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ASF1A (human)

Overview ASF1A Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Ubiquitously expressed. Belongs to the ASF1 family. Note: This description may include information from UniProtKB. Protein type: DNA repair; Histone-binding protein Cellular Component: chromatin remodeling complex; nucleus Molecular Function: protein binding; histone binding; chromatin binding Biological Process: nucleosome assembly; negative regulation of chromatin silencing; transcription, DNA-dependent; chromatin modification; DNA repair Reference #:  Q9Y294 (UniProtKB) Alt. Names/Synonyms: anti-silencing function 1A; Anti-silencing function protein 1 homolog A; ASF1 anti-silencing function 1 homolog A (S. cerevisiae); ASF1A; CCG1-interacting factor A; CGI-98; CIA; DKFZp547E2110; hAsf1; hAsf1a; hCIA; Histone chaperone ASF1A; HSPC146 Gene Symbols: ASF1A Molecular weight: 22,969 Da Basal Isoelectric point: 4.29  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ASF1A 1TEY - A=1-156 (human) 2IIJ - A=1-156 (human) 2IO5 - A=1-172 (human) 3AAD - D/B=1-155 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1TEY 2IIJ 2IO5 3AAD  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
protein stabilization: S192‑p ubiquitination: S192‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T120-p	VNNEYTEtELRENPP
0	1		T157-p	HINWEDNtEKLEDAE
0	3		K159	NWEDNtEKLEDAEss
0	2		S165-p	EKLEDAEssNPNLQs
0	3		S166-p	KLEDAEssNPNLQsL
0	2		S172-p	ssNPNLQsLLStDAL
0	1		T176-p	NLQsLLStDALPSAS
1	1		S192-p	GWSTSENsLNVMLES

	mouse
T120	VNNEYTETELRENPP
T157	HINWEDNTEkLEDAE
K159-u	NWEDNTEkLEDAEsS
S165-p	EkLEDAEsSNPNLQS
S166	kLEDAEsSNPNLQSL
S172	sSNPNLQSLLSTDAL
T176	NLQSLLSTDALPSAS
S192	GWSTSENSLNVMLES

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