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CTNND1 iso3 (human)

Overview CTNND1 iso3 an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. A downstream modulator of Wnt/beta-catenin signaling pathway whose stability may be regulated downstream of Dsh. Required for the invasiveness of E-cadherin-deficient cells. A signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during dendritic spine and synapse development. The association of catenins with cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Thirty two splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; G protein regulator, misc.; Actin binding protein; Motility/polarity/chemotaxis; Cell adhesion Cellular Component: cell-cell adherens junction; lamellipodium; cytoplasm; plasma membrane; intercellular junction; midbody; cytosol; nucleus Molecular Function: protein domain specific binding; protein binding; cadherin binding; protein phosphatase binding; receptor binding Biological Process: keratinocyte differentiation; intercellular junction assembly and maintenance; cell-cell adhesion; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; salivary gland morphogenesis; cell adhesion; morphogenesis of a polarized epithelium Reference #:  O60716-3 (UniProtKB) Alt. Names/Synonyms: Cadherin-associated Src substrate; CAS; catenin (cadherin-associated protein), delta 1; Catenin delta-1; CTND1; CTNND; CTNND1; KIAA0384; p120; p120 catenin; p120(cas); p120(ctn); P120CAS; P120CTN Gene Symbols: CTNND1 Molecular weight: 104,977 Da Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling

Select Structure to View Below CTNND1 iso3 3L6X - A=324-937 (human) 3L6Y - A/C/E=324-937 (human)

Scansite  |  Pfam  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	2		S4-p	____MDDsEVESTAS
0	4		K25-u	EQEAQFEkLtRALEE
0	1		T27-p	EAQFEkLtRALEEER
0	1		S38-p	EEERRHVsAQLERVR
0	8		S47-p	QLERVRVsPQDANPL
0	2		P53	VsPQDANPLMANGtL
0	3		T59-p	NPLMANGtLTRRHQN
0	1		K84	RQKFSDLKLNGPQDH
2	740		Y96-p	QDHSHLLystIPRMQ
0	31		S97-p	DHSHLLystIPRMQE
0	4		T98-p	HSHLLystIPRMQEP
2	0		Y112	PGQIVETYTEEDPEG
1	0		S122	EDPEGAMSVVSVETS
0	1		T134-p	ETSDDGTtRRTETTV
0	1		T140	TtRRTETTVKKVVKt
0	1		T147-p	TVKKVVKtVtTRtVQ
0	1		T149-p	KKVVKtVtTRtVQPV
0	1		T150	KVVKtVtTRtVQPVA
0	2		T152-p	VKtVtTRtVQPVAMG
0	1		S168-p	DGLPVDAssVsNNyI
0	6		S169-p	GLPVDAssVsNNyIQ
0	24		S171-p	PVDAssVsNNyIQtL
0	200		Y174-p	AssVsNNyIQtLGRD
0	9		T177-p	VsNNyIQtLGRDFRK
0	1		K184	tLGRDFRKNGNGGPG
0	120		Y193-p	GNGGPGPyVGQAGtA
0	3		T199-p	PyVGQAGtAtLPRNF
0	20		T201-p	VGQAGtAtLPRNFHy
0	12		Y208-p	tLPRNFHyPPDGysR
0	80		Y213-p	FHyPPDGysRHyEDG
