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TNFRSF11A (human)

Overview TNFRSF11A Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2. Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: integral to membrane; external side of plasma membrane Molecular Function: protein binding; tumor necrosis factor receptor activity; transmembrane receptor activity; cytokine binding; metal ion binding; receptor activity Biological Process: positive regulation of JNK activity; circadian thermoregulation; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to lipopolysaccharide; osteoclast differentiation; signal transduction; activation of NF-kappaB transcription factor; monocyte chemotaxis; cell-cell signaling; tumor necrosis factor-mediated signaling pathway; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of transcription factor activity Reference #:  Q9Y6Q6 (UniProtKB) Alt. Names/Synonyms: CD265; FEO; LOH18CR1; loss of heterozygosity, 18, chromosomal region 1; ODFR; OFE; OPTB7; Osteoclast differentiation factor receptor; OSTS; PDB2; RANK; Receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; TNFRSF11A; TNR11; TRANCER; Tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily, member 11a, activator of NFKB; tumor necrosis factor receptor superfamily, member 11a, NFKB activator Gene Symbols: TNFRSF11A Molecular weight: 66,034 Da Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TNFRSF11A 3ME2 - R=26-210 (mouse) 3ME4 - A/B=26-210 (mouse) 3QBQ - D/B=32-201 (mouse) 4GIQ - R=31-198 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE 174810 259500 602080 603499 612301  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y40	PCTSEKHYEHLGRCC
0	1		S197	SDAVCSSSLPARKPP
0	1		S463-p	DCEPLVGsPKRGPLP
0	9		S580-p	ETLARRDsFAGNGPR

	mouse
Y41	PCTQERHYEHLGRCC
S198-p	SDVVCSSsMTLRRPP
S457	DHEPFPGSLKCGPLP
S571	ETLAHRDSFAGTAPR

	rat
Y41-p	PCTQERHyEHLGRCC
S198	SDVVCSSSLTLIKPP
S457	DHEPLPGSLKCGPLP
S579	ETLAHRDSFAGTAPR

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