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Nck1 (human)

Overview Nck1 adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis Cellular Component: endoplasmic reticulum; cytoplasm; plasma membrane; vesicle membrane; nucleus; cytosol Molecular Function: protein domain specific binding; protein binding; receptor signaling complex scaffold activity; cytoskeletal adaptor activity; receptor binding Biological Process: lamellipodium biogenesis; regulation of translation; axon guidance; cell migration; positive regulation of actin filament polymerization; T cell activation; actin filament organization; signal complex assembly; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; T cell receptor signaling pathway Reference #:  P16333 (UniProtKB) Alt. Names/Synonyms: Cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK; NCK adaptor protein 1; NCK tyrosine kinase; Nck-1; NCK1; NCKalpha; non-catalytic region of tyrosine kinase; SH2/SH3 adaptor protein NCK-alpha Gene Symbols: NCK1 Molecular weight: 42,864 Da Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  Regulation of Actin Dynamics  |  T Cell Receptor Signaling  |  Translation: eIF2  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Nck1 2CI8 - A=281-377 (human) 2CI9 - A/B=279-377 (human) 2CUB - A=99-174 (human) 2JS0 - A=107-165 (human) 2JS2 - A=1-61 (human) 2JW4 - A=1-63 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2CI8 2CI9 2CUB 2JS0 2JS2 2JW4  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y13-p	VVVAKFDyVAQQEQE
0	4		S61-p	NYVERKNsARKAsIV
0	5		S66-p	KNsARKAsIVKNLKD
0	2		T74-p	IVKNLKDtLGIGKVK
0	378		S85-p	GKVKRKPsVPdsAsP
0	2		D88-ca	KRKPsVPdsAsPADD
0	35		S89-p	RKPsVPdsAsPADDs
0	14		S91-p	PsVPdsAsPADDsFV
0	56		S96-p	sAsPADDsFVDPGER
1	860		Y105-p	VDPGERLyDLNMPAy
0	100		Y112-p	yDLNMPAyVKFNYMA
0	1		Y148	DGWWRGSYNGQVGWF
0	1		Y159	VGWFPSNYVTEEGDs
0	1		T161	WFPSNYVTEEGDsPL
0	6		S166-p	YVTEEGDsPLGDHVG
0	13		Y268-p	PSPPQCDyIRPSLTG
0	17		Y339-p	VQLKETVyCIGQRKF
0	2		S347-p	CIGQRKFsTMEELVE
0	2		T348	IGQRKFsTMEELVEH
0	2		Y371	SEQGEKLYLVKHLS_

	mouse
Y13	VVVAKFDYVAQQEQE
S61	NYVERKNSARKASIV
S66	KNSARKASIVKNLKD
T74-p	IVKNLKDtLGIGKVK
S85-p	GKVKRKPsVPDtAsP
D88	KRKPsVPDtAsPADD
T89-p	RKPsVPDtAsPADDs
S91-p	PsVPDtAsPADDsFV
S96-p	tAsPADDsFVDPGER
Y105-p	VDPGERLyDLNMPAF
F112	yDLNMPAFVKFNYMA
Y148-p	DGWWRGSyNGQIGWF
Y159-p	IGWFPSNyVtEEGDs
T161-p	WFPSNyVtEEGDsPL
S166-p	yVtEEGDsPLGDHVG
Y268-p	PSPPQCDyIRPSLTG
Y339	VQLKETVYCIGQRKF
S347-p	CIGQRKFstMEELVE
T348-p	IGQRKFstMEELVEH
Y371-p	SEQGEKLyLVKHLS_

	rat
Y13	VVVAKFDYVAQQEQE
S61	NYVERKNSARKAsIV
S66-p	KNSARKAsIVKNLKD
T74	IVKNLKDTLGIGKVK
S85-p	GKVKRKPsVPDTASP
D88	KRKPsVPDTASPADD
T89	RKPsVPDTASPADDS
S91	PsVPDTASPADDSFV
S96	TASPADDSFVDPGER
Y105-p	VDPGERLyDLNMPAF
F112	yDLNMPAFVKFNYMA
Y148	DGWWRGSYNGQIGWF
Y159	IGWFPSNYVTEEGDS
T161	WFPSNYVTEEGDSPL
S166	YVTEEGDSPLGDHVG
Y268	PSPPQCDYIRPSLTG
Y339	VQLKETVYCIGQRKF
S347-p	CIGQRKFsTMEELVE
T348	IGQRKFsTMEELVEH
Y371	SEQGEKLYLVKHLS_

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