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Protein Page:
TFAM (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TFAM regulates mitochondrial transcription. Induced in humans by caloric restriction. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Involved in cisplatin resistance. Interacts with TFB1M and TFB2M. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation; DNA binding protein
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: protein binding; heat shock protein binding; chromatin binding; transcription factor activity; DNA bending activity
Biological Process: mitochondrial respiratory chain complex assembly; regulation of transcription from RNA polymerase I promoter; positive regulation of transcription, DNA-dependent; gene expression; DNA-dependent DNA replication; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter
Reference #:  Q00059 (UniProtKB)
Alt. Names/Synonyms: Mitochondrial transcription factor 1; mitochondrial transcription factor A; MtTF1; mtTFA; TCF-6; TCF6; TCF6L1; TCF6L2; TCF6L3; TFAM; Transcription factor 6; Transcription factor 6-like 2; Transcription factor 6-like 2 (mitochondrial transcription factor); Transcription factor A, mitochondrial
Gene Symbols: TFAM
Molecular weight: 29,097 Da
Basal Isoelectric point: 9.74  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TFAM

Protein Structure Not Found.


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Sites Implicated In
transcription, inhibited: S55‑p
intracellular localization: S55‑p
protein degradation: S55‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K52-u VLASCPKkPVssYLR
1 2 S55-p SCPKkPVssYLRFsk
1 1 S56-p CPKkPVssYLRFskE
1 1 S61-p VssYLRFskEQLPIF
0 1 K62-u ssYLRFskEQLPIFK
0 1 K76-u KAQNPDAkTTELIRR
0 1 K118-u KEEISRFkEQLtPsQ
1 4 T122-p SRFkEQLtPsQIMsL
1 6 S124-p FkEQLtPsQIMsLEK
0 1 S128-p LtPsQIMsLEKEIMD
1 1 S160-p GKPKRPRsAYNVYVA
0 5 S193-p KENWKNLsDsEKELY
0 2 S195-p NWKNLsDsEKELYIQ
0 1 - gap
  mouse

 
K51 SMGSYPKKPMSSYLR
S54 SYPKKPMSSYLRFST
S55 YPKKPMSSYLRFSTE
S60 MSSYLRFSTEQLPKF
T61 SSYLRFSTEQLPKFK
K75 KAKHPDAKLSELVRK
K117 KEAVSKYKEQLTPSQ
T121 SKYKEQLTPSQLMGM
S123 YKEQLTPSQLMGMEK
G127 LTPSQLMGMEKEARQ
S159 GKPKRPRSAYNIYVS
S192 NEAWKNLSPEEKQAY
E194 AWKNLSPEEKQAYIQ
S241-p VKRSGDIsEH_____
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