regulates mitochondrial transcription. Induced in humans by caloric restriction. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Involved in cisplatin resistance. Interacts with TFB1M and TFB2M. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription regulation
Cellular Component: mitochondrial matrix; nucleus
Molecular Function: protein binding; heat shock protein binding; chromatin binding; transcription factor activity; DNA bending activity
Biological Process: mitochondrial respiratory chain complex assembly; regulation of transcription from RNA polymerase I promoter; positive regulation of transcription, DNA-dependent; gene expression; DNA-dependent DNA replication; transcription initiation from mitochondrial promoter; transcription from mitochondrial promoter
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.