPSARTDEQA
T48 HsLPSARTDEQALLs
S55-p TDEQALLssILAKTA
S56-p DEQALLssILAKTAs
K60 LLssILAKTAsNIID
S63-p sILAKTAsNIIDVsA
S69-p AsNIIDVsAADsQGM
S73-p IDVsAADsQGMEQHE
S98-p RLAVLSSsLtHWKKL
T100-p AVLSSsLtHWKKLPP
K104 SsLtHWKKLPPLPSL
Y138-p QVSRIAAyAySALSQ
Y140-p SRIAAyAySALSQIR
S141 RIAAyAySALSQIRV
S144 AyAySALSQIRVDAK
  rat

 
Y5 ___MGCCYSSENEDS
S6 __MGCCYSSENEDSD
S7 _MGCCYSSENEDSDQ
K20 DQDQEERKLLLDPSN
S26 RKLLLDPSNtPtKAL
N27 KLLLDPSNtPtKALN
T28-p LLLDPSNtPtKALNG
T30-p LDPSNtPtKALNGAE
K31 DPSNtPtKALNGAEP
Y40 LNGAEPSYHSLPSAR
S42 GAEPSYHSLPSARTD
S45 PSYHSLPSARTDEQA
T48 HSLPSARTDEQALLS
S55 TDEQALLSSILAKTA
S56 DEQALLSSILAKTAS
K60 LLSSILAKTASNIID
S63 SILAKTASNIIDVSA
S69 ASNIIDVSAADSQGM
S73 IDVSAADSQGMEQHE
S98 RLAVLSSSLTHWKKL
T100 AVLSSSLTHWKKLPP
K104 SSLTHWKKLPPLPSL
Y138 QVSRIAAYAySALSQ
Y140-p SRIAAYAySALSQIR
S141 RIAAYAySALSQIRV
S144 AYAySALSQIRVDAK
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.