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Protein Page:
SYVN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SYVN1 Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Belongs to the HRD1 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Membrane protein, multi-pass; Ubiquitin ligase; Endoplasmic reticulum; EC 6.3.2.19; EC 6.3.2.-; Membrane protein, integral; Ligase
Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; nucleolus; integral to membrane; nucleus
Molecular Function: protein binding; acid-amino acid ligase activity; zinc ion binding
Biological Process: ER-associated protein catabolic process; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; in utero embryonic development; protein ubiquitination; protein amino acid N-linked glycosylation via asparagine
Reference #:  Q86TM6 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase synoviolin; HRD1; KIAA1810; MGC40372; Synovial apoptosis inhibitor 1; synovial apoptosis inhibitor 1, synoviolin; SYVN1
Gene Symbols: SYVN1
Molecular weight: 67,685 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SYVN1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T93-p TETCLAFtVFRDDFS
0 2 K191-ub MVLTIFIkYVLHSVD
0 37 K257-ub LAMRQFKkAVtDAIM
0 1 T260-p RQFKkAVtDAIMsRR
0 1 S265-p AVtDAIMsRRAIRNM
0 3 K303-ub EEMVTGAkRLPCNHI
0 1 T557-p VVAAASStsIPSsEA
0 1 S558-p VAAASStsIPSsEAt
0 1 S562-p SStsIPSsEAtTPTP
0 1 T565-p sIPSsEAtTPTPGAs
0 1 S572-p tTPTPGAsPPAPEME
0 1 K610 LRRRRLQKLEsPVAH
0 9 S613-p RRLQKLEsPVAH___
  mouse

 
T93 TETCLAFTVFRDDFS
K191 MVLTIFIKYVLHSVD
K257-ub LAMRQFKkAVTDAIM
T260 RQFKkAVTDAIMSRR
S265 AVTDAIMSRRAIRNM
K303 EEMVTGAKRLPCNHI
T551 VVSAAPSTSAPSSEA
S552 VSAAPSTSAPSSEAP
S556 PSTSAPSSEAPTPSP
P559 SAPSSEAPTPSPGAS
S566 PTPSPGASPPIPEAE
K605-ub LRRRRLQkLEsPVAH
S608-p RRLQkLEsPVAH___
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