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hnRNP A1 (human)

Overview hnRNP A1 Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: RNA splicing; RNA binding protein Cellular Component: nucleoplasm; spliceosome; intermediate filament cytoskeleton; cytoplasm; nucleolus; ribonucleoprotein complex; nucleus Molecular Function: single-stranded RNA binding; RNA binding; nucleotide binding; single-stranded DNA binding Biological Process: alternative nuclear mRNA splicing, via spliceosome; nuclear mRNA splicing, via spliceosome; mRNA transport; RNA export from nucleus; virus-host interaction; RNA splicing; nuclear import; nuclear export; gene expression; mRNA processing Reference #:  P09651 (UniProtKB) Alt. Names/Synonyms: Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; heterogeneous nuclear ribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoprotein B2 protein; heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP core protein A1; hnRNP-A1; HNRNPA1; HNRPA1; MGC102835; nuclear ribonucleoprotein particle A1 protein; ROA1; single-strand DNA-binding protein UP1; Single-strand RNA-binding protein Gene Symbols: HNRNPA1 Molecular weight: 38,747 Da Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below hnRNP A1 1HA1 - A=1-184 (human) 1L3K - A=1-196 (human) 1PGZ - A=1-196 (human) 1PO6 - A=8-190 (human) 1U1K - A=1-196 (human) 1U1L - A=1-196 (human) 1U1M - A=1-196 (human) 1U1N - A=1-196 (human) 1U1O - A=1-196 (human) 1U1P - A=1-196 (human) 1U1Q - A=1-196 (human) 1U1R - A=1-196 (human) 1UP1 - A=3-184 (human) 2H4M - C/D=309-357 (human) 2LYV - A=2-196 (human) 2UP1 - A=8-190 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1HA1 1L3K 1PGZ 1PO6 1U1K 1U1L 1U1M 1U1N 1U1O 1U1P 1U1Q 1U1R 1UP1 2H4M 2LYV 2UP1  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
inhibition: S199‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	7		S2-p	______MsksEsPkE
0	1		K3-u	_____MsksEsPkEP
0	8		K3-a	_____MsksEsPkEP
0	20		S4-p	____MsksEsPkEPE
0	39		S6-p	__MsksEsPkEPEQL
0	16		K8-u	MsksEsPkEPEQLRk
0	25		K15-u	kEPEQLRkLFIGGLs
0	4		S22-p	kLFIGGLsFETTDES
0	3		R31-m1	ETTDESLrSHFEQWG
0	210		K52-a	VMRDPNTkRSRGFGF
0	14		K52-u	VMRDPNTkRSRGFGF
0	1		T61-p	SRGFGFVtYATVEEV
0	2		K78-u	AMNARPHkVDGRVVE
0	1		K87-a	DGRVVEPkRAVsRED
0	2		K87-u	DGRVVEPkRAVsRED
0	1		S91-p	VEPkRAVsREDsQRP
