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Protein Page:
hnRNP A1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
hnRNP A1 Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; RNA splicing; Spliceosome
Cellular Component: nucleoplasm; spliceosome; intermediate filament cytoskeleton; cytoplasm; nucleolus; nucleus; ribonucleoprotein complex
Molecular Function: protein binding; single-stranded RNA binding; RNA binding; nucleotide binding; single-stranded DNA binding
Biological Process: nuclear mRNA splicing, via spliceosome; mRNA transport; viral reproduction; RNA export from nucleus; RNA splicing; nuclear export; nuclear import; gene expression; mRNA processing
Reference #:  P09651 (UniProtKB)
Alt. Names/Synonyms: Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; heterogeneous nuclear ribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoprotein B2 protein; heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP core protein A1; hnRNP-A1; HNRNPA1; HNRPA1; MGC102835; nuclear ribonucleoprotein particle A1 protein; ROA1; single-strand DNA-binding protein UP1; Single-strand RNA-binding protein
Gene Symbols: HNRNPA1
Molecular weight: 38,747 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

hnRNP A1

Protein Structure Not Found.


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Sites Implicated In
activity, inhibited: S199‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 8 S2-p ______MsksEsPkE
0 1 K3-u _____MsksEsPkEP
0 8 K3-a _____MsksEsPkEP
0 22 S4-p ____MsksEsPkEPE
0 45 S6-p __MsksEsPkEPEQL
0 16 K8-u MsksEsPkEPEQLRk
0 25 K15-u kEPEQLRkLFIGGLs
0 5 S22-p kLFIGGLsFETTDES
0 3 R31-m1 ETTDESLrSHFEQWG
0 210 K52-a VMRDPNTkRSRGFGF
0 14 K52-u VMRDPNTkRSRGFGF
0 2 K78-u AMNARPHkVDGRVVE
0 2 K87-u DGRVVEPkRAVsRED
0 2 S91-p VEPkRAVsREDsQRP
1 6 S95-p RAVsREDsQRPGAHL
1 0 T103 QRPGAHLTVkkIFVG
0 4 K105-a PGAHLTVkkIFVGGI
0 16 K105-u PGAHLTVkkIFVGGI
0 17 K106-u GAHLTVkkIFVGGIk
0 2 K113-a kIFVGGIkEDTEEHH
0 5 K113-u kIFVGGIkEDTEEHH
0 1 K113-s kIFVGGIkEDTEEHH
0 2 T138-p IEVIEIMtDrGsGkk
0 2 R140-m1 VIEIMtDrGsGkkRG
0 2 S142-p EIMtDrGsGkkRGFA
0 20 K144-a MtDrGsGkkRGFAFV
