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Protein Page:
FLNB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FLNB a ubiquitous cytoskeletal protein that links actin filaments to membrane glycoproteins. Six alternatively spliced isoforms have been described. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoforms 1 and 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells, retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord and platelets. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer's disease. Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Actin binding protein
Cellular Component: focal adhesion; cytoplasm; stress fiber; plasma membrane; integral to membrane; cell cortex; Z disc; cytosol; actin cytoskeleton
Molecular Function: identical protein binding; protein binding; actin binding
Biological Process: skeletal muscle development; cytoskeletal anchoring; cytokine and chemokine mediated signaling pathway; actin cytoskeleton organization and biogenesis; signal transduction; cell differentiation
Reference #:  O75369 (UniProtKB)
Alt. Names/Synonyms: ABP-278; ABP-280; ABP-280 homolog; actin binding protein 278; Actin-binding-like protein; AOI; Beta-filamin; DKFZp686A1668; DKFZp686O033; Fh1; filamin 1 (actin-binding protein-280)-like; filamin B, beta; Filamin homolog 1; Filamin-3; Filamin-B; FLN-B; FLN1L; FLN3; FLNB; LRS1; SCT; TABP; TAP; Thyroid autoantigen; Truncated ABP; Truncated actin-binding protein
Gene Symbols: FLNB
Molecular weight: 278,164 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FLNB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K6-sc __MPVTEkDLAEDAP
0 4 K15-ac LAEDAPWkkIQQNTF
0 4 K16-ub AEDAPWkkIQQNTFT
0 3 K60-ub LLEVLSQkRMYRKYH
0 1 K93 FLDRESIKLVSIDSK
0 1 K142-ac DAKKQTPkQRLLGWI
0 1 K169-ac NQNWQDGkALGALVD
0 1 T216-p LGVPQVItPEEIIHP
0 2 T267-p YGRGIEPtGNMVKQP
0 1 K313-sc TPDSDKNkTYSVEYL
0 1 S339-p LFAGQHIsKSPFEVs
0 2 S346-p sKSPFEVsVDKAQGD
0 1 Y376-p NIANKPTyFDIYTAG
0 1 S440-p AGDTIPKsPFVVQVG
0 1 T472-p KGVRIREttDFKVDT
0 1 T473-p GVRIREttDFKVDTk
0 1 K480-ac tDFKVDTkAAGsGEL
0 1 S484-p VDTkAAGsGELGVTM
0 2 K492-ac GELGVTMkGPkGLEE
0 1 K492 GELGVTMKGPkGLEE
0 3 K495-ub GVTMkGPkGLEELVk
0 1 K502-ac kGLEELVkQKDFLDG
0 2 K502-ub kGLEELVkQKDFLDG
0 2 Y511 KDFLDGVYAFEYYPs
0 6 S518-p YAFEYYPstPGRYSI
0 25 T519-p AFEYYPstPGRYSIA
0 1 T528-p GRYSIAItWGGHHIP
0 2 S537-p GGHHIPKsPFEVQVG
