Home

KIAA1530 (human)

Overview KIAA1530 Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage. Defects in UVSSA are a cause of UV-sensitive syndrome type 3 (UVSS3). A rare autosomal recessive disorder characterized by photosensitivity and mild freckling but without neurological abnormalities or skin tumors. Belongs to the UVSSA family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Molecular Function: protein binding Biological Process: transcription-coupled nucleotide-excision repair; protein ubiquitination; response to UV Reference #:  Q2YD98 (UniProtKB) Alt. Names/Synonyms: hypothetical protein LOC57654; K1530; KIAA1530; MGC117169; Uncharacterized protein KIAA1530 Gene Symbols: UVSSA Molecular weight: 80,591 Da Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states

Select Structure to View Below KIAA1530

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S273-p	AGGGAQPsQTATGDP
0	1		S281-p	QTATGDPsDEDEDsD
0	2		S287-p	PsDEDEDsDLEEFVR
0	1		S311-p	TLDVELCsEGLKVQE
0	2		Y378-p	LELVLRKyKELDIEP
0	1		A399	RTEALGDAEEDEDDE
0	1		S478-p	LPPPSSAsPSRALPE
0	1		K647-a	GSSRYSGkGRGKkRR
0	1		K652-a	SGkGRGKkRRYPsLT
0	1		S657-p	GKkRRYPsLTNLKAQ

	mouse
L275	SVVGLKALPQTAMKD
S284	QTAMKDSSRDEDEPs
S291-p	SRDEDEPsDPDDFLR
S315	TLDVEVPSDGLKVQE
Y382	LELALKKYEELNIEP
S403-p	RTEALEDsEDEDQDF
S487	LSSPSPSSTRVLPGP
K655	GSSRSSKKGKGKKKK
K660	SKKGKGKKKKHPNLT
N665	GKKKKHPNLTDLRER

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.