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4E-BP2 (human)

Overview 4E-BP2 eukaryotic translation initiation factor 4E binding protein 2 Note: This description may include information from UniProtKB. Protein type: Translation initiation; Translation Molecular Function: protein binding; eukaryotic initiation factor 4E binding Biological Process: cAMP-mediated signaling; negative regulation of translational initiation; translation; insulin receptor signaling pathway Reference #:  Q13542 (UniProtKB) Alt. Names/Synonyms: 4E-BP2; 4EBP2; eIF4E-binding protein 2; EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2; Eukaryotic translation initiation factor 4E-binding protein 2; PHASII; phosphorylated, heat and acid stable regulated by insulin protein II Gene Symbols: EIF4EBP2 Molecular weight: 12,939 Da Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below 4E-BP2 3AM7 - B=47-65 (human)

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S4-p	____MSSsAGSGHQP
0	1		S25-p	PTRTVAIsDAAQLPH
0	74		Y34-p	AAQLPHDyCttPGGt
0	18		T36-p	QLPHDyCttPGGtLF
1	57		T37-p	LPHDyCttPGGtLFs
0	9		T41-p	yCttPGGtLFsttPG
0	15		S44-p	tPGGtLFsttPGGtR
0	14		T45-p	PGGtLFsttPGGtRI
1	84		T46-p	GGtLFsttPGGtRII
0	4		T50-p	FsttPGGtRIIyDRK
0	4		Y54-p	PGGtRIIyDRKFLLD
0	5		S65-p	FLLDRRNsPMAQtPP
0	7		T70-p	RNsPMAQtPPCHLPN

	mouse
S4	____MSASAGGSHQP
S25	PTRTVAISDAAQLPQ
Y34-p	AAQLPQDyCttPGGt
T36-p	QLPQDyCttPGGtLF
T37-p	LPQDyCttPGGtLFs
T41-p	yCttPGGtLFsttPG
S44-p	tPGGtLFsttPGGtR
T45-p	PGGtLFsttPGGtRI
T46-p	GGtLFsttPGGtRII
T50-p	FsttPGGtRIIyDRK
Y54-p	PGGtRIIyDRKFLLD
S65-p	FLLDRRNsPMAQtPP
T70-p	RNsPMAQtPPCHLPN

	rat
S4	____MSASAGGGHQP
S25	PTRTVAISDAAQLPQ
Y34	AAQLPQDYCTtPGGT
T36	QLPQDYCTtPGGTLF
T37-p	LPQDYCTtPGGTLFs
T41	YCTtPGGTLFsTtPG
S44-p	tPGGTLFsTtPGGTR
T45	PGGTLFsTtPGGTRI
T46-p	GGTLFsTtPGGTRII
T50	FsTtPGGTRIIYDRK
Y54	PGGTRIIYDRKFLLD
S65	FLLDRRNSPMAQTPP
T70	RNSPMAQTPPCHLPN

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