1	4		S95-p	RAVsREDsQRPGAHL
1	0		T103	QRPGAHLTVkkIFVG
0	4		K105-a	PGAHLTVkkIFVGGI
0	16		K105-u	PGAHLTVkkIFVGGI
0	17		K106-u	GAHLTVkkIFVGGIk
0	2		K113-a	kIFVGGIkEDTEEHH
0	5		K113-u	kIFVGGIkEDTEEHH
0	1		K113-s	kIFVGGIkEDTEEHH
0	2		T138-p	IEVIEIMtDrGsGkk
0	1		R140-m1	VIEIMtDrGsGkkRG
0	2		S142-p	EIMtDrGsGkkRGFA
0	20		K144-a	MtDrGsGkkRGFAFV
0	7		K145-a	tDrGsGkkRGFAFVT
0	5		K161-u	DDHDSVDkIVIQkyH
0	3		K166-a	VDkIVIQkyHtVNGH
0	5		K166-u	VDkIVIQkyHtVNGH
0	9		Y167-p	DkIVIQkyHtVNGHN
0	4		T169-p	IVIQkyHtVNGHNCE
0	1		S190-p	KQEMASAsssQrGrs
0	2		S191-p	QEMASAsssQrGrsG
2	1		S192-p	EMASAsssQrGrsGs
1	16		R194-m1	ASAsssQrGrsGsGN
2	5		R194-m2	ASAsssQrGrsGsGN
0	3		R196-m1	AsssQrGrsGsGNFG
1	1		S197-p	sssQrGrsGsGNFGG
4	4		S199-p	sQrGrsGsGNFGGGr
0	50		R206-m1	sGNFGGGrGGGFGGN
1	12		R206-m2	sGNFGGGrGGGFGGN
0	22		R218-m1	GGNDNFGrGGNFSGr
1	8		R218-m2	GGNDNFGrGGNFSGr
1	0		S223	FGrGGNFSGrGGFGG
0	33		R225-m1	rGGNFSGrGGFGGSr
1	9		R225-m2	rGGNFSGrGGFGGSr
1	0		S231	GrGGFGGSrGGGGYG
0	15		R232-m1	rGGFGGSrGGGGYGG
0	4		R232-m2	rGGFGGSrGGGGYGG
0	5		Y244-p	YGGSGDGyNGFGNDG
0	2		Y253-p	GFGNDGGyGGGGPGY
0	1		G257	DGGyGGGGPGYSGGS
0	1		S311	SNFGGGGSyNDFGNy
1	3		Y312-p	NFGGGGSyNDFGNyN
0	2		Y318-p	SyNDFGNyNNQSSNF
0	19		R336-m1	KGGNFGGrssGPyGG
0	11		S337-p	GGNFGGrssGPyGGG
0	12		S338-p	GNFGGrssGPyGGGG
0	236		Y341-p	GGrssGPyGGGGQyF
0	606		Y347-p	PyGGGGQyFAkPrNQ
2	68		K350-a	GGGQyFAkPrNQGGy
0	55		K350-u	GGGQyFAkPrNQGGy
0	15		R352-m1	GQyFAkPrNQGGyGG
0	8		R352-m2	GQyFAkPrNQGGyGG
0	288		Y357-p	kPrNQGGyGGsssss
0	2		S360-p	NQGGyGGssssssyG
0	7		S361-p	QGGyGGssssssyGs
1	12		S362-p	GGyGGssssssyGsG
1	8		S363-p	GyGGssssssyGsGr
1	20		S364-p	yGGssssssyGsGrr
0	18		S365-p	GGssssssyGsGrrF
0	410		Y366-p	GssssssyGsGrrF_
0	13		S368-p	sssssyGsGrrF___
0	11		R370-m1	sssyGsGrrF_____
0	1		R370-m2	sssyGsGrrF_____
0	2		R371-m1	ssyGsGrrF______

	mouse ► Hide Isoforms
S2-p	______MsksEsPkE
K3	_____MsKsEsPkEP
K3-a	_____MsksEsPkEP
S4-p	____MsksEsPkEPE
S6-p	__MsksEsPkEPEQL
K8-u	MsksEsPkEPEQLRK
K15	kEPEQLRKLFIGGLs
S22-p	KLFIGGLsFETTDES
R31	ETTDESLRSHFEQWG
K52-a	VMRDPNTkRSRGFGF
K52	VMRDPNTKRSRGFGF
T61	SRGFGFVTYATVEEV
K78	AMNARPHKVDGRVVE
K87	DGRVVEPKRAVSRED
K87	DGRVVEPKRAVSRED
S91	VEPKRAVSREDSQRP
S95	RAVSREDSQRPGAHL
T103	QRPGAHLTVKKIFVG
K105	PGAHLTVKKIFVGGI
K105	PGAHLTVKKIFVGGI
K106	GAHLTVKKIFVGGIK
K113	KIFVGGIKEDTEEHH
K113	KIFVGGIKEDTEEHH
