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Protein Page:
ASF1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ASF1A Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Ubiquitously expressed. Belongs to the ASF1 family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Histone-binding protein
Chromosomal Location of Human Ortholog: 6q22.31
Cellular Component: nucleoplasm; protein complex; nuclear chromatin; nucleus
Molecular Function: protein binding; histone binding; chromatin binding
Biological Process: osteoblast differentiation; nucleosome assembly; muscle cell differentiation; transcription, DNA-dependent; DNA replication-independent nucleosome assembly; negative regulation of chromatin silencing; chromatin modification; DNA repair; DNA replication-dependent nucleosome assembly
Reference #:  Q9Y294 (UniProtKB)
Alt. Names/Synonyms: anti-silencing function 1A; Anti-silencing function protein 1 homolog A; ASF1 anti-silencing function 1 homolog A (S. cerevisiae); ASF1A; CCG1-interacting factor A; CGI-98; CIA; DKFZp547E2110; hAsf1; hAsf1a; hCIA; Histone chaperone ASF1A; HSPC146
Gene Symbols: ASF1A
Molecular weight: 22,969 Da
Basal Isoelectric point: 4.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ASF1A

Protein Structure Not Found.


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Sites Implicated In
protein stabilization: S192‑p
ubiquitination: S192‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T120-p VNNEYTEtELRENPP
0 1 T157-p HINWEDNtEKLEDAE
0 3 K159 NWEDNtEKLEDAEss
0 3 S165-p EKLEDAEssNPNLQs
0 5 S166-p KLEDAEssNPNLQsL
0 3 S172-p ssNPNLQsLLStDAL
0 1 T176-p NLQsLLStDALPSAS
1 1 S192-p GWSTSENsLNVMLES
  mouse

 
T120 VNNEYTETELRENPP
T157 HINWEDNTEkLEDAE
K159-ub NWEDNTEkLEDAEsS
S165-p EkLEDAEsSNPNLQS
S166 kLEDAEsSNPNLQSL
S172 sSNPNLQSLLSTDAL
T176 NLQSLLSTDALPSAS
S192 GWSTSENSLNVMLES
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