0 2 Y596-p PSQAKIEyNDQNDGs
0 1 S603-p yNDQNDGsCDVKYWP
0 2 S630-p DDEDIKDsPyMAFIH
0 2 Y632-p EDIKDsPyMAFIHPA
0 2 T640-p MAFIHPAtGGYNPDL
0 3 S658-p YGPGLEKsGCIVNNL
0 4 K677-ac VDPKDAGkAPLkIFA
0 16 K681-ac DAGkAPLkIFAQDGE
0 1 K681-ub DAGkAPLkIFAQDGE
0 1 K697 QRIDIQMKNRMDGTy
0 122 Y704-p KNRMDGTyACsytPV
0 1 S707-p MDGTyACsytPVKAI
0 3 Y708-p DGTyACsytPVKAIK
0 3 T709-p GTyACsytPVKAIKH
0 3 S730-p GGVNIPHsPyRVNIG
0 1 Y732-p VNIPHsPyRVNIGQG
0 2 S740-p RVNIGQGsHPQKVKV
0 1 S789-p KCDARVLsEDEEDVD
0 1 S827-p TIKVLFAsQEIPAsP
0 7 S833-p AsQEIPAsPFRVKVD
0 3 S886-p PLNVQFNsPLPGDAV
0 1 Y902-p DLDIIDNyDySHtVK
0 19 Y904-p DIIDNyDySHtVKYT
0 1 T907-p DNyDySHtVKYTPTQ
0 3 S932-p GGDPIPKsPFTVGVA
0 1 S945-p VAAPLDLskIKLNGL
0 1 K946-ac AAPLDLskIKLNGLE
0 1 T965-p VGKDQEFtVDtRGAG
0 1 T968-p DQEFtVDtRGAGGQG
0 3 T980-p GQGKLDVtILsPsRK
0 12 S983-p KLDVtILsPsRKVVP
0 2 S985-p DVtILsPsRKVVPCL
0 1 T994-p KVVPCLVtPVtGREN
0 1 T997-p PCLVtPVtGRENSTA
0 1 Y1020-p LYAVDVTydGHPVPG
0 1 D1021-ca YAVDVTydGHPVPGs
0 2 S1028-p dGHPVPGsPYTVEAs
0 1 S1035-p sPYTVEAsLPPDPSK
1 0 K1147-ub GPGLEHGkVGEAGLL
0 1 S1174-p GLEAVSDsGTKAEVs
0 1 S1181-p sGTKAEVsIQNNKDG
0 1 T1189-p IQNNKDGtYAVTYVP
0 1 T1198-p AVTYVPLtAGMYtLT
0 1 T1203-p PLtAGMYtLTMKYGG
0 1 K1241 FGPGIEGKDVFREAT
0 1 T1259-p TVDSRPLtQVGGDHI
0 1 S1277-p IANPSGAsTECFVTD
0 1 T1307-p GLHVVEVtYDDVPIP
0 6 S1316-p DDVPIPNsPFKVAVT
0 1 S1329-p VTEGCQPsRVQAQGP
0 1 K1339 QAQGPGLKEAFTNkP
0 1 K1345-sc LKEAFTNkPNVFTVV
0 1 S1369-p GITVEGPsESKINCR
0 1 Y1395 IPFAPGDYDVNITYG
0 1 K1416-ac SPFRVPVkDVVDPsK
0 1 S1422-p VkDVVDPsKVKIAGP
0 6 S1433-p IAGPGLGsGVRARVL
0 2 S1442-p VRARVLQsFTVDssk
0 1 S1447-p LQsFTVDsskAGLAP
0 1 S1448-p QsFTVDsskAGLAPL
0 1 K1449-ub sFTVDsskAGLAPLE
0 2 - gap
0 1 D1476-ca VNVVDNGdGTHTVTY
0 21 S1505-p ADEEIPRsPFKVKVL
0 1 K1508 EIPRsPFKVKVLPTY
0 1 S1528-p TASGPGLssyGVPAs
0 1 S1529-p ASGPGLssyGVPAsL
0 58 Y1530-p SGPGLssyGVPAsLP
0 1 S1535-p ssyGVPAsLPVDFAI
0 1 T1557 GLLAVQITDQEGKPK
0 1 K1572 RAIVHDNKDGTyAVt
0 2 Y1576-p HDNKDGTyAVtYIPD
0 1 T1579-p KDGTyAVtYIPDKtG
0 2 T1585-p VtYIPDKtGRYMIGV
0 2 S1602-p GGDDIPLsPYRIRAt
0 9 T1609-p sPYRIRAtQTGDASk
0 1 K1616-ac tQTGDASkCLATGPG
0 1 K1641-ac VGFVVDAkTAGKGKV
0 1 K1641 VGFVVDAKTAGKGKV
0 2 Y1684-p TAAKPGTyVIyVRFG
0 10 Y1687-p KPGTyVIyVRFGGVD
0 3 Y1733-p PWVTEEAyVPVSDMN
0 1 K1757-ub VIPFAVRkGEITGEV
0 1 T1773-p MPSGKTAtPEIVDNk
0 1 K1780 tPEIVDNKDGtVtVR
0 1 K1780-sc tPEIVDNkDGtVtVR
0 1 T1783-p IVDNkDGtVtVRYAP