K113	KIFVGGIKEDTEEHH
T138-p	IEVIEIMtDRGsGkk
R140	VIEIMtDRGsGkkRG
S142-p	EIMtDRGsGkkRGFA
K144-a	MtDRGsGkkRGFAFV
K145-a	tDRGsGkkRGFAFVT
K161	DDHDSVDKIVIQKYH
K166	VDKIVIQKYHTVNGH
K166	VDKIVIQKYHTVNGH
Y167	DKIVIQKYHTVNGHN
T169	IVIQKYHTVNGHNCE
S190	KQEMASASSSQrGrS
S191	QEMASASSSQrGrSG
S192	EMASASSSQrGrSGS
R194-m1	ASASSSQrGrSGSGN
R194	ASASSSQRGrSGSGN
R196-m1	ASSSQrGrSGSGNFG
S197	SSSQrGrSGSGNFGG
S199	SQrGrSGSGNFGGGr
R206-m1	SGNFGGGrGGGFGGN
R206-m2	SGNFGGGrGGGFGGN
R218-m1	GGNDNFGrGGNFSGr
R218	GGNDNFGRGGNFSGr
S223	FGrGGNFSGrGGFGG
R225-m1	rGGNFSGrGGFGGSr
R225-m2	rGGNFSGrGGFGGSr
S231	GrGGFGGSrGGGGYG
R232-m1	rGGFGGSrGGGGYGG
R232	rGGFGGSRGGGGYGG
Y244	YGGSGDGYNGFGNDG
-	gap
-	gap
S259-p	SNFGGGGsyNDFGNy
Y260-p	NFGGGGsyNDFGNyN
Y266-p	syNDFGNyNNQSSNF
R284-m1	KGGNFGGrsSGPyGG
S285-p	GGNFGGrsSGPyGGG
S286	GNFGGrsSGPyGGGG
Y289-p	GGrsSGPyGGGGQyF
Y295-p	PyGGGGQyFAkPrNQ
K298-a	GGGQyFAkPrNQGGy
K298-u	GGGQyFAkPrNQGGy
R300-m1	GQyFAkPrNQGGyGG
R300-m2	GQyFAkPrNQGGyGG
Y305-p	kPrNQGGyGGSSsss
S308	NQGGyGGSSssssyG
S309	QGGyGGSSssssyGs
S310-p	GGyGGSSssssyGsG
S311-p	GyGGSSssssyGsGr
S312-p	yGGSSssssyGsGrr
S313-p	GGSSssssyGsGrrF
Y314-p	GSSssssyGsGrrF_
S316-p	SssssyGsGrrF___
R318-m1	sssyGsGrrF_____
R318	sssyGsGRrF_____
R319-m1	ssyGsGrrF______

	hnRNP A1 iso2
S2	______MSKSEsPKE
K3	_____MSKSEsPKEP
K3	_____MSKSEsPKEP
S4	____MSKSEsPKEPE
S6-p	__MSKSEsPKEPEQL
K8	MSKSEsPKEPEQLRK
K15	KEPEQLRKLFIGGLs
S22-p	KLFIGGLsFETTDES
R31	ETTDESLRSHFEQWG
K52	VMRDPNTKRSRGFGF
K52	VMRDPNTKRSRGFGF
T61	SRGFGFVTYATVEEV
K78	AMNARPHKVDGRVVE
K87	DGRVVEPKRAVSRED
K87	DGRVVEPKRAVSRED
S91	VEPKRAVSREDSQRP
S95	RAVSREDSQRPGAHL
T103	QRPGAHLTVKKIFVG
K105	PGAHLTVKKIFVGGI
K105	PGAHLTVKKIFVGGI
K106	GAHLTVKKIFVGGIK
K113	KIFVGGIKEDTEEHH
K113	KIFVGGIKEDTEEHH
K113	KIFVGGIKEDTEEHH
T138	IEVIEIMTDRGSGKK
R140	VIEIMTDRGSGKKRG
S142	EIMTDRGSGKKRGFA
K144	MTDRGSGKKRGFAFV
K145	TDRGSGKKRGFAFVT
K161	DDHDSVDKIVIQKYH
K166	VDKIVIQKYHTVNGH
K166	VDKIVIQKYHTVNGH
Y167	DKIVIQKYHTVNGHN
T169	IVIQKYHTVNGHNCE
S190	KQEMASASSSQRGRS
S191	QEMASASSSQRGRSG
S192	EMASASSSQRGRSGS
R194	ASASSSQRGRSGSGN
R194	ASASSSQRGRSGSGN
R196	ASSSQRGRSGSGNFG
S197	SSSQRGRSGSGNFGG
S199	SQRGRSGSGNFGGGR
R206	SGNFGGGRGGGFGGN
R206	SGNFGGGRGGGFGGN
R218	GGNDNFGRGGNFSGR
R218	GGNDNFGRGGNFSGR
S223	FGRGGNFSGRGGFGG
R225	RGGNFSGRGGFGGSr
R225	RGGNFSGRGGFGGSr
S231	GRGGFGGSrGGGGYG
R232-m1	RGGFGGSrGGGGYGG
