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CD3E (human)

Overview CD3E a T cell surface glycoprotein that is a component of the T cell antigen receptor. The recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Contains 1 immunoglobulin-like domain and 1 ITAM domain. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Receptor, misc. Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; immunological synapse; alpha-beta T cell receptor complex; external side of plasma membrane Molecular Function: transmembrane receptor activity; receptor signaling complex scaffold activity; protein heterodimerization activity; receptor signaling protein activity; T cell receptor binding; SH3 domain binding; protein kinase binding Biological Process: regulation of immune response; T cell activation; positive regulation of interleukin-2 biosynthetic process; signal complex assembly; positive regulation of calcium-mediated signaling; negative thymic T cell selection; T cell receptor signaling pathway; positive regulation of interleukin-4 production; regulation of apoptosis; G-protein coupled receptor protein signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; negative regulation of smoothened signaling pathway; T cell costimulation; positive regulation of T cell proliferation; positive regulation of alpha-beta T cell proliferation; protein complex assembly; positive regulation of T cell anergy; response to nutrient; transmembrane receptor protein tyrosine kinase signaling pathway Reference #:  P07766 (UniProtKB) Alt. Names/Synonyms: CD3-epsilon; CD3E; CD3E antigen, epsilon polypeptide; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); FLJ18683; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3E; TCRE Gene Symbols: CD3E Molecular weight: 23,147 Da Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states CST Pathways:  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CD3E 1A81 - B/D/F/H/J/L=186-203 (human) 1SY6 - A=21-118 (human) 1XIW - A/E=23-126 (human) 2JXB - A=177-188 (human) 2ROL - B=181-192 (human) 1JBJ - A=- (mouse) 1XMW - A=22-100 (mouse) 2K4F - A=134-189 (mouse) 3R08 - E=22-100 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A81 1SY6 1XIW 2JXB 2ROL  |  Phospho3D  |  DISEASE 186830 608971  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: Y188‑p phosphorylation: Y188‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S77-p	EDDKNIGsDEDHLsL
0	1		S83-p	GsDEDHLsLKEFSEL
0	3		K177-u	GRQRGQNkERPPPVP
4	404		Y188-p	PPVPNPDyEPIRKGQ
4	424		Y199-p	RKGQRDLysGLNQRR
0	18		S200-p	KGQRDLysGLNQRRI

	mouse
-	gap
V68	QKHDKHLVLQDFSEV
K159-u	SRPRGQNkERPPPVP
Y170-p	PPVPNPDyEPIRKGQ
Y181-p	RKGQRDLySGLNQRA
S182	KGQRDLySGLNQRAV

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