0 7 K145-a tDrGsGkkRGFAFVT
0 5 K161-u DDHDSVDkIVIQkyH
0 3 K166-a VDkIVIQkyHtVNGH
0 5 K166-u VDkIVIQkyHtVNGH
0 9 Y167-p DkIVIQkyHtVNGHN
0 4 T169-p IVIQkyHtVNGHNCE
0 1 S190-p KQEMASAsssQrGrs
0 2 S191-p QEMASAsssQrGrsG
2 1 S192-p EMASAsssQrGrsGs
1 17 R194-m1 ASAsssQrGrsGsGN
2 6 R194-m2 ASAsssQrGrsGsGN
0 4 R196-m1 AsssQrGrsGsGNFG
1 1 S197-p sssQrGrsGsGNFGG
4 5 S199-p sQrGrsGsGNFGGGr
0 51 R206-m1 sGNFGGGrGGGFGGN
1 13 R206-m2 sGNFGGGrGGGFGGN
0 23 R218-m1 GGNDNFGrGGNFsGr
1 9 R218-m2 GGNDNFGrGGNFsGr
1 0 S223-p FGrGGNFsGrGGFGG
0 34 R225-m1 rGGNFsGrGGFGGSr
1 10 R225-m2 rGGNFsGrGGFGGSr
1 0 S231 GrGGFGGSrGGGGYG
0 16 R232-m1 rGGFGGSrGGGGYGG
0 4 R232-m2 rGGFGGSrGGGGYGG
0 5 Y244-p YGGSGDGyNGFGNDG
0 2 Y253-p GFGNDGGyGGGGPGY
0 1 G257 DGGyGGGGPGYSGGS
1 3 Y312-p NFGGGGSyNDFGNyN
0 2 Y318-p SyNDFGNyNNQSSNF
0 20 R336-m1 KGGNFGGrssGPyGG
0 12 S337-p GGNFGGrssGPyGGG
0 12 S338-p GNFGGrssGPyGGGG
0 239 Y341-p GGrssGPyGGGGQyF
0 608 Y347-p PyGGGGQyFAkPrNQ
2 68 K350-a GGGQyFAkPrNQGGy
0 55 K350-u GGGQyFAkPrNQGGy
0 16 R352-m1 GQyFAkPrNQGGyGG
0 8 R352-m2 GQyFAkPrNQGGyGG
0 289 Y357-p kPrNQGGyGGsssss
0 2 S360-p NQGGyGGssssssyG
0 8 S361-p QGGyGGssssssyGs
1 13 S362-p GGyGGssssssyGsG
1 9 S363-p GyGGssssssyGsGr
1 22 S364-p yGGssssssyGsGrr
0 19 S365-p GGssssssyGsGrrF
0 411 Y366-p GssssssyGsGrrF_
0 15 S368-p sssssyGsGrrF___
0 12 R370-m1 sssyGsGrrF_____
0 1 R370-m2 sssyGsGrrF_____
0 2 R371-m1 ssyGsGrrF______
  mouse

► Hide Isoforms
 
S2-p ______MsksEsPkE
K3 _____MsKsEsPkEP
K3-a _____MsksEsPkEP
S4-p ____MsksEsPkEPE
S6-p __MsksEsPkEPEQL
K8-u MsksEsPkEPEQLRK
K15 kEPEQLRKLFIGGLs
S22-p KLFIGGLsFETTDES
R31 ETTDESLRSHFEQWG
K52-a VMRDPNTkRSRGFGF
K52 VMRDPNTKRSRGFGF
K78 AMNARPHKVDGRVVE
K87 DGRVVEPKRAVSRED
S91 VEPKRAVSREDsQRP
S95-p RAVSREDsQRPGAHL
T103 QRPGAHLTVKKIFVG
K105 PGAHLTVKKIFVGGI
K105 PGAHLTVKKIFVGGI
K106 GAHLTVKKIFVGGIK
K113 KIFVGGIKEDTEEHH
K113 KIFVGGIKEDTEEHH
K113 KIFVGGIKEDTEEHH
T138-p IEVIEIMtDRGsGkk
R140 VIEIMtDRGsGkkRG
S142-p EIMtDRGsGkkRGFA
K144-a MtDRGsGkkRGFAFV
K145-a tDRGsGkkRGFAFVT
K161 DDHDSVDKIVIQKYH
K166 VDKIVIQKYHTVNGH
K166 VDKIVIQKYHTVNGH
Y167 DKIVIQKYHTVNGHN
T169 IVIQKYHTVNGHNCE
