Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
EB1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EB1 a microtubule-associated protein of the RP/EB family. Binds to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. Localizes to microtubules, especially the growing ends, in interphase cells. Associates with the centrosomes and spindle microtubules during mitosis. Also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. May be involved in the regulation of microtubule structures and chromosome stability. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Cellular Component: Golgi apparatus; centrosome; microtubule; cell projection membrane; cytoplasmic microtubule; cytoplasm; cortical microtubule cytoskeleton; spindle; cytosol
Molecular Function: protein C-terminus binding; microtubule plus-end binding; protein binding
Biological Process: mitosis; cell proliferation; negative regulation of microtubule polymerization; mitotic cell cycle; G2/M transition of mitotic cell cycle
Reference #:  Q15691 (UniProtKB)
Alt. Names/Synonyms: adenomatous polyposis coli-binding protein EB1; APC-binding protein EB1; EB1; End-binding protein 1; MAPRE1; MARE1; MGC117374; MGC129946; Microtubule-associated protein RP/EB family member 1; microtubule-associated protein, RP/EB family, member 1
Gene Symbols: MAPRE1
Molecular weight: 29,999 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EB1

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y6-p __MAVNVySTsVTSD
0 1 S9-p AVNVySTsVTSDNLS
0 2 K60-ac PGSIALKkVKFQAkL
0 1 K66-ac KkVKFQAkLEHEYIQ
0 2 K66-ub KkVKFQAkLEHEYIQ
0 1 K76-ac HEYIQNFkILQAGFk
0 2 K76-ub HEYIQNFkILQAGFk
0 11 K83-ac kILQAGFkRMGVDKI
0 3 K83-ub kILQAGFkRMGVDKI
0 1 K83-sc kILQAGFkRMGVDKI
0 2 K100-ub VDKLVKGkFQDNFEF
0 2 Y119-p KKFFDANyDGKDyDP
0 260 Y124-p ANyDGKDyDPVAARQ
0 10 K148-ub LVAPALNkPkkPLTs
0 10 K150-ub APALNkPkkPLTsSS
0 2 K151-ub PALNkPkkPLTsSSA
1 5 S155-p kPkkPLTsSSAAPQR
0 3 S165-p AAPQRPIstQRTAAA
1 4 T166-p APQRPIstQRTAAAP
0 1 K174 QRTAAAPKAGPGVVR
0 1 K182 AGPGVVRKNPGVGNG
0 1 K212-ub LTVEDLEkERDFYFG
1 1 K220-ac ERDFYFGkLRNIELI
0 21 K220-ub ERDFYFGkLRNIELI
0 2 Y268-p PQEEQEEy_______
  mouse

 
Y6 __MAVNVYSTSVTSD
S9 AVNVYSTSVTSDNLS
K60 PGSIALKKVKFQAKL
K66 KKVKFQAKLEHEYIQ
K66 KKVKFQAKLEHEYIQ
K76 HEYIQNFKILQAGFk
K76 HEYIQNFKILQAGFk
K83-ac KILQAGFkRMGVDKI
K83 KILQAGFKRMGVDKI
K83-sc KILQAGFkRMGVDKI
K100-ub VDKLVKGkFQDNFEF
Y119 KKFFDANYDGKEYDP
Y124 ANYDGKEYDPVAARQ
K148-ub LVAPALSkPkKPLGs
K150-ub APALSkPkKPLGsST
K151 PALSkPkKPLGsSTA
S155-p kPkKPLGsSTAAPQR
A165 AAPQRPIAtQRTTAA
T166-p APQRPIAtQRTTAAP
K174-ub QRTTAAPkAGPGMVR
K182-ub AGPGMVRkNPGVGNG
K212 LTVEDLEKERDFYFG
K220 ERDFYFGKLRNIELI
K220-ub ERDFYFGkLRNIELI
Y268 PQEEQEEY_______
  rat

 
Y6 __MAVNVYSTSVTSD
S9 AVNVYSTSVTSDNLS
K60 PGSIALKKVKFQAKL
K66 KKVKFQAKLEHEYIQ
K66 KKVKFQAKLEHEYIQ
K76 HEYIQNFKILQAGFK
K76 HEYIQNFKILQAGFK
K83 KILQAGFKRMGVDKI
K83 KILQAGFKRMGVDKI
K83 KILQAGFKRMGVDKI
K100 VDKLVKGKFQDNFEF
Y119 KKFFDANYDGKEYDP
Y124 ANYDGKEYDPVAARQ
K148 LVAPALSKPKKPLGS
K150 APALSKPKKPLGSGS
K151 PALSKPKKPLGSGSA
S155 KPKKPLGSGSAAPQR
A165 AAPQRPIATQRTTAA
T166 APQRPIATQRTTAAP
K174 QRTTAAPKAGPGMVR
K182 AGPGMVRKNPGMGNG
K212 LTVEDLEKERDFYFG
K220 ERDFYFGKLRNIELI
K220 ERDFYFGKLRNIELI
Y268 PQEEQEEY_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.