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ARRB2 (human)

Overview ARRB2 a member of the arrestin/beta-arrestin protein family. These proteins participate in agonist-mediated desensitization of G-protein-coupled receptors. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Expressed at high levels in the CNS and peripheral blood leukocytes. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; coated pit; cytoplasmic vesicle; nucleus; cytosol Molecular Function: angiotensin receptor binding; protein kinase B binding; protein binding; G-protein-coupled receptor binding; ubiquitin protein ligase binding; protein complex scaffold; receptor binding Biological Process: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; transcription from RNA polymerase II promoter; platelet activation; proteasomal ubiquitin-dependent protein catabolic process; regulation of protein amino acid phosphorylation; negative regulation of interleukin-12 production; Notch signaling pathway; negative regulation of natural killer cell mediated cytotoxicity; positive regulation of synaptic transmission, dopaminergic; protein ubiquitination; negative regulation of interleukin-1 beta production; negative regulation of tumor necrosis factor production; adult walking behavior; positive regulation of protein kinase B signaling cascade; protein transport; G-protein coupled receptor internalization; inhibition of NF-kappaB transcription factor; positive regulation of protein ubiquitination; receptor internalization; transforming growth factor beta receptor signaling pathway; negative regulation of interleukin-6 production; negative regulation of toll-like receptor signaling pathway; negative regulation of protein ubiquitination; blood coagulation Reference #:  P32121 (UniProtKB) Alt. Names/Synonyms: ARB2; ARR2; ARRB2; arrestin 3; Arrestin beta-2; arrestin, beta 2; BARR2; Beta-arrestin-2; DKFZp686L0365 Gene Symbols: ARRB2 Molecular weight: 46,106 Da Basal Isoelectric point: 7.59  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  Hedgehog Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ARRB2 3P2D - A/B=1-393 (cow)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S13-p	GTRVFKKssPNCKLt
0	1		S14-p	TRVFKKssPNCKLtV
1	0		K18	KKssPNCKLtVYLGK
0	1		T20-p	ssPNCKLtVYLGKRD
0	70		Y48-p	VVLVDPDyLKDRKVF
0	1		K78-u	VLGLSFRkDLFIATY
1	0		R107	RLQDRLLRKLGQHAH
1	0		K108	LQDRLLRKLGQHAHP
0	1		S159-p	AKSLEEKsHKRNSVR
0	1		K178-u	KVQFAPEkPGPQPSA
0	2		S197	HFLMSDRSLHLEASL
1	0		K206	HLEASLDKELYYHGE
0	1		K230-a	NNSTKTVkkIkVSVR
0	1		K231-a	NSTKTVkkIkVSVRQ
0	1		K233-a	TKTVkkIkVSVRQYA
1	0		K293	RGLALDGKLKHEDTN
1	0		K295	LALDGKLKHEDTNLA
1	0		K295	LALDGKLKHEDTNLA
1	0		S360	IPLPRPQSAAPETDV
3	2		T382-p	EFDTNYAtDDDIVFE
1	0		K397	DFARLRLKGMKDDDy
1	0		K400	RLRLKGMKDDDyDDQ
0	297		Y404-p	KGMKDDDyDDQLC__

	mouse
S13	GTRVFKKSSPNCkLT
S14	TRVFKKSSPNCkLTV
K18-u	KKSSPNCkLTVYLGK
T20	SSPNCkLTVYLGKRD
Y48-p	VVLVDPDyLKDRKVF
K78	VLGLSFRKDLFIATY
K107-u	RLQDRLLkkLGQHAH
K108-u	LQDRLLkkLGQHAHP
S159	AKSIEEKSHKRNSVR
T178	KVQFAPETPGPQPSA
S198-p	FLMSDRRsLHLEASL
K207-u	HLEASLDkELYYHGE
K231	NNSAKTVKKIRVSVR
K232	NSAKTVKKIRVSVRQ
R234	AKTVKKIRVSVRQYA
Q294	RGLALDGQLkHEDTN
K296	LALDGQLKHEDTNLA
K296-u	LALDGQLkHEDTNLA
S361-p	ITLPRPQsAPRETDV
T383-p	EFDTNYAtDDDIVFE
K398	DFARLRLKGMKDDDC
K401	RLRLKGMKDDDCDDQ
C405	KGMKDDDCDDQFC__

	rat
S13	GTRVFKKSSPNCKLT
S14	TRVFKKSSPNCKLTV
K18	KKSSPNCKLTVYLGK
T20	SSPNCKLTVYLGKRD
Y48-p	VVLVDPDyLKDRKVF
K78	VLGLSFRKDLFIATY
K107	RLQDRLLKKLGQHAH
K108	LQDRLLKKLGQHAHP
S159	AKSIEEKSHKRNSVR
T178	KVQFAPETPGPQPSA
S198	FLMSDRRSLHLEASL
K207	HLEASLDKELYYHGE
K231	NNSAKTVKKIRVSVR
K232	NSAKTVKKIRVSVRQ
R234	AKTVKKIRVSVRQYA
Q294	RGLALDGQLKHEDTN
K296	LALDGQLKHEDTNLA
K296	LALDGQLKHEDTNLA
S361	ITLPRPQSAPREIDI
T383	EFDTNYATDDDIVFE
K398	DFARLRLKGMKDDDC
K401	RLRLKGMKDDDCDDQ
C405	KGMKDDDCDDQFC__

	cow ► Hide Isoforms
S13	GTRVFKKSSPNCKLT
S14	TRVFKKSSPNCKLTV
K18	KKSSPNCKLTVYLGK
T20	SSPNCKLTVYLGKRD
Y48	VVLVDPDYLKDRKVF
K78	VLGLSFRKDLFIANY
R107	RLQERLLRKLGQHAH
K108	LQERLLRKLGQHAHP
S159	AKSLEEKSHKRNSVR
K178	KVQFAPEKPGPQPSA
S197	HFLMSDRSLHLEASL
K206	HLEASLDKELYYHGE
K230	NNSTKTVKKIKVSVR
K231	NSTKTVKKIKVSVRQ
K233	TKTVKKIKVSVRQYA
K293	RGLALDGKLKHEDTN
K295	LALDGKLKHEDTNLA
K295	LALDGKLKHEDTNLA
S371	HPPTLLPSAVPETDA
T393	EFETNYATDDDIVFE
K408	DFARLRLKGLKDEDY
K411	RLRLKGLKDEDYDDQ
Y415	KGLKDEDYDDQFC__

	ARRB2 iso2
S13	GTRVFKKSSPNCKLT
S14	TRVFKKSSPNCKLTV
K18	KKSSPNCKLTVYLGK
T20	SSPNCKLTVYLGKRD
Y48	VVLVDPDYLKDRKVF
K78	VLGLSFRKDLFIANY
R107	RLQERLLRKLGQHAH
K108	LQERLLRKLGQHAHP
S159	AKSLEEKSHKRNSVR
K178	KVQFAPEKPGPQPSA
S197	HFLMSDRSLHLEASL
K206	HLEASLDKELYYHGE
K230	NNSTKTVKKIKVSVR
K231	NSTKTVKKIKVSVRQ
K233	TKTVKKIKVSVRQYA
K293-s	RGLALDGkLkHEDTN
K295-s	LALDGkLkHEDTNLA
K295	LALDGkLKHEDTNLA
S360	IALPRPQSAAPETDA
T382-p	EFETNYAtDDDIVFE
K397-s	DFARLRLkGLkDEDY
K400-s	RLRLkGLkDEDYDDQ
Y404	kGLkDEDYDDQFC__

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