Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
HEXIM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HEXIM1 Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. Interacts with ESR1 and NR3C1. May interact with NF-kappa-B through RELA. Up-regulated by HMBA (hexamethylene bisacetamide). Down-regulated by estrogen. Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. Belongs to the HEXIM family. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Motility/polarity/chemotaxis
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; snRNA binding
Biological Process: transcription, DNA-dependent; heart development; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Reference #:  O94992 (UniProtKB)
Alt. Names/Synonyms: Cardiac lineage protein 1; CLP1; EDG1; Estrogen down-regulated gene 1 protein; FLJ13562; hexamethylene bis-acetamide inducible 1; Hexamethylene bis-acetamide-inducible protein 1; hexamethylene bisacetamide-inducible protein; hexamethylene-bis-acetamide-inducible transcript 1; hexamthylene bis-acetamide inducible 1; HEXI1; HEXIM1; HIS1; HMBA-inducible; MAQ1; menage a quatre 1; Menage a quatre protein 1; Protein HEXIM1
Gene Symbols: HEXIM1
Molecular weight: 40,623 Da
Basal Isoelectric point: 4.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HEXIM1

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
transcription, altered: Y271‑p
molecular association, regulation: Y271‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S66-p PGPEGEGsLESQPPP
0 1 S97-p KGQNGDDssAGGDFP
0 3 S98-p GQNGDDssAGGDFPP
0 1 A99 QNGDDssAGGDFPPP
0 5 P104 ssAGGDFPPPAEVEP
0 1 P106 AGGDFPPPAEVEPTP
0 1 S128 PCHDSEASKLGAPAA
1 0 R146-me EEWGQQQrQLGKKKH
1 0 S158-p KKHRRRPsKKKRHWk
0 2 K165-ac sKKKRHWkPyYKLTW
0 2 Y167-p KKRHWkPyYKLTWEE
0 1 S183-p KKFDEKQsLRASRIR
0 1 K196-ub IRAEMFAkGQPVAPY
0 1 T206-p PVAPYNTtQFLMDDH
1 8 S233-p SKRAAAKsDDtsDDD
1 9 T236-p AAAKsDDtsDDDFME
1 8 S237-p AAKsDDtsDDDFMEE
1 6 S252-p GGEEDGGsDGMGGDG
0 1 S260 DGMGGDGSEFLQRDF
1 0 T270-p LQRDFSEtyEryHtE
2 0 Y271-p QRDFSEtyEryHtES
1 0 R273-me DFSEtyEryHtESLQ
1 1 Y274-p FSEtyEryHtESLQN
0 1 T276-p EtyEryHtESLQNMs
0 1 S283-p tESLQNMskQELIkE
1 0 K284-ub ESLQNMskQELIkEY
1 1 K284-ac ESLQNMskQELIkEY
1 0 K289-ac MskQELIkEYLELEk
1 1 K289-ub MskQELIkEYLELEk
1 0 K296-me kEYLELEkCLSRMED
1 0 K296-ub kEYLELEkCLSRMED
0 1 K296-ac kEYLELEkCLSRMED
1 0 R347-me LTENELHrQQERAPL
1 0 S355-p QQERAPLsKFGD___
  mouse

 
G66 PGQEGEGGLKHQLPP
L97 KGQNGEDLstGGAsP
S98-p GQNGEDLstGGAsPs
T99-p QNGEDLstGGAsPsA
S103-p DLstGGAsPsAEGEP
S105-p stGGAsPsAEGEPMS
T125-p PGHDSEAtKQEAPAA
R143 EPWGQQQRQLGKKKH
S155 KKHRRRPSKKKRHWK
K162 SKKKRHWKPYYKLTW
Y164 KKRHWKPYYKLTWEE
S180 KKFDEKQSLRASRVR
K193 VRAEMFAKGQPVAPY
T203 PVAPYNTTQFLMDDH
S230-p PKRAAAKsDDtsDED
T233-p AAAKsDDtsDEDFVE
S234-p AAKsDDtsDEDFVEE
S249-p AGEEDGGsDGMGGDG
S257-p DGMGGDGsEFLQRDF
T267 LQRDFSETYERYHAE
Y268 QRDFSETYERYHAES
R270 DFSETYERYHAESLQ
Y271 FSETYERYHAESLQN
A273 ETYERYHAESLQNMS
S280 AESLQNMSKQELIkE
K281 ESLQNMSKQELIkEY
K281 ESLQNMSKQELIkEY
K286 MSKQELIKEYLELEK
K286-ub MSKQELIkEYLELEK
K293 kEYLELEKCLSRKED
K293 kEYLELEKCLSRKED
K293 kEYLELEKCLSRKED
R344 LTENELHRQQERAPL
S352 QQERAPLSKFGD___
  rat

 
G66 PGQEGDGGLKHQLPP
L97 KGQNGEDLSTGGASP
S98 GQNGEDLSTGGASPS
T99 QNGEDLSTGGASPSA
S103 DLSTGGASPSAEGEP
S105 STGGASPSAEGEPMS
T125 PGHDSEATKLEAPVA
R143 EPWGQQQRQLGKKKH
S155 KKHRRRPSKKKRHWK
K162 SKKKRHWKPYYKLTW
Y164 KKRHWKPYYKLTWEE
S180 KKFDEKQSLRASRVR
K193 VRAEMFAKGQPVAPY
T203 PVAPYNTTQFLMDDH
S230 PKRAAAKSDDTSDED
T233 AAAKSDDTSDEDFVE
S234 AAKSDDTSDEDFVEE
S249-p AGEEDGGsDGMGGDG
S257 DGMGGDGSEFLQRDF
T267 LQRDFSETYERYHAE
Y268 QRDFSETYERYHAES
R270 DFSETYERYHAESLQ
Y271 FSETYERYHAESLQN
A273 ETYERYHAESLQNMS
S280 AESLQNMSKQELIKE
K281 ESLQNMSKQELIKEY
K281 ESLQNMSKQELIKEY
K286 MSKQELIKEYLELEK
K286 MSKQELIKEYLELEK
K293 KEYLELEKCLSRKED
K293 KEYLELEKCLSRKED
K293 KEYLELEKCLSRKED
R344 LTENELHRQQERAPP
S352 QQERAPPSKFGD___
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.