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DERL1 (human)

Overview DERL1 Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. Forms homo- and heterooligomers with DERL2 and DERL3; binding to DERL3 is poorer than that between DERL2 and DERL3. Interacts with AMFR, VIMP/SELS, SEL1L, SYVN1 and VCP, as well as with SEL1L-SYVN1 and VCP-VIMP protein complexes; this interaction is weaker than that observed between DERL2 and these complexes. Interacts with the cytomegalovirus US11 protein. Interacts with NGLY1 and YOD1. Does not bind to EDEM1. Interacts with RNF103. Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR). Ubiquitous. Belongs to the derlin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Chaperone; Membrane protein, integral; Endoplasmic reticulum Cellular Component: endoplasmic reticulum; late endosome; early endosome; integral to membrane; integral to endoplasmic reticulum membrane Molecular Function: protein binding; MHC class I protein binding; receptor activity Biological Process: retrograde protein transport, ER to cytosol; intracellular transport of viral proteins in host cell; ER-associated protein catabolic process; establishment of protein localization; unfolded protein response; response to unfolded protein Reference #:  Q9BUN8 (UniProtKB) Alt. Names/Synonyms: Degradation in endoplasmic reticulum protein 1; DER-1; DER1; Der1-like domain family, member 1; Der1-like protein 1; DERL1; Derlin-1; DERtrin-1; FLJ13784; FLJ42092; MGC3067; PRO2577 Gene Symbols: DERL1 Molecular weight: 28,801 Da Basal Isoelectric point: 9.54  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DERL1

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	9		S201-p	LGGRNFLstPQFLYR
0	1		Y190-p	YFFLMFRyPMDLGGR
0	5		T202-p	GGRNFLstPQFLYRW
0	2		S218-p	PSRRGGVsGFGVPPA
0	6		S226-p	GFGVPPAsMRRAADQ

	mouse
S201-p	LGGRNFLsTPQFLYR
Y190	YFFLMFRYPMDLGGR
T202	GGRNFLsTPQFLYRW
S218	PSRRGGVSGFGVPPA
S226	GFGVPPASMRRAADQ

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