Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2. Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: integral to membrane; external side of plasma membrane
Molecular Function: protein binding; tumor necrosis factor receptor activity; transmembrane receptor activity; cytokine binding; metal ion binding; receptor activity
Biological Process: positive regulation of JNK activity; circadian thermoregulation; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to lipopolysaccharide; osteoclast differentiation; signal transduction; activation of NF-kappaB transcription factor; monocyte chemotaxis; cell-cell signaling; tumor necrosis factor-mediated signaling pathway; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of transcription factor activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.