the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Receptor, misc.; Membrane protein, integral
Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; mitochondrion; basolateral plasma membrane; recycling endosome membrane; integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; melanosome; plasma membrane; endosome; external side of plasma membrane
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity; chaperone binding; double-stranded RNA binding; Hsp70 protein binding; transferrin transmembrane transporter activity; glycoprotein binding
Biological Process: receptor-mediated endocytosis; response to retinoic acid; viral reproduction; cellular iron ion homeostasis; transferrin transport; osteoclast differentiation; regulation of cell proliferation; response to manganese ion; response to copper ion; response to hypoxia; acute-phase response; positive regulation of bone resorption; regulation of cell growth; response to iron ion; transmembrane transport; response to nutrient; aging
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.