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Protein Page:
TUBA4A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TUBA4A Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Belongs to the tubulin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: microtubule; extracellular region; cytosol
Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton
Biological Process: protein polymerization; platelet activation; 'de novo' posttranslational protein folding; cellular protein metabolic process; platelet degranulation; protein folding; mitotic cell cycle; G2/M transition of mitotic cell cycle; blood coagulation; microtubule-based process
Reference #:  P68366 (UniProtKB)
Alt. Names/Synonyms: Alpha-tubulin 1; FLJ30169; H2-ALPHA; TBA4A; Testis-specific alpha-tubulin; TUBA1; TUBA4A; Tubulin alpha-1 chain; Tubulin alpha-4A chain; Tubulin H2-alpha; tubulin, alpha 1 (testis specific); tubulin, alpha 4a
Gene Symbols: TUBA4A
Molecular weight: 49,924 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TUBA4A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 K40 DGQMPSDKtIGGGDD
0 1 T41-p GQMPSDKtIGGGDDs
0 4 S48-p tIGGGDDsFTTFFCE
0 2 K60-u FCETGAGkHVPRAVF
0 4 K96-a PEQLITGkEDAANNy
0 142 K96-u PEQLITGkEDAANNy
0 588 Y103-p kEDAANNyARGHytI
0 21 Y108-p NNyARGHytIGkEII
0 2 T109-p NyARGHytIGkEIID
0 2 K112-a RGHytIGkEIIDPVL
0 23 K112-u RGHytIGkEIIDPVL
0 2 K124-m2 PVLDRIRkLSDQCTG
0 2 K124-u PVLDRIRkLSDQCTG
0 4 S158-p SLLMERLsVDyGkkS
0 51 Y161-p MERLsVDyGkkSkLE
0 29 K163-a RLsVDyGkkSkLEFS
0 86 K163-u RLsVDyGkkSkLEFS
0 28 K164-u LsVDyGkkSkLEFSI
0 22 K166-u VDyGkkSkLEFSIYP
0 29 Y185-p STAVVEPyNSILttH
0 15 T190-p EPyNSILttHTTLEH
0 8 T191-p PyNSILttHTTLEHS
0 386 Y210-p MVDNEAIyDICRRNL
0 34 T223-p NLDIERPtytNLNRL
0 242 Y224-p LDIERPtytNLNRLI
0 3 T225-p DIERPtytNLNRLIs
0 27 S232-p tNLNRLIsQIVSSIT
0 5 Y262-p FQTNLVPyPRIHFPL
0 24 T271-p RIHFPLAtyAPVIsA
0 463 Y272-p IHFPLAtyAPVIsAE
0 17 S277-p AtyAPVIsAEkAyHE
0 3 K280-a APVIsAEkAyHEQLs
0 12 K280-u APVIsAEkAyHEQLs
0 75 Y282-p VIsAEkAyHEQLsVA
0 38 S287-p kAyHEQLsVAEITNA
0 93 K304-u EPANQMVkCDPRHGk
0 19 K311-a kCDPRHGkyMACCLL
0 79 K311-u kCDPRHGkyMACCLL
0 68 Y312-p CDPRHGkyMACCLLy
0 169 Y319-p yMACCLLyRGDVVPk
0 7 K326-u yRGDVVPkDVNAAIA
0 37 K336-u NAAIAAIkTkRsIQF
0 3 K338-u AIAAIkTkRsIQFVD
0 26 S340-p AAIkTkRsIQFVDWC
0 45 K352-a DWCPTGFkVGINyQP
0 42 K352-u DWCPTGFkVGINyQP
0 697 Y357-p GFkVGINyQPPtVVP
0 84 T361-p GINyQPPtVVPGGDL
0 165 K370-u VPGGDLAkVQRAVCM
0 2 S379-p QRAVCMLsNTTAIAE
0 10 K394-a AWARLDHkFDLMyAk
0 121 K394-u AWARLDHkFDLMyAk
0 421 Y399-p DHkFDLMyAkRAFVH
0 19 K401-a kFDLMyAkRAFVHWY
0 117 K401-u kFDLMyAkRAFVHWY
0 20 Y432-p MAALEKDyEEVGIDs
0 2 S439-p yEEVGIDsyEDEDEG
