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Protein Page:
ARRB2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ARRB2 a member of the arrestin/beta-arrestin protein family. These proteins participate in agonist-mediated desensitization of G-protein-coupled receptors. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Expressed at high levels in the CNS and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: postsynaptic membrane; basolateral plasma membrane; endocytic vesicle; postsynaptic density; cytoplasm; dendritic spine; plasma membrane; coated pit; cytoplasmic vesicle; nucleus; cytosol
Molecular Function: angiotensin receptor binding; protein kinase B binding; protein domain specific binding; follicle stimulating hormone receptor binding; type 2A serotonin receptor binding; alpha-1B adrenergic receptor binding; alpha-1A adrenergic receptor binding; protein binding; enzyme binding; G-protein-coupled receptor binding; ubiquitin protein ligase binding; protein complex binding; mitogen-activated protein kinase binding; type 1 angiotensin receptor binding; protein complex scaffold; D1 dopamine receptor binding; receptor binding
Biological Process: transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; follicle-stimulating hormone signaling pathway; positive regulation of apoptosis; positive regulation of receptor internalization; protein ubiquitination; adult walking behavior; protein transport; receptor internalization; transforming growth factor beta receptor signaling pathway; negative regulation of interleukin-6 production; DNA fragmentation during apoptosis; detection of temperature stimulus involved in sensory perception of pain; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; platelet activation; Notch signaling pathway; negative regulation of interleukin-12 production; negative regulation of natural killer cell mediated cytotoxicity; positive regulation of synaptic transmission, dopaminergic; negative regulation of interleukin-1 beta production; negative regulation of tumor necrosis factor production; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; G-protein coupled receptor internalization; inhibition of NF-kappaB transcription factor; positive regulation of protein ubiquitination; negative regulation of toll-like receptor signaling pathway; negative regulation of protein ubiquitination; brain development; blood coagulation; positive regulation of calcium ion transport
Reference #:  P32121 (UniProtKB)
Alt. Names/Synonyms: ARB2; ARR2; ARRB2; arrestin 3; Arrestin beta-2; arrestin, beta 2; BARR2; Beta-arrestin-2; DKFZp686L0365
Gene Symbols: ARRB2
Molecular weight: 46,106 Da
Basal Isoelectric point: 7.59  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ARRB2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S13-p GTRVFKKssPNCKLt
0 1 S14-p TRVFKKssPNCKLtV
1 0 K18 KKssPNCKLtVYLGK
0 1 T20-p ssPNCKLtVYLGKRD
0 74 Y48-p VVLVDPDyLKDRKVF
0 1 S75 DLDVLGLSFRkDLFI
0 1 K78-ub VLGLSFRkDLFIATY
1 0 R107 RLQDRLLRKLGQHAH
1 0 K108 LQDRLLRKLGQHAHP
0 1 S159-p AKSLEEKsHKRNSVR
1 0 K178 KVQFAPEKPGPQPSA
0 1 K178-ub KVQFAPEkPGPQPSA
0 2 S197 HFLMSDRSLHLEASL
1 0 K206 HLEASLDKELYYHGE
0 1 K230-ac NNSTKTVkkIkVSVR
0 1 K231-ac NSTKTVkkIkVSVRQ
0 1 K233-ac TKTVkkIkVSVRQYA
1 0 K293 RGLALDGKLKHEDTN
1 0 K295 LALDGKLKHEDTNLA
1 0 K295 LALDGKLKHEDTNLA
1 0 S360 IPLPRPQSAAPETDV
3 2 T382-p EFDTNYAtDDDIVFE
1 0 K397 DFARLRLKGMKDDDy
1 0 K400 RLRLKGMKDDDyDDQ
0 268 Y404-p KGMKDDDyDDQLC__
  mouse