R232	RGGFGGSRGGGGYGG
Y244	YGGSGDGYNGFGNDG
Y253	GFGNDGGYGGGsPGY
S257-p	DGGYGGGsPGYSGGS
S312	SNFGGGGSYNDFGNY
Y313	NFGGGGSYNDFGNYN
Y319	SYNDFGNYNNQSSNF
R337	KGGNFGGRSSGPYGG
S338	GGNFGGRSSGPYGGG
S339	GNFGGRSSGPYGGGG
Y342	GGRSSGPYGGGGQYF
Y348	PYGGGGQYFAKPRNQ
K351	GGGQYFAKPRNQGGY
K351	GGGQYFAKPRNQGGY
R353	GQYFAKPRNQGGYGG
R353	GQYFAKPRNQGGYGG
Y358	KPRNQGGYGGSSsSs
S361	NQGGYGGSSsSsSyG
S362	QGGYGGSSsSsSyGS
S363-p	GGYGGSSsSsSyGSG
S364	GYGGSSsSsSyGSGR
S365-p	YGGSSsSsSyGSGRR
S366	GGSSsSsSyGSGRRF
Y367-p	GSSsSsSyGSGRRF_
S369	SsSsSyGSGRRF___
R371	SsSyGSGRRF_____
R371	SsSyGSGRRF_____
R372	sSyGSGRRF______

	rat
S2	______MSKsEsPKE
K3	_____MSKsEsPKEP
K3	_____MSKsEsPKEP
S4-p	____MSKsEsPKEPE
S6-p	__MSKsEsPKEPEQL
K8	MSKsEsPKEPEQLRK
K15	KEPEQLRKLFIGGLS
S22	KLFIGGLSFETTDES
R31	ETTDESLRSHFEQWG
K52	VMRDPNTKRSRGFGF
K52	VMRDPNTKRSRGFGF
T61	SRGFGFVTYATVEEV
K78	AMNARPHKVDGRVVE
K87	DGRVVEPKRAVSRED
K87	DGRVVEPKRAVSRED
S91	VEPKRAVSREDsQRP
S95-p	RAVSREDsQRPGAHL
T103-p	QRPGAHLtVKKIFVG
K105	PGAHLtVKKIFVGGI
K105	PGAHLtVKKIFVGGI
K106	GAHLtVKKIFVGGIK
K113	KIFVGGIKEDTEEHH
K113	KIFVGGIKEDTEEHH
K113	KIFVGGIKEDTEEHH
T138	IEVIEIMTDRGSGKK
R140	VIEIMTDRGSGKKRG
S142	EIMTDRGSGKKRGFA
K144	MTDRGSGKKRGFAFV
K145	TDRGSGKKRGFAFVT
K161	DDHDSVDKIVIQKYH
K166	VDKIVIQKYHTVNGH
K166	VDKIVIQKYHTVNGH
Y167	DKIVIQKYHTVNGHN
T169	IVIQKYHTVNGHNCE
S190	KQEMASASSsQRGRs
S191	QEMASASSsQRGRsG
S192-p	EMASASSsQRGRsGs
R194	ASASSsQRGRsGsGN
R194	ASASSsQRGRsGsGN
R196	ASSsQRGRsGsGNFG
S197-p	SSsQRGRsGsGNFGG
S199-p	sQRGRsGsGNFGGGr
R206-m1	sGNFGGGrGGGFGGN
R206	sGNFGGGRGGGFGGN
R218-m1	GGNDNFGrGGNFsGr
R218	GGNDNFGRGGNFsGr
S223-p	FGrGGNFsGrGGFGG
R225-m1	rGGNFsGrGGFGGsr
R225	rGGNFsGRGGFGGsr
S231-p	GrGGFGGsrGGGGYG
R232-m1	rGGFGGsrGGGGYGG
R232	rGGFGGsRGGGGYGG
Y244	YGGSGDGYNGFGNDG
-	gap
-	gap
S259	SNFGGGGSYNDFGNY
Y260	NFGGGGSYNDFGNYN
Y266	SYNDFGNYNNQSSNF
R284-m1	KGGNFGGrSSGPYGG
S285	GGNFGGrSSGPYGGG
S286	GNFGGrSSGPYGGGG
Y289	GGrSSGPYGGGGQYF
Y295	PYGGGGQYFAKPrNQ
K298	GGGQYFAKPrNQGGY
K298	GGGQYFAKPrNQGGY
R300-m1	GQYFAKPrNQGGYGG
R300	GQYFAKPRNQGGYGG
Y305	KPrNQGGYGGSSSSS
S308	NQGGYGGSSSSSSYG
S309	QGGYGGSSSSSSYGS
S310	GGYGGSSSSSSYGSG
S311	GYGGSSSSSSYGSGr
S312	YGGSSSSSSYGSGrR
S313	GGSSSSSSYGSGrRF
Y314	GSSSSSSYGSGrRF_
S316	SSSSSYGSGrRF___
R318-m1	SSSYGSGrRF_____
R318	SSSYGSGRRF_____
R319	SSYGSGrRF______

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