0 1 Y440-p EEVGIDsyEDEDEGE
  mouse

 
K40 DGQMPSDKTIGGGDD
T41 GQMPSDKTIGGGDDS
S48 TIGGGDDSFTTFFCE
K60-u FCETGAGkHVPRAVF
K96 PEQLITGKEDAANNy
K96-u PEQLITGkEDAANNy
Y103-p kEDAANNyARGHYtI
Y108 NNyARGHYtIGkEII
T109-p NyARGHYtIGkEIID
K112 RGHYtIGKEIIDPVL
K112-u RGHYtIGkEIIDPVL
K124 PVLDRIRKLSDQCTG
K124 PVLDRIRKLSDQCTG
S158-p SLLMERLsVDyGkkS
Y161-p MERLsVDyGkkSkLE
K163-a RLsVDyGkkSkLEFS
K163-u RLsVDyGkkSkLEFS
K164-u LsVDyGkkSkLEFSI
K166-u VDyGkkSkLEFSIYP
Y185 STAVVEPYNSILTTH
T190 EPYNSILTTHTTLEH
T191 PYNSILTTHTTLEHS
Y210-p MVDNEAIyDICRRNL
T223-p NLDIERPtytNLNRL
Y224-p LDIERPtytNLNRLI
T225-p DIERPtytNLNRLIs
S232-p tNLNRLIsQIVSSIT
Y262 FQTNLVPYPRIHFPL
T271 RIHFPLATyAPVIsA
Y272-p IHFPLATyAPVIsAE
S277-p ATyAPVIsAEkAYHE
K280 APVIsAEKAYHEQLS
K280-u APVIsAEkAYHEQLS
Y282 VIsAEkAYHEQLSVA
S287 kAYHEQLSVAEITNA
K304-u EPANQMVkCDPRHGk
K311 kCDPRHGKYMACCLL
K311-u kCDPRHGkYMACCLL
Y312 CDPRHGkYMACCLLY
Y319 YMACCLLYRGDVVPk
K326-u YRGDVVPkDVNAAIA
K336-u NAAIAAIkTKRsIQF
K338 AIAAIkTKRsIQFVD
S340-p AAIkTKRsIQFVDWC
K352-a DWCPTGFkVGINyQP
K352-u DWCPTGFkVGINyQP
Y357-p GFkVGINyQPPtVVP
T361-p GINyQPPtVVPGGDL
K370-u VPGGDLAkVQRAVCM
S379 QRAVCMLSNTTAIAE
K394 AWARLDHKFDLMyAk
K394-u AWARLDHkFDLMyAk
Y399-p DHkFDLMyAkRAFVH
K401-a kFDLMyAkRAFVHWY
K401-u kFDLMyAkRAFVHWY
Y432-p MAALEKDyEEVGIDs
S439-p yEEVGIDsYEDEDEG
Y440 EEVGIDsYEDEDEGE
  rat

 
K40-m3 DGQMPSDkTIGGGDD
T41 GQMPSDkTIGGGDDS
S48 TIGGGDDSFTTFFCE
K60 FCETGAGKHVPRAVF
K96 PEQLITGKEDAANNy
K96-u PEQLITGkEDAANNy
Y103-p kEDAANNyARGHYTI
Y108 NNyARGHYTIGkEII
T109 NyARGHYTIGkEIID
K112 RGHYTIGKEIIDPVL
K112-u RGHYTIGkEIIDPVL
K124 PVLDRIRKLSDQCTG
K124 PVLDRIRKLSDQCTG
S158 SLLMERLSVDYGkkS
Y161 MERLSVDYGkkSKLE
K163-a RLSVDYGkkSKLEFS
K163-u RLSVDYGkkSKLEFS
K164-u LSVDYGkkSKLEFSI
K166 VDYGkkSKLEFSIYP
Y185 STAVVEPYNSILTTH
T190 EPYNSILTTHTTLEH
T191 PYNSILTTHTTLEHS
Y210 MVDNEAIYDICRRNL
T223 NLDIERPTyTNLNRL
Y224-p LDIERPTyTNLNRLI
T225 DIERPTyTNLNRLIs
S232-p TNLNRLIsQIVSSIT
Y262 FQTNLVPYPRIHFPL
T271 RIHFPLATyAPVISA
Y272-p IHFPLATyAPVISAE
S277 ATyAPVISAEKAyHE
K280 APVISAEKAyHEQLS
K280 APVISAEKAyHEQLS
Y282-p VISAEKAyHEQLSVA
S287 KAyHEQLSVAEITNA
K304-u EPANQMVkCDPRHGk
K311 kCDPRHGKyMACCLL
K311-u kCDPRHGkyMACCLL
Y312-p CDPRHGkyMACCLLy
Y319-p yMACCLLyRGDVVPk
K326-u yRGDVVPkDVNAAIA
K336-u NAAIAAIkTKRSIQF
K338 AIAAIkTKRSIQFVD
S340 AAIkTKRSIQFVDWC
K352 DWCPTGFKVGINyQP
K352-u DWCPTGFkVGINyQP
Y357-p GFkVGINyQPPTVVP
T361 GINyQPPTVVPGGDL
K370-u VPGGDLAkVQRAVCM
S379 QRAVCMLSNTTAIAE
K394-a AWARLDHkFDLMyAk
K394-u AWARLDHkFDLMyAk
Y399-p DHkFDLMyAkRAFVH
K401-a kFDLMyAkRAFVHWY
K401-u kFDLMyAkRAFVHWY
Y432 MAALEKDYEEVGIDS
S439 YEEVGIDSYEDEDEG
Y440 EEVGIDSYEDEDEGE
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