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Protein Page:
NKEF-A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NKEF-A a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.11.1.15
Cellular Component: extracellular space; peroxisomal matrix; mitochondrial matrix; cytoplasm; nucleolus; melanosome; cytosol; nucleus
Molecular Function: protein binding; peroxidase activity; protein homodimerization activity; thioredoxin peroxidase activity; heme binding
Biological Process: cell proliferation; retinal homeostasis; regulation of stress-activated MAPK cascade; erythrocyte homeostasis; removal of superoxide radicals; hydrogen peroxide catabolic process; natural killer cell mediated cytotoxicity; skeletal development; regulation of NF-kappaB import into nucleus
Reference #:  Q06830 (UniProtKB)
Alt. Names/Synonyms: MSP23; Natural killer cell-enhancing factor A; natural killer-enhancing factor A; NKEF-A; NKEFA; PAG; PAGA; PAGB; peroxiredoxin 1; Peroxiredoxin-1; PRDX1; proliferation-associated gene A; Proliferation-associated gene protein; PRX1; PRXI; TDPX2; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2
Gene Symbols: PRDX1
Molecular weight: 22,110 Da
Basal Isoelectric point: 8.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NKEF-A

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S32‑p
enzymatic activity, induced: S32‑p
enzymatic activity, inhibited: T90‑p, T183‑p, Y194‑p
intracellular localization: Y194‑p
molecular association, regulation: T90‑p, Y194‑p
protein conformation: S32‑p, T90‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K7-ac _MSSGNAkIGHPAPN
0 1 K7 _MSSGNAKIGHPAPN
0 1 K7-sc _MSSGNAkIGHPAPN
0 45 H10 SGNAkIGHPAPNFkA
0 1 N14 kIGHPAPNFkAtAVM
0 5 K16-ac GHPAPNFkAtAVMPD
0 4 K16-ub GHPAPNFkAtAVMPD
0 1 K16-sc GHPAPNFkAtAVMPD
1 2 T18-p PAPNFkAtAVMPDGQ
0 7 K27-ac VMPDGQFkDIsLsDy
0 10 K27-ub VMPDGQFkDIsLsDy
0 1 K27-sc VMPDGQFkDIsLsDy
0 3 S30-p DGQFkDIsLsDykGk
1 6 S32-p QFkDIsLsDykGkYV
0 2 Y34-p kDIsLsDykGkYVVF
0 67 K35-ac DIsLsDykGkYVVFF
0 36 K35-ub DIsLsDykGkYVVFF
0 1 K35-sc DIsLsDykGkYVVFF
0 1 K37-ac sLsDykGkYVVFFFY
0 1 K37-ub sLsDykGkYVVFFFY
0 6 K67-ac SDRAEEFkkLNCQVI
0 2 K68-ub DRAEEFkkLNCQVIG
3 1 T90-p CHLAWVNtPkkQGGL
0 2 K92-ac LAWVNtPkkQGGLGP
0 1 K92-sc LAWVNtPkkQGGLGP
0 1 K93-ac AWVNtPkkQGGLGPM
0 4 K93-ub AWVNtPkkQGGLGPM
0 1 S106-p PMNIPLVsDPkRtIA
0 58 K109-ac IPLVsDPkRtIAQDy
0 9 K109-ub IPLVsDPkRtIAQDy
0 1 K109-sc IPLVsDPkRtIAQDy
1 1 T111-p LVsDPkRtIAQDyGV
0 7 Y116-p kRtIAQDyGVLkADE
0 12 K120-ub AQDyGVLkADEGISF
0 1 K120-sc AQDyGVLkADEGISF
0 3 K136-ac GLFIIDDkGILRQIT
0 14 K136-ub GLFIIDDkGILRQIT
1 0 T156-p VGRSVDEtLRLVQAF
0 1 T166-p LVQAFQFtDkHGEVC
0 6 K168-ac QAFQFtDkHGEVCPA
0 6 K168-ub QAFQFtDkHGEVCPA
0 1 K178 EVCPAGWKPGsDtIk
0 16 K178-ub EVCPAGWkPGsDtIk
0 1 S181-p PAGWkPGsDtIkPDV
1 2 T183-p GWkPGsDtIkPDVQk
0 1 K185-ac kPGsDtIkPDVQkSk
0 5 K185-ub kPGsDtIkPDVQkSk
0 3 K190-ub tIkPDVQkSkEyFSk
0 1 K192 kPDVQkSKEyFSkQK
0 3 K192-ub kPDVQkSkEyFSkQK
1 124 Y194-p DVQkSkEyFSkQK__
0 1 K197-ac kSkEyFSkQK_____
0 3 K197-ub kSkEyFSkQK_____
  mouse