S190 KQEMASASSSQrGrS
S191 QEMASASSSQrGrSG
S192 EMASASSSQrGrSGS
R194-m1 ASASSSQrGrSGSGN
R194-m2 ASASSSQrGrSGSGN
R196-m1 ASSSQrGrSGSGNFG
S197 SSSQrGrSGSGNFGG
S199 SQrGrSGSGNFGGGr
R206-m1 SGNFGGGrGGGFGGN
R206-m2 SGNFGGGrGGGFGGN
R218-m1 GGNDNFGrGGNFSGr
R218-m2 GGNDNFGrGGNFSGr
S223 FGrGGNFSGrGGFGG
R225-m1 rGGNFSGrGGFGGSr
R225-m2 rGGNFSGrGGFGGSr
S231 GrGGFGGSrGGGGYG
R232-m1 rGGFGGSrGGGGYGG
R232 rGGFGGSRGGGGYGG
Y244 YGGSGDGYNGFGNDG
- gap
- gap
Y260-p NFGGGGSyNDFGNyN
Y266-p SyNDFGNyNNQSSNF
R284-m1 KGGNFGGrssGPyGG
S285-p GGNFGGrssGPyGGG
S286-p GNFGGrssGPyGGGG
Y289-p GGrssGPyGGGGQyF
Y295-p PyGGGGQyFAkPrNQ
K298-a GGGQyFAkPrNQGGy
K298-u GGGQyFAkPrNQGGy
R300-m1 GQyFAkPrNQGGyGG
R300-m2 GQyFAkPrNQGGyGG
Y305-p kPrNQGGyGGSSsss
S308 NQGGyGGSSssssyG
S309 QGGyGGSSssssyGs
S310-p GGyGGSSssssyGsG
S311-p GyGGSSssssyGsGr
S312-p yGGSSssssyGsGrr
S313-p GGSSssssyGsGrrF
Y314-p GSSssssyGsGrrF_
S316-p SssssyGsGrrF___
R318-m1 sssyGsGrrF_____
R318 sssyGsGRrF_____
R319-m1 ssyGsGrrF______
  hnRNP A1 iso2  
S2 ______MSKSEsPKE
K3 _____MSKSEsPKEP
K3 _____MSKSEsPKEP
S4 ____MSKSEsPKEPE
S6-p __MSKSEsPKEPEQL
K8 MSKSEsPKEPEQLRK
K15 KEPEQLRKLFIGGLs
S22-p KLFIGGLsFETTDES
R31 ETTDESLRSHFEQWG
K52 VMRDPNTKRSRGFGF
K52 VMRDPNTKRSRGFGF
K78 AMNARPHKVDGRVVE
K87 DGRVVEPKRAVSRED
S91 VEPKRAVSREDSQRP
S95 RAVSREDSQRPGAHL
T103 QRPGAHLTVKKIFVG
K105 PGAHLTVKKIFVGGI
K105 PGAHLTVKKIFVGGI
K106 GAHLTVKKIFVGGIK
K113 KIFVGGIKEDTEEHH
K113 KIFVGGIKEDTEEHH
K113 KIFVGGIKEDTEEHH
T138 IEVIEIMTDRGSGKK
R140 VIEIMTDRGSGKKRG
S142 EIMTDRGSGKKRGFA
K144 MTDRGSGKKRGFAFV
K145 TDRGSGKKRGFAFVT
K161 DDHDSVDKIVIQKYH
K166 VDKIVIQKYHTVNGH
K166 VDKIVIQKYHTVNGH
Y167 DKIVIQKYHTVNGHN
T169 IVIQKYHTVNGHNCE
S190 KQEMASASSSQRGRS
S191 QEMASASSSQRGRSG
S192 EMASASSSQRGRSGS
R194 ASASSSQRGRSGSGN
R194 ASASSSQRGRSGSGN
R196 ASSSQRGRSGSGNFG
S197 SSSQRGRSGSGNFGG
S199 SQRGRSGSGNFGGGR
R206 SGNFGGGRGGGFGGN
R206 SGNFGGGRGGGFGGN
R218 GGNDNFGRGGNFSGR
R218 GGNDNFGRGGNFSGR
S223 FGRGGNFSGRGGFGG
R225 RGGNFSGRGGFGGSr
R225 RGGNFSGRGGFGGSr
S231 GRGGFGGSrGGGGYG
R232-m1 RGGFGGSrGGGGYGG
R232 RGGFGGSRGGGGYGG
Y244 YGGSGDGYNGFGNDG
Y253 GFGNDGGYGGGsPGY
S257-p DGGYGGGsPGYSGGS
Y313 NFGGGGSYNDFGNYN