0 1 T1785-p DNkDGtVtVRYAPtE
0 1 T1791-p VtVRYAPtEVGLHEM
0 1 K1801 GLHEMHIKYMGSHIP
0 1 S1823-p VNYPNSGsVsAyGPG
0 1 S1825-p YPNSGsVsAyGPGLV
0 1 Y1827-p NSGsVsAyGPGLVyG
0 2 Y1833-p AyGPGLVyGVANKTA
0 1 T1883-p CTVTYLPtLPGDYsI
0 1 S1889-p PtLPGDYsILVKYND
0 1 K1897-ac ILVKYNDkHIPGSPF
0 2 K1897-ub ILVKYNDkHIPGSPF
0 1 S1916-p TDDSRRCsQVKLGsA
0 2 S1922-p CsQVKLGsAADFLLD
0 1 K1955-ub RDEPCLLkRLPNNHI
0 1 S1988-p NGNHVANsPVsIMVV
0 1 S1991-p HVANsPVsIMVVQsE
0 1 S1997-p VsIMVVQsEIGDARR
0 1 R2010-m1 RRAKVYGrGLsEGRt
0 2 S2013-p KVYGrGLsEGRtFEM
0 1 T2017-p rGLsEGRtFEMsDFI
0 1 S2021-p EGRtFEMsDFIVDTR
0 1 S2036-p DAGYGGIsLAVEGPS
0 1 Y2061-p DGTCKVSyFPTVPGV
0 7 S2083-p ADEHVPGsPFtVKIS
0 2 T2086-p HVPGsPFtVKISGEG
0 1 K2088 PGsPFtVKISGEGRV
0 1 S2098-p GEGRVKEsITRtSRA
0 1 T2100 GRVKEsITRtSRAPs
0 2 T2102-p VKEsITRtSRAPsVA
0 14 S2107-p TRtSRAPsVAtVGsI
0 1 T2110-p SRAPsVAtVGsICDL
0 1 S2113-p PsVAtVGsICDLNLK
0 2 S2135-p DMSAHVTsPSGRVTE
0 2 K2170-ac GVHTVSVkYRGQHVT
0 1 T2239-p GPSKAEItFDDHKNG
0 1 Y2260-p IAQEPGNyEVSIKFN
0 1 Y2276-p EHIPESPyLVPVIAP
0 2 T2291-p SDDARRLtVMSLQEs
0 1 S2298-p tVMSLQEsGLKVNQP
0 1 S2325-p KIDAKVHsPsGAVEE
0 1 S2327-p DAKVHsPsGAVEECH
0 1 S2336-p AVEECHVsELEPDKy
0 28 Y2343-p sELEPDKyAVRFIPH
0 1 S2364-p IDVKFNGsHVVGsPF
0 7 S2369-p NGsHVVGsPFKVRVG
0 1 S2403-p GGTTGIQsEFFINTt
0 1 T2410-p sEFFINTtRAGPGTL
0 1 S2425-p SVTIEGPsKVKMDCQ
0 1 Y2438-p CQETPEGyKVMYTPM
0 1 S2453-p APGNYLIsVKYGGPN
0 1 Y2456 NYLIsVKYGGPNHIV
0 1 V2463 YGGPNHIVGsPFKAK
0 11 S2465-p GPNHIVGsPFKAKVt
0 1 T2472-p sPFKAKVtGQRLVsP
0 15 S2478-p VtGQRLVsPGsANET
0 7 S2481-p QRLVsPGsANETSsI
0 1 S2487-p GsANETSsILVEsVt
0 1 S2492-p TSsILVEsVtRSSTE
0 1 T2494-p sILVEsVtRSSTEtC
0 2 T2500-p VtRSSTEtCysAIPK
0 779 Y2502-p RSSTEtCysAIPKAS
0 3 S2503-p SSTEtCysAIPKASs
0 1 S2510-p sAIPKASsDASKVTs
0 1 S2517-p sDASKVTsKGAGLSk
0 2 K2524-ac sKGAGLSkAFVGQKS
0 2 K2524-ub sKGAGLSkAFVGQKS
0 1 S2542-p VDCSKAGsNMLLIGV
0 2 T2553-p LIGVHGPttPCEEVS
0 9 T2554-p IGVHGPttPCEEVSM
0 1 N2566 VSMKHVGNQQYNVTY
0 2 K2576-ac YNVTYVVkERGDYVL
0 1 K2576-sc YNVTYVVkERGDYVL
  FLNB iso8  
K6 __MPVTEKDLAEDAP
K15 LAEDAPWKKIQQNTF
K16 AEDAPWKKIQQNTFT
K60 LLEVLSQKRMYRKYH
K93 FLDRESIKLVSIDSK
K142 DAKKQTPKQRLLGWI
K169 NQNWQDGKALGALVD
T216 LGVPQVITPEEIIHP
T267 YGRGIEPTGNMVKQP
K313 TPDSDKNKTYSVEYL
S339 LFAGQHISKSPFEVS
S346 SKSPFEVSVDKAQGD
Y376 NIANKPTYFDIYTAG
S440 AGDTIPKSPFVVQVG
T472 KGVRIRETTDFKVDT
T473 GVRIRETTDFKVDTK
K480 TDFKVDTKAAGSGEL
S484 VDTKAAGSGELGVTM