 
K7 _MSSGNAKIGyPAPN
K7-ub _MSSGNAkIGyPAPN
K7-sc _MSSGNAkIGyPAPN
Y10-p SGNAkIGyPAPNFkA
N14 kIGyPAPNFkATAVM
K16-ac GyPAPNFkATAVMPD
K16-ub GyPAPNFkATAVMPD
K16 GyPAPNFKATAVMPD
T18 PAPNFkATAVMPDGQ
K27-ac VMPDGQFkDIsLsEY
K27-ub VMPDGQFkDIsLsEY
K27-sc VMPDGQFkDIsLsEY
S30-p DGQFkDIsLsEYkGK
S32-p QFkDIsLsEYkGKYV
Y34 kDIsLsEYkGKYVVF
K35-ac DIsLsEYkGKYVVFF
K35-ub DIsLsEYkGKYVVFF
K35-sc DIsLsEYkGKYVVFF
K37 sLsEYkGKYVVFFFY
K37 sLsEYkGKYVVFFFY
K67-ac SDRADEFkKLNCQVI
K68 DRADEFkKLNCQVIG
T90 CHLAWINTPKkQGGL
K92 LAWINTPKkQGGLGP
K92 LAWINTPKkQGGLGP
K93 AWINTPKKQGGLGPM
K93-ub AWINTPKkQGGLGPM
S106 PMNIPLISDPkRTIA
K109-ac IPLISDPkRTIAQDY
K109-ub IPLISDPkRTIAQDY
K109-sc IPLISDPkRTIAQDY
T111 LISDPkRTIAQDYGV
Y116 kRTIAQDYGVLkADE
K120-ub AQDYGVLkADEGISF
K120 AQDYGVLKADEGISF
K136-ac GLFIIDDkGILRQIT
K136-ub GLFIIDDkGILRQIT
I156 VGRSVDEIIRLVQAF
T166 LVQAFQFTDkHGEVC
K168-ac QAFQFTDkHGEVCPA
K168-ub QAFQFTDkHGEVCPA
K178-ac EVCPAGWkPGSDTIk
K178-ub EVCPAGWkPGSDTIk
S181 PAGWkPGSDTIkPDV
T183 GWkPGSDTIkPDVNk
K185-ac kPGSDTIkPDVNkSk
K185-ub kPGSDTIkPDVNkSk
K190-ub TIkPDVNkSkEyFSK
K192-ac kPDVNkSkEyFSKQK
K192 kPDVNkSKEyFSKQK
Y194-p DVNkSkEyFSKQK__
K197 kSkEyFSKQK_____
K197 kSkEyFSKQK_____
  rat

 
K7 _MSSGNAKIGHPAPs
K7 _MSSGNAKIGHPAPs
K7 _MSSGNAKIGHPAPs
H10 SGNAKIGHPAPsFkA
S14-p KIGHPAPsFkAtAVM
K16-ac GHPAPsFkAtAVMPD
K16 GHPAPsFKAtAVMPD
K16 GHPAPsFKAtAVMPD
T18-p PAPsFkAtAVMPDGQ
K27-ac VMPDGQFkDIsLsDy
K27 VMPDGQFKDIsLsDy
K27 VMPDGQFKDIsLsDy
S30-p DGQFkDIsLsDykGK
S32-p QFkDIsLsDykGKYV
Y34-p kDIsLsDykGKYVVF
K35-ac DIsLsDykGKYVVFF
K35 DIsLsDyKGKYVVFF
K35 DIsLsDyKGKYVVFF
K37 sLsDykGKYVVFFFY
K37 sLsDykGKYVVFFFY
K67-ac SDRAEEFkKLNCQVI
K68 DRAEEFkKLNCQVIG
T90 CHLAWINTPKKQGGL
K92 LAWINTPKKQGGLGP
K92 LAWINTPKKQGGLGP
K93 AWINTPKKQGGLGPM
K93 AWINTPKKQGGLGPM
S106 PMNIPLVSDPkRTIA
K109-ac IPLVSDPkRTIAQDY
K109 IPLVSDPKRTIAQDY
K109 IPLVSDPKRTIAQDY
T111 LVSDPkRTIAQDYGV
Y116 kRTIAQDYGVLKADE
K120 AQDYGVLKADEGISF
K120 AQDYGVLKADEGISF
K136-ac GLFIIDDkGILRQIT
K136 GLFIIDDKGILRQIT
I156 VGRSVDEILRLVQAF
T166 LVQAFQFTDKHGEVC
K168 QAFQFTDKHGEVCPA
K168 QAFQFTDKHGEVCPA
K178 EVCPAGWKPGSDTIK
K178 EVCPAGWKPGSDTIK
S181 PAGWKPGSDTIKPDV
T183 GWKPGSDTIKPDVNK
K185 KPGSDTIKPDVNKSk
K185 KPGSDTIKPDVNKSk
K190 TIKPDVNKSkEyFSk
K192-ac KPDVNKSkEyFSkQK
K192 KPDVNKSKEyFSkQK
Y194-p DVNKSkEyFSkQK__
K197-ac KSkEyFSkQK_____
K197 KSkEyFSKQK_____
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