0	56		S214-p	HyPPDGysRHyEDGy
1	84		Y217-p	PDGysRHyEDGyPGG
0	89		Y221-p	sRHyEDGyPGGsDNy
0	22		S225-p	EDGyPGGsDNyGsLs
3	1083		Y228-p	yPGGsDNyGsLsRVt
0	368		S230-p	GGsDNyGsLsRVtRI
0	66		S232-p	sDNyGsLsRVtRIEE
0	1		T235-p	yGsLsRVtRIEERyR
0	36		Y241-p	VtRIEERyRPsMEGy
0	15		S244-p	IEERyRPsMEGyRAP
0	198		Y248-p	yRPsMEGyRAPsRQD
1	173		S252-p	MEGyRAPsRQDVyGP
1	722		Y257-p	APsRQDVyGPQPQVR
3	77		S268-p	PQVRVGGssVDLHRF
1	21		S269-p	QVRVGGssVDLHRFH
1	173		Y280-p	HRFHPEPyGLEDDQR
3	39		S288-p	GLEDDQRsMGyDDLD
1	39		Y291-p	DDQRsMGyDDLDyGM
1	121		Y296-p	MGyDDLDyGMMsDyG
0	35		S300-p	DLDyGMMsDyGtARR
1	93		Y302-p	DyGMMsDyGtARRtG
0	7		T304-p	GMMsDyGtARRtGtP
0	6		T308-p	DyGtARRtGtPsDPR
2	29		T310-p	GtARRtGtPsDPRRR
1	3		S312-p	ARRtGtPsDPRRRLR
0	162		S320-p	DPRRRLRsyEDMIGE
0	63		Y321-p	PRRRLRsyEDMIGEE
0	35		S331-p	MIGEEVPsDQyyWAP
0	164		Y334-p	EEVPsDQyyWAPLAQ
0	108		Y335-p	EVPsDQyyWAPLAQH
0	24		S346-p	LAQHERGsLAsLDsL
0	76		S349-p	HERGsLAsLDsLRkG
0	28		S352-p	GsLAsLDsLRkGGPP
0	1		K355-a	AsLDsLRkGGPPPPN
0	28		K355-u	AsLDsLRkGGPPPPN
0	1		K383	GFRLDAVKSNAAAYL
0	3		Y395-p	AYLQHLCyRNDKVKT
0	1		K421	VGLLDHPKKEVHLGA
0	1		K433	LGACGALKNISFGRD
0	1		T469-p	KARDMDLtEVITGTL
0	9		K517-u	REPNEDCkPRHIEWE
0	1		S539-p	GCLRNVSsERsEARR
0	1		S542-p	RNVSsERsEARRKLR
0	1		S587-p	VCLLRNLsyQVHREI
0	2		Y588-p	CLLRNLsyQVHREIP
0	25		Y600-p	EIPQAERyQEAAPNV
0	25		K622-a	AASCFGAkkGKDEWF
0	1		K622	AASCFGAKkGKDEWF
0	2		K623-a	ASCFGAkkGKDEWFS
0	1		K625	CFGAkkGKDEWFSRG
0	2		K633-u	DEWFSRGkkPIEDPA
0	2		K634-u	EWFSRGkkPIEDPAN
0	1		I636	FSRGkkPIEDPANDT
0	1		S651-p	VDFPKRTsPARGyEL
0	1		Y656-p	RTsPARGyELLFQPE
0	1		S670-p	EVVRIYIsLLKEsKT
0	1		S675-p	YIsLLKEsKTPAILE
0	1		K676	IsLLKEsKTPAILEA
0	5		K710-u	RSALRQEkALsAIAD
0	1		S713-p	LRQEkALsAIADLLt
0	2		T720-p	sAIADLLtNEHERVV
0	1		K728	NEHERVVKAAsGALR
0	1		S731-p	ERVVKAAsGALRNLA
0	1		K749	RNKELIGKHAIPNLV
0	1		T774-p	SWNFSEDtVIsILNT
0	1		S777-p	FSEDtVIsILNTINE
0	1		K810	EKLVLINKsGNRSEK
0	1		S811-p	KLVLINKsGNRSEKE
0	1		K846-u	LEKEGWKksDFQVNL
0	5		S847-p	EKEGWKksDFQVNLN
0	6		S857-p	QVNLNNAsRsQssHs
0	4		S859-p	NLNNAsRsQssHsyD
0	8		S861-p	NNAsRsQssHsyDDs
0	6		S862-p	NAsRsQssHsyDDst
0	23		S864-p	sRsQssHsyDDstLP
0	50		Y865-p	RsQssHsyDDstLPL
0	3		S868-p	ssHsyDDstLPLIDR
0	31		T869-p	sHsyDDstLPLIDRN
0	2		K878-u	PLIDRNQksDkkPDR
4	2		S879-p	LIDRNQksDkkPDRE
0	1		K881-u	DRNQksDkkPDREEI
0	1		K882-u	RNQksDkkPDREEIQ
0	2		K898-u	SNMGSNTksLDNNys
0	40		S899-p	NMGSNTksLDNNyst
0	1356		Y904-p	TksLDNNystPNERG
0	24		S905-p	ksLDNNystPNERGD
0	75		T906-p	sLDNNystPNERGDH
2	14		T916-p	ERGDHNRtLDRsGDL
0	15		S920-p	HNRtLDRsGDLGDME
0	2		K930	LGDMEPLKGTTPLMQ
