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ENO1 (human)

Overview ENO1 an abundant cytoplasmic enzyme with 2-phospho-D-glycerate hydro-lyase activity. A target of excess protein nitration in Alzheimer disease (AD) brain. Tau-crystallin, a structural lens protein, is produced from an alternative translation start in the enolase gene. Note: This description may include information from UniProtKB. Protein type: EC 4.2.1.11; Lyase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Transcription, coactivator/corepressor Cellular Component: phosphopyruvate hydratase complex; cytoplasm; plasma membrane; M band; cytosol; nucleus Molecular Function: protein binding; DNA binding; magnesium ion binding; phosphopyruvate hydratase activity; transcription factor activity; transcription corepressor activity Biological Process: glycolysis; transcription, DNA-dependent; response to virus; carbohydrate metabolic process; glucose metabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; gluconeogenesis Reference #:  P06733 (UniProtKB) Alt. Names/Synonyms: 2-phospho-D-glycerate hydro-lyase; alpha enolase like 1; Alpha-enolase; C-myc promoter-binding protein; ENO1; ENO1L1; ENOA; Enolase 1; enolase 1, (alpha); MBP-1; MBPB1; MPB-1; MPB1; MYC promoter-binding protein 1; NNE; Non-neural enolase; Phosphopyruvate hydratase; Plasminogen-binding protein; PPH; tau-crystallin Gene Symbols: ENO1 Molecular weight: 47,169 Da Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ENO1 1PDZ (human) 2PSN - A/D/C/B=1-434 (human) 3B97 - A/D/C/B=2-434 (human) 2GUA - A=1-434 (chicken)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K5-a	___MSILkIHAREIF
0	1		K5-u	___MSILkIHAREIF
0	1		S14-p	HAREIFDsRGNPTVE
0	79		F25	PTVEVDLFtskGLFR
0	1		T26-p	TVEVDLFtskGLFRA
0	2		S27-p	VEVDLFtskGLFRAA
0	1		K28-a	EVDLFtskGLFRAAV
0	24		K28-u	EVDLFtskGLFRAAV
0	4		S37-p	LFRAAVPsGAstGIy
0	12		S40-p	AAVPsGAstGIyEAL
0	66		T41-p	AVPsGAstGIyEALE
2	1946		Y44-p	sGAstGIyEALELRD
0	2		K54-u	LELRDNDktRyMGkG
0	2		T55-p	ELRDNDktRyMGkGV
0	1		Y57-p	RDNDktRyMGkGVSk
0	4		K60-a	DktRyMGkGVSkAVE
0	22		K60-u	DktRyMGkGVSkAVE
0	2		K64-a	yMGkGVSkAVEHINk
0	87		K64-u	yMGkGVSkAVEHINk
0	5		K71-a	kAVEHINkTIAPALV
