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Overview |
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RING1
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. Component of chromatin-associated Polycomb (PcG) complexes. Interacts with BMI1. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2 MBLR, L3MBTL2 and YAF2. Interacts with CBX2 and PCGF6. Component of a PRC1-like complex. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2. Interacts with PCGF2, RNF2; CBX6, CBX7 and CBX8. Interacts with PHC2. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Ligase; EC 6.3.2.19; Ubiquitin conjugating system; Transcription factor; EC 6.3.2.-; Ubiquitin ligase |
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Cellular Component: sex chromatin; cytoplasm; nucleolus; nuclear speck; PcG protein complex; nucleus; ubiquitin ligase complex
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Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; chromatin binding
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Biological Process: anterior/posterior pattern formation; camera-type eye morphogenesis; transcription, DNA-dependent; chromatin modification; negative regulation of transcription, DNA-dependent
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Reference #:
Q06587 (UniProtKB)
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| Alt. Names/Synonyms: E3 ubiquitin-protein ligase RING1; Polycomb complex protein RING1; Really interesting new gene 1 protein; RING finger protein 1; RING1; RING1A; RNF1 |
| Gene Symbols: RING1 |
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Molecular weight: 42,429 Da
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Basal Isoelectric point: 5.44
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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Select Structure to View Below |
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RING1 |
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