0	19		Y962-p	DEGGQVSyPSMQKI_

	CTNND1 iso3
S4	____MDDSEVESTAS
K25	EQEAQFEKLTRALEE
T27	EAQFEKLTRALEEER
S38	EEERRHVSAQLERVR
S47	QLERVRVSPQDANPL
P53	VSPQDANPLMANGTL
T59	NPLMANGTLTRRHQN
K84	RQKFSDLKLNGPQDH
Y96-p	QDHSHLLySTIPRMQ
S97	DHSHLLySTIPRMQE
T98	HSHLLySTIPRMQEP
Y112	PGQIVETYTEEDPEG
S122	EDPEGAMSVVSVETS
T134	ETSDDGTTRRTETTV
T140	TTRRTETTVKKVVKT
T147	TVKKVVKTVTTRTVQ
T149	KKVVKTVTTRTVQPV
T150	KVVKTVTTRTVQPVA
T152	VKTVTTRTVQPVAMG
S168	DGLPVDASSVSNNyI
S169	GLPVDASSVSNNyIQ
S171	PVDASSVSNNyIQTL
Y174-p	ASSVSNNyIQTLGRD
T177	VSNNyIQTLGRDFRK
K184	TLGRDFRKNGNGGPG
Y193-p	GNGGPGPyVGQAGTA
T199	PyVGQAGTATLPRNF
T201	VGQAGTATLPRNFHY
Y208	TLPRNFHYPPDGySR
Y213-p	FHYPPDGySRHyEDG
S214	HYPPDGySRHyEDGy
Y217-p	PDGySRHyEDGyPGG
Y221-p	SRHyEDGyPGGSDNy
S225	EDGyPGGSDNyGSLS
Y228-p	yPGGSDNyGSLSRVT
S230	GGSDNyGSLSRVTRI
S232	SDNyGSLSRVTRIEE
T235	yGSLSRVTRIEERyR
Y241-p	VTRIEERyRPSMEGy
S244	IEERyRPSMEGyRAP
Y248-p	yRPSMEGyRAPsRQD
S252-p	MEGyRAPsRQDVyGP
Y257-p	APsRQDVyGPQPQVR
S268-p	PQVRVGGssVDLHRF
S269-p	QVRVGGssVDLHRFH
Y280-p	HRFHPEPyGLEDDQR
S288	GLEDDQRSMGyDDLD
Y291-p	DDQRSMGyDDLDyGM
Y296-p	MGyDDLDyGMMSDyG
S300	DLDyGMMSDyGTARR
Y302-p	DyGMMSDyGTARRtG
T304	GMMSDyGTARRtGtP
T308-p	DyGTARRtGtPSDPR
T310-p	GTARRtGtPSDPRRR
S312	ARRtGtPSDPRRRLR
S320-p	DPRRRLRsyEDMIGE
Y321-p	PRRRLRsyEDMIGEE
S331-p	MIGEEVPsDQyyWAP
Y334-p	EEVPsDQyyWAPLAQ
Y335-p	EVPsDQyyWAPLAQH
S346	LAQHERGSLASLDSL
S349	HERGSLASLDSLRKG
S352	GSLASLDSLRKGGPP
K355	ASLDSLRKGGPPPPN
K355	ASLDSLRKGGPPPPN
K383	GFRLDAVKSNAAAYL
Y395	AYLQHLCYRNDKVKT
K421	VGLLDHPKKEVHLGA
K433	LGACGALKNISFGRD
T469	KARDMDLTEVITGTL
K517	REPNEDCKPRHIEWE
S539	GCLRNVSSERSEARR
S542	RNVSSERSEARRKLR
S587	VCLLRNLSYQVHREI
Y588	CLLRNLSYQVHREIP
Y600-p	EIPQAERyQEAAPNV
K622-a	AASCFGAkKGKDEWF
K622	AASCFGAKKGKDEWF
K623	ASCFGAkKGKDEWFS
K625	CFGAkKGKDEWFSRG
K633	DEWFSRGKKPIEDPA
K634	EWFSRGKKPIEDPAN
I636	FSRGKKPIEDPANDT
S651	VDFPKRTSPARGYEL
Y656	RTSPARGYELLFQPE
S670	EVVRIYISLLKESKT
S675	YISLLKESKTPAILE
K676	ISLLKESKTPAILEA
K710	RSALRQEKALSAIAD
S713	LRQEKALSAIADLLT
T720	SAIADLLTNEHERVV
K728	NEHERVVKAASGALR
S731	ERVVKAASGALRNLA
K749	RNKELIGKHAIPNLV
T774	SWNFSEDTVISILNT
S777	FSEDTVISILNTINE
K810	EKLVLINKSGNRSEK
S811	KLVLINKSGNRSEKE
K846	LEKEGWKKSDFQVNL
S847	EKEGWKKSDFQVNLN
S857	QVNLNNASRSQSSHS
S859	NLNNASRSQSSHSyD
S861	NNASRSQSSHSyDDS
S862	NASRSQSSHSyDDST
S864	SRSQSSHSyDDSTLP
Y865-p	RSQSSHSyDDSTLPL
S868	SSHSyDDSTLPLIDR
T869	SHSyDDSTLPLIDRN
K878	PLIDRNQKSDKKPDR
S879	LIDRNQKSDKKPDRE
K881	DRNQKSDKKPDREEI
K882	RNQKSDKKPDREEIQ
K898	SNMGSNTKSLDNNyS
S899	NMGSNTKSLDNNySt
Y904-p	TKSLDNNyStPNERG
S905	KSLDNNyStPNERGD
T906-p	SLDNNyStPNERGDH
