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Protein Page:
Nck1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Nck1 adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: endoplasmic reticulum; cytoplasm; plasma membrane; vesicle membrane; nucleus; cytosol
Molecular Function: protein domain specific binding; protein binding; receptor signaling complex scaffold activity; protein kinase inhibitor activity; cytoskeletal adaptor activity; receptor tyrosine kinase binding; receptor binding
Biological Process: lamellipodium biogenesis; axon guidance; cell migration; T cell activation; signal complex assembly; actin filament organization; response to other organism; T cell receptor signaling pathway; regulation of translation; positive regulation of actin filament polymerization; innate immune response; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation
Reference #:  P16333 (UniProtKB)
Alt. Names/Synonyms: Cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK; NCK adaptor protein 1; NCK tyrosine kinase; Nck-1; NCK1; NCKalpha; non-catalytic region of tyrosine kinase; SH2/SH3 adaptor protein NCK-alpha
Gene Symbols: NCK1
Molecular weight: 42,864 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Nck1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y13-p VVVAKFDyVAQQEQE
0 4 S61-p NYVERKNsARKAsIV
0 5 S66-p KNsARKAsIVKNLKD
0 4 T74-p IVKNLKDtLGIGKVK
0 393 S85-p GKVKRKPsVPdsAsP
0 2 D88-ca KRKPsVPdsAsPADD
0 38 S89-p RKPsVPdsAsPADDs
0 20 S91-p PsVPdsAsPADDsFV
0 65 S96-p sAsPADDsFVDPGER
2 864 Y105-p VDPGERLyDLNMPAy
0 107 Y112-p yDLNMPAyVKFNYMA
0 1 S147 SDGWWRGSyNGQVGW
0 1 Y148-p DGWWRGSyNGQVGWF
0 1 Y159-p VGWFPSNyVtEEGDs
0 1 T161-p WFPSNyVtEEGDsPL
0 12 S166-p yVtEEGDsPLGDHVG
0 2 S262-p LTSGLEPsPPQCDyI
0 14 Y268-p PsPPQCDyIRPSLTG
0 2 S313-p LIRDSESsPNDFSVS
0 18 Y339-p VQLKETVyCIGQRKF
0 2 S347-p CIGQRKFsTMEELVE
0 2 T348 IGQRKFsTMEELVEH
0 2 Y371 SEQGEKLYLVKHLS_
  Nck1 iso2  
- gap
- gap
- gap
- gap
S21-p GKVKRKPsVPDSAsP
D24 KRKPsVPDSAsPADD
S25 RKPsVPDSAsPADDS
S27-p PsVPDSAsPADDSFV
S32 SAsPADDSFVDPGER
Y41 VDPGERLYDLNMPAY
Y48 YDLNMPAYVKFNYMA
S83 SDGWWRGSYNGQVGW
Y84 DGWWRGSYNGQVGWF
Y95 VGWFPSNYVTEEGDS
T97 WFPSNYVTEEGDSPL
S102 YVTEEGDSPLGDHVG
S198 LTSGLEPSPPQCDYI
Y204 PSPPQCDYIRPSLTG
S249 LIRDSESSPNDFSVS
Y275 VQLKETVYCIGQRKF
S283 CIGQRKFSTMEELVE
T284 IGQRKFSTMEELVEH
Y307 SEQGEKLYLVKHLS_
  mouse

 
Y13 VVVAKFDYVAQQEQE
S61 NYVERKNSARKAsIV
S66-p KNSARKAsIVKNLKD
T74-p IVKNLKDtLGIGKVK
S85-p GKVKRKPsVPDtAsP
D88 KRKPsVPDtAsPADD
T89-p RKPsVPDtAsPADDs
S91-p PsVPDtAsPADDsFV
S96-p tAsPADDsFVDPGER
Y105-p VDPGERLyDLNMPAF
F112 yDLNMPAFVKFNYMA
S147-p SDGWWRGsyNGQIGW
Y148-p DGWWRGsyNGQIGWF
Y159-p IGWFPSNyVtEEGDs
T161-p WFPSNyVtEEGDsPL
S166-p yVtEEGDsPLGDHVG
S262 LTSGLEPSPPQCDyI
Y268-p PSPPQCDyIRPSLTG
S313 LIRDSESSPNDFSVS
Y339 VQLKETVYCIGQRKF
S347-p CIGQRKFstMEELVE
T348-p IGQRKFstMEELVEH
Y371-p SEQGEKLyLVKHLS_
  rat

 
Y13 VVVAKFDYVAQQEQE
S61 NYVERKNSARKAsIV
S66-p KNSARKAsIVKNLKD
T74 IVKNLKDTLGIGKVK
S85-p GKVKRKPsVPDTASP
D88 KRKPsVPDTASPADD
T89 RKPsVPDTASPADDS
S91 PsVPDTASPADDSFV
S96 TASPADDSFVDPGER
Y105-p VDPGERLyDLNMPAF
F112 yDLNMPAFVKFNYMA
S147 SDGWWRGSYNGQIGW
Y148 DGWWRGSYNGQIGWF
Y159 IGWFPSNYVTEEGDs
T161 WFPSNYVTEEGDsPL
S166-p YVTEEGDsPLGDHVG
S262 LTSGLEPSPPQCDYI
Y268 PSPPQCDYIRPSLTG
S313 LIRDSESSPNDFSVS
Y339 VQLKETVYCIGQRKF
S347-p CIGQRKFsTMEELVE
T348 IGQRKFsTMEELVEH
Y371 SEQGEKLYLVKHLS_
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