0	14		K71-u	kAVEHINkTIAPALV
0	2		S79-p	TIAPALVskkLNVTE
0	29		K80-a	IAPALVskkLNVTEQ
0	25		K80-u	IAPALVskkLNVTEQ
0	2		K81-a	APALVskkLNVTEQE
0	7		K81-u	APALVskkLNVTEQE
0	4		K89-a	LNVTEQEkIDkLMIE
0	36		K89-u	LNVTEQEkIDkLMIE
0	3		K92-a	TEQEkIDkLMIEMDG
0	5		K92-u	TEQEkIDkLMIEMDG
0	1		T100-p	LMIEMDGtENkSkFG
0	1		K103-a	EMDGtENkSkFGANA
0	2		K103-u	EMDGtENkSkFGANA
0	1		K105-a	DGtENkSkFGANAIL
0	1		K105-u	DGtENkSkFGANAIL
0	45		K120-u	GVSLAVCkAGAVEkG
0	4		K126-a	CkAGAVEkGVPLyRH
0	11		K126-u	CkAGAVEkGVPLyRH
0	7		Y131-p	VEkGVPLyRHIADLA
0	158		Y189-p	MRIGAEVyHNLkNVI
0	8		K193-a	AEVyHNLkNVIkEkY
0	32		K193-u	AEVyHNLkNVIkEkY
0	12		K197-a	HNLkNVIkEkYGkDA
0	44		K197-u	HNLkNVIkEkYGkDA
0	9		K199-a	LkNVIkEkYGkDATN
0	12		K202-a	VIkEkYGkDATNVGD
0	59		K202-u	VIkEkYGkDATNVGD
0	4		K221-a	APNILENkEGLELLk
0	27		K221-u	APNILENkEGLELLk
0	6		K228-a	kEGLELLkTAIGkAG
0	10		K228-u	kEGLELLkTAIGkAG
0	2		K233-a	LLkTAIGkAGytDkV
0	5		K233-u	LLkTAIGkAGytDkV
0	1		Y236-p	TAIGkAGytDkVVIG
0	1		T237-p	AIGkAGytDkVVIGM
0	1		K239-a	GkAGytDkVVIGMDV
0	5		S254-p	AASEFFRsGkyDLDF
0	18		K256-a	SEFFRsGkyDLDFks
0	33		K256-u	SEFFRsGkyDLDFks
0	3		Y257-p	EFFRsGkyDLDFksP
0	1		K262-a	GkyDLDFksPDDPSR
0	2		K262-u	GkyDLDFksPDDPSR
0	33		S263-p	kyDLDFksPDDPSRY
0	2		S268	FksPDDPSRYIsPDQ
0	1		Y270	sPDDPSRYIsPDQLA
0	7		S272-p	DDPSRYIsPDQLADL
0	4		Y280-p	PDQLADLyksFIkDy
0	9		K281-a	DQLADLyksFIkDyP
0	4		K281-u	DQLADLyksFIkDyP
0	10		S282-p	QLADLyksFIkDyPV
0	3		K285-a	DLyksFIkDyPVVsI
0	21		K285-u	DLyksFIkDyPVVsI
0	181		Y287-p	yksFIkDyPVVsIED
0	3		S291-p	IkDyPVVsIEDPFDQ
0	1		K306-a	DDWGAWQkFTASAGI
0	1		S310	AWQkFTASAGIQVVG
0	37		K326-a	DLTVTNPkRIAkAVN
0	11		K326-u	DLTVTNPkRIAkAVN
0	1		K330-a	TNPkRIAkAVNEksC
0	9		K330-u	TNPkRIAkAVNEksC
0	1		N333	kRIAkAVNEksCNCL
0	11		K335-a	IAkAVNEksCNCLLL
0	10		K335-u	IAkAVNEksCNCLLL
0	1		S336-p	AkAVNEksCNCLLLk
0	62		K343-a	sCNCLLLkVNQIGSV
0	93		K343-u	sCNCLLLkVNQIGSV
0	1		S349	LkVNQIGSVTESLQA
0	1		K358-a	TESLQACkLAQANGW
0	1		A362	QACkLAQANGWGVMV
0	1		S370-p	NGWGVMVsHRSGETE
0	3		K394-u	GLCTGQIkTGAPCRS
1	15		K406-a	CRSERLAkYNQLLRI
0	3		K406-u	CRSERLAkYNQLLRI
1	12		S419-p	RIEEELGskAkFAGR
0	2		K420-a	IEEELGskAkFAGRN
0	38		K420-u	IEEELGskAkFAGRN
0	3		K422-u	EELGskAkFAGRNFR
