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Protein Page:
BIRC2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
BIRC2 Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3 ubiquitin- protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with CASP9. Interacts (via BIR domains) with TRAF2. Interacts with E2F1, RIPK1, RIPK2, RIPK3, RIPK4, BIRC5/survivin and USP19. Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain- mediated autoinhibition of the E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability of BIRC2/c-IAP1 by preventing its ubiquitination. Belongs to the IAP family. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; Ligase
Cellular Component: XY body; internal side of plasma membrane; nucleus; cytosol; lipid raft
Molecular Function: protein binding; zinc ion binding; transcription coactivator activity; ubiquitin-protein ligase activity; protein N-terminus binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; regulation of toll-like receptor signaling pathway; protein polyubiquitination; response to cAMP; apoptosis; protein heterooligomerization; regulation of cell cycle; toll-like receptor 3 signaling pathway; regulation of apoptosis; cell surface receptor linked signal transduction; regulation of transcription, DNA-dependent; regulation of cell differentiation; toll-like receptor 4 signaling pathway; cell structure disassembly during apoptosis; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; regulation of innate immune response; regulation of cell proliferation; response to ethanol; regulation of inflammatory response; response to hypoxia; toll-like receptor signaling pathway; innate immune response; negative regulation of apoptosis
Reference #:  Q13490 (UniProtKB)
Alt. Names/Synonyms: API1; apoptosis inhibitor 1; baculoviral IAP repeat-containing 2; Baculoviral IAP repeat-containing protein 2; BIRC2; C-IAP1; cIAP1; hIAP-2; hIAP2; IAP homolog B; IAP-2; IAP2; Inhibitor of apoptosis protein 2; MIHB; NFR2-TRAF signalling complex protein; RING finger protein 48; RNF48; TNFR2-TRAF-signaling complex protein 2
Gene Symbols: BIRC2
Molecular weight: 69,900 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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BIRC2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K19-u GPSYQNIkSIMEDST
0 1 K36-u SDWTNSNkQKMkYDF
0 1 K40-u NSNkQKMkYDFSCEL
0 1 S98-p DNWKLGDsPIQKHKQ
0 4 K126-u ASLGSTSkNTSPMRN
0 1 S140-p NSFAHSLsPTLEHSS
0 2 - gap
0 1 S157-p SGSYSSLsPNPLNSR
0 1 N159 SYSSLsPNPLNSRAV
0 4 Y177-p SSSRTNPySYAMSTE
0 2 K226-u ACFACGGkLSNWEPk
0 4 K233-u kLSNWEPkDDAMSEH
0 1 K340-u CEFLIRMkGQEFVDE
0 1 K410-u GFNRDLVkQTVQSkI
0 1 K416-u VkQTVQSkILTTGEN
0 2 K425-u LTTGENYkTVNDIVS
0 4 K441-u LLNAEDEkREEEkEk
0 5 K446-u DEkREEEkEkQAEEM
0 4 K448-u kREEEkEkQAEEMAS
0 1 K537-u EIDSTLYkNLFVDKN
  mouse

 
K19 GTLHQKLKRIMEKST
E36 SNWTKESEEKMKFDF
K40 KESEEKMKFDFSCEL
S98 DNWKQGDSPVEKHRQ
K126 ASLQSPSKNMSPVKS
S139 KSRFAHSSPLErGGI
R143-m1 AHSSPLErGGIHSNL
C151 GGIHSNLCSsPLNSR
S153-p IHSNLCSsPLNSRAV
C170 FSSRMDPCSYAMSTE
K219 ACFACGGKLSNWEPK
K226 KLSNWEPKDDAMSEH
K333 CEFLIRMKGQEFVDE
R404 GFSRSLVRQTVQRQI
Q410 VRQTVQRQILATGEN
R419 LATGENYRTVNDIVS
R435 LLNAEDERREEEKER
K440 DERREEEKERQTEEM
R442 RREEEKERQTEEMAS
E531 EIDSTLYENLFVEKN
  rat

 
- gap
K15 SNWTKENKEKMKYDF
K19 KENKEKMKYDFSCEL
S77 DNWKQGDSPTEKHRQ
K105 GGLQSAAKNTSPAKS
L118 KSRFAHSLPLEQGGI
Q122 AHSLPLEQGGIHSSL
P130 GGIHSSLPSNPLNSR
N132 IHSSLPSNPLNSRAV
C149 FSLRMNPCSYAMSTE
K198 ACFACGGKLSNWEPN
N205 KLSNWEPNDDPLSEH
K312 CEFLIRMKGQEFVDE
R381 GFSRSLVRQTVQRQI
Q387 VRQTVQRQILATGEN
R396 LATGENYRTVSDIVS
R412 LLNAEDERREEEKER
K417 DERREEEKERQSEET
R419 RREEEKERQSEETAS
E508 EVDSTLYEHLFVEKT
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