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Protein Page:
SIRT6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SIRT6 NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8. Belongs to the sirtuin family. Class IV subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transferase; EC 2.4.2.31; Deacetylase; EC 3.5.1.-
Cellular Component: nucleoplasm; nuclear telomeric heterochromatin; nucleolus; nucleus
Molecular Function: NAD(P)+-protein-arginine ADP-ribosyltransferase activity; protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); zinc ion binding; NAD-dependent histone deacetylase activity; NAD+ ADP-ribosyltransferase activity
Biological Process: protein amino acid ADP-ribosylation; histone deacetylation
Reference #:  Q8N6T7 (UniProtKB)
Alt. Names/Synonyms: NAD-dependent deacetylase sirtuin-6; SIR2-like protein 6; sir2-related protein type 6; SIR2L6; SIRT6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin type 6
Gene Symbols: SIRT6
Molecular weight: 39,119 Da
Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SIRT6

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S338‑p
molecular association, regulation: S338‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 5 S10-p VNYAAGLsPYADKGK
0 1 T146-p EECAKCKtQyVRDTV
0 1 Y148-p CAKCKtQyVRDTVVG
0 1 K160-ub VVGTMGLkAtGRLCT
0 1 T162-p GTMGLkAtGRLCTVA
0 1 K267-ub EVMTRLMkHLGLEIP
1 54 T294-p PPLPRPPtPKLEPKE
1 8 S303-p KLEPKEEsPtRINGs
0 1 T305-p EPKEEsPtRINGsIP
0 4 S310-p sPtRINGsIPAGPKQ
0 1 S326-p PCAQHNGsEPAsPKR
1 6 S330-p HNGsEPAsPKRERPt
0 9 T337-p sPKRERPtsPAPHRP
1 8 S338-p PKRERPtsPAPHRPP
  mouse

 
S10 VNYAAGLSPYADKGK
T146 EECPKCKTQYVRDTV
Y148 CPKCKTQYVRDTVVG
K160 VVGTMGLKATGRLCT
T162 GTMGLKATGRLCTVA
K267 EVMCRLMKHLGLEIP
A294 PPLPRPVALKAEPPV
- gap
- gap
- gap
- gap
- gap
N316 VSYKSKPNSPILHRP
S317 SYKSKPNSPILHRPP
  rat

 
S10 VNYAAGLSPYADKGK
T146 EECPKCKTQYVRDTV
Y148 CPKCKTQYVRDTVVG
K160 VVGTMGLKATGRLCT
T162 GTMGLKATGRLCTVA
K267 EVMCKLMKHLGLEIP
A294 PPLPRPVAPKAEPPV
- gap
- gap
- gap
- gap
- gap
D312 GSYKPKPDSPVPHRP
S313 SYKPKPDSPVPHRPP
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