0	1		R426	skAkFAGRNFRNPLA
0	4		N427	kAkFAGRNFRNPLAk
0	1		K434-a	NFRNPLAk_______

	mouse
R5	___MSILRIHAREIF
R5	___MSILRIHAREIF
S14	HAREIFDSRGNPTVE
Y25-p	PTVEVDLyTAkGLFR
T26	TVEVDLyTAkGLFRA
A27	VEVDLyTAkGLFRAA
K28	EVDLyTAKGLFRAAV
K28-u	EVDLyTAkGLFRAAV
S37-p	LFRAAVPsGAstGIy
S40-p	AAVPsGAstGIyEAL
T41-p	AVPsGAstGIyEALE
Y44-p	sGAstGIyEALELRD
K54-u	LELRDNDkTRFMGkG
T55	ELRDNDkTRFMGkGV
F57	RDNDkTRFMGkGVSQ
K60-a	DkTRFMGkGVSQAVE
K60-u	DkTRFMGkGVSQAVE
Q64	FMGkGVSQAVEHINk
Q64	FMGkGVSQAVEHINk
K71-a	QAVEHINkTIAPALV
K71-u	QAVEHINkTIAPALV
S79-p	TIAPALVskkVNVVE
K80-a	IAPALVskkVNVVEQ
K80-u	IAPALVskkVNVVEQ
K81-a	APALVskkVNVVEQE
K81-u	APALVskkVNVVEQE
K89-a	VNVVEQEkIDkLMIE
K89-u	VNVVEQEkIDkLMIE
K92-a	VEQEkIDkLMIEMDG
K92-u	VEQEkIDkLMIEMDG
T100	LMIEMDGTENkSKFG
K103	EMDGTENKSKFGANA
K103-u	EMDGTENkSKFGANA
K105	DGTENkSKFGANAIL
K105	DGTENkSKFGANAIL
K120	GVSLAVCKAGAVEKG
K126	CKAGAVEKGVPLYRH
K126	CKAGAVEKGVPLYRH
Y131	VEKGVPLYRHIADLA
Y189-p	MRIGAEVyHNLkNVI
K193-a	AEVyHNLkNVIkEKY
K193-u	AEVyHNLkNVIkEKY
K197-a	HNLkNVIkEKYGkDA
K197	HNLkNVIKEKYGkDA
K199	LkNVIkEKYGkDATN
K202-a	VIkEKYGkDATNVGD
K202-u	VIkEKYGkDATNVGD
K221-a	APNILENkEALELLk
K221-u	APNILENkEALELLk
K228-a	kEALELLkTAIAKAG
K228-u	kEALELLkTAIAKAG
K233	LLkTAIAKAGYTDQV
K233	LLkTAIAKAGYTDQV
Y236	TAIAKAGYTDQVVIG
T237	AIAKAGYTDQVVIGM
Q239	AKAGYTDQVVIGMDV
S254-p	AASEFYRsGkYDLDF
K256-a	SEFYRsGkYDLDFKs
K256-u	SEFYRsGkYDLDFKs
Y257	EFYRsGkYDLDFKsP
K262	GkYDLDFKsPDDPsR
K262	GkYDLDFKsPDDPsR
S263-p	kYDLDFKsPDDPsRy
S268-p	FKsPDDPsRyItPDQ
Y270-p	sPDDPsRyItPDQLA
T272-p	DDPsRyItPDQLADL
Y280	PDQLADLYKsFVQNy
K281	DQLADLYKsFVQNyP
K281	DQLADLYKsFVQNyP
S282-p	QLADLYKsFVQNyPV
Q285	DLYKsFVQNyPVVSI
Q285	DLYKsFVQNyPVVSI
Y287-p	YKsFVQNyPVVSIED
S291	VQNyPVVSIEDPFDQ
K306	DDWGAWQKFTAsAGI
S310-p	AWQKFTAsAGIQVVG
K326-a	DLTVTNPkRIAKAAs
K326-u	DLTVTNPkRIAKAAs
K330	TNPkRIAKAAsEkSC
K330	TNPkRIAKAAsEkSC
S333-p	kRIAKAAsEkSCNCL
K335	IAKAAsEKSCNCLLL
K335-u	IAKAAsEkSCNCLLL
S336	AKAAsEkSCNCLLLk
K343-a	SCNCLLLkVNQIGsV
K343-u	SCNCLLLkVNQIGsV
S349-p	LkVNQIGsVTESLQA
K358	TESLQACKLAQsNGW
S362-p	QACKLAQsNGWGVMV
S370	NGWGVMVSHRSGETE
K394-u	GLCTGQIkTGAPCRS
K406	CRSERLAKYNQILRI
K406-u	CRSERLAkYNQILRI
S419-p	RIEEELGskAKFAGr
K420	IEEELGsKAKFAGrs
