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TUBA4A (human)

Overview TUBA4A Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Belongs to the tubulin family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: microtubule cytoskeleton; microtubule; extracellular region; cytosol Molecular Function: GTPase activity; GTP binding; structural molecule activity Biological Process: protein polymerization; 'de novo' posttranslational protein folding; platelet activation; cellular protein metabolic process; platelet degranulation; protein folding; mitotic cell cycle; G2/M transition of mitotic cell cycle; blood coagulation; microtubule-based movement Reference #:  P68366 (UniProtKB) Alt. Names/Synonyms: Alpha-tubulin 1; FLJ30169; H2-ALPHA; TBA4A; Testis-specific alpha-tubulin; TUBA1; TUBA4A; Tubulin alpha-1 chain; Tubulin alpha-4A chain; Tubulin H2-alpha; tubulin, alpha 1 (testis specific); tubulin, alpha 4a Gene Symbols: TUBA4A Molecular weight: 49,924 Da Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TUBA4A

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K40-a	DGQMPSDkTIGGGDD
1	1		K40	DGQMPSDKTIGGGDD
0	3		S48-p	TIGGGDDsFTTFFCE
0	2		K60-u	FCETGAGkHVPRAVF
0	1		T73-p	VFVDLEPtVIDEIRN
0	4		K96-a	PEQLITGkEDAANNy
0	142		K96-u	PEQLITGkEDAANNy
0	587		Y103-p	kEDAANNyARGHytI
0	21		Y108-p	NNyARGHytIGkEII
0	2		T109-p	NyARGHytIGkEIID
0	2		K112-a	RGHytIGkEIIDPVL
0	23		K112-u	RGHytIGkEIIDPVL
0	2		K124-m2	PVLDRIRkLSDQCTG
0	2		K124-u	PVLDRIRkLSDQCTG
0	4		S158-p	SLLMERLsVDyGkkS
0	51		Y161-p	MERLsVDyGkkSkLE
0	29		K163-a	RLsVDyGkkSkLEFS
0	86		K163-u	RLsVDyGkkSkLEFS
0	28		K164-u	LsVDyGkkSkLEFSI
0	22		K166-u	VDyGkkSkLEFSIYP
0	29		Y185-p	STAVVEPyNSILttH
0	15		T190-p	EPyNSILttHTTLEH
0	8		T191-p	PyNSILttHTTLEHS
0	386		Y210-p	MVDNEAIyDICRRNL
0	33		T223-p	NLDIERPtytNLNRL
0	241		Y224-p	LDIERPtytNLNRLI
0	2		T225-p	DIERPtytNLNRLIs
0	27		S232-p	tNLNRLIsQIVSSIT
0	5		Y262-p	FQTNLVPyPRIHFPL
0	24		T271-p	RIHFPLAtyAPVIsA
0	461		Y272-p	IHFPLAtyAPVIsAE
0	16		S277-p	AtyAPVIsAEkAyHE
0	3		K280-a	APVIsAEkAyHEQLs
0	12		K280-u	APVIsAEkAyHEQLs
0	75		Y282-p	VIsAEkAyHEQLsVA
0	37		S287-p	kAyHEQLsVAEITNA
0	93		K304-u	EPANQMVkCDPRHGk
0	19		K311-a	kCDPRHGkyMACCLL
0	79		K311-u	kCDPRHGkyMACCLL
0	68		Y312-p	CDPRHGkyMACCLLy
0	169		Y319-p	yMACCLLyRGDVVPk
0	7		K326-u	yRGDVVPkDVNAAIA
0	37		K336-u	NAAIAAIkTkRsIQF
0	3		K338-u	AIAAIkTkRsIQFVD
0	24		S340-p	AAIkTkRsIQFVDWC
0	45		K352-a	DWCPTGFkVGINyQP
0	42		K352-u	DWCPTGFkVGINyQP
0	696		Y357-p	GFkVGINyQPPtVVP
0	84		T361-p	GINyQPPtVVPGGDL
0	165		K370-u	VPGGDLAkVQRAVCM
0	2		S379-p	QRAVCMLsNTTAIAE
0	10		K394-a	AWARLDHkFDLMyAk
0	121		K394-u	AWARLDHkFDLMyAk
0	420		Y399-p	DHkFDLMyAkRAFVH
0	19		K401-a	kFDLMyAkRAFVHWY
0	117		K401-u	kFDLMyAkRAFVHWY
0	20		Y432-p	MAALEKDyEEVGIDs
0	2		S439-p	yEEVGIDsyEDEDEG
0	1		Y440-p	EEVGIDsyEDEDEGE

	mouse
K40	DGQMPSDKTIGGGDD
K40	DGQMPSDKTIGGGDD
S48	TIGGGDDSFTTFFCE
K60-u	FCETGAGkHVPRAVF
T73	VFVDLEPTVIDEIRN
K96	PEQLITGKEDAANNy
K96-u	PEQLITGkEDAANNy
Y103-p	kEDAANNyARGHYtI
Y108	NNyARGHYtIGkEII
T109-p	NyARGHYtIGkEIID
K112	RGHYtIGKEIIDPVL
K112-u	RGHYtIGkEIIDPVL
K124	PVLDRIRKLSDQCTG
K124	PVLDRIRKLSDQCTG
S158-p	SLLMERLsVDyGkkS
Y161-p	MERLsVDyGkkSkLE
K163-a	RLsVDyGkkSkLEFS
K163-u	RLsVDyGkkSkLEFS
K164-u	LsVDyGkkSkLEFSI
K166-u	VDyGkkSkLEFSIYP
Y185	STAVVEPYNSILTTH
T190	EPYNSILTTHTTLEH
T191	PYNSILTTHTTLEHS
Y210-p	MVDNEAIyDICRRNL
T223-p	NLDIERPtytNLNRL
Y224-p	LDIERPtytNLNRLI
T225-p	DIERPtytNLNRLIs
S232-p	tNLNRLIsQIVSSIT
Y262	FQTNLVPYPRIHFPL
T271	RIHFPLATyAPVIsA
Y272-p	IHFPLATyAPVIsAE
S277-p	ATyAPVIsAEkAYHE
K280	APVIsAEKAYHEQLS
K280-u	APVIsAEkAYHEQLS
Y282	VIsAEkAYHEQLSVA
S287	kAYHEQLSVAEITNA
K304-u	EPANQMVkCDPRHGk
K311	kCDPRHGKYMACCLL
K311-u	kCDPRHGkYMACCLL
Y312	CDPRHGkYMACCLLY
Y319	YMACCLLYRGDVVPk
K326-u	YRGDVVPkDVNAAIA
K336-u	NAAIAAIkTKRsIQF
K338	AIAAIkTKRsIQFVD
S340-p	AAIkTKRsIQFVDWC
K352-a	DWCPTGFkVGINyQP
K352-u	DWCPTGFkVGINyQP
Y357-p	GFkVGINyQPPtVVP
T361-p	GINyQPPtVVPGGDL
K370-u	VPGGDLAkVQRAVCM
S379	QRAVCMLSNTTAIAE
K394	AWARLDHKFDLMyAk
K394-u	AWARLDHkFDLMyAk
Y399-p	DHkFDLMyAkRAFVH
K401-a	kFDLMyAkRAFVHWY
K401-u	kFDLMyAkRAFVHWY
Y432-p	MAALEKDyEEVGIDs
S439-p	yEEVGIDsYEDEDEG
Y440	EEVGIDsYEDEDEGE

	rat
K40	DGQMPSDKTIGGGDD
K40-m3	DGQMPSDkTIGGGDD
S48	TIGGGDDSFTTFFCE
K60	FCETGAGKHVPRAVF
T73	VFVDLEPTVIDEIRN
K96	PEQLITGKEDAANNy
K96-u	PEQLITGkEDAANNy
Y103-p	kEDAANNyARGHYTI
Y108	NNyARGHYTIGkEII
T109	NyARGHYTIGkEIID
K112	RGHYTIGKEIIDPVL
K112-u	RGHYTIGkEIIDPVL
K124	PVLDRIRKLSDQCTG
K124	PVLDRIRKLSDQCTG
S158	SLLMERLSVDYGkkS
Y161	MERLSVDYGkkSKLE
K163-a	RLSVDYGkkSKLEFS
K163-u	RLSVDYGkkSKLEFS
K164-u	LSVDYGkkSKLEFSI
K166	VDYGkkSKLEFSIYP
Y185	STAVVEPYNSILTTH
T190	EPYNSILTTHTTLEH
T191	PYNSILTTHTTLEHS
Y210	MVDNEAIYDICRRNL
T223	NLDIERPTyTNLNRL
Y224-p	LDIERPTyTNLNRLI
T225	DIERPTyTNLNRLIs
S232-p	TNLNRLIsQIVSSIT
Y262	FQTNLVPYPRIHFPL
T271	RIHFPLATyAPVISA
Y272-p	IHFPLATyAPVISAE
S277	ATyAPVISAEKAyHE
K280	APVISAEKAyHEQLS
K280	APVISAEKAyHEQLS
Y282-p	VISAEKAyHEQLSVA
S287	KAyHEQLSVAEITNA
K304-u	EPANQMVkCDPRHGk
K311	kCDPRHGKyMACCLL
K311-u	kCDPRHGkyMACCLL
Y312-p	CDPRHGkyMACCLLy
Y319-p	yMACCLLyRGDVVPk
K326-u	yRGDVVPkDVNAAIA
K336-u	NAAIAAIkTKRSIQF
K338	AIAAIkTKRSIQFVD
S340	AAIkTKRSIQFVDWC
K352	DWCPTGFKVGINyQP
K352-u	DWCPTGFkVGINyQP
Y357-p	GFkVGINyQPPTVVP
T361	GINyQPPTVVPGGDL
K370-u	VPGGDLAkVQRAVCM
S379	QRAVCMLSNTTAIAE
K394-a	AWARLDHkFDLMyAk
K394-u	AWARLDHkFDLMyAk
Y399-p	DHkFDLMyAkRAFVH
K401-a	kFDLMyAkRAFVHWY
K401-u	kFDLMyAkRAFVHWY
Y432	MAALEKDYEEVGIDS
S439	YEEVGIDSYEDEDEG
Y440	EEVGIDSYEDEDEGE

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