Y319 SYNDFGNYNNQSSNF
R337 KGGNFGGRSSGPYGG
S338 GGNFGGRSSGPYGGG
S339 GNFGGRSSGPYGGGG
Y342 GGRSSGPYGGGGQYF
Y348 PYGGGGQYFAKPRNQ
K351 GGGQYFAKPRNQGGY
K351 GGGQYFAKPRNQGGY
R353 GQYFAKPRNQGGYGG
R353 GQYFAKPRNQGGYGG
Y358 KPRNQGGYGGSSsSs
S361 NQGGYGGSSsSsSyG
S362 QGGYGGSSsSsSyGS
S363-p GGYGGSSsSsSyGSG
S364 GYGGSSsSsSyGSGR
S365-p YGGSSsSsSyGSGRR
S366 GGSSsSsSyGSGRRF
Y367-p GSSsSsSyGSGRRF_
S369 SsSsSyGSGRRF___
R371 SsSyGSGRRF_____
R371 SsSyGSGRRF_____
R372 sSyGSGRRF______
  rat

 
S2 ______MSKsEsPKE
K3 _____MSKsEsPKEP
K3 _____MSKsEsPKEP
S4-p ____MSKsEsPKEPE
S6-p __MSKsEsPKEPEQL
K8 MSKsEsPKEPEQLRK
K15 KEPEQLRKLFIGGLS
S22 KLFIGGLSFETTDES
R31 ETTDESLRSHFEQWG
K52 VMRDPNTKRSRGFGF
K52 VMRDPNTKRSRGFGF
K78 AMNARPHKVDGRVVE
K87 DGRVVEPKRAVSRED
S91 VEPKRAVSREDsQRP
S95-p RAVSREDsQRPGAHL
T103-p QRPGAHLtVKKIFVG
K105 PGAHLtVKKIFVGGI
K105 PGAHLtVKKIFVGGI
K106 GAHLtVKKIFVGGIK
K113 KIFVGGIKEDTEEHH
K113 KIFVGGIKEDTEEHH
K113 KIFVGGIKEDTEEHH
T138 IEVIEIMTDRGSGKK
R140 VIEIMTDRGSGKKRG
S142 EIMTDRGSGKKRGFA
K144 MTDRGSGKKRGFAFV
K145 TDRGSGKKRGFAFVT
K161 DDHDSVDKIVIQKYH
K166 VDKIVIQKYHTVNGH
K166 VDKIVIQKYHTVNGH
Y167 DKIVIQKYHTVNGHN
T169 IVIQKYHTVNGHNCE
S190 KQEMASASSsQRGRs
S191 QEMASASSsQRGRsG
S192-p EMASASSsQRGRsGs
R194 ASASSsQRGRsGsGN
R194 ASASSsQRGRsGsGN
R196 ASSsQRGRsGsGNFG
S197-p SSsQRGRsGsGNFGG
S199-p sQRGRsGsGNFGGGr
R206-m1 sGNFGGGrGGGFGGN
R206 sGNFGGGRGGGFGGN
R218-m1 GGNDNFGrGGNFsGr
R218 GGNDNFGRGGNFsGr
S223-p FGrGGNFsGrGGFGG
R225-m1 rGGNFsGrGGFGGsr
R225 rGGNFsGRGGFGGsr
S231-p GrGGFGGsrGGGGYG
R232-m1 rGGFGGsrGGGGYGG
R232 rGGFGGsRGGGGYGG
Y244 YGGSGDGYNGFGNDG
- gap
- gap
Y260 NFGGGGSYNDFGNYN
Y266 SYNDFGNYNNQSSNF
R284-m1 KGGNFGGrSSGPYGG
S285 GGNFGGrSSGPYGGG
S286 GNFGGrSSGPYGGGG
Y289 GGrSSGPYGGGGQYF
Y295 PYGGGGQYFAKPrNQ
K298 GGGQYFAKPrNQGGY
K298 GGGQYFAKPrNQGGY
R300-m1 GQYFAKPrNQGGYGG
R300 GQYFAKPRNQGGYGG
Y305 KPrNQGGYGGSSSSS
S308 NQGGYGGSSSSSSYG
S309 QGGYGGSSSSSSYGS
S310 GGYGGSSSSSSYGSG
S311 GYGGSSSSSSYGSGr
S312 YGGSSSSSSYGSGrR
S313 GGSSSSSSYGSGrRF
Y314 GSSSSSSYGSGrRF_
S316 SSSSSYGSGrRF___
R318-m1 SSSYGSGrRF_____
R318 SSSYGSGRRF_____
R319 SSYGSGrRF______
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