T916-p	ERGDHNRtLDRsGDL
S920-p	HNRtLDRsGDLGDME
K930-u	LGDMEPLkGTTPLMQ
-	gap

	CTNND1 iso4
S4	____MDDSEVESTAS
K25	EQEAQFEKLTRALEE
T27	EAQFEKLTRALEEER
S38	EEERRHVSAQLERVR
S47	QLERVRVSPQDANPL
P53	VSPQDANPLMANGTL
T59	NPLMANGTLTRRHQN
K84	RQKFSDLKLNGPQDH
Y96-p	QDHSHLLySTIPRMQ
S97	DHSHLLySTIPRMQE
T98	HSHLLySTIPRMQEP
Y112	PGQIVETYTEEDPEG
S122	EDPEGAMSVVSVETS
T134	ETSDDGTTRRTETTV
T140	TTRRTETTVKKVVKT
T147	TVKKVVKTVTTRTVQ
T149	KKVVKTVTTRTVQPV
T150	KVVKTVTTRTVQPVA
T152	VKTVTTRTVQPVAMG
S168	DGLPVDASSVSNNyI
S169	GLPVDASSVSNNyIQ
S171	PVDASSVSNNyIQTL
Y174-p	ASSVSNNyIQTLGRD
T177	VSNNyIQTLGRDFRK
K184	TLGRDFRKNGNGGPG
Y193-p	GNGGPGPyVGQAGTA
T199	PyVGQAGTATLPRNF
T201	VGQAGTATLPRNFHY
Y208	TLPRNFHYPPDGySR
Y213-p	FHYPPDGySRHyEDG
S214	HYPPDGySRHyEDGy
Y217-p	PDGySRHyEDGyPGG
Y221-p	SRHyEDGyPGGSDNy
S225	EDGyPGGSDNyGSLS
Y228-p	yPGGSDNyGSLSRVT
S230	GGSDNyGSLSRVTRI
S232	SDNyGSLSRVTRIEE
T235	yGSLSRVTRIEERyR
Y241-p	VTRIEERyRPSMEGy
S244	IEERyRPSMEGyRAP
Y248-p	yRPSMEGyRAPsRQD
S252-p	MEGyRAPsRQDVyGP
Y257-p	APsRQDVyGPQPQVR
S268	PQVRVGGSSVDLHRF
S269	QVRVGGSSVDLHRFH
Y280-p	HRFHPEPyGLEDDQR
S288	GLEDDQRSMGyDDLD
Y291-p	DDQRSMGyDDLDyGM
Y296-p	MGyDDLDyGMMSDyG
S300	DLDyGMMSDyGTARR
Y302-p	DyGMMSDyGTARRtG
T304	GMMSDyGTARRtGtP
T308-p	DyGTARRtGtPSDPR
T310-p	GTARRtGtPSDPRRR
S312	ARRtGtPSDPRRRLR
S320-p	DPRRRLRsyEDMIGE
Y321-p	PRRRLRsyEDMIGEE
S331-p	MIGEEVPsDQyyWAP
Y334-p	EEVPsDQyyWAPLAQ
Y335-p	EVPsDQyyWAPLAQH
S346	LAQHERGSLASLDSL
S349	HERGSLASLDSLRKG
S352	GSLASLDSLRKGGPP
K355	ASLDSLRKGGPPPPN
K355	ASLDSLRKGGPPPPN
K383	GFRLDAVKSNAAAYL
Y395	AYLQHLCYRNDKVKT
K421	VGLLDHPKKEVHLGA
K433	LGACGALKNISFGRD
T469	KARDMDLTEVITGTL
K517	REPNEDCKPRHIEWE
S539	GCLRNVSSERSEARR
S542	RNVSSERSEARRKLR
S587	VCLLRNLSYQVHREI
Y588	CLLRNLSYQVHREIP
Y600-p	EIPQAERyQEAAPNV
K622-a	AASCFGAkKGKDEWF
K622	AASCFGAKKGKDEWF
K623	ASCFGAkKGKDEWFS
K625	CFGAkKGKDEWFSRG
K633	DEWFSRGKKPIEDPA
K634	EWFSRGKKPIEDPAN
I636	FSRGKKPIEDPANDT
S651	VDFPKRTSPARGYEL
Y656	RTSPARGYELLFQPE
S670	EVVRIYISLLKESKT
S675	YISLLKESKTPAILE
K676	ISLLKESKTPAILEA
K710	RSALRQEKALSAIAD
S713	LRQEKALSAIADLLT
T720	SAIADLLTNEHERVV
K728	NEHERVVKAASGALR
S731	ERVVKAASGALRNLA
K749	RNKELIGKHAIPNLV
T774	SWNFSEDTVISILNT
S777	FSEDTVISILNTINE
K810	EKLVLINKSGNRSEK
S811	KLVLINKSGNRSEKE
K846	LEKEGWKKSDFQVNL
S847	EKEGWKKSDFQVNLN
S857	QVNLNNASRSQSSHS
S859	NLNNASRSQSSHSyD
S861	NNASRSQSSHSyDDS
S862	NASRSQSSHSyDDST
S864	SRSQSSHSyDDSTLP
Y865-p	RSQSSHSyDDSTLPL
S868	SSHSyDDSTLPLIDR
T869	SHSyDDSTLPLIDRN
K878	PLIDRNQKSDDNNyS
S879	LIDRNQKSDDNNySt
-	gap
-	gap
-	gap
-	gap
Y884-p	QKSDDNNyStPNERG
S885	KSDDNNyStPNERGD
T886-p	SDDNNyStPNERGDH
T896	ERGDHNRTLDRSGDL
S900	HNRTLDRSGDLGDME