K492 GELGVTMKGPKGLEE
K492 GELGVTMKGPKGLEE
K495 GVTMKGPKGLEELVK
K502 KGLEELVKQKDFLDG
K502 KGLEELVKQKDFLDG
Y511 KDFLDGVYAFEYYPS
S518 YAFEYYPSTPGRYSI
T519 AFEYYPSTPGRYSIA
T528 GRYSIAITWGGHHIP
S537 GGHHIPKSPFEVQVG
Y596 PSQAKIEYNDQNDGS
S603 YNDQNDGSCDVKYWP
S630 DDEDIKDSPYMAFIH
Y632 EDIKDSPYMAFIHPA
T640 MAFIHPATGGYNPDL
S658 YGPGLEKSGCIVNNL
K677 VDPKDAGKAPLKIFA
K681 DAGKAPLKIFAQDGE
K681 DAGKAPLKIFAQDGE
K697 QRIDIQMKNRMDGTY
Y704 KNRMDGTYACSYTPV
S707 MDGTYACSYTPVKAI
Y708 DGTYACSYTPVKAIK
T709 GTYACSYTPVKAIKH
S730 GGVNIPHSPYRVNIG
Y732 VNIPHSPYRVNIGQG
S740 RVNIGQGSHPQKVKV
S789 KCDARVLSEDEEDVD
S827 TIKVLFASQEIPASP
S833 ASQEIPASPFRVKVD
S886 PLNVQFNSPLPGDAV
Y902 DLDIIDNYDYSHTVK
Y904 DIIDNYDYSHTVKYT
T907 DNYDYSHTVKYTPTQ
S932 GGDPIPKSPFTVGVA
S945 VAAPLDLSKIKLNGL
K946 AAPLDLSKIKLNGLE
T965 VGKDQEFTVDTRGAG
T968 DQEFTVDTRGAGGQG
T980 GQGKLDVTILSPSRK
S983 KLDVTILSPSRKVVP
S985 DVTILSPSRKVVPCL
T994 KVVPCLVTPVTGREN
T997 PCLVTPVTGRENSTA
Y1020 LYAVDVTYDGHPVPG
D1021 YAVDVTYDGHPVPGS
S1028 DGHPVPGSPYTVEAS
S1035 SPYTVEASLPPDPSK
K1147 GPGLEHGKVGEAGLL
S1174 GLEAVSDSGTKAEVS
S1181 SGTKAEVSIQNNKDG
T1189 IQNNKDGTYAVTYVP
T1198 AVTYVPLTAGMYTLT
T1203 PLTAGMYTLTMKYGG
K1241 FGPGIEGKDVFREAT
T1259 TVDSRPLTQVGGDHI
S1277 IANPSGASTECFVTD
T1307 GLHVVEVTYDDVPIP
S1316 DDVPIPNSPFKVAVT
S1329 VTEGCQPSRVQAQGP
K1339 QAQGPGLKEAFTNKP
K1345 LKEAFTNKPNVFTVV
S1369 GITVEGPSESKINCR
Y1395 IPFAPGDYDVNITYG
K1416 SPFRVPVKDVVDPSK
S1422 VKDVVDPSKVKIAGP
S1433 IAGPGLGSGVRARVL
S1442 VRARVLQSFTVDSSK
S1447 LQSFTVDSSKAGLAP
S1448 QSFTVDSSKAGLAPL
K1449 SFTVDSSKAGLAPLE
S1474-p TDSQSWRsPLKALSE
D1507 VNVVDNGDGTHTVTY
S1536 ADEEIPRSPFKVKVL
K1539 EIPRSPFKVKVLPTY
S1559 TASGPGLSSYGVPAS
S1560 ASGPGLSSYGVPASL
Y1561 SGPGLSSYGVPASLP
S1566 SSYGVPASLPVDFAI
T1588 GLLAVQITDQEGKPK
K1603 RAIVHDNKDGTYAVT
Y1607 HDNKDGTYAVTYIPD
T1610 KDGTYAVTYIPDKTG
T1616 VTYIPDKTGRYMIGV
S1633 GGDDIPLSPYRIRAT
T1640 SPYRIRATQTGDASK
K1647 TQTGDASKCLATGPG
K1672 VGFVVDAKTAGKGKV
K1672 VGFVVDAKTAGKGKV
Y1715 TAAKPGTYVIYVRFG
Y1718 KPGTYVIYVRFGGVD
Y1764 PWVTEEAYVPVSDMN
K1788 VIPFAVRKGEITGEV
T1804 MPSGKTATPEIVDNK
K1811 TPEIVDNKDGTVTVR
K1811 TPEIVDNKDGTVTVR
T1814 IVDNKDGTVTVRYAP
T1816 DNKDGTVTVRYAPTE
T1822 VTVRYAPTEVGLHEM
K1832 GLHEMHIKYMGSHIP
S1854 VNYPNSGSVSAYGPG
S1856 YPNSGSVSAYGPGLV
Y1858 NSGSVSAYGPGLVYG
Y1864 AYGPGLVYGVANKTA
T1914 CTVTYLPTLPGDYSI
S1920 PTLPGDYSILVKYND
K1928 ILVKYNDKHIPGSPF
K1928 ILVKYNDKHIPGSPF
S1947 TDDSRRCSQVKLGSA
S1953 CSQVKLGSAADFLLD
