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EB1 (human)

Overview EB1 a microtubule-associated protein of the RP/EB family. Binds to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. Localizes to microtubules, especially the growing ends, in interphase cells. Associates with the centrosomes and spindle microtubules during mitosis. Also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. May be involved in the regulation of microtubule structures and chromosome stability. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: Golgi apparatus; microtubule; centrosome; cytoplasmic microtubule; cell projection membrane; cytoplasm; cortical microtubule cytoskeleton; spindle; cytosol Molecular Function: protein C-terminus binding; microtubule plus-end binding; protein binding Biological Process: M phase of mitotic cell cycle; cell proliferation; cell division; negative regulation of microtubule polymerization; mitotic cell cycle; G2/M transition of mitotic cell cycle; mitotic prometaphase Reference #:  Q15691 (UniProtKB) Alt. Names/Synonyms: adenomatous polyposis coli-binding protein EB1; APC-binding protein EB1; EB1; End-binding protein 1; MAPRE1; MARE1; MGC117374; MGC129946; Microtubule-associated protein RP/EB family member 1; microtubule-associated protein, RP/EB family, member 1 Gene Symbols: MAPRE1 Molecular weight: 29,999 Da Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states CST Pathways:  Regulation of Microtubule Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below EB1 1PA7 - A=1-130 (human) 1TXQ - B=183-268 (human) 1UEG - A=1-130 (human) 1VKA - A/B=1-140 (human) 1WU9 - A/B=189-268 (human) 1YIB - A=185-255 (human) 1YIG - A/B=185-255 (human) 2HKQ - A=189-268 (human) 2HL5 - A/B=189-268 (human) 2QJZ - A/B=12-133 (human) 2R8U - A/B=1-268 (human) 3GJO - A/D/C/B=191-260 (human) 3TQ7 - A=191-268 (human) 1V5K - A=12-117 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL5 2QJZ 2R8U 3GJO 3TQ7  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y6-p	__MAVNVySTSVTSD
0	2		K60-a	PGSIALKkVKFQAkL
0	1		K66-a	KkVKFQAkLEHEYIQ
0	2		K66-u	KkVKFQAkLEHEYIQ
0	2		K76-u	HEYIQNFkILQAGFk
0	10		K83-a	kILQAGFkRMGVDKI
0	3		K83-u	kILQAGFkRMGVDKI
0	2		K100-u	VDKLVKGkFQDNFEF
0	2		Y119-p	KKFFDANyDGKDyDP
0	295		Y124-p	ANyDGKDyDPVAARQ
0	10		K148-u	LVAPALNkPkkPLTs
0	10		K150-u	APALNkPkkPLTsSS
0	2		K151-u	PALNkPkkPLTsSSA
0	1		S155-p	kPkkPLTsSSAAPQR
0	4		T166-p	APQRPIStQRTAAAP
0	1		K174	QRTAAAPKAGPGVVR
0	1		K182	AGPGVVRKNPGVGNG
0	1		K212-u	LTVEDLEkERDFYFG
1	1		K220-a	ERDFYFGkLRNIELI
0	21		K220-u	ERDFYFGkLRNIELI
0	3		Y268-p	PQEEQEEy_______

	mouse
Y6	__MAVNVYSTSVTSD
K60	PGSIALKKVKFQAKL
K66	KKVKFQAKLEHEYIQ
K66	KKVKFQAKLEHEYIQ
K76	HEYIQNFKILQAGFk
K83-a	KILQAGFkRMGVDKI
K83	KILQAGFKRMGVDKI
K100-u	VDKLVKGkFQDNFEF
Y119	KKFFDANYDGKEYDP
Y124	ANYDGKEYDPVAARQ
K148-u	LVAPALSkPkKPLGS
K150-u	APALSkPkKPLGSST
K151	PALSkPkKPLGSSTA
S155	kPkKPLGSSTAAPQR
T166-p	APQRPIAtQRTTAAP
K174-u	QRTTAAPkAGPGMVR
K182-u	AGPGMVRkNPGVGNG
K212	LTVEDLEKERDFYFG
K220	ERDFYFGKLRNIELI
K220-u	ERDFYFGkLRNIELI
Y268	PQEEQEEY_______

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