K910	LGDMEPLKGTTPLMQ
Y942-p	DEGGQVSyPSMQKI_

	CTNND1 iso14
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
Y11	PGQIVETYTEEDPEG
S21	EDPEGAMSVVSVETS
T33	ETSDDGTTRRTETTV
T39	TTRRTETTVKKVVKT
T46	TVKKVVKTVTTRTVQ
T48	KKVVKTVTTRTVQPV
T49	KVVKTVTTRTVQPVA
T51	VKTVTTRTVQPVAMG
S67	DGLPVDASSVSNNYI
S68	GLPVDASSVSNNYIQ
S70	PVDASSVSNNYIQTL
Y73	ASSVSNNYIQTLGRD
T76	VSNNYIQTLGRDFRK
K83	TLGRDFRKNGNGGPG
Y92	GNGGPGPYVGQAGTA
T98	PYVGQAGTATLPRNF
T100	VGQAGTATLPRNFHY
Y107	TLPRNFHYPPDGYSR
Y112	FHYPPDGYSRHYEDG
S113	HYPPDGYSRHYEDGY
Y116	PDGYSRHYEDGYPGG
Y120	SRHYEDGYPGGSDNY
S124	EDGYPGGSDNYGSLS
Y127	YPGGSDNYGSLSRVT
S129	GGSDNYGSLSRVTRI
S131	SDNYGSLSRVTRIEE
T134	YGSLSRVTRIEERYR
Y140	VTRIEERYRPSMEGY
S143	IEERYRPSMEGYRAP
Y147	YRPSMEGYRAPSRQD
S151	MEGYRAPSRQDVYGP
Y156	APSRQDVYGPQPQVR
S167	PQVRVGGSSVDLHRF
S168	QVRVGGSSVDLHRFH
Y179	HRFHPEPYGLEDDQR
S187	GLEDDQRSMGYDDLD
Y190	DDQRSMGYDDLDYGM
Y195	MGYDDLDYGMMSDYG
S199	DLDYGMMSDYGTARR
Y201	DYGMMSDYGTARRTG
T203	GMMSDYGTARRTGTP
T207	DYGTARRTGTPSDPR
T209	GTARRTGTPSDPRRR
S211	ARRTGTPSDPRRRLR
S219	DPRRRLRSYEDMIGE
Y220	PRRRLRSYEDMIGEE
S230	MIGEEVPSDQYYWAP
Y233	EEVPSDQYYWAPLAQ
Y234	EVPSDQYYWAPLAQH
S245	LAQHERGSLASLDSL
S248	HERGSLASLDSLRKG
S251	GSLASLDSLRKGGPP
K254	ASLDSLRKGGPPPPN
K254	ASLDSLRKGGPPPPN
K282	GFRLDAVKSNAAAYL
Y294	AYLQHLCYRNDKVKT
K320	VGLLDHPKKEVHLGA
K332	LGACGALKNISFGRD
T368	KARDMDLTEVITGTL
K416	REPNEDCKPRHIEWE
S438	GCLRNVSSERSEARR
S441	RNVSSERSEARRKLR
S486	VCLLRNLSYQVHREI
Y487	CLLRNLSYQVHREIP
Y499	EIPQAERYQEAAPNV
K521	AASCFGAKKGKGKKP
K521	AASCFGAKKGKGKKP
K522	ASCFGAKKGKGKKPI
K524	CFGAKKGKGKKPIED
K526	GAKKGKGKKPIEDPA
K527	AKKGKGKKPIEDPAN
I529	KGKGKKPIEDPANDT
S544	VDFPKRTSPARGYEL
Y549	RTSPARGYELLFQPE
S563	EVVRIYISLLKESKT
S568	YISLLKESKTPAILE
K569	ISLLKESKTPAILEA
K603	RSALRQEKALSAIAD
S606	LRQEKALSAIADLLT
T613	SAIADLLTNEHERVV
K621	NEHERVVKAASGALR
S624	ERVVKAASGALRNLA
K642	RNKELIGKHAIPNLV
T667	SWNFSEDTVISILNT
S670	FSEDTVISILNTINE
K703	EKLVLINKSGNRSEK
S704	KLVLINKSGNRSEKE
K739	LEKEGWKKSDFQVNL
S740	EKEGWKKSDFQVNLN
S750	QVNLNNASRSQSSHS
S752	NLNNASRSQSSHSYD
S754	NNASRSQSSHSYDDS
S755	NASRSQSSHSYDDST
S757	SRSQSSHSYDDSTLP
Y758	RSQSSHSYDDSTLPL
S761	SSHSYDDSTLPLIDR
T762	SHSYDDSTLPLIDRN
K771	PLIDRNQKSDNNyST
S772	LIDRNQKSDNNySTP
-	gap
-	gap
-	gap
-	gap
Y776-p	NQKSDNNySTPNERG
S777	QKSDNNySTPNERGD
T778	KSDNNySTPNERGDH
T788	ERGDHNRTLDRSGDL
S792	HNRTLDRSGDLGDME
K802	LGDMEPLKGTTPLMQ
Y834	DEGGQVSYPSMQKI_

	mouse ► Hide Isoforms
S4	____MDDSEVESTAS
K25-u	EQEAQFEkLTRALEE
T27	EAQFEkLTRALEEER
S38	EEERRHVSAQLERVR
S47-p	QLERVRVsPQDANsL
S53-p	VsPQDANsLMANGtL
T59-p	NsLMANGtLTRRHQN
K84-u	RQKFSDLkLNGPQDH
Y96-p	QDHNHLLysTIPRMQ