K1986 RDEPCLLKRLPNNHI
S2019 NGNHVANSPVSIMVV
S2022 HVANSPVSIMVVQSE
S2028 VSIMVVQSEIGDARR
R2041 RRAKVYGRGLSEGRT
S2044 KVYGRGLSEGRTFEM
T2048 RGLSEGRTFEMSDFI
S2052 EGRTFEMSDFIVDTR
S2067 DAGYGGISLAVEGPS
Y2092 DGTCKVSYFPTVPGV
S2114 ADEHVPGSPFTVKIS
T2117 HVPGSPFTVKISGEG
K2119 PGSPFTVKISGEGRV
S2129 GEGRVKESITRTSRA
T2131 GRVKESITRTSRAPS
T2133 VKESITRTSRAPSVA
S2138 TRTSRAPSVATVGSI
T2141 SRAPSVATVGSICDL
S2144 PSVATVGSICDLNLK
S2166 DMSAHVTSPSGRVTE
K2201 GVHTVSVKYRGQHVT
T2270 GPSKAEITFDDHKNG
Y2291 IAQEPGNYEVSIKFN
Y2307 EHIPESPYLVPVIAP
T2322 SDDARRLTVMSLQES
S2329 TVMSLQESGLKVNQP
S2356 KIDAKVHSPSGAVEE
S2358 DAKVHSPSGAVEECH
S2367 AVEECHVSELEPDKY
Y2374 SELEPDKYAVRFIPH
S2395 IDVKFNGSHVVGSPF
S2400 NGSHVVGSPFKVRVG
S2434 GGTTGIQSEFFINTT
T2441 SEFFINTTRAGPGTL
S2456 SVTIEGPSKVKMDCQ
Y2469 CQETPEGYKVMYTPM
S2484 APGNYLISVKYGGPN
Y2487 NYLISVKYGGPNHIV
V2494 YGGPNHIVGSPFKAK
S2496 GPNHIVGSPFKAKVT
T2503 SPFKAKVTGQRLVSP
S2509 VTGQRLVSPGSANET
S2512 QRLVSPGSANETSSI
S2518 GSANETSSILVESVT
S2523 TSSILVESVTRSSTE
T2525 SILVESVTRSSTETC
T2531 VTRSSTETCYSAIPK
Y2533 RSSTETCYSAIPKAS
S2534 SSTETCYSAIPKASS
S2541 SAIPKASSDASKVTS
S2548 SDASKVTSKGAGLSK
K2555 SKGAGLSKAFVGQKS
K2555 SKGAGLSKAFVGQKS
S2573 VDCSKAGSNMLLIGV
T2584 LIGVHGPTTPCEEVS
T2585 IGVHGPTTPCEEVSM
N2597 VSMKHVGNQQYNVTY
K2607 YNVTYVVKERGDYVL
K2607 YNVTYVVKERGDYVL
  mouse

 
K6 __MPVTEKDLAEDAP
K15-ac LAEDAPWkkIQQNTF
K16-ub AEDAPWkkIQQNTFT
K60 LLEVLSQKRMHHKYH
K93-ac FLDHESIkLVSIDSK
K142 DAKKQTPKQRLLGWI
K169 NQNWQDGKALGALVD
T216 LGVPQVITPEEIIHP
T267-p YGRGIEPtGNMVKQP
K313 TPDSDKNKTYSVEYL
S339 LFAGQHISKSPFEVN
N346 SKSPFEVNVDKAQGD
Y376 NIANKPTYFDIYTAG
S440 AGDAIPKSPFGVQIG
T472 KGVRIRETADFKVDT
A473 GVRIRETADFKVDTK
K480 ADFKVDTKAAGSGEL
S484 VDTKAAGSGELGVTV
K492 GELGVTVKGPkGLEE
K492-ub GELGVTVkGPkGLEE
K495-ub GVTVkGPkGLEELVk
K502 kGLEELVKQKGFLDG
K502-ub kGLEELVkQKGFLDG
Y511-p KGFLDGVySFEYYPS
S518 ySFEYYPStPGKYSV
T519-p SFEYYPStPGKYSVA
T528 GKYSVAVTWGGHHIP
S537 GGHHIPKSPFEVQVG
Y596 PSQAKIEYDDQNDGS
S603 YDDQNDGSCDVKYWP
S630 DDEDIKDSPYMAFIH
Y632 EDIKDSPYMAFIHPA
T640 MAFIHPATGDYNPDL
S658-p YGPGLEKsGCTINNP
S677 VDPKDAGSAPLKILA
K681 DAGSAPLKILAQDGE
K681 DAGSAPLKILAQDGE
K697-ub QPIDIQMkSRMDGTy
Y704-p kSRMDGTyACSYtPL
S707 MDGTyACSYtPLKAI
Y708 DGTyACSYtPLKAIK
T709-p GTyACSYtPLKAIKH
S730 GGVNIPHSPYRVNIG
Y732 VNIPHSPYRVNIGQG
S740 RVNIGQGSHPQKVKV
S789 KCDARVLSDDEEDVD
S827 TIKVLFASQEIPAsP
S833-p ASQEIPAsPFRVKVD
S886 PLNVQFSSPLPGEAV
Y902 DLDIIDNYDySHTVK
