valosin-containing protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope and of the transitional endoplasmic reticulum (tER). Regulates NFKappaB pathway, which is important for metastasis of osteosarcoma. Tyrosine phosphorylation regulates its cell cycle-dependent nuclear localization. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Hydrolase; Endoplasmic reticulum; Chaperone
Cellular Component: proteasome complex; intracellular membrane-bound organelle; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; nucleolus; lipid particle; nucleus; cytosol
Molecular Function: protein domain specific binding; identical protein binding; protein binding; ATPase activity; protein complex binding; polyubiquitin binding; ADP binding; protein phosphatase binding; lipid binding; ATP binding; receptor binding
Biological Process: caspase activation; proteasomal ubiquitin-dependent protein catabolic process; ER-associated protein catabolic process; ER to Golgi vesicle-mediated transport; unfolded protein response; protein ubiquitination; DNA repair; regulation of apoptosis; retrograde protein transport, ER to cytosol; establishment of protein localization; bypass DNA synthesis; positive regulation of protein complex assembly; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; double-strand break repair; positive regulation of protein catabolic process; protein amino acid N-linked glycosylation via asparagine; response to DNA damage stimulus; protein homooligomerization
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.