 
S13 GTRVFKKSSPNCkLT
S14 TRVFKKSSPNCkLTV
K18-ub KKSSPNCkLTVYLGK
T20 SSPNCkLTVYLGKRD
Y48-p VVLVDPDyLKDRKVF
S75-p DLDVLGLsFRKDLFI
K78 VLGLsFRKDLFIATY
K107-ub RLQDRLLkkLGQHAH
K108-ub LQDRLLkkLGQHAHP
S159 AKSIEEKSHKRNSVR
T178 KVQFAPETPGPQPSA
T178 KVQFAPETPGPQPSA
S198-p FLMSDRRsLHLEASL
K207-ub HLEASLDkELYYHGE
K231 NNSAKTVKKIRVSVR
K232 NSAKTVKKIRVSVRQ
R234 AKTVKKIRVSVRQYA
Q294 RGLALDGQLkHEDTN
K296 LALDGQLKHEDTNLA
K296-ub LALDGQLkHEDTNLA
S361-p ITLPRPQsAPRETDV
T383-p EFDTNYAtDDDIVFE
K398 DFARLRLKGMKDDDC
K401 RLRLKGMKDDDCDDQ
C405 KGMKDDDCDDQFC__
  rat

 
S13 GTRVFKKSSPNCKLT
S14 TRVFKKSSPNCKLTV
K18 KKSSPNCKLTVYLGK
T20 SSPNCKLTVYLGKRD
Y48-p VVLVDPDyLKDRKVF
S75-p DLDVLGLsFRKDLFI
K78 VLGLsFRKDLFIATY
K107 RLQDRLLKKLGQHAH
K108 LQDRLLKKLGQHAHP
S159 AKSIEEKSHKRNSVR
T178-p KVQFAPEtPGPQPSA
T178 KVQFAPETPGPQPSA
S198 FLMSDRRSLHLEASL
K207 HLEASLDKELYYHGE
K231 NNSAKTVKKIRVSVR
K232 NSAKTVKKIRVSVRQ
R234 AKTVKKIRVSVRQYA
Q294 RGLALDGQLKHEDTN
K296 LALDGQLKHEDTNLA
K296 LALDGQLKHEDTNLA
S361-p ITLPRPQsAPREIDI
T383 EFDTNYATDDDIVFE
K398 DFARLRLKGMKDDDC
K401 RLRLKGMKDDDCDDQ
C405 KGMKDDDCDDQFC__
  cow

► Hide Isoforms
 
S13 GTRVFKKSSPNCKLT
S14 TRVFKKSSPNCKLTV
K18 KKSSPNCKLTVYLGK
T20 SSPNCKLTVYLGKRD
Y48 VVLVDPDYLKDRKVF
S75 DLDVLGLSFRKDLFI
K78 VLGLSFRKDLFIANY
R107 RLQERLLRKLGQHAH
K108 LQERLLRKLGQHAHP
S159 AKSLEEKSHKRNSVR
K178 KVQFAPEKPGPQPSA
K178 KVQFAPEKPGPQPSA
S197 HFLMSDRSLHLEASL
K206 HLEASLDKELYYHGE
K230 NNSTKTVKKIKVSVR
K231 NSTKTVKKIKVSVRQ
K233 TKTVKKIKVSVRQYA
K293 RGLALDGKLKHEDTN
K295 LALDGKLKHEDTNLA
K295 LALDGKLKHEDTNLA
S371 HPPTLLPSAVPETDA
T393 EFETNYATDDDIVFE
K408 DFARLRLKGLKDEDY
K411 RLRLKGLKDEDYDDQ
Y415 KGLKDEDYDDQFC__
  ARRB2 iso2  
S13 GTRVFKKSSPNCKLT
S14 TRVFKKSSPNCKLTV
K18 KKSSPNCKLTVYLGK
T20 SSPNCKLTVYLGKRD
Y48 VVLVDPDYLKDRKVF
S75 DLDVLGLSFRKDLFI
K78 VLGLSFRKDLFIANY
R107 RLQERLLRKLGQHAH
K108 LQERLLRKLGQHAHP
S159 AKSLEEKSHKRNSVR
K178 KVQFAPEKPGPQPSA
K178 KVQFAPEKPGPQPSA
S197 HFLMSDRSLHLEASL
K206 HLEASLDKELYYHGE
K230 NNSTKTVKKIKVSVR
K231 NSTKTVKKIKVSVRQ
K233 TKTVKKIKVSVRQYA
K293-sm RGLALDGkLkHEDTN
K295-sm LALDGkLkHEDTNLA
K295 LALDGkLKHEDTNLA
S360 IALPRPQSAAPETDA
T382-p EFETNYAtDDDIVFE
K397-sm DFARLRLkGLkDEDY
K400-sm RLRLkGLkDEDYDDQ
Y404 kGLkDEDYDDQFC__
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