K420-u	IEEELGskAKFAGrs
K422	EELGskAKFAGrsFR
R426-m1	skAKFAGrsFRNPLA
S427-p	kAKFAGrsFRNPLAK
K434	sFRNPLAK_______

	rat
K5	___MSILKIHAREIF
K5	___MSILKIHAREIF
S14	HAREIFDSRGNPTVE
Y25	PTVEVDLYTAKGLFR
T26	TVEVDLYTAKGLFRA
A27	VEVDLYTAKGLFRAA
K28	EVDLYTAKGLFRAAV
K28	EVDLYTAKGLFRAAV
S37	LFRAAVPSGAsTGIy
S40-p	AAVPSGAsTGIyEAL
T41	AVPSGAsTGIyEALE
Y44-p	SGAsTGIyEALELRD
K54	LELRDNDKTRFMGKG
T55	ELRDNDKTRFMGKGV
F57	RDNDKTRFMGKGVSk
K60	DKTRFMGKGVSkAVE
K60	DKTRFMGKGVSkAVE
K64	FMGKGVSKAVEHINK
K64-u	FMGKGVSkAVEHINK
K71	kAVEHINKTIAPALV
K71	kAVEHINKTIAPALV
S79-p	TIAPALVsKKLNVVE
K80	IAPALVsKKLNVVEQ
K80	IAPALVsKKLNVVEQ
K81	APALVsKKLNVVEQE
K81	APALVsKKLNVVEQE
K89	LNVVEQEKIDQLMIE
K89	LNVVEQEKIDQLMIE
Q92	VEQEKIDQLMIEMDG
Q92	VEQEKIDQLMIEMDG
T100	LMIEMDGTENKSKFG
K103	EMDGTENKSKFGANA
K103	EMDGTENKSKFGANA
K105	DGTENKSKFGANAIL
K105	DGTENKSKFGANAIL
K120	GVSLAVCKAGAVEKG
K126	CKAGAVEKGVPLYRH
K126	CKAGAVEKGVPLYRH
Y131	VEKGVPLYRHIADLA
Y189	MRIGAEVYHNLKNVI
K193	AEVYHNLKNVIKEKY
K193	AEVYHNLKNVIKEKY
K197	HNLKNVIKEKYGKDA
K197	HNLKNVIKEKYGKDA
K199	LKNVIKEKYGKDATN
K202	VIKEKYGKDATNVGD
K202	VIKEKYGKDATNVGD
K221	APNILENKEALELLK
K221	APNILENKEALELLK
K228	KEALELLKSAIAKAG
K228	KEALELLKSAIAKAG
K233	LLKSAIAKAGYTDQV
K233	LLKSAIAKAGYTDQV
Y236	SAIAKAGYTDQVVIG
T237	AIAKAGYTDQVVIGM
Q239	AKAGYTDQVVIGMDV
A254	AASEFYRAGKYDLDF
K256	SEFYRAGKYDLDFKS
K256	SEFYRAGKYDLDFKS
Y257	EFYRAGKYDLDFKSP
K262	GKYDLDFKSPDDASR
K262	GKYDLDFKSPDDASR
S263	KYDLDFKSPDDASRY
S268	FKSPDDASRYITPDQ
Y270	SPDDASRYITPDQLA
T272	DDASRYITPDQLADL
Y280	PDQLADLYKSFIKDY
K281	DQLADLYKSFIKDYP
K281	DQLADLYKSFIKDYP
S282	QLADLYKSFIKDYPV
K285	DLYKSFIKDYPVVSI
K285	DLYKSFIKDYPVVSI
Y287	YKSFIKDYPVVSIED
S291	IKDYPVVSIEDPFDQ
K306	DDWDAWQKFTATAGI
T310	AWQKFTATAGIQVVG
K326	DLTVTNPKRIAKAAG
K326	DLTVTNPKRIAKAAG
K330	TNPKRIAKAAGEKSC
K330	TNPKRIAKAAGEKSC
G333	KRIAKAAGEKSCNCL
K335	IAKAAGEKSCNCLLL
K335	IAKAAGEKSCNCLLL
S336	AKAAGEKSCNCLLLK
K343	SCNCLLLKVNQIGSV
K343	SCNCLLLKVNQIGSV
S349	LKVNQIGSVTESLQA
K358	TESLQACKLAQSNGW
S362	QACKLAQSNGWGVMV
S370	NGWGVMVSHRSGETE
K394	GLCTGQIKTGAPCRS
K406	CRSERLAKYNQILRI
K406	CRSERLAKYNQILRI
S419-p	RIEEELGsKAKFAGR
K420	IEEELGsKAKFAGRS
K420	IEEELGsKAKFAGRS
K422	EELGsKAKFAGRSFR
R426	sKAKFAGRSFRNPLA
S427	KAKFAGRSFRNPLAK