Y904-p DIIDNYDySHTVKYT
T907 DNYDySHTVKYTPTQ
S932 GGDPIPKSPFTVGVA
S945 VAAPLDLSKIKINGL
K946 AAPLDLSKIKINGLE
A965 VGKDQEFAIDTNGAG
T968 DQEFAIDTNGAGGQG
T980 GQGKLDVTILsPsRK
S983-p KLDVTILsPsRKVVP
S985-p DVTILsPsRKVVPCL
A994 KVVPCLVAPVAGREC
A997 PCLVAPVAGRECSTA
Y1020 LFAVDVTYDGHPVPG
D1021 FAVDVTYDGHPVPGS
S1028 DGHPVPGSPYTVEAS
S1035 SPYTVEASLPPDPTK
K1147 GPGLEHGKVGEPGIL
S1174 GLEAVSDSGAKAEVS
S1181 SGAKAEVSIQNNKDG
T1189 IQNNKDGTYAVTYVP
T1198 AVTYVPLTAGMYTLT
T1203 PLTAGMYTLTMKYGG
K1241-ub FGPGIEGkDVFREAT
T1259 TVDSRPLTQVGGDHI
S1277 ITNPSGASTECFVKD
T1307 GFHVVEVTYDDVPIP
S1316-p DDVPIPNsPFKVAVT
S1329 VTEGCQPSRVHAQGP
K1339-ub HAQGPGLkEAFTNKS
K1345 LkEAFTNKSNVFTVV
S1369 GITVEGPSESKINCR
Y1395-p IPFAPGDyDVNITYG
K1416 SPFRVPSKDVVDPSK
S1422 SKDVVDPSKVKIAGP
S1433 IAGPGLSSCVRACIP
S1442 VRACIPQSFTVDSSK
S1447 PQSFTVDSSKAGLAP
S1448 QSFTVDSSKAGLAPL
K1449 SFTVDSSKAGLAPLE
- gap
D1476 VNVVDNGDGTHTVTY
S1505-p ADEEIPRsPFkVKVL
K1508-ub EIPRsPFkVKVLPTY
S1528 TASGPGLSAYGVPAS
A1529 ASGPGLSAYGVPASL
Y1530 SGPGLSAYGVPASLP
S1535 SAYGVPASLPVEFAI
T1557-p GLLAVQItDQEGKPQ
K1572-ub RATVHDNkDGTYAVT
Y1576 HDNkDGTYAVTYIPD
T1579 kDGTYAVTYIPDKTG
T1585 VTYIPDKTGRYMIGV
S1602 GGDNIPLSPYRIRAT
T1609 SPYRIRATQTGDASK
K1616 TQTGDASKCLATGPG
K1641 VGFVVDAKTAGKGKV
K1641-ub VGFVVDAkTAGKGKV
Y1684 TAAKPGTYVIYVRFG
Y1687 KPGTYVIYVRFGGVD
Y1733 PWVTEEAYVPVSDMN
K1757 VIPFAVRKGEITGTV
T1773 MPSGKKATPEIVDNk
K1780-ub TPEIVDNkDGTVTVR
K1780 TPEIVDNKDGTVTVR
T1783 IVDNkDGTVTVRYAP
T1785 DNkDGTVTVRYAPTE
T1791 VTVRYAPTEVGLHEM
K1801-ac GLHEMHIkYRGSHIP
S1823 VNYPNSGSVSAYGPG
S1825 YPNSGSVSAYGPGLV
Y1827 NSGSVSAYGPGLVYG
Y1833 AYGPGLVYGVANKTA
T1883 CTVTYLPTLPGDYSI
S1889 PTLPGDYSILVKYND
K1897 ILVKYNDKHIPGSPF
K1897-ub ILVKYNDkHIPGSPF
S1916-p TDDNRRCsQVKLGSA
S1922 CsQVKLGSAADFLLD
K1955 RDEPCLLKRLPNNHI
S1988 NGNHVANSPVSIMVV
S1991 HVANSPVSIMVVQSE
S1997 VSIMVVQSEIGDARR
Q2010 RRAKVYGQGLSEGRT
S2013 KVYGQGLSEGRTFEM
T2017 QGLSEGRTFEMSDFI
S2021 EGRTFEMSDFIVDTR
S2036 DAGYGGISLAVEGPS
Y2061 DGTCKVSYFPTVPGV
S2083-p ADEHVPGsPFTVkIS
T2086 HVPGsPFTVkISGEG
K2088-ub PGsPFTVkISGEGRV
S2098-p GEGRVREsItRTSRA
T2100-p GRVREsItRTSRAPA
T2102 VREsItRTSRAPAVA
A2107 tRTSRAPAVATVGSI
T2110 SRAPAVATVGSICDL
S2113 PAVATVGSICDLNLK
S2135 DMSAHVTSPSGHVTE
K2170 GVHTVSVKYRGQHVT
T2239 GPSKAEITFDDHKNG
Y2260 IAQEPGNYEVSIKFN
Y2276 EHIPDSPYLVPVIAP
T2291 SDDARCLTVLSLQES
S2298 TVLSLQESGLKVNQP
S2325 KIDAKVHSPSGAVEE
S2327 DAKVHSPSGAVEECH
S2336 AVEECHVSELEPDKY