S97-p	DHNHLLysTIPRMQE
T98	HNHLLysTIPRMQEP
Y112-p	PGQIVETyTEEDPEG
S122-p	EDPEGAMsVVSVETT
T134	ETTDDGTTRRTETtV
T140-p	TTRRTETtVKKVVKT
T147	tVKKVVKTMTtRTVQ
T149	KKVVKTMTtRTVQPV
T150-p	KVVKTMTtRTVQPVP
T152	VKTMTtRTVQPVPMG
S168	DGLPVDASAVSNNyI
A169	GLPVDASAVSNNyIQ
S171	PVDASAVSNNyIQTL
Y174-p	ASAVSNNyIQTLGRD
T177	VSNNyIQTLGRDFRk
K184-u	TLGRDFRkNGNGGPG
Y193-p	GNGGPGPyVGQAGTA
T199	PyVGQAGTAtLPRNF
T201-p	VGQAGTAtLPRNFHY
Y208	tLPRNFHYPPDGYGR
Y213	FHYPPDGYGRHyEDG
G214	HYPPDGYGRHyEDGy
Y217-p	PDGYGRHyEDGyPGG
Y221-p	GRHyEDGyPGGsDNy
S225-p	EDGyPGGsDNyGsLs
Y228-p	yPGGsDNyGsLsRVT
S230-p	GGsDNyGsLsRVTRI
S232-p	sDNyGsLsRVTRIEE
T235	yGsLsRVTRIEERyR
Y241-p	VTRIEERyRPsMEGy
S244-p	IEERyRPsMEGyRAP
Y248-p	yRPsMEGyRAPsRQD
S252-p	MEGyRAPsRQDVyGP
Y257-p	APsRQDVyGPQPQVR
S268-p	PQVRVGGssVDLHRF
S269-p	QVRVGGssVDLHRFH
Y280-p	HRFHPEPyGLEDDQR
S288-p	GLEDDQRsMGyDDLD
Y291-p	DDQRsMGyDDLDyGM
Y296-p	MGyDDLDyGMMsDyG
S300-p	DLDyGMMsDyGtARR
Y302-p	DyGMMsDyGtARRtG
T304-p	GMMsDyGtARRtGtP
T308-p	DyGtARRtGtPsDPR
T310-p	GtARRtGtPsDPRRR
S312-p	ARRtGtPsDPRRRLR
S320-p	DPRRRLRsyEDMIGE
Y321-p	PRRRLRsyEDMIGEE
P331	MIGEEVPPDQyyWAP
Y334-p	EEVPPDQyyWAPLAQ
Y335-p	EVPPDQyyWAPLAQH
S346-p	LAQHERGsLAsLDsL
S349-p	HERGsLAsLDsLRkG
S352-p	GsLAsLDsLRkGMPP
K355	AsLDsLRKGMPPPSN
K355-u	AsLDsLRkGMPPPSN
K383-u	GFRLDAVkSNAAAYL
Y395	AYLQHLCYRNDKVKT
K421-u	VGLLDHPkKEVHLGA
K433-u	LGACGALkNISFGRD
T469	KARDMDLTEVITGTL
K517-u	REPNEDCkPRHIEWE
S539	GCLRNVSSERSEARR
S542	RNVSSERSEARRKLR
S587	VCLLRNLSYQVHREI
Y588	CLLRNLSYQVHREIP
Y600	EIPQAERYQEALPTV
K622-a	AASCFGAkkGkDEWF
K622-u	AASCFGAkkGkDEWF
K623-a	ASCFGAkkGkDEWFS
K625-a	CFGAkkGkDEWFSRG
K633-u	DEWFSRGkkPtEDPA
K634-u	EWFSRGkkPtEDPAN
T636-p	FSRGkkPtEDPANDT
S651	VDFPKRTSPARGYEL
Y656	RTSPARGYELLFQPE
S670	EVVRIYISLLKESkT
S675	YISLLKESkTPAILE
K676-u	ISLLKESkTPAILEA
K710-u	RSALRQEkALsAIAE
S713-p	LRQEkALsAIAELLT
T720	sAIAELLTSEHERVV
K728-u	SEHERVVkAASGALR
S731	ERVVkAASGALRNLA
K749-u	RNKELIGkHAIPNLV
T774	SWNFSEDTVVSILNT
S777	FSEDTVVSILNTINE
K810-u	EKLVLINkSGNRSEK
S811	KLVLINkSGNRSEKE
K846	LEKEGWKKsDFQVNL
S847-p	EKEGWKKsDFQVNLN
S857-p	QVNLNNAsRsQssHs
S859-p	NLNNAsRsQssHsyD
S861-p	NNAsRsQssHsyDDs
S862-p	NAsRsQssHsyDDst
S864-p	sRsQssHsyDDstLP
Y865-p	RsQssHsyDDstLPL
S868-p	ssHsyDDstLPLIDR
T869-p	sHsyDDstLPLIDRN
K878	PLIDRNQKsDKKPDR
S879-p	LIDRNQKsDKKPDRE
K881	DRNQKsDKKPDREEI
K882	RNQKsDKKPDREEIP
K898-u	SNMGSNTksLDNNys
S899-p	NMGSNTksLDNNyst
Y904-p	TksLDNNystLNERG
S905-p	ksLDNNystLNERGD
T906-p	sLDNNystLNERGDH
T916-p	ERGDHNRtLDRsGDL
S920-p	HNRtLDRsGDLGDME
K930-u	LGDMEPLkGAPLMQK
-	gap

	CTNND1 iso3
S4	____MDDSEVESTAS
K25	EQEAQFEKLTRALEE