K434	SFRNPLAK_______

	chicken
K5	___MSILKIHAREIF
K5	___MSILKIHAREIF
S14	HAREIFDSRGNPTVE
Y25	PTVEVDLYTNKGLFR
T26	TVEVDLYTNKGLFRA
N27	VEVDLYTNKGLFRAA
K28	EVDLYTNKGLFRAAV
K28	EVDLYTNKGLFRAAV
S37	LFRAAVPSGASTGIy
S40	AAVPSGASTGIyEAL
T41	AVPSGASTGIyEALE
Y44-p	SGASTGIyEALELRD
K54	LELRDNDKTRYLGKG
T55	ELRDNDKTRYLGKGV
Y57	RDNDKTRYLGKGVSK
K60	DKTRYLGKGVSKAVE
K60	DKTRYLGKGVSKAVE
K64	YLGKGVSKAVEHVNK
K64	YLGKGVSKAVEHVNK
K71	KAVEHVNKTIAPALI
K71	KAVEHVNKTIAPALI
S79	TIAPALISKNVNVVE
K80	IAPALISKNVNVVEQ
K80	IAPALISKNVNVVEQ
N81	APALISKNVNVVEQE
N81	APALISKNVNVVEQE
K89	VNVVEQEKIDKLMLE
K89	VNVVEQEKIDKLMLE
K92	VEQEKIDKLMLEMDG
K92	VEQEKIDKLMLEMDG
T100	LMLEMDGTENKSKFG
K103	EMDGTENKSKFGANA
K103	EMDGTENKSKFGANA
K105	DGTENKSKFGANAIL
K105	DGTENKSKFGANAIL
K120	GVSLAVCKAGAAEKG
K126	CKAGAAEKGVPLYRH
K126	CKAGAAEKGVPLYRH
Y131	AEKGVPLYRHIADLA
Y189	MRIGAEVYHNLKNVI
K193	AEVYHNLKNVIKEKY
K193	AEVYHNLKNVIKEKY
K197	HNLKNVIKEKYGKDA
K197	HNLKNVIKEKYGKDA
K199	LKNVIKEKYGKDATN
K202	VIKEKYGKDATNVGD
K202	VIKEKYGKDATNVGD
K221	APNILENKEALELLK
K221	APNILENKEALELLK
K228	KEALELLKTAIGKAG
K228	KEALELLKTAIGKAG
K233	LLKTAIGKAGYSDKV
K233	LLKTAIGKAGYSDKV
Y236	TAIGKAGYSDKVVIG
S237	AIGKAGYSDKVVIGM
K239	GKAGYSDKVVIGMDV
D254	AASEFYRDGKYDLDF
K256	SEFYRDGKYDLDFKS
K256	SEFYRDGKYDLDFKS
Y257	EFYRDGKYDLDFKSP
K262	GKYDLDFKSPDDPSR
K262	GKYDLDFKSPDDPSR
S263	KYDLDFKSPDDPSRY
S268	FKSPDDPSRYISPDQ
Y270	SPDDPSRYISPDQLA
S272	DDPSRYISPDQLADL
Y280	PDQLADLYLGFVKNY
L281	DQLADLYLGFVKNYP
L281	DQLADLYLGFVKNYP
G282	QLADLYLGFVKNYPV
K285	DLYLGFVKNYPVVSI
K285	DLYLGFVKNYPVVSI
Y287	YLGFVKNYPVVSIED
S291	VKNYPVVSIEDPFDQ
K306	DDWAAWKKFTASVGI
S310	AWKKFTASVGIQVVG
K326	DLTVTNPKRIAKAVE
K326	DLTVTNPKRIAKAVE
K330	TNPKRIAKAVEEKSC
K330	TNPKRIAKAVEEKSC
E333	KRIAKAVEEKSCNCL
K335	IAKAVEEKSCNCLLL
K335	IAKAVEEKSCNCLLL
S336	AKAVEEKSCNCLLLK
K343	SCNCLLLKVNQIGSV
K343	SCNCLLLKVNQIGSV
S349	LKVNQIGSVTESLQA
K358	TESLQACKLAQSNGW
S362	QACKLAQSNGWGVMV
S370	NGWGVMVSHRSGETE
K394	GLCTGQIKTGAPCRS
K406	CRSERLAKYNQLLRI
K406	CRSERLAKYNQLLRI
S419	RIEEELGSKARFAGR
K420	IEEELGSKARFAGRN
K420	IEEELGSKARFAGRN
R422	EELGSKARFAGRNFR
R426	SKARFAGRNFRNPRI
N427	KARFAGRNFRNPRIN
N434	NFRNPRIN_______

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