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Protein Page:
UVSSA (human)

Overview
UVSSA Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage. Defects in UVSSA are a cause of UV-sensitive syndrome type 3 (UVSS3). A rare autosomal recessive disorder characterized by photosensitivity and mild freckling but without neurological abnormalities or skin tumors. Belongs to the UVSSA family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: chromosome
Molecular Function: protein binding
Biological Process: transcription-coupled nucleotide-excision repair; protein ubiquitination; response to UV
Reference #:  Q2YD98 (UniProtKB)
Alt. Names/Synonyms: hypothetical protein LOC57654; K1530; KIAA1530; MGC117169; Uncharacterized protein KIAA1530
Gene Symbols: UVSSA
Molecular weight: 80,591 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
Select Structure to View Below

UVSSA

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S281-p QTATGDPsDEDEDsD
0 2 S287-p PsDEDEDsDLEEFVR
0 2 Y378-p LELVLRKyKELDIEP
0 2 A399 RTEALGDAEEDEDDE
0 1 S476-p DHLPPPSsAsPSRAL
0 1 S478-p LPPPSsAsPSRALPE
0 1 S657-p GKKRRYPsLTNLKAQ
  mouse

 
S284 QTAMKDSSRDEDEPs
S291-p SRDEDEPsDPDDFLR
Y382 LELALKKYEELNIEP
S403-p RTEALEDsEDEDQDF
P485 DCLSSPSPSSTRVLP
S487 LSSPSPSSTRVLPGP
N665 GKKKKHPNLTDLRER
  rat

 
- under review  
S294 EDRHSEHSDPEDFLR
Y385 LELALKKYEELNIEP
S406 RTEALEDSEEEDQDF
- under review  
S490 LSSPSSSSTRGPLGP
- under review  
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