T27	EAQFEKLTRALEEER
S38	EEERRHVSAQLERVR
S47-p	QLERVRVsPQDANsL
S53-p	VsPQDANsLMANGtL
T59-p	NsLMANGtLTRRHQN
K84	RQKFSDLKLNGPQDH
Y96-p	QDHNHLLySTIPRMQ
S97	DHNHLLySTIPRMQE
T98	HNHLLySTIPRMQEP
Y112	PGQIVETYTEEDPEG
S122	EDPEGAMSVVSVETT
T134	ETTDDGTTRRTETTV
T140	TTRRTETTVKKVVKT
T147	TVKKVVKTMTTRTVQ
T149	KKVVKTMTTRTVQPV
T150	KVVKTMTTRTVQPVP
T152	VKTMTTRTVQPVPMG
S168	DGLPVDASAVSNNyI
A169	GLPVDASAVSNNyIQ
S171	PVDASAVSNNyIQTL
Y174-p	ASAVSNNyIQTLGRD
T177	VSNNyIQTLGRDFRK
K184	TLGRDFRKNGNGGPG
Y193-p	GNGGPGPyVGQAGTA
T199	PyVGQAGTATLPRNF
T201	VGQAGTATLPRNFHY
Y208	TLPRNFHYPPDGYGR
Y213	FHYPPDGYGRHyEDG
G214	HYPPDGYGRHyEDGy
Y217-p	PDGYGRHyEDGyPGG
Y221-p	GRHyEDGyPGGsDNy
S225-p	EDGyPGGsDNyGsLs
Y228-p	yPGGsDNyGsLsRVT
S230-p	GGsDNyGsLsRVTRI
S232-p	sDNyGsLsRVTRIEE
T235	yGsLsRVTRIEERYR
Y241	VTRIEERYRPSMEGY
S244	IEERYRPSMEGYRAP
Y248	YRPSMEGYRAPsRQD
S252-p	MEGYRAPsRQDVyGP
Y257-p	APsRQDVyGPQPQVR
S268-p	PQVRVGGssVDLHRF
S269-p	QVRVGGssVDLHRFH
Y280-p	HRFHPEPyGLEDDQR
S288-p	GLEDDQRsMGyDDLD
Y291-p	DDQRsMGyDDLDyGM
Y296-p	MGyDDLDyGMMsDyG
S300-p	DLDyGMMsDyGtARR
Y302-p	DyGMMsDyGtARRTG
T304-p	GMMsDyGtARRTGTP
T308	DyGtARRTGTPSDPR
T310	GtARRTGTPSDPRRR
S312	ARRTGTPSDPRRRLR
S320-p	DPRRRLRsyEDMIGE
Y321-p	PRRRLRsyEDMIGEE
P331	MIGEEVPPDQyyWAP
Y334-p	EEVPPDQyyWAPLAQ
Y335-p	EVPPDQyyWAPLAQH
S346-p	LAQHERGsLAsLDsL
S349-p	HERGsLAsLDsLRKG
S352-p	GsLAsLDsLRKGMPP
K355	AsLDsLRKGMPPPSN
K355	AsLDsLRKGMPPPSN
K383	GFRLDAVKSNAAAYL
Y395	AYLQHLCYRNDKVKT
K421	VGLLDHPKKEVHLGA
K433	LGACGALKNISFGRD
T469	KARDMDLTEVITGTL
K517	REPNEDCKPRHIEWE
S539	GCLRNVSSERSEARR
S542	RNVSSERSEARRKLR
S587	VCLLRNLSYQVHREI
Y588	CLLRNLSYQVHREIP
Y600	EIPQAERYQEALPTV
K622	AASCFGAKKGKDEWF
K622	AASCFGAKKGKDEWF
K623	ASCFGAKKGKDEWFS
K625	CFGAKKGKDEWFSRG
K633	DEWFSRGKKPTEDPA
K634	EWFSRGKKPTEDPAN
T636	FSRGKKPTEDPANDT
S651	VDFPKRTSPARGYEL
Y656	RTSPARGYELLFQPE
S670	EVVRIYISLLKESKT
S675	YISLLKESKTPAILE
K676	ISLLKESKTPAILEA
K710	RSALRQEKALsAIAE
S713-p	LRQEKALsAIAELLT
T720	sAIAELLTSEHERVV
K728	SEHERVVKAASGALR
S731	ERVVKAASGALRNLA
K749	RNKELIGKHAIPNLV
T774	SWNFSEDTVVSILNT
S777	FSEDTVVSILNTINE
K810	EKLVLINKSGNRSEK
S811	KLVLINKSGNRSEKE
K846	LEKEGWKKsDFQVNL
S847-p	EKEGWKKsDFQVNLN
S857-p	QVNLNNAsRsQssHs
S859-p	NLNNAsRsQssHsyD
S861-p	NNAsRsQssHsyDDs
S862-p	NAsRsQssHsyDDst
S864-p	sRsQssHsyDDstLP
Y865-p	RsQssHsyDDstLPL
S868-p	ssHsyDDstLPLIDR
T869-p	sHsyDDstLPLIDRN
K878-u	PLIDRNQkSDNNyst
S879	LIDRNQkSDNNystL
-	gap
-	gap
-	gap
-	gap
Y883-p	NQkSDNNystLNERG
S884-p	QkSDNNystLNERGD
T885-p	kSDNNystLNERGDH
T895	ERGDHNRTLDRsGDL
S899-p	HNRTLDRsGDLGDME
K909	LGDMEPLKGAPLMQK
-	gap

	rat
S4	____MDDSEVESTAS
K25	EQEAQFEKLTRALEE
T27	EAQFEKLTRALEEER