Y2343 SELEPDKYAVRFIPH
S2364 IDVKFNGSHVVGsPF
S2369-p NGSHVVGsPFKVRVG
S2403 TGTTGIQSEFFINTT
T2410 SEFFINTTQAGPGTL
S2425 SVTIEGPSKVKMDCQ
Y2438 CQEIPEGYKVMYTPM
G2453 APGNYLIGVKyGGPN
Y2456-p NYLIGVKyGGPNHIs
S2463-p yGGPNHIsRsPFKAK
S2465-p GPNHIsRsPFKAKVT
T2472 sPFKAKVTGQRLVsP
S2478-p VTGQRLVsPGsANET
S2481-p QRLVsPGsANETSSI
S2487 GsANETSSILVESVT
S2492 TSSILVESVTRSSTE
T2494 SILVESVTRSSTETC
T2500 VTRSSTETCysAIPK
Y2502-p RSSTETCysAIPKSS
S2503-p SSTETCysAIPKSSS
S2510 sAIPKSSSDASKVTS
S2517 SDASKVTSKGAGLSk
K2524 SKGAGLSKAFVGQKS
K2524-ub SKGAGLSkAFVGQKS
S2542 VDCSKAGSNMLLIGV
T2553-p LIGVHGPttPCEEVS
T2554-p IGVHGPttPCEEVSM
K2566-ub VSMKHVGkQQYNVTY
K2576 YNVTYVVKERGDYVL
K2576 YNVTYVVKERGDYVL
  rat

 
K6 __MPVTEKDLAEDAP
K15 LAEDAPWKKIQQNTF
K16 AEDAPWKKIQQNTFT
K60 LLEVLSQKRMHHKYH
K93 FLDHESIKLVSIDSK
K142 DAKKQTPKQRLLGWI
K169 NQNWQDGKALGALVD
T216 LGVPQVITPEEIIHP
T267 YGRGIESTGNMVKQP
K313 TPDSDKNKTYSVEYL
S339 LFAGQHISKSPFEVN
N346 SKSPFEVNVDKAQGD
Y376 NIANKPTYFDIYTAG
S440 AGDAIPKSPFGVQIG
T472 KGVRIRETADFKVDT
A473 GVRIRETADFKVDTK
K480 ADFKVDTKAAGSGEL
S484 VDTKAAGSGELAVTV
K492 GELAVTVKGPKGLEE
K492 GELAVTVKGPKGLEE
K495 AVTVKGPKGLEELVK
K502 KGLEELVKQKGFLDG
K502 KGLEELVKQKGFLDG
Y511 KGFLDGVYSFEYYPS
S518 YSFEYYPSTPGKYSI
T519 SFEYYPSTPGKYSIA
T528 GKYSIAVTWGGHHIP
S537 GGHHIPKSPFEVQVG
Y596 PSQAKIEYDDQNDGS
S603 YDDQNDGSCDVKYWP
S630 DDEDIKDSPYMAFIH
Y632 EDIKDSPYMAFIHPA
T640 MAFIHPATGDYNPDL
T658 YGPGLEKTGCTINNP
N677 VDPKDAGNAPLKILA
K681 DAGNAPLKILAQDGE
K681 DAGNAPLKILAQDGE
K697 QPIDIQMKSRMDGTY
Y704 KSRMDGTYVCSYTPV
S707 MDGTYVCSYTPVKAI
Y708 DGTYVCSYTPVKAIK
T709 GTYVCSYTPVKAIKH
S730 GGVNIPHSPYRVNIG
Y732 VNIPHSPYRVNIGQG
S740 RVNIGQGSHPQKVKV
S789 KCDARVLSDDEEDVD
S827 TIKVLFASEEIPASP
S833 ASEEIPASPFRVKVD
S886 PLNVQFSSPVPGEAV
Y902 DLDIIDNYDYSHTVK
Y904 DIIDNYDYSHTVKYT
T907 DNYDYSHTVKYTPTQ
S932 GGDPIPKSPFTVGVA
S945 VAAPLDLSKIKINGL
K946 AAPLDLSKIKINGLE
A965 VGKDQEFAIDTNGAG
T968 DQEFAIDTNGAGGQG
T980 GQGKLDVTILSPSRK
S983 KLDVTILSPSRKVVP
S985 DVTILSPSRKVVPCL
A994 KVVPCLVAPVAGREC
A997 PCLVAPVAGRECSTA
Y1020 LFAVDVTYDGHPVPG
D1021 FAVDVTYDGHPVPGS
S1028 DGHPVPGSPYTVEAS
S1035 SPYTVEASLPPDPTK
K1147 GPGLEHGKVGEPGIL
S1174 GLEAVSDSGAKAEVS
S1181 SGAKAEVSIQNNKDG
S1189 IQNNKDGSYAVTYVP
T1198 AVTYVPLTAGMYTLT
T1203 PLTAGMYTLTMKYGG
K1241 FGPGIEGKDVFREAT
T1259 TVDARPLTQVGGDHI
S1277 IANPSGASTECFVKD
T1307 GFHVVEVTYDDAPIP
S1316 DDAPIPNSPFKVAVN
S1329 VNEGCQPSRVHAQGP
K1339 HAQGPGLKEAFTNKP
K1345 LKEAFTNKPNVFTVV
