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SIRT6 (human)

Overview SIRT6 NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8. Belongs to the sirtuin family. Class IV subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 2.4.2.31; EC 3.5.1.-; Deacetylase; Transferase Cellular Component: nucleoplasm; nuclear telomeric heterochromatin; nucleolus; nucleus Molecular Function: NAD(P)+-protein-arginine ADP-ribosyltransferase activity; protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); zinc ion binding; NAD-dependent histone deacetylase activity; NAD+ ADP-ribosyltransferase activity Biological Process: protein amino acid ADP-ribosylation Reference #:  Q8N6T7 (UniProtKB) Alt. Names/Synonyms: NAD-dependent deacetylase sirtuin-6; SIR2-like protein 6; sir2-related protein type 6; SIR2L6; SIRT6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin type 6 Gene Symbols: SIRT6 Molecular weight: 39,119 Da Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states CST Pathways:  Protein Acetylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SIRT6 3K35 - F/A/D/C/E/B=3-318 (human) 3PKI - F/A/D/C/E/B=2-355 (human) 3PKJ - F/A/D/C/E/B=2-355 (human) 3ZG6 - A=1-296 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 3K35 3PKI 3PKJ 3ZG6  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S10-p	VNYAAGLsPYADKGK
0	1		T146-p	EECAKCKtQyVRDTV
0	1		Y148-p	CAKCKtQyVRDTVVG
0	1		K160-u	VVGTMGLkAtGRLCT
0	1		T162-p	GTMGLkAtGRLCTVA
0	1		K267-u	EVMTRLMkHLGLEIP
0	41		T294-p	PPLPRPPtPKLEPKE
0	3		S303-p	KLEPKEEsPTRINGs
0	4		S310-p	sPTRINGsIPAGPKQ
0	1		S326-p	PCAQHNGsEPAsPKR
0	2		S330-p	HNGsEPAsPKRERPt
0	10		T337-p	sPKRERPtsPAPHRP
0	6		S338-p	PKRERPtsPAPHRPP

	mouse
S10	VNYAAGLSPYADKGK
T146	EECPKCKTQYVRDTV
Y148	CPKCKTQYVRDTVVG
K160	VVGTMGLKATGRLCT
T162	GTMGLKATGRLCTVA
K267	EVMCRLMKHLGLEIP
A294	PPLPRPVALKAEPPV
-	gap
-	gap
-	gap
-	gap
N316	VSYKSKPNSPILHRP
S317	SYKSKPNSPILHRPP

	rat
S10	VNYAAGLSPYADKGK
T146	EECPKCKTQYVRDTV
Y148	CPKCKTQYVRDTVVG
K160	VVGTMGLKATGRLCT
T162	GTMGLKATGRLCTVA
K267	EVMCKLMKHLGLEIP
A294	PPLPRPVAPKAEPPV
-	gap
-	gap
-	gap
-	gap
D312	GSYKPKPDSPVPHRP
S313	SYKPKPDSPVPHRPP

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