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TFAM (human)

Overview TFAM regulates mitochondrial transcription. Induced in humans by caloric restriction. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Involved in cisplatin resistance. Interacts with TFB1M and TFB2M. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription regulation Cellular Component: mitochondrion; mitochondrial matrix Molecular Function: protein binding; chromatin binding; transcription factor activity; DNA bending activity Biological Process: mitochondrial respiratory chain complex assembly; regulation of transcription from RNA polymerase I promoter; positive regulation of transcription, DNA-dependent; gene expression; DNA-dependent DNA replication; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter Reference #:  Q00059 (UniProtKB) Alt. Names/Synonyms: Mitochondrial transcription factor 1; mitochondrial transcription factor A; MtTF1; mtTFA; TCF-6; TCF6; TCF6L1; TCF6L2; TCF6L3; TFAM; Transcription factor 6; Transcription factor 6-like 2; Transcription factor 6-like 2 (mitochondrial transcription factor); Transcription factor A, mitochondrial Gene Symbols: TFAM Molecular weight: 29,097 Da Basal Isoelectric point: 9.74  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TFAM 3FGH - A=153-219 (human) 3TMM - A=43-246 (human) 3TQ6 - A/B=43-246 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 3FGH 3TMM 3TQ6  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K52-u	VLASCPKkPVssYLR
1	1		S55-p	SCPKkPVssYLRFsk
1	0		S56-p	CPKkPVssYLRFskE
1	0		S61-p	VssYLRFskEQLPIF
0	1		K62-u	ssYLRFskEQLPIFK
0	1		K76-u	KAQNPDAkTTELIRR
0	1		K118-u	KEEISRFkEQLtPsQ
1	3		T122-p	SRFkEQLtPsQIMsL
1	5		S124-p	FkEQLtPsQIMsLEK
0	1		S128-p	LtPsQIMsLEKEIMD
0	1		K146-m3	KRKAMTKkkELTLLG
0	1		K147-m3	RKAMTKkkELTLLGK
1	0		S160-p	GKPKRPRsAYNVYVA
0	1		K186-u	QEKLKTVkENWkNLs
0	1		K190-u	KTVkENWkNLsDsEK
0	4		S193-p	kENWkNLsDsEKELY
0	1		S195-p	NWkNLsDsEKELYIQ
0	1		-	gap

	mouse
K51	SMGSYPKKPMSSYLR
S54	SYPKKPMSSYLRFST
S55	YPKKPMSSYLRFSTE
S60	MSSYLRFSTEQLPKF
T61	SSYLRFSTEQLPKFK
K75	KAKHPDAKLSELVRK
K117	KEAVSKYKEQLTPSQ
T121	SKYKEQLTPSQLMGM
S123	YKEQLTPSQLMGMEK
G127	LTPSQLMGMEKEARQ
R145	KKKALVKRRELILLG
R146	KKALVKRRELILLGK
S159	GKPKRPRSAYNIYVS
N185	QGKLKLVNEAWKNLS
K189	KLVNEAWKNLSPEEK
S192	NEAWKNLSPEEKQAY
E194	AWKNLSPEEKQAYIQ
S241-p	VKRSGDIsEH_____

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