S1369 GITVEGPSESKINCR
Y1395 IPFAPGDYDVNITYG
K1416 SPFRVPSKDVVDPSK
S1422 SKDVVDPSKVKIAGP
S1433 IAGPGLSSCVRACIP
S1442 VRACIPQSFTVDTSK
T1447 PQSFTVDTSKAGLAP
S1448 QSFTVDTSKAGLAPL
K1449 SFTVDTSKAGLAPLE
- gap
D1476 VDVVDNGDGTHTVTY
S1505 ADEEIPRSPFKVKVL
K1508 EIPRSPFKVKVLPTY
S1528 TASGPGLSAYGVPAS
A1529 ASGPGLSAYGVPASL
Y1530 SGPGLSAYGVPASLP
S1535 SAYGVPASLPVEFAI
T1557 GLLAVQITDQEGKPQ
K1572 RATVHDNKDGTYAVT
Y1576 HDNKDGTYAVTYIPD
T1579 KDGTYAVTYIPDKTG
T1585 VTYIPDKTGRYMIGV
S1602 GGDNIPLSPYRIRAT
T1609 SPYRIRATQTGDASK
K1616 TQTGDASKCLATGPG
K1641 VGFVVDAKTAGKGKV
K1641 VGFVVDAKTAGKGKV
Y1684 TAAKPGTYVIYVRFG
Y1687 KPGTYVIYVRFGGVD
Y1709 VMVTEEAYVPVSDMN
K1733 VIPFAVRKGEITGQV
T1749 MPSGKKATPEIVDNK
K1756 TPEIVDNKDGTVTVR
K1756 TPEIVDNKDGTVTVR
T1759 IVDNKDGTVTVRYAP
T1761 DNKDGTVTVRYAPTE
T1767 VTVRYAPTEVGLHEM
K1777 GLHEMHIKYMGSHIP
S1799 VNYPNSGSVSAYGPG
S1801 YPNSGSVSAYGPGLV
Y1803 NSGSVSAYGPGLVYG
Y1809 AYGPGLVYGVANKTA
T1859 CTVTYLPTLPGDYSI
S1865 PTLPGDYSILVKYND
K1873 ILVKYNDKHIPGSPF
K1873 ILVKYNDKHIPGSPF
S1892 TDDSRRCSQVKLGSA
S1898 CSQVKLGSAADFLLD
K1931 RDEPCLLKRLPNNHI
S1964 NGNHVANSPVSIMVV
S1967 HVANSPVSIMVVQSE
S1973 VSIMVVQSEIGDARR
R1986 RRAKVYGRGLSEGRT
S1989 KVYGRGLSEGRTFEM
T1993 RGLSEGRTFEMSDFI
S1997 EGRTFEMSDFIVDTR
S2012 DAGYGGISLAVEGPS
Y2037 DGTCKVSYFPTVPGV
S2059 ADEHVPGSPFTVKIS
T2062 HVPGSPFTVKISGEG
K2064 PGSPFTVKISGEGRV
S2074 GEGRVKESITRTSRA
T2076 GRVKESITRTSRAPs
T2078 VKESITRTSRAPsVA
S2083-p TRTSRAPsVATVGSI
T2086 SRAPsVATVGSICDL
S2089 PsVATVGSICDLNLK
S2111 DMSAHVTSPSGHVTE
K2146 GVHTVSVKYRGQHVT
T2215 GPSKAEITFDDHKNG
Y2236 IAQEPGNYEVSIKFN
Y2252 EHIPDSPYLVPVIAP
T2267 SDDARCLTVLSLQES
S2274 TVLSLQESGLKVNQP
S2301 KIDAKVHSPSGAVEE
S2303 DAKVHSPSGAVEECH
S2312 AVEECHVSELEPDKY
Y2319 SELEPDKYAVRFIPH
S2340 IDVKFNGSHVVGSPF
S2345 NGSHVVGSPFKVRVG
S2379 AGTTGIQSEFFINTT
T2386 SEFFINTTQAGPGTL
S2401 SVTIEGPSKVKMDCQ
Y2414 CQEIPEGYKVMYTPM
S2429 APGNYLISVKYGGPN
Y2432 NYLISVKYGGPNHIS
S2439 YGGPNHISRSPFKAK
S2441 GPNHISRSPFKAKVT
T2448 SPFKAKVTGQRLVTP
T2454 VTGQRLVTPGSANET
S2457 QRLVTPGSANETSSI
S2463 GSANETSSILVESVT
S2468 TSSILVESVTRSSTE
T2470 SILVESVTRSSTETC
T2476 VTRSSTETCYSAIPK
Y2478 RSSTETCYSAIPKSS
S2479 SSTETCYSAIPKSSS
S2486 SAIPKSSSDASKVTS
S2493 SDASKVTSKGAGLSK
K2500 SKGAGLSKAFVGQKS
K2500 SKGAGLSKAFVGQKS
S2518 VDCSKAGSNMLLIGV
T2529 LIGVHGPTTPCEEVS
T2530 IGVHGPTTPCEEVSM
K2542 VSMKHVGKQQYNVTY
K2552 YNVTYVVKEKGDYVL
K2552 YNVTYVVKEKGDYVL
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