S38	EEERRHVSAQLERVR
S47	QLERVRVSPQDANsL
S53-p	VSPQDANsLMANGtL
T59-p	NsLMANGtLTRRHQN
K84	RQKFSDLKLNGPQDH
Y96-p	QDHNHLLysTIPRMQ
S97-p	DHNHLLysTIPRMQE
T98	HNHLLysTIPRMQEP
Y112	PGQIVETYTEEDPEG
S122	EDPEGAMSVVSVETS
T134	ETSDDGTTRRTETTV
T140	TTRRTETTVKKVVKT
T147	TVKKVVKTMTTRTVQ
T149	KKVVKTMTTRTVQPV
T150	KVVKTMTTRTVQPVP
T152	VKTMTTRTVQPVPMG
S168	DGLPVDASAVSNNYI
A169	GLPVDASAVSNNYIQ
S171	PVDASAVSNNYIQTL
Y174	ASAVSNNYIQTLGRD
T177	VSNNYIQTLGRDFRK
K184	TLGRDFRKNGNGGPG
Y193	GNGGPGPYVGQAGtA
T199-p	PYVGQAGtATLPRNF
T201	VGQAGtATLPRNFHY
Y208	TLPRNFHYPPDGYGR
Y213	FHYPPDGYGRHYEDG
G214	HYPPDGYGRHYEDGy
Y217	PDGYGRHYEDGyPGG
Y221-p	GRHYEDGyPGGSDNy
S225	EDGyPGGSDNyGsLs
Y228-p	yPGGSDNyGsLsRVT
S230-p	GGSDNyGsLsRVTRI
S232-p	SDNyGsLsRVTRIEE
T235	yGsLsRVTRIEERYR
Y241	VTRIEERYRPSMEGy
S244	IEERYRPSMEGyRAP
Y248-p	YRPSMEGyRAPsRQD
S252-p	MEGyRAPsRQDVyGP
Y257-p	APsRQDVyGPQPQVR
S268-p	PQVRVGGsSVDLHRF
S269	QVRVGGsSVDLHRFH
Y280	HRFHPEPYGLEDDQR
S288	GLEDDQRSMGYDDLD
Y291	DDQRSMGYDDLDyGM
Y296-p	MGYDDLDyGMMSDYG
S300	DLDyGMMSDYGTARR
Y302	DyGMMSDYGTARRTG
T304	GMMSDYGTARRTGtP
T308	DYGTARRTGtPSDPR
T310-p	GTARRTGtPSDPRRR
S312	ARRTGtPSDPRRRLR
S320-p	DPRRRLRsYEDMIGE
Y321	PRRRLRsYEDMIGEE
P331	MIGEEVPPDQYYWAP
Y334	EEVPPDQYYWAPLAQ
Y335	EVPPDQYYWAPLAQH
S346-p	LAQHERGsLAsLDsL
S349-p	HERGsLAsLDsLRKG
S352-p	GsLAsLDsLRKGMPP
K355	AsLDsLRKGMPPPPN
K355	AsLDsLRKGMPPPPN
K383	GFRLDAVKSNAAAYL
Y395	AYLQHLCYRNDKVKT
K421	VGLLDHPKKEVHLGA
K433	LGACGALKNISFGRD
T469	KARDMDLTEVITGTL
K517	REPNEDCKPRHIEWE
S539	GCLRNVSSERSEARR
S542	RNVSSERSEARRKLR
S587	VCLLRNLSYQVHREI
Y588	CLLRNLSYQVHREIP
Y600	EIPQAERYQEALPSV
K622	AASCFGAKKGKDEWF
K622	AASCFGAKKGKDEWF
K623	ASCFGAKKGKDEWFS
K625	CFGAKKGKDEWFSRG
K633	DEWFSRGKKPTEDPA
K634	EWFSRGKKPTEDPAN
T636	FSRGKKPTEDPANDT
S651	VDFPKRTSPARGYEL
Y656	RTSPARGYELLFQPE
S670	EVVRIYISLLKESKT
S675	YISLLKESKTPAILE
K676	ISLLKESKTPAILEA
K710	RSALRQEKALSAIAD
S713	LRQEKALSAIADLLT
T720	SAIADLLTSEHERVV
K728	SEHERVVKAASGALR
S731	ERVVKAASGALRNLA
K749	RNKELIGKHAIPNLV
T774	SWNFSEDTVVSILNT
S777	FSEDTVVSILNTINE
K810	EKLVLINKSGNRSEK
S811	KLVLINKSGNRSEKE
K846	LEKEGWKKSDFQVNL
S847	EKEGWKKSDFQVNLN
S857	QVNLNNASRSQSSHS
S859	NLNNASRSQSSHSYD
S861	NNASRSQSSHSYDDS
S862	NASRSQSSHSYDDST
S864	SRSQSSHSYDDSTLP
Y865	RSQSSHSYDDSTLPL
S868	SSHSYDDSTLPLIDR
T869	SHSYDDSTLPLIDRN
K878	PLIDRNQKSDKKPDR
S879	LIDRNQKSDKKPDRE
K881	DRNQKSDKKPDREEI
K882	RNQKSDKKPDREEIP
K898	SNMGSNTKsLDNNys
S899-p	NMGSNTKsLDNNyst
Y904-p	TKsLDNNystLNERG
S905-p	KsLDNNystLNERGD
T906-p	sLDNNystLNERGDH
T916	ERGDHNRTLDRsGDL
S920-p	HNRTLDRsGDLGDME
K930	LGDMEPLKGAPLMQK
-	gap

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