adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: endoplasmic reticulum; cytoplasm; plasma membrane; ribosome; intercellular junction; protein phosphatase type 1 complex; vesicle membrane; cytosol; nucleus
Molecular Function: protein binding, bridging; protein domain specific binding; protein binding; receptor signaling complex scaffold activity; SH3/SH2 adaptor activity; protein kinase inhibitor activity; cytoskeletal adaptor activity; receptor tyrosine kinase binding; receptor binding
Biological Process: lamellipodium biogenesis; axon guidance; positive regulation of translation in response to stress; T cell activation; negative regulation of peptidyl-serine phosphorylation; signal complex assembly; actin filament organization; response to other organism; substrate-bound cell migration, cell extension; T cell receptor signaling pathway; positive regulation of actin filament polymerization; innate immune response; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; vascular endothelial growth factor receptor signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.