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UBE1 (human)

Overview UBE1 an enzyme of the ubiquitin-activating E1 family. Adenylates ubiquitin at its carboxy-terminal glycine residue and thereafter links this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester. There are two active sites within the E1 molecule, allowing it to accomodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. Complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. Note: This description may include information from UniProtKB. Protein type: Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19 Molecular Function: protein binding; small protein activating enzyme activity; ATP binding; ligase activity Biological Process: cell death; protein ubiquitination Reference #:  P22314 (UniProtKB) Alt. Names/Synonyms: A1S9; A1S9T; A1S9T and BN75 temperature sensitivity complementing; A1ST; AMCX1; GXP1; MGC4781; POC20; POC20 centriolar protein homolog; Protein A1S9; SMAX2; UBA1; UBA1, ubiquitin-activating enzyme E1 homolog A; UBA1A; UBE1; UBE1X; Ubiquitin-activating enzyme E1; ubiquitin-like modifier activating enzyme 1; Ubiquitin-like modifier-activating enzyme 1 Gene Symbols: UBA1 Molecular weight: 117,849 Da Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below UBE1 1Z7L - A/B/C=626-891 (mouse) 2V31 - A=203-312 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
2	1		S4-p	____MSSsPLSKKRR
0	26		S13-p	LSKKRRVsGPDPKPG
0	5		S21-p	GPDPKPGsNCsPAQS
0	5		S24-p	PKPGsNCsPAQSVLS
0	2		S28	sNCsPAQSVLSEVPS
0	1		S31	sPAQSVLSEVPSVPT
0	24		S46-p	NGMAKNGsEADIDEG
0	416		Y55-p	ADIDEGLysRQLyVL
0	2		S56-p	DIDEGLysRQLyVLG
0	8		Y60-p	GLysRQLyVLGHEAM
0	1		K68-a	VLGHEAMkRLQTSSV
0	3		K68-u	VLGHEAMkRLQTSSV
0	9		K89-a	GLGVEIAkNIILGGV
0	2		K89-u	GLGVEIAkNIILGGV
0	1		S140-p	PRLAELNsYVPVTAY
0	19		K185-u	FCHNRGIkLVVADtR
0	1		T191-p	IkLVVADtRGLFGQL
0	1		Y273-p	EIKVLGPytFSICDT
0	1		T274-p	IKVLGPytFSICDTS
0	1		S281	tFSICDTSNFsDyIR
0	1		S284-p	ICDTSNFsDyIRGGI
0	1		Y286-p	DTSNFsDyIRGGIVs
0	1		S293-p	yIRGGIVsQVkVPKK
0	2		K296-u	GGIVsQVkVPKKISF
0	1		K299	VsQVkVPKKISFksL
0	3		K304-u	VPKKISFksLVAsLA
0	2		S305-p	PKKISFksLVAsLAE
0	1		S309-p	SFksLVAsLAEPDFV
0	1		T318-p	AEPDFVVtDFAkFSR
0	2		K322-u	FVVtDFAkFSRPAQL
0	1		Q374	ARALPAVQQNNLDED
0	1		N377	LPAVQQNNLDEDLIR
0	3		K385-u	LDEDLIRkLAyVAAG
0	17		Y388-p	DLIRkLAyVAAGDLA
0	2		K411-u	LAAQEVMkACSGkFM
0	1		K416-u	VMkACSGkFMPIMQW
0	2		K443-u	KEVLTEDkCLQRQNR
0	10		K465-u	FGSDLQEkLGkQkYF
0	3		K468-u	DLQEkLGkQkYFLVG
0	1		K470-a	QEkLGkQkYFLVGAG
0	16		K470-u	QEkLGkQkYFLVGAG
0	2		K526-u	FRPWDVTkLkSDTAA
0	9		K528-u	PWDVTkLkSDTAAAA
0	7		Y560-p	GPDTERIyDDDFFQN
0	3		Y590-p	YMDRRCVyYRkPLLE
0	1		K593-a	RRCVyYRkPLLESGT
0	71		K593-u	RRCVyYRkPLLESGT
0	1		T603-p	LESGTLGtkGNVQVV
0	1		K604-a	ESGTLGtkGNVQVVI
0	33		K604-u	ESGTLGtkGNVQVVI
0	35		K627-u	SSQDPPEkSIPICTL
0	114		K635-u	SIPICTLkNFPNAIE
0	30		K657-u	DEFEGLFkQPAENVN
0	1		P670	VNQYLTDPkFVERTL
0	2		K671-a	NQYLTDPkFVERTLR
0	17		K671-u	NQYLTDPkFVERTLR
0	1		T682-p	RTLRLAGtQPLEVLE
0	73		K746-u	APFWSGPkRCPHPLT
0	1		S781-p	QTYGLTGsQDRAAVA
0	5		T800-p	SVQVPEFtPkSGVkI
0	8		K802-u	QVPEFtPkSGVkIHV
0	11		K806-u	FtPkSGVkIHVsDQE
0	11		S810-p	SGVkIHVsDQELQsA
0	7		S816-p	VsDQELQsANAsVDD
0	6		S820-p	ELQsANAsVDDsRLE
0	1		S824-p	ANAsVDDsRLEELKA
0	14		S835-p	ELKATLPsPDkLPGF
0	3		K838-u	ATLPsPDkLPGFkMY
0	2		K843-u	PDkLPGFkMYPIDFE
0	1		S866-p	MDFIVAAsNLRAENy
0	15		Y873-p	sNLRAENyDIPSADR
0	2		P876	RAENyDIPSADRHKS
0	1		K882	IPSADRHKSKLIAGk
0	1		S883	PSADRHKSKLIAGkI
0	28		K889-u	KSKLIAGkIIPAIAT
0	4		K923-u	HRQLDSYkNGFLNLA
0	1		K980-a	KQFLDYFkTEHKLEI
0	1		K980-u	KQFLDYFkTEHKLEI
0	4		K1024-a	EIVSRVSkRKLGRHV

	mouse
S4	____MSSSPLSKKRR
S13-p	LSKKRRVsGPDPKPG
S21-p	GPDPKPGsNCsPAQs
S24-p	PKPGsNCsPAQsALs
S28-p	sNCsPAQsALsEVSS
S31-p	sPAQsALsEVSSVPT
S46-p	NGMAKNGsEADIDES
Y55-p	ADIDESLySRQLYVL
S56	DIDESLySRQLYVLG
Y60	SLySRQLYVLGHEAM
K68	VLGHEAMKMLQTSSV
K68	VLGHEAMKMLQTSSV
K89	GLGVEIAKNIILGGV
K89	GLGVEIAKNIILGGV
S140	PRLAELNSYVPVTAY
K185-u	FCHSRGIkLVVADTR
T191	IkLVVADTRGLFGQL
Y273	EIKVLGPYTFSICDT
T274	IKVLGPYTFSICDTs
S281-p	TFSICDTsNFSDYIR
S284	ICDTsNFSDYIRGGI
Y286	DTsNFSDYIRGGIVS
S293	YIRGGIVSQVkVPkK
K296-u	GGIVSQVkVPkKISF
K299-u	VSQVkVPkKISFkSL
K304-u	VPkKISFkSLPASLV
S305	PkKISFkSLPASLVE
S309	SFkSLPASLVEPDFV
T318	VEPDFVMTDFAkYSR
K322-u	FVMTDFAkYSRPAQL
K374-u	ARSPPSVkQNsLDED
S377-p	PPSVkQNsLDEDLIR
K385-u	LDEDLIRkLAyVAAG
Y388-p	DLIRkLAyVAAGDLA
K411	LAAQEVMKACSGKFM
K416	VMKACSGKFMPIMQW
K443-u	KEALTEEkCLPRQNR
K465-u	FGSDFQEkLSKQKYF
K468	DFQEkLSKQKYFLVG
K470	QEkLSKQKYFLVGAG
K470	QEkLSKQKYFLVGAG
K526-u	FRPWDVTkLkSDTAA
K528-u	PWDVTkLkSDTAAAA
Y560	GPDTERIYDDDFFQN
Y590	YMDRRCVYYRkPLLE
K593	RRCVYYRKPLLESGT
K593-u	RRCVYYRkPLLESGT
T603	LESGTLGTkGNVQVV
K604	ESGTLGTKGNVQVVI
K604-u	ESGTLGTkGNVQVVI
K627-u	SSQDPPEkSIPICTL
K635-u	SIPICTLkNFPNAIE
K657-u	DEFEGLFkQPAENVN
S670-p	VNQYLTDskFVERTL
K671	NQYLTDsKFVERTLR
K671-u	NQYLTDskFVERTLR
T682	RTLRLAGTQPLEVLE
K746-u	APFWSGPkRCPHPLT
S781	QTYGLTGSQDRAAVA
T800-p	SVQVPEFtPkSGVkI
K802-u	QVPEFtPkSGVkIHV
K806-u	FtPkSGVkIHVsDQE
S810-p	SGVkIHVsDQELQsA
S816-p	VsDQELQsANAsVDD
S820-p	ELQsANAsVDDSRLE
S824	ANAsVDDSRLEELKA
S835-p	ELKATLPsPDkLPGF
K838-u	ATLPsPDkLPGFkMY
K843-u	PDkLPGFkMYPIDFE
S866	MDFIVAASNLRAENY
Y873	SNLRAENYDIsPADR
S876-p	RAENYDIsPADRHks
K882-u	IsPADRHksKLIAGk
S883-p	sPADRHksKLIAGkI
K889-u	ksKLIAGkIIPAIAT
K923-u	HQQLDSYkNGFLNLA
K980	KQFLDYFKTEHKLEI
K980	KQFLDYFKTEHKLEI
K1024	EIVSRVSKRKLGRHV

	rat
S4	____MSSSPLSKKRR
S13-p	LSKKRRVsGPDPKPG
S21	GPDPKPGSNCSSAQS
S24	PKPGSNCSSAQSVLS
S28	SNCSSAQSVLSEVSS
S31	SSAQSVLSEVSSVPT
S46-p	NGMAKNGsEADIDES
Y55	ADIDESLYSRQLYVL
S56	DIDESLYSRQLYVLG
Y60	SLYSRQLYVLGHEAM
K68	VLGHEAMKMLQTSSV
K68	VLGHEAMKMLQTSSV
K89	GLGVEIAKNIILGGV
K89	GLGVEIAKNIILGGV
S140	PRLAELNSYVPVTAY
K185	FCHSRGIKLVVADTR
T191	IKLVVADTRGLFGQL
Y273	EIKVLGPYTFSICDT
T274	IKVLGPYTFSICDTS
S281	TFSICDTSNFSDYIR
S284	ICDTSNFSDYIRGGI
Y286	DTSNFSDYIRGGIVS
S293	YIRGGIVSQVKVPKK
K296	GGIVSQVKVPKKISF
K299	VSQVKVPKKISFKSL
K304	VPKKISFKSLPASLA
S305	PKKISFKSLPASLAE
S309	SFKSLPASLAEPDFV
T318	AEPDFVMTDFAKYSR
K322	FVMTDFAKYSRPAQL
Q374	ARSPPAVQQDNVDED
N377	PPAVQQDNVDEDLIR
K385	VDEDLIRKLAyVAAG
Y388-p	DLIRKLAyVAAGDLA
K411	LAAQEVMKACSGKFM
K416	VMKACSGKFMPIMQW
K443	KEALTEDKCLPRQNR
K465	FGSDLQEKLGKQKYF
K468	DLQEKLGKQKYFLVG
K470	QEKLGKQKYFLVGAG
K470	QEKLGKQKYFLVGAG
K526	FRPWDVTKLKSDTAA
K528	PWDVTKLKSDTAAAA
Y560	GPDTERIYDDDFFQN
Y590	YMDRRCVYYRKPLLE
K593	RRCVYYRKPLLESGT
K593	RRCVYYRKPLLESGT
T603	LESGTLGTKGNVQVV
K604	ESGTLGTKGNVQVVI
K604	ESGTLGTKGNVQVVI
K627	SSQDPPEKSIPICTL
K635	SIPICTLKNFPNAIE
K657	DEFEGLFKQPAENVN
S670	VNQYLTDSKFVERTL
K671	NQYLTDSKFVERTLR
K671	NQYLTDSKFVERTLR
T682	RTLRLAGTQPLEVLE
K746	APFWSGPKRCPHPLT
S781	QTYGLTGSQDRAAVA
T800	SVQVPEFTPKSGVKI
K802	QVPEFTPKSGVKIHV
K806	FTPKSGVKIHVSDQE
S810	SGVKIHVSDQELQsA
S816-p	VSDQELQsANAsVDD
S820-p	ELQsANAsVDDSRLE
S824	ANAsVDDSRLEELKA
S835	ELKATLPSPDKLPGF
K838	ATLPSPDKLPGFKMY
K843	PDKLPGFKMYPIDFE
S866	MDFIVAASNLRAENy
Y873-p	SNLRAENyDISPADR
S876	RAENyDISPADRHKS
K882	ISPADRHKSKLIAGK
S883	SPADRHKSKLIAGKI
K889	KSKLIAGKIIPAIAT
K923	HQQLDSYKNGFLNLA
K980	KQFLDYFKTEHKLEI
K980	KQFLDYFKTEHKLEI
K1024	EIVSRVSKRKLGRHV

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