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Protein Page:
VCP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VCP valosin-containing protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope and of the transitional endoplasmic reticulum (tER). Regulates NFKappaB pathway, which is important for metastasis of osteosarcoma. Tyrosine phosphorylation regulates its cell cycle-dependent nuclear localization. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; DNA repair, damage; Chaperone; Endoplasmic reticulum
Cellular Component: proteasome complex; endoplasmic reticulum membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; nucleolus; lipid particle; nucleus; cytosol
Molecular Function: protein domain specific binding; identical protein binding; protein binding; ATPase activity; protein complex binding; polyubiquitin binding; ADP binding; protein phosphatase binding; lipid binding; ATP binding; receptor binding
Biological Process: caspase activation; ATP catabolic process; proteasomal ubiquitin-dependent protein catabolic process; ER to Golgi vesicle-mediated transport; ER-associated protein catabolic process; unfolded protein response; protein ubiquitination; DNA repair; retrograde protein transport, ER to cytosol; regulation of apoptosis; establishment of protein localization; bypass DNA synthesis; positive regulation of protein complex assembly; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; double-strand break repair; positive regulation of protein catabolic process; protein amino acid N-linked glycosylation via asparagine; response to DNA damage stimulus; protein homooligomerization
Reference #:  P55072 (UniProtKB)
Alt. Names/Synonyms: 15S Mg(2+)-ATPase p97 subunit; IBMPFD; MGC131997; MGC148092; MGC8560; p97; TER ATPase; TERA; Transitional endoplasmic reticulum ATPase; Valosin-containing protein; VCP; yeast Cdc48p homolog
Gene Symbols: VCP
Molecular weight: 89,322 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VCP

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S352‑p, S746‑p, S748‑p
enzymatic activity, induced: K696‑ac, T761‑p
intracellular localization: S784‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S3-p _____MAsGADskGD
0 4 S7-p _MAsGADskGDDLst
0 31 K8-ac MAsGADskGDDLstA
0 2 K8-ub MAsGADskGDDLstA
0 2 S13-p DskGDDLstAILkQk
0 3 T14-p skGDDLstAILkQkN
0 1 K18-ac DLstAILkQkNRPNR
0 95 K18-ub DLstAILkQkNRPNR
0 5 K20-ub stAILkQkNRPNRLI
0 2 S37-p EAINEDNsVVsLSQP
0 1 S40-p NEDNsVVsLSQPkMD
0 1 S42 DNsVVsLSQPkMDEL
0 12 K45-ub VVsLSQPkMDELQLF
0 1 T56-p LQLFRGDtVLLkGKK
0 1 K60-ac RGDtVLLkGKKRREA
0 1 K60 RGDtVLLKGKKRREA
0 1 S73-p EAVCIVLsDDTCSDE
0 1 K81-ac DDTCSDEkIRMNRVV
0 3 K81-ub DDTCSDEkIRMNRVV
0 1 S101-p VRLGDVIsIQPCPDV
0 7 K109-ac IQPCPDVkyGkRIHV
0 96 K109-ub IQPCPDVkyGkRIHV
0 1 Y110-p QPCPDVkyGkRIHVL
0 3 K112-ac CPDVkyGkRIHVLPI
0 36 K112-ub CPDVkyGkRIHVLPI
0 1 Y138-p FEVYLKPyFLEAyRP
0 1 Y143-p KPyFLEAyRPIRkGD
0 2 K148-ub EAyRPIRkGDIFLVR
0 1 K164-ac GMRAVEFkVVEtDPS
0 1 T168-p VEFkVVEtDPSPyCI
0 3 Y173-p VEtDPSPyCIVAPDT
0 3 S197-p KREDEEEsLNEVGyD
0 1 Y203-p EsLNEVGyDDIGGCR
0 10 K211-ub DDIGGCRkQLAQIkE
0 16 K217-ub RkQLAQIkEMVELPL
0 33 K231-ub LRHPALFkAIGVkPP
0 18 K236-ub LFkAIGVkPPRGILL
0 9 Y244-p PPRGILLyGPPGtGk
0 2 T249-p LLyGPPGtGkTLIAR
0 1 K251-ac yGPPGtGkTLIARAV
0 14 K251-ub yGPPGtGkTLIARAV
0 1 S276-p INGPEIMsKLAGEsE
0 1 K277 NGPEIMsKLAGEsEs
0 4 S282-p MsKLAGEsEsNLRkA
0 3 S284-p KLAGEsEsNLRkAFE
0 5 K288-ub EsEsNLRkAFEEAEk
0 15 K295-ub kAFEEAEkNAPAIIF
0 1 K312-ac ELDAIAPkREktHGE
0 14 K312-ub ELDAIAPkREktHGE
0 1 K315-ac AIAPkREktHGEVER
0 1 K315-m2 AIAPkREktHGEVER
1 2 K315-m3 AIAPkREktHGEVER
0 1 T316-p IAPkREktHGEVERR
1 4 S326-p EVERRIVsQLLtLMD
0 1 T330-p RIVsQLLtLMDGLkQ
0 1 K336-ac LtLMDGLkQRAHVIV
0 106 K336-ub LtLMDGLkQRAHVIV
0 3 T347-p HVIVMAAtNRPNsID
2 2 S352-p AAtNRPNsIDPALRR
0 1 T375-p DIGIPDAtGRLEILQ
0 2 T385-p LEILQIHtkNMkLAD
0 1 K386-ac EILQIHtkNMkLADD
0 16 K386-ub EILQIHtkNMkLADD
0 7 K389-ub QIHtkNMkLADDVDL
0 1 T436-p LIDLEDEtIDAEVMN
0 2 S457-p DDFRWALsQsNPsAL
0 1 S459-p FRWALsQsNPsALRE
0 2 S462-p ALsQsNPsALRETVV
0 40 K486-ub IGGLEDVkRELQELV
0 2 Y495-p ELQELVQyPVEHPDk
0 43 K502-ub yPVEHPDkFLkFGMt
0 2 K505-ac EHPDkFLkFGMtPsk
0 28 K505-ub EHPDkFLkFGMtPsk
0 10 T509-p kFLkFGMtPskGVLF
0 1 S511-p LkFGMtPskGVLFYG
0 1 K512-ac kFGMtPskGVLFYGP
0 16 K512-ub kFGMtPskGVLFYGP
0 1 K524-ac YGPPGCGktLLAkAI
0 10 K524-ub YGPPGCGktLLAkAI
0 1 T525-p GPPGCGktLLAkAIA
0 1 K529-ac CGktLLAkAIANECQ
0 31 K529-ub CGktLLAkAIANECQ
0 2 S541-p ECQANFIsIkGPELL
0 1 K543-ub QANFIsIkGPELLTM
0 1 S555-p LTMWFGEsEANVREI
0 3 K565-ub NVREIFDkARQAAPC
0 28 K584-ub DELDSIAkARGGNIG
0 2 T606-p RVINQILtEMDGMst
0 1 S612-p LtEMDGMstkkNVFI
0 3 T613-p tEMDGMstkkNVFII
0 1 K614-ac EMDGMstkkNVFIIG
0 5 K614-ub EMDGMstkkNVFIIG
0 8 K615-ub MDGMstkkNVFIIGA
0 1 T623-p NVFIIGAtNRPDIID
0 28 Y644-p GRLDQLIyIPLPDEk
0 1 K651-ac yIPLPDEksRVAILk
0 86 K651-ub yIPLPDEksRVAILk
0 1 K651-sc yIPLPDEksRVAILk
0 1 S652-p IPLPDEksRVAILkA
0 2 K658-ac ksRVAILkANLRksP
0 91 K658-ub ksRVAILkANLRksP
0 1 K663-ac ILkANLRksPVAkDV
0 13 K663-ub ILkANLRksPVAkDV
0 1 S664-p LkANLRksPVAkDVD
0 2 K668-ac LRksPVAkDVDLEFL
0 114 K668-ub LRksPVAkDVDLEFL
0 1 K668 LRksPVAKDVDLEFL
0 1 K677-ac VDLEFLAkMtNGFsG
0 6 K677-ub VDLEFLAkMtNGFsG
0 2 T679-p LEFLAkMtNGFsGAD
0 2 S683-p AkMtNGFsGADLtEI
0 1 T688-p GFsGADLtEICQRAC
1 1 K696-ac EICQRACkLAIREsI
0 4 K696-ub EICQRACkLAIREsI
0 8 S702-p CkLAIREsIEsEIRR
0 3 S705-p AIREsIEsEIRRERE
0 1 S718-p RERQTNPsAMEVEED
2 3 S746-p AMRFARRsVsDNDIR
2 5 S748-p RFARRsVsDNDIRky
0 1 K754-ac VsDNDIRkyEMFAQt
0 9 K754-ub VsDNDIRkyEMFAQt
0 2 Y755-p sDNDIRkyEMFAQtL
1 2 T761-p kyEMFAQtLQQsRGF
0 1 S765-p FAQtLQQsRGFGsFR
0 24 S770-p QQsRGFGsFRFPsGN
0 26 S775-p FGsFRFPsGNQGGAG
1 31 S784-p NQGGAGPsQGsGGGt
0 13 S787-p GAGPsQGsGGGtGGs
0 6 T791-p sQGsGGGtGGsVytE
0 3 S794-p sGGGtGGsVytEDND
2 55 Y796-p GGtGGsVytEDNDDD
0 1 T797-p GtGGsVytEDNDDDL
4 255 Y805-p EDNDDDLyG______
  mouse

 
S3 _____MASGADskGD
S7-p _MASGADskGDDLST
K8-ac MASGADskGDDLSTA
K8 MASGADsKGDDLSTA
S13 DskGDDLSTAILkQK
T14 skGDDLSTAILkQKN
K18 DLSTAILKQKNRPNR
K18-ub DLSTAILkQKNRPNR
K20 STAILkQKNRPNRLI
S37 EAINEDNSVVSLsQP
S40 NEDNSVVSLsQPkMD
S42-p DNSVVSLsQPkMDEL
K45-ub VVSLsQPkMDELQLF
T56 LQLFRGDTVLLkGKK
K60 RGDTVLLKGKKRREA
K60-ub RGDTVLLkGKKRREA
S73 EAVCIVLSDDTCSDE
K81 DDTCSDEKIRMNRVV
K81 DDTCSDEKIRMNRVV
S101 VRLGDVISIQPCPDV
K109 IQPCPDVKYGkRIHV
K109-ub IQPCPDVkYGkRIHV
Y110 QPCPDVkYGkRIHVL
K112 CPDVkYGKRIHVLPI
K112-ub CPDVkYGkRIHVLPI
Y138 FEVYLKPYFLEAYRP
Y143 KPYFLEAYRPIRkGD
K148-ub EAYRPIRkGDIFLVR
K164 GMRAVEFKVVETDPS
T168 VEFKVVETDPSPyCI
Y173-p VETDPSPyCIVAPDT
S197-p KREDEEEsLNEVGYD
Y203 EsLNEVGYDDIGGCR
K211-ub DDIGGCRkQLAQIkE
K217-ub RkQLAQIkEMVELPL
K231-ub LRHPALFkAIGVkPP
K236-ub LFkAIGVkPPRGILL
Y244-p PPRGILLyGPPGTGk
T249 LLyGPPGTGkTLIAR
K251 yGPPGTGKTLIARAV
K251-ub yGPPGTGkTLIARAV
S276 INGPEIMSkLAGEsE
K277-ub NGPEIMSkLAGEsEs
S282-p MSkLAGEsEsNLRkA
S284-p kLAGEsEsNLRkAFE
K288-ub EsEsNLRkAFEEAEk
K295-ub kAFEEAEkNAPAIIF
K312 ELDAIAPKREKTHGE
K312-ub ELDAIAPkREKTHGE
K315 AIAPkREKTHGEVER
K315 AIAPkREKTHGEVER
K315 AIAPkREKTHGEVER
T316 IAPkREKTHGEVERR
S326 EVERRIVSQLLTLMD
T330 RIVSQLLTLMDGLkQ
K336 LTLMDGLKQRAHVIV
K336-ub LTLMDGLkQRAHVIV
T347 HVIVMAATNRPNsID
S352-p AATNRPNsIDPALRR
T375 DIGIPDATGRLEILQ
T385 LEILQIHTkNMkLAD
K386 EILQIHTKNMkLADD
K386-ub EILQIHTkNMkLADD
K389-ub QIHTkNMkLADDVDL
T436 LIDLEDETIDAEVMN
S457 DDFRWALSQSNPSAL
S459 FRWALSQSNPSALRE
S462 ALSQSNPSALRETVV
K486-ub IGGLEDVkRELQELV
Y495 ELQELVQYPVEHPDk
K502-ub YPVEHPDkFLkFGMt
K505 EHPDkFLKFGMtPSk
K505-ub EHPDkFLkFGMtPSk
T509-p kFLkFGMtPSkGVLF
S511 LkFGMtPSkGVLFYG
K512 kFGMtPSKGVLFYGP
K512-ub kFGMtPSkGVLFYGP
K524 YGPPGCGKTLLAkAI
K524-ub YGPPGCGkTLLAkAI
T525 GPPGCGkTLLAkAIA
K529 CGkTLLAKAIANECQ
K529-ub CGkTLLAkAIANECQ
S541 ECQANFISIKGPELL
K543 QANFISIKGPELLTM
S555 LTMWFGESEANVREI
K565 NVREIFDKARQAAPC
K584-ub DELDSIAkARGGNIG
T606 RVINQILTEMDGMST
S612 LTEMDGMSTkkNVFI
T613 TEMDGMSTkkNVFII
K614 EMDGMSTKkNVFIIG
K614-ub EMDGMSTkkNVFIIG
K615-ub MDGMSTkkNVFIIGA
T623 NVFIIGATNRPDIID
Y644-p GRLDQLIyIPLPDEk
K651-ac yIPLPDEkSRVAILk
K651-ub yIPLPDEkSRVAILk
K651-sc yIPLPDEkSRVAILk
S652 IPLPDEkSRVAILkA
K658-ac kSRVAILkANLRkSP
K658-ub kSRVAILkANLRkSP
K663 ILkANLRKSPVAkDV
K663-ub ILkANLRkSPVAkDV
S664 LkANLRkSPVAkDVD
K668-ac LRkSPVAkDVDLEFL
K668-ub LRkSPVAkDVDLEFL
K668-sc LRkSPVAkDVDLEFL
K677 VDLEFLAKMTNGFSG
K677 VDLEFLAKMTNGFSG
T679 LEFLAKMTNGFSGAD
S683 AKMTNGFSGADLTEI
T688 GFSGADLTEICQRAC
K696 EICQRACKLAIREsI
K696-ub EICQRACkLAIREsI
S702-p CkLAIREsIEsEIRR
S705-p AIREsIEsEIRRERE
S718 RERQTNPSAMEVEED
S746-p AMRFARRsVsDNDIR
S748-p RFARRsVsDNDIRky
K754 VsDNDIRKyEMFAQT
K754-ub VsDNDIRkyEMFAQT
Y755-p sDNDIRkyEMFAQTL
T761 kyEMFAQTLQQSRGF
S765 FAQTLQQSRGFGsFR
S770-p QQSRGFGsFRFPsGN
S775-p FGsFRFPsGNQGGAG
S784 NQGGAGPSQGsGGGT
S787-p GAGPSQGsGGGTGGS
T791 SQGsGGGTGGSVyTE
S794 sGGGTGGSVyTEDND
Y796-p GGTGGSVyTEDNDDD
T797 GTGGSVyTEDNDDDL
Y805-p EDNDDDLyG______
  rat

 
S3 _____MASGADSKGD
S7 _MASGADSKGDDLST
K8 MASGADSKGDDLSTA
K8 MASGADSKGDDLSTA
S13 DSKGDDLSTAILKQK
T14 SKGDDLSTAILKQKN
K18 DLSTAILKQKNRPNR
K18 DLSTAILKQKNRPNR
K20 STAILKQKNRPNRLI
S37 EAINEDNSVVSLSQP
S40 NEDNSVVSLSQPKMD
S42 DNSVVSLSQPKMDEL
K45 VVSLSQPKMDELQLF
T56 LQLFRGDTVLLKGKK
K60 RGDTVLLKGKKRREA
K60 RGDTVLLKGKKRREA
S73 EAVCIVLSDDTCSDE
K81 DDTCSDEKIRMNRVV
K81 DDTCSDEKIRMNRVV
S101 VRLGDVISIQPCPDV
K109 IQPCPDVKYGKRIHV
K109 IQPCPDVKYGKRIHV
Y110 QPCPDVKYGKRIHVL
K112 CPDVKYGKRIHVLPI
K112 CPDVKYGKRIHVLPI
Y138 FEVYLKPYFLEAYRP
Y143 KPYFLEAYRPIRKGD
K148 EAYRPIRKGDIFLVR
K164 GMRAVEFKVVETDPS
T168 VEFKVVETDPSPYCI
Y173 VETDPSPYCIVAPDT
S197 KREDEEESLNEVGYD
Y203 ESLNEVGYDDIGGCR
K211 DDIGGCRKQLAQIKE
K217 RKQLAQIKEMVELPL
K231 LRHPALFKAIGVKPP
K236 LFKAIGVKPPRGILL
Y244 PPRGILLYGPPGTGK
T249 LLYGPPGTGKTLIAR
K251 YGPPGTGKTLIARAV
K251 YGPPGTGKTLIARAV
S276 INGPEIMSKLAGESE
K277 NGPEIMSKLAGESES
S282 MSKLAGESESNLRKA
S284 KLAGESESNLRKAFE
K288 ESESNLRKAFEEAEK
K295 KAFEEAEKNAPAIIF
K312 ELDAIAPKREKTHGE
K312 ELDAIAPKREKTHGE
K315 AIAPKREKTHGEVER
K315 AIAPKREKTHGEVER
K315 AIAPKREKTHGEVER
T316 IAPKREKTHGEVERR
S326 EVERRIVSQLLTLMD
T330 RIVSQLLTLMDGLkQ
K336 LTLMDGLKQRAHVIV
K336-ub LTLMDGLkQRAHVIV
T347 HVIVMAATNRPNSID
S352 AATNRPNSIDPALRR
T375 DIGIPDATGRLEILQ
T385 LEILQIHTKNMKLAD
K386 EILQIHTKNMKLADD
K386 EILQIHTKNMKLADD
K389 QIHTKNMKLADDVDL
T436 LIDLEDETIDAEVMN
S457 DDFRWALSQSNPSAL
S459 FRWALSQSNPSALRE
S462 ALSQSNPSALRETVV
K486 IGGLEDVKRELQELV
Y495 ELQELVQYPVEHPDK
K502 YPVEHPDKFLKFGMT
K505 EHPDKFLKFGMTPSK
K505 EHPDKFLKFGMTPSK
T509 KFLKFGMTPSKGVLF
S511 LKFGMTPSKGVLFYG
K512 KFGMTPSKGVLFYGP
K512 KFGMTPSKGVLFYGP
K524 YGPPGCGKTLLAKAI
K524 YGPPGCGKTLLAKAI
T525 GPPGCGKTLLAKAIA
K529 CGKTLLAKAIANECQ
K529 CGKTLLAKAIANECQ
S541 ECQANFISIKGPELL
K543 QANFISIKGPELLTM
S555 LTMWFGESEANVREI
K565 NVREIFDKARQAAPC
K584 DELDSIAKARGGNIG
T606 RVINQILTEMDGMST
S612 LTEMDGMSTKKNVFI
T613 TEMDGMSTKKNVFII
K614 EMDGMSTKKNVFIIG
K614 EMDGMSTKKNVFIIG
K615 MDGMSTKKNVFIIGA
T623 NVFIIGATNRPDIID
Y644 GRLDQLIYIPLPDEk
K651 YIPLPDEKSRVAILk
K651-ub YIPLPDEkSRVAILk
K651 YIPLPDEKSRVAILk
S652 IPLPDEkSRVAILkA
K658 kSRVAILKANLRKSP
K658-ub kSRVAILkANLRKSP
K663 ILkANLRKSPVAKDV
K663 ILkANLRKSPVAKDV
S664 LkANLRKSPVAKDVD
K668 LRKSPVAKDVDLEFL
K668 LRKSPVAKDVDLEFL
K668 LRKSPVAKDVDLEFL
K677 VDLEFLAKMTNGFSG
K677 VDLEFLAKMTNGFSG
T679 LEFLAKMTNGFSGAD
S683 AKMTNGFSGADLTEI
T688 GFSGADLTEICQRAC
K696 EICQRACKLAIRESI
K696 EICQRACKLAIRESI
S702 CKLAIRESIESEIRR
S705 AIRESIESEIRRERE
S718 RERQTNPSAMEVEED
S746 AMRFARRSVSDNDIR
S748 RFARRSVSDNDIRKY
K754 VSDNDIRKYEMFAQT
K754 VSDNDIRKYEMFAQT
Y755 SDNDIRKYEMFAQTL
T761 KYEMFAQTLQQSRGF
S765 FAQTLQQSRGFGSFR
S770 QQSRGFGSFRFPSGN
S775 FGSFRFPSGNQGGAG
S784 NQGGAGPSQGSGGGT
S787 GAGPSQGSGGGTGGN
T791 SQGSGGGTGGNVYTE
N794 SGGGTGGNVYTEDND
Y796 GGTGGNVYTEDNDDD
T797 GTGGNVYTEDNDDDL
